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Protein

Integrin beta-like protein 1

Gene

Itgbl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-like protein 1
Gene namesi
Name:Itgbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2443439. Itgbl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000032302324 – 494Integrin beta-like protein 1Add BLAST471

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi405N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDV0.
PRIDEiQ8VDV0.

PTM databases

PhosphoSitePlusiQ8VDV0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032925.
CleanExiMM_ITGBL1.
ExpressionAtlasiQ8VDV0. baseline and differential.
GenevisibleiQ8VDV0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059019.

Structurei

3D structure databases

ProteinModelPortaliQ8VDV0.
SMRiQ8VDV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 95IAdd BLAST45
Repeati96 – 142IIAdd BLAST47
Repeati143 – 184IIIAdd BLAST42
Repeati185 – 230IVAdd BLAST46
Repeati231 – 275VAdd BLAST45
Repeati276 – 326VIAdd BLAST51
Repeati327 – 367VIIAdd BLAST41
Repeati368 – 414VIIIAdd BLAST47
Repeati415 – 454IXAdd BLAST40
Repeati455 – 494XAdd BLAST40

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni51 – 494Cysteine-rich tandem repeatsAdd BLAST444

Domaini

Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiQ8VDV0.
OMAiLCQHPRK.
OrthoDBiEOG091G05SQ.
PhylomeDBiQ8VDV0.
TreeFamiTF332636.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VDV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPPGFRNFL LLVSSLLFIG LSAAPQSFLP SLRSLSGAPC RLSRAESERR
60 70 80 90 100
CRAPGQPPGS ALCHDRGRCE CGVCICHVTE PGTYFGPLCE CHEWICETYD
110 120 130 140 150
GKTCAGHGNC DCGKCKCDVG WSGEACQYPT KCDLTKKISN QMCKNSQDVI
160 170 180 190 200
CSNAGTCHCG RCKCDNSDGH GLIYGKFCEC DDRECIDDET EEVCGGHGKC
210 220 230 240 250
YCGNCYCEAG WHGDKCEFQC DITPWESKRR CTSPDGKVCS NRGTCVCGEC
260 270 280 290 300
SCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
310 320 330 340 350
CRAGWYGKKC EHPRNCPLSA EESTKKCQGS SDLPCSGRGR CECGRCTCYP
360 370 380 390 400
PGDSRVYGKT CECDDRRCED LDGVVCGGHG MCSCGRCVCE KGWFGKLCQH
410 420 430 440 450
LRKCNMTEEQ SRSLCESADG TLCSGKGSCH CGKCICSGEE WYISGEFCDC
460 470 480 490
DDRDCDKHDG LICTGNGICS CGNCECWDGW NGNACEIWLG TEYP
Length:494
Mass (Da):53,978
Last modified:March 18, 2008 - v2
Checksum:i6192CDC83E7F9005
GO
Isoform 2 (identifier: Q8VDV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-210: HGKCYCGNCYCEAG → QGKGHIGCLICIII
     211-494: Missing.

Show »
Length:210
Mass (Da):22,689
Checksum:i9432859786AB8A22
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95I → V in AAH20152 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032005197 – 210HGKCY…YCEAG → QGKGHIGCLICIII in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_032006211 – 494Missing in isoform 2. 1 PublicationAdd BLAST284

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029068 mRNA. Translation: BAC26275.1.
AK051773 mRNA. Translation: BAC34761.1.
CT033773
, AC154590, AC160988, AC161001 Genomic DNA. Translation: CAP19194.1.
BC020152 mRNA. Translation: AAH20152.1.
CCDSiCCDS27354.1. [Q8VDV0-1]
RefSeqiNP_663442.2. NM_145467.2. [Q8VDV0-1]
UniGeneiMm.383176.

Genome annotation databases

EnsembliENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925. [Q8VDV0-1]
ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925. [Q8VDV0-2]
GeneIDi223272.
KEGGimmu:223272.
UCSCiuc007vbu.2. mouse. [Q8VDV0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029068 mRNA. Translation: BAC26275.1.
AK051773 mRNA. Translation: BAC34761.1.
CT033773
, AC154590, AC160988, AC161001 Genomic DNA. Translation: CAP19194.1.
BC020152 mRNA. Translation: AAH20152.1.
CCDSiCCDS27354.1. [Q8VDV0-1]
RefSeqiNP_663442.2. NM_145467.2. [Q8VDV0-1]
UniGeneiMm.383176.

3D structure databases

ProteinModelPortaliQ8VDV0.
SMRiQ8VDV0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059019.

PTM databases

PhosphoSitePlusiQ8VDV0.

Proteomic databases

PaxDbiQ8VDV0.
PRIDEiQ8VDV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925. [Q8VDV0-1]
ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925. [Q8VDV0-2]
GeneIDi223272.
KEGGimmu:223272.
UCSCiuc007vbu.2. mouse. [Q8VDV0-1]

Organism-specific databases

CTDi9358.
MGIiMGI:2443439. Itgbl1.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiQ8VDV0.
OMAiLCQHPRK.
OrthoDBiEOG091G05SQ.
PhylomeDBiQ8VDV0.
TreeFamiTF332636.

Miscellaneous databases

PROiQ8VDV0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032925.
CleanExiMM_ITGBL1.
ExpressionAtlasiQ8VDV0. baseline and differential.
GenevisibleiQ8VDV0. MM.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiITGBL_MOUSE
AccessioniPrimary (citable) accession number: Q8VDV0
Secondary accession number(s): Q8BKJ4, Q8BMS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.