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Protein

Integrin beta-like protein 1

Gene

Itgbl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta-like protein 1
Gene namesi
Name:Itgbl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2443439. Itgbl1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 494471Integrin beta-like protein 1PRO_0000323023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi405 – 4051N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDV0.
PRIDEiQ8VDV0.

Expressioni

Gene expression databases

BgeeiQ8VDV0.
CleanExiMM_ITGBL1.
ExpressionAtlasiQ8VDV0. baseline and differential.
GenevisibleiQ8VDV0. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059019.

Structurei

3D structure databases

ProteinModelPortaliQ8VDV0.
SMRiQ8VDV0. Positions 37-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 9545IAdd
BLAST
Repeati96 – 14247IIAdd
BLAST
Repeati143 – 18442IIIAdd
BLAST
Repeati185 – 23046IVAdd
BLAST
Repeati231 – 27545VAdd
BLAST
Repeati276 – 32651VIAdd
BLAST
Repeati327 – 36741VIIAdd
BLAST
Repeati368 – 41447VIIIAdd
BLAST
Repeati415 – 45440IXAdd
BLAST
Repeati455 – 49440XAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni51 – 494444Cysteine-rich tandem repeatsAdd
BLAST

Domaini

Contains ten tandem EGF-like repeats strikingly similar to those found in the cysteine rich 'stalk-like' structure of integrin beta-subunits.

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiQ8VDV0.
OMAiLCQHPRK.
OrthoDBiEOG7ZWD1H.
PhylomeDBiQ8VDV0.
TreeFamiTF332636.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VDV0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHPPGFRNFL LLVSSLLFIG LSAAPQSFLP SLRSLSGAPC RLSRAESERR
60 70 80 90 100
CRAPGQPPGS ALCHDRGRCE CGVCICHVTE PGTYFGPLCE CHEWICETYD
110 120 130 140 150
GKTCAGHGNC DCGKCKCDVG WSGEACQYPT KCDLTKKISN QMCKNSQDVI
160 170 180 190 200
CSNAGTCHCG RCKCDNSDGH GLIYGKFCEC DDRECIDDET EEVCGGHGKC
210 220 230 240 250
YCGNCYCEAG WHGDKCEFQC DITPWESKRR CTSPDGKVCS NRGTCVCGEC
260 270 280 290 300
SCHDVDPTGD WGDIHGDTCE CDERDCRAVY DRYSDDFCSG HGQCNCGRCD
310 320 330 340 350
CRAGWYGKKC EHPRNCPLSA EESTKKCQGS SDLPCSGRGR CECGRCTCYP
360 370 380 390 400
PGDSRVYGKT CECDDRRCED LDGVVCGGHG MCSCGRCVCE KGWFGKLCQH
410 420 430 440 450
LRKCNMTEEQ SRSLCESADG TLCSGKGSCH CGKCICSGEE WYISGEFCDC
460 470 480 490
DDRDCDKHDG LICTGNGICS CGNCECWDGW NGNACEIWLG TEYP
Length:494
Mass (Da):53,978
Last modified:March 18, 2008 - v2
Checksum:i6192CDC83E7F9005
GO
Isoform 2 (identifier: Q8VDV0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     197-210: HGKCYCGNCYCEAG → QGKGHIGCLICIII
     211-494: Missing.

Show »
Length:210
Mass (Da):22,689
Checksum:i9432859786AB8A22
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951I → V in AAH20152 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei197 – 21014HGKCY…YCEAG → QGKGHIGCLICIII in isoform 2. 1 PublicationVSP_032005Add
BLAST
Alternative sequencei211 – 494284Missing in isoform 2. 1 PublicationVSP_032006Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029068 mRNA. Translation: BAC26275.1.
AK051773 mRNA. Translation: BAC34761.1.
CT033773
, AC154590, AC160988, AC161001 Genomic DNA. Translation: CAP19194.1.
BC020152 mRNA. Translation: AAH20152.1.
CCDSiCCDS27354.1. [Q8VDV0-1]
RefSeqiNP_663442.2. NM_145467.2. [Q8VDV0-1]
UniGeneiMm.383176.

Genome annotation databases

EnsembliENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925. [Q8VDV0-1]
ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925. [Q8VDV0-2]
GeneIDi223272.
KEGGimmu:223272.
UCSCiuc007vbu.2. mouse. [Q8VDV0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029068 mRNA. Translation: BAC26275.1.
AK051773 mRNA. Translation: BAC34761.1.
CT033773
, AC154590, AC160988, AC161001 Genomic DNA. Translation: CAP19194.1.
BC020152 mRNA. Translation: AAH20152.1.
CCDSiCCDS27354.1. [Q8VDV0-1]
RefSeqiNP_663442.2. NM_145467.2. [Q8VDV0-1]
UniGeneiMm.383176.

3D structure databases

ProteinModelPortaliQ8VDV0.
SMRiQ8VDV0. Positions 37-486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000059019.

Proteomic databases

PaxDbiQ8VDV0.
PRIDEiQ8VDV0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049681; ENSMUSP00000059019; ENSMUSG00000032925. [Q8VDV0-1]
ENSMUST00000142161; ENSMUSP00000121659; ENSMUSG00000032925. [Q8VDV0-2]
GeneIDi223272.
KEGGimmu:223272.
UCSCiuc007vbu.2. mouse. [Q8VDV0-1]

Organism-specific databases

CTDi9358.
MGIiMGI:2443439. Itgbl1.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000113115.
HOVERGENiHBG052797.
InParanoidiQ8VDV0.
OMAiLCQHPRK.
OrthoDBiEOG7ZWD1H.
PhylomeDBiQ8VDV0.
TreeFamiTF332636.

Miscellaneous databases

PROiQ8VDV0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VDV0.
CleanExiMM_ITGBL1.
ExpressionAtlasiQ8VDV0. baseline and differential.
GenevisibleiQ8VDV0. MM.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR027070. Integrin_b-like_p1.
IPR015812. Integrin_bsu.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PTHR10082:SF3. PTHR10082:SF3. 1 hit.
PfamiPF07974. EGF_2. 3 hits.
[Graphical view]
SMARTiSM00181. EGF. 6 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 5 hits.
PS00243. INTEGRIN_BETA. 9 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Skin and Spinal ganglion.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiITGBL_MOUSE
AccessioniPrimary (citable) accession number: Q8VDV0
Secondary accession number(s): Q8BKJ4, Q8BMS0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: June 8, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.