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Protein

SNF-related serine/threonine-protein kinase

Gene

Snrk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

Activated by phosphorylation on Thr-173.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451ATPPROSITE-ProRule annotationBy similarity
Active sitei139 – 1391Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi22 – 309ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SNF-related serine/threonine-protein kinase (EC:2.7.11.1)
Alternative name(s):
SNF1-related kinase
Gene namesi
Name:SnrkImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:108104. Snrk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748SNF-related serine/threonine-protein kinaseCuratedPRO_0000225606Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei162 – 1621PhosphoserineCombined sources
Modified residuei173 – 1731Phosphothreonine; by LKB1By similarity
Modified residuei362 – 3621PhosphoserineCombined sources
Modified residuei390 – 3901PhosphoserineBy similarity
Modified residuei482 – 4821PhosphoserineCombined sources
Modified residuei495 – 4951PhosphoserineBy similarity
Modified residuei518 – 5181PhosphoserineBy similarity

Post-translational modificationi

Autophosphorylated. Phosphorylation on Thr-173 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8VDU5.
MaxQBiQ8VDU5.
PaxDbiQ8VDU5.
PRIDEiQ8VDU5.

PTM databases

iPTMnetiQ8VDU5.
PhosphoSiteiQ8VDU5.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined.1 Publication

Developmental stagei

Expressed from day 8 dpc along the epithelium of the differentiating neural tube. Expression persists along the dorsal axis until 12.5 dpc, but becomes progressively restricted to the more caudal part of the neural tube with much stronger intensity in the caudal neuropore. Also observed in the endoderm of the primitive gut between 8.5 and 11.5 dpc, at 10.5 dpc, in the endocardium and pericardium of the developing heart, and in both the endothelium and blood cells clustered at the ventral part of the dorsal aorta. Later in development (12.5 dpc), expressed in the endocardium and the interventricular septum of the heart.1 Publication

Gene expression databases

BgeeiQ8VDU5.
CleanExiMM_SNRK.
ExpressionAtlasiQ8VDU5. baseline and differential.
GenevisibleiQ8VDU5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112919.

Structurei

3D structure databases

ProteinModelPortaliQ8VDU5.
SMRiQ8VDU5. Positions 14-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 269254Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini291 – 33444UBAPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 UBA domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4717. Eukaryota.
ENOG410XR6N. LUCA.
GeneTreeiENSGT00840000129774.
HOGENOMiHOG000059616.
HOVERGENiHBG093970.
InParanoidiQ8VDU5.
KOiK08802.
OMAiTTSGRKC.
OrthoDBiEOG7CZK55.
PhylomeDBiQ8VDU5.
TreeFamiTF351991.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGFKRGYDG KIAGLYDLDK TLGRGHFAVV KLARHVFTGE KVAVKVIDKT
60 70 80 90 100
KLDTLATGHL FQEVRCMKLV QHPNIVRLYE VIDTQTKLYL ILELGDGGDM
110 120 130 140 150
FDYIMKHEEG LNEDLAKKYF AQIVHAISYC HKLHVVHRDL KPENVVFFEK
160 170 180 190 200
QGLVKLTDFG FSNKFQPGKK LTTSCGSLAY SAPEILLGDE YDAPAVDIWS
210 220 230 240 250
LGVILFMLVC GQPPFQEAND SETLTMIMDC KYTVPPRVSA GCRDLITRML
260 270 280 290 300
QRDPKRRASL EEIESHPWLQ GVDPSPATKY NIPLVSYKNL SEEEHNSIIQ
310 320 330 340 350
RMVLGDIADR DAIVEALETN RYNHITATYF LLAERILREK QEKEIQTRSA
360 370 380 390 400
SPSNIKAQFR QSWPTKIDVP QDLEDDLTAT PLSHATVPQS PARAGDNVLN
410 420 430 440 450
GHRSKGLCDP AKKDELPELA GPALSTVPPA SMKPAASGRK CLFRVEEDEE
460 470 480 490 500
EDEEDKKPVS LSTQVVLRRK PSVTNRLTSR KSAPVLNQIF EEGESDDEFD
510 520 530 540 550
MDENLPPKLS RLKMNIASPG TVHKRYHRRK SQGRGSSCSS SETSDDDSES
560 570 580 590 600
RRRLDKDSGF AYSWHRRDSS EGPPGSEGDG GGQSKPSSGG GVDKASPGEQ
610 620 630 640 650
GTGGGSQGGS GGTPSGTAGS SRRCAGPDSS SPSPASASAA PRGAELVQSL
660 670 680 690 700
KLVSLCLGSQ LHGAKYILDP QKALFSSVKV QEKSTWKMCI SAPGPSPSAD
710 720 730 740
LDPVRTKKLR NNALQLPLCE KTISVNIQRS RKEGLLCASS PASCCHVI
Length:748
Mass (Da):81,913
Last modified:March 1, 2002 - v1
Checksum:i9E3F7EA90136FCDA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51K → R in AAK97440 (PubMed:12234663).Curated
Sequence conflicti112 – 1121N → D in AAK97440 (PubMed:12234663).Curated
Sequence conflicti549 – 5491E → K in AAK97440 (PubMed:12234663).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387809 mRNA. Translation: AAK97440.1.
BC020189 mRNA. Translation: AAH20189.1.
BC094658 mRNA. Translation: AAH94658.1.
CCDSiCCDS23644.1.
RefSeqiNP_001158044.1. NM_001164572.1.
NP_598502.2. NM_133741.2.
XP_006512061.1. XM_006511998.2.
XP_006512062.1. XM_006511999.2.
XP_006512063.1. XM_006512000.2.
XP_006512065.1. XM_006512002.2.
XP_006512066.1. XM_006512003.2.
UniGeneiMm.257989.

Genome annotation databases

EnsembliENSMUST00000118886; ENSMUSP00000114132; ENSMUSG00000038145.
ENSMUST00000120173; ENSMUSP00000112919; ENSMUSG00000038145.
GeneIDi20623.
KEGGimmu:20623.
UCSCiuc009sen.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387809 mRNA. Translation: AAK97440.1.
BC020189 mRNA. Translation: AAH20189.1.
BC094658 mRNA. Translation: AAH94658.1.
CCDSiCCDS23644.1.
RefSeqiNP_001158044.1. NM_001164572.1.
NP_598502.2. NM_133741.2.
XP_006512061.1. XM_006511998.2.
XP_006512062.1. XM_006511999.2.
XP_006512063.1. XM_006512000.2.
XP_006512065.1. XM_006512002.2.
XP_006512066.1. XM_006512003.2.
UniGeneiMm.257989.

3D structure databases

ProteinModelPortaliQ8VDU5.
SMRiQ8VDU5. Positions 14-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000112919.

PTM databases

iPTMnetiQ8VDU5.
PhosphoSiteiQ8VDU5.

Proteomic databases

EPDiQ8VDU5.
MaxQBiQ8VDU5.
PaxDbiQ8VDU5.
PRIDEiQ8VDU5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118886; ENSMUSP00000114132; ENSMUSG00000038145.
ENSMUST00000120173; ENSMUSP00000112919; ENSMUSG00000038145.
GeneIDi20623.
KEGGimmu:20623.
UCSCiuc009sen.2. mouse.

Organism-specific databases

CTDi54861.
MGIiMGI:108104. Snrk.

Phylogenomic databases

eggNOGiKOG4717. Eukaryota.
ENOG410XR6N. LUCA.
GeneTreeiENSGT00840000129774.
HOGENOMiHOG000059616.
HOVERGENiHBG093970.
InParanoidiQ8VDU5.
KOiK08802.
OMAiTTSGRKC.
OrthoDBiEOG7CZK55.
PhylomeDBiQ8VDU5.
TreeFamiTF351991.

Miscellaneous databases

ChiTaRSiSnrk. mouse.
PROiQ8VDU5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VDU5.
CleanExiMM_SNRK.
ExpressionAtlasiQ8VDU5. baseline and differential.
GenevisibleiQ8VDU5. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases."
    Kertesz N., Samson J., Debacker C., Wu H., Labastie M.-C.
    Gene 294:13-24(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: BALB/cJImported.
    Tissue: Yolk sacImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported and FVB/NImported.
    Tissue: BrainImported and Mammary glandImported.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-362 AND SER-482, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney and Lung.

Entry informationi

Entry nameiSNRK_MOUSE
AccessioniPrimary (citable) accession number: Q8VDU5
Secondary accession number(s): Q91WX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.