Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ATP-dependent RNA helicase DDX39A

Gene

Ddx39a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi88 – 95ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase
Biological processmRNA processing, mRNA splicing
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-109688 Cleavage of Growing Transcript in the Termination Region
R-MMU-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-MMU-72187 mRNA 3'-end processing

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX39A (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 39
Gene namesi
Name:Ddx39a
Synonyms:Ddx39
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1915528 Ddx39

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000550682 – 427ATP-dependent RNA helicase DDX39AAdd BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei35N6-acetyllysine; alternateBy similarity1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei37PhosphoserineBy similarity1
Cross-linki154Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki162Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei171PhosphothreonineBy similarity1
Cross-linki240Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki255Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei426PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8VDW0
PaxDbiQ8VDW0
PeptideAtlasiQ8VDW0
PRIDEiQ8VDW0
TopDownProteomicsiQ8VDW0-1 [Q8VDW0-1]

PTM databases

iPTMnetiQ8VDW0
PhosphoSitePlusiQ8VDW0
SwissPalmiQ8VDW0

Expressioni

Gene expression databases

BgeeiENSMUSG00000005481
CleanExiMM_DDX39
ExpressionAtlasiQ8VDW0 baseline and differential
GenevisibleiQ8VDW0 MM

Interactioni

Subunit structurei

Binds ALYREF/THOC4 and DDX39B/BAT1. Interacts with SARNP (By similarity). Interacts with MX1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212781, 2 interactors
IntActiQ8VDW0, 1 interactor
MINTiQ8VDW0
STRINGi10090.ENSMUSP00000019576

Structurei

3D structure databases

ProteinModelPortaliQ8VDW0
SMRiQ8VDW0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 248Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST174
Domaini260 – 421Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi44 – 72Q motifAdd BLAST29
Motifi195 – 198DECD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0329 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00830000128348
HOVERGENiHBG107334
InParanoidiQ8VDW0
KOiK13182
OMAiVCADEAP
OrthoDBiEOG091G0H5W
PhylomeDBiQ8VDW0
TreeFamiTF300442

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VDW0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQDVENEL LDYDEDEEPQ APQESTPAPP KKDVKGSYVS IHSSGFRDFL
60 70 80 90 100
LKPELLRAIV DCGFEHPSEV QHECIPQAIL GMDVLCQAKS GMGKTAVFVL
110 120 130 140 150
ATLQQIEPVN GQVSVLVMCH TRELAFQISK EYERFSKYMP SVKVSVFFGG
160 170 180 190 200
LSIKKDEDVL KKNCPHVVVG TPGRILALVR SRSLNLRNVK HFVLDECDKM
210 220 230 240 250
LEQLDMRRDV QEIFRLTPHE KQCMMFSATL SKEIRPVCRK FMQDPMEVFV
260 270 280 290 300
DDETKLTLHG LQQYYVKLKD SEKNRKLFDL LDVLEFNQVV IFVKSVQRCM
310 320 330 340 350
ALAQLLVEQN FPAIAIHRGM AQEERLSRYQ QFKDFQRRIL VATNLFGRGM
360 370 380 390 400
DIERVNIVFN YDMPEDSDTY LHRVARAGRF GTKGLAVTFV SDENDAKILN
410 420
DVQDRFEVNV AELPEEIDIS TYIEQSR
Length:427
Mass (Da):49,067
Last modified:March 1, 2002 - v1
Checksum:i4A94699142FCABA8
GO
Isoform 2 (identifier: Q8VDW0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Note: No experimental confirmation available.
Show »
Length:182
Mass (Da):21,244
Checksum:i8720C875760F3E5F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0130641 – 245Missing in isoform 2. 1 PublicationAdd BLAST245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088894 mRNA Translation: BAC40637.1
AK145927 mRNA Translation: BAE26758.1
AK146294 mRNA Translation: BAE27051.1
AK150997 mRNA Translation: BAE30021.1
AK162752 mRNA Translation: BAE37049.1
AK168079 mRNA Translation: BAE40052.1
BC020134 mRNA Translation: AAH20134.1
CCDSiCCDS22460.1 [Q8VDW0-1]
RefSeqiNP_932099.2, NM_197982.3 [Q8VDW0-1]
XP_006531395.1, XM_006531332.3 [Q8VDW0-1]
UniGeneiMm.28222

Genome annotation databases

EnsembliENSMUST00000019576; ENSMUSP00000019576; ENSMUSG00000005481 [Q8VDW0-1]
ENSMUST00000109810; ENSMUSP00000105435; ENSMUSG00000005481 [Q8VDW0-1]
ENSMUST00000172396; ENSMUSP00000132222; ENSMUSG00000005481 [Q8VDW0-1]
ENSMUST00000212949; ENSMUSP00000148329; ENSMUSG00000005481 [Q8VDW0-1]
GeneIDi68278
KEGGimmu:68278
UCSCiuc009mla.2 mouse [Q8VDW0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDX39A_MOUSE
AccessioniPrimary (citable) accession number: Q8VDW0
Secondary accession number(s): Q3UJV4, Q8C2C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health