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Protein

MIT domain-containing protein 1

Gene

Mitd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Cell division, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
MIT domain-containing protein 1
Gene namesi
Name:Mitd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1916278 Mitd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002604961 – 249MIT domain-containing protein 1Add BLAST249

Proteomic databases

EPDiQ8VDV8
MaxQBiQ8VDV8
PaxDbiQ8VDV8
PeptideAtlasiQ8VDV8
PRIDEiQ8VDV8

PTM databases

iPTMnetiQ8VDV8
PhosphoSitePlusiQ8VDV8

Expressioni

Gene expression databases

BgeeiENSMUSG00000026088
GenevisibleiQ8VDV8 MM

Interactioni

Subunit structurei

Homodimer. Interacts (via MIT domain) with CHMP1A, CHMP1B, CHMP2A and IST1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi213179, 1 interactor
IntActiQ8VDV8, 1 interactor
STRINGi10090.ENSMUSP00000027257

Structurei

Secondary structure

1249
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 27Combined sources17
Helixi31 – 50Combined sources20
Helixi55 – 85Combined sources31

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WFDNMR-A8-87[»]
ProteinModelPortaliQ8VDV8
SMRiQ8VDV8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VDV8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 86MITAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni168 – 231Important for association with membranesBy similarityAdd BLAST64

Domaini

The C-terminal domain interacts with lipid membranes containing acidic phosphoinositides and is required for location at the midbody.By similarity
The MIT domain interacts with the MIT-interacting motifs of several components of the ESCRT-III complex.By similarity

Phylogenomic databases

eggNOGiKOG4509 Eukaryota
ENOG410XQAH LUCA
GeneTreeiENSGT00390000010868
HOGENOMiHOG000006736
HOVERGENiHBG056049
InParanoidiQ8VDV8
OMAiVECDQNA
OrthoDBiEOG091G0LZH
PhylomeDBiQ8VDV8
TreeFamiTF313066

Family and domain databases

Gene3Di3.30.870.30, 1 hit
InterProiView protein in InterPro
IPR007330 MIT
IPR032341 MIT_C
IPR038113 MIT_C_sf
IPR036181 MIT_dom_sf
PfamiView protein in Pfam
PF04212 MIT, 1 hit
PF16565 MIT_C, 1 hit
SMARTiView protein in SMART
SM00745 MIT, 1 hit
SUPFAMiSSF116846 SSF116846, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VDV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSSLGQDS DSTAAVAVLK RAVELDAESR YQQALVCYQE GIDMLLQVLK
60 70 80 90 100
GTKESSKRCV LRTKISGYMD RAENIKKYLD QEKEDGKYHK QIKIEENATG
110 120 130 140 150
FSYESLFREY LHETVTEVWI EDPYIRQTHQ LYNFLRFCEM LIKKPCKVRT
160 170 180 190 200
IHLLTSGYEG LGNTQQSSGL EEIKQSLGSH GVVLEINYSS SIHDREIRFN
210 220 230 240
NGWMIKIGRG LDYFKKPQGR FSLGYYDLDL RPCHETTVDI FHNKHTKKI
Length:249
Mass (Da):28,847
Last modified:March 1, 2002 - v1
Checksum:i90E909D461728B61
GO

Sequence cautioni

The sequence BAB23964 differs from that shown. Reason: Frameshift at position 244.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210G → A in BAB23964 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005342 mRNA Translation: BAB23964.1 Frameshift.
AK171903 mRNA Translation: BAE42727.1
BC020137 mRNA Translation: AAH20137.1
CCDSiCCDS35542.1
RefSeqiNP_081189.1, NM_026913.2
UniGeneiMm.63984

Genome annotation databases

EnsembliENSMUST00000027257; ENSMUSP00000027257; ENSMUSG00000026088
ENSMUST00000139725; ENSMUSP00000123009; ENSMUSG00000026088
GeneIDi69028
KEGGimmu:69028
UCSCiuc007asi.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMITD1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDV8
Secondary accession number(s): Q9DB13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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