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Protein

MIT domain-containing protein 1

Gene

Mitd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
MIT domain-containing protein 1
Gene namesi
Name:Mitd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1916278. Mitd1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002604961 – 249MIT domain-containing protein 1Add BLAST249

Proteomic databases

EPDiQ8VDV8.
MaxQBiQ8VDV8.
PaxDbiQ8VDV8.
PeptideAtlasiQ8VDV8.
PRIDEiQ8VDV8.

PTM databases

iPTMnetiQ8VDV8.
PhosphoSitePlusiQ8VDV8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026088.
GenevisibleiQ8VDV8. MM.

Interactioni

Subunit structurei

Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VDV8. 1 interactor.
MINTiMINT-1640137.
STRINGi10090.ENSMUSP00000027257.

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 27Combined sources17
Helixi31 – 50Combined sources20
Helixi55 – 85Combined sources31

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFDNMR-A8-87[»]
ProteinModelPortaliQ8VDV8.
SMRiQ8VDV8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VDV8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86MITAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 231Important for association with membranesBy similarityAdd BLAST64

Domaini

The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.By similarity
The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex.By similarity

Sequence similaritiesi

Contains 1 MIT domain.Curated

Phylogenomic databases

eggNOGiKOG4509. Eukaryota.
ENOG410XQAH. LUCA.
GeneTreeiENSGT00390000010868.
HOGENOMiHOG000006736.
HOVERGENiHBG056049.
InParanoidiQ8VDV8.
OMAiNYQYQNL.
OrthoDBiEOG091G0LZH.
PhylomeDBiQ8VDV8.
TreeFamiTF313066.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR007330. MIT.
IPR032341. MIT_C.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF16565. MIT_C. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VDV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSSLGQDS DSTAAVAVLK RAVELDAESR YQQALVCYQE GIDMLLQVLK
60 70 80 90 100
GTKESSKRCV LRTKISGYMD RAENIKKYLD QEKEDGKYHK QIKIEENATG
110 120 130 140 150
FSYESLFREY LHETVTEVWI EDPYIRQTHQ LYNFLRFCEM LIKKPCKVRT
160 170 180 190 200
IHLLTSGYEG LGNTQQSSGL EEIKQSLGSH GVVLEINYSS SIHDREIRFN
210 220 230 240
NGWMIKIGRG LDYFKKPQGR FSLGYYDLDL RPCHETTVDI FHNKHTKKI
Length:249
Mass (Da):28,847
Last modified:March 1, 2002 - v1
Checksum:i90E909D461728B61
GO

Sequence cautioni

The sequence BAB23964 differs from that shown. Reason: Frameshift at position 244.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210G → A in BAB23964 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005342 mRNA. Translation: BAB23964.1. Frameshift.
AK171903 mRNA. Translation: BAE42727.1.
BC020137 mRNA. Translation: AAH20137.1.
CCDSiCCDS35542.1.
RefSeqiNP_081189.1. NM_026913.2.
UniGeneiMm.63984.

Genome annotation databases

EnsembliENSMUST00000027257; ENSMUSP00000027257; ENSMUSG00000026088.
ENSMUST00000139725; ENSMUSP00000123009; ENSMUSG00000026088.
GeneIDi69028.
KEGGimmu:69028.
UCSCiuc007asi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005342 mRNA. Translation: BAB23964.1. Frameshift.
AK171903 mRNA. Translation: BAE42727.1.
BC020137 mRNA. Translation: AAH20137.1.
CCDSiCCDS35542.1.
RefSeqiNP_081189.1. NM_026913.2.
UniGeneiMm.63984.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFDNMR-A8-87[»]
ProteinModelPortaliQ8VDV8.
SMRiQ8VDV8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VDV8. 1 interactor.
MINTiMINT-1640137.
STRINGi10090.ENSMUSP00000027257.

PTM databases

iPTMnetiQ8VDV8.
PhosphoSitePlusiQ8VDV8.

Proteomic databases

EPDiQ8VDV8.
MaxQBiQ8VDV8.
PaxDbiQ8VDV8.
PeptideAtlasiQ8VDV8.
PRIDEiQ8VDV8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027257; ENSMUSP00000027257; ENSMUSG00000026088.
ENSMUST00000139725; ENSMUSP00000123009; ENSMUSG00000026088.
GeneIDi69028.
KEGGimmu:69028.
UCSCiuc007asi.1. mouse.

Organism-specific databases

CTDi129531.
MGIiMGI:1916278. Mitd1.

Phylogenomic databases

eggNOGiKOG4509. Eukaryota.
ENOG410XQAH. LUCA.
GeneTreeiENSGT00390000010868.
HOGENOMiHOG000006736.
HOVERGENiHBG056049.
InParanoidiQ8VDV8.
OMAiNYQYQNL.
OrthoDBiEOG091G0LZH.
PhylomeDBiQ8VDV8.
TreeFamiTF313066.

Miscellaneous databases

EvolutionaryTraceiQ8VDV8.
PROiQ8VDV8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026088.
GenevisibleiQ8VDV8. MM.

Family and domain databases

Gene3Di1.20.58.280. 1 hit.
InterProiIPR007330. MIT.
IPR032341. MIT_C.
[Graphical view]
PfamiPF04212. MIT. 1 hit.
PF16565. MIT_C. 1 hit.
[Graphical view]
SMARTiSM00745. MIT. 1 hit.
[Graphical view]
SUPFAMiSSF116846. SSF116846. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMITD1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDV8
Secondary accession number(s): Q9DB13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.