Unreviewed, UniProtKB/TrEMBL Q8VDU4 (Q8VDU4_MOUSE)

Names and origin

Protein names

Submitted name:
    Vav1 protein EMBL AAH20487.1

Gene names

Name:

Vav1 MGI 98923

Organism

Mus musculus (Mouse) EMBL AAH20487.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	806 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Contains 1 DH (DBL-homology) domain. Contains 1 PH domain. Contains 1 SH2 domain. Contains 2 SH3 domains.

Ontologies

Keywords
Domain	SH3 domain RuleBase RU003338V3
Ligand	Metal-binding Spearmint SPM002219 Zinc Spearmint SPM002219
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro regulation of Rho protein signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8VDU4-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F4368CD13A62D695	FASTA	806	93,869
	10 20 30 40 50 60 MELWRQCTHW LIQCRVLPPS HRVTWEGAQV CELAQALRDG VLLCQLLNNL LPQAINLREV 70 80 90 100 110 120 NLRPQMSQFL CLKNIRTFLS TCCEKFGLKR SELFEAFDLF DVQDFGKVIY TLSALSWTPI 130 140 150 160 170 180 AQNKGIMPFP TEDSALNDED IYSGLSDQID DTAEEDEDLY DCVENEEAEG DEIYEDLMRL 190 200 210 220 230 240 ESVPTPPKMT EYDKRCCCLR EIQQTEEKYT DTLGSIQQHF MKPLQRFLKP QDMETIFVNI 250 260 270 280 290 300 EELFSVHTHF LKELKDALAG PGATTLYQVF IKYKERFLVY GRYCSQVESA SKHLDQVATA 310 320 330 340 350 360 REDVQMKLEE CSQRANNGRF TLRDLLMVPM QRVLKYHLLL QELVKHTQDA TEKENLRLAL 370 380 390 400 410 420 DAMRDLAQCV NEVKRDNETL RQITNFQLSI ENLDQSLANY GRPKIDGELK ITSVERRSKT 430 440 450 460 470 480 DRYAFLLDKA LLICKRRGDS YDLKASVNLH SFQVRDDSSG ERDNKKWSHM FLLIEDQGAQ 490 500 510 520 530 540 GYELFFKTRE LKKKWMEQFE MAISNIYPEN ATANGHDFQM FSFEETTSCK ACQMLLRGTF 550 560 570 580 590 600 YQGYRCYRCR APAHKECLGR VPPCGRHGQD FAGTMKKDKL HRRAQDKKRN ELGLPKMEVF 610 620 630 640 650 660 QEYYGIPPPP GAFGPFLRLN PGDIVELTKA EAEHNWWEGR NTATNEVGWF PCNRVHPYVH 670 680 690 700 710 720 GPPQDLSVHL WYNVEVKHIK IMTSEGLYRI TEKKAFRGLL ELVEFYQQNS LKDCFKSLDT 730 740 750 760 770 780 TLQFPYKEPE RRAISKPPAG STKYFGTAKA RYDFCARDRS ELSLKEGDII KILNKKGQQG 790 800 WWRGEIYGRI GWFPSNYVEE DYSEYC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N EMBL AAH20487.1. Tissue: Mammary tumor. Metallothionien-TGF alpha model. 10 month old virgin mouse. Taken by biopsy. EMBL AAH20487.1.
[2]	"Cloning of mouse full open reading frames in Gateway(R) system entry vector (pDONR201)." Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J., Wiemann S., Schick M., Korn B. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC020487 mRNA. Translation: AAH20487.1. CT010321 mRNA. Translation: CAJ18529.1.
IPI	IPI00762759.
RefSeq	NP_001157288.1.
UniGene	Mm.248172
3D structure databases
HSSP	HSSP built from PDB template 1F5X based on UniProtKB P27870.
SMR	Q8VDU4. Positions 1-135, 190-564, 596-660, 747-801.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VDU4.
Proteomic databases
PRIDE	Q8VDU4.
Genome annotation databases
Ensembl	ENSMUST00000112870; ENSMUSP00000108491; ENSMUSG00000034116; Mus musculus. [Genome view]
GeneID	22324.
UCSC	uc008deq.1. mouse.
Organism-specific databases
CTD	22324.
MGI	MGI:98923. Vav1.
Phylogenomic databases
HOVERGEN	Q8VDU4.
OrthoDB	EOG94N1BJ.
Gene expression databases
ArrayExpress	Q8VDU4.
Bgee	Q8VDU4.
Genevestigator	Q8VDU4.
Family and domain databases
InterPro	IPR016146. Calponin-homology. IPR001715. Calponin_act_bd. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR001849. Pleckstrin_homology. IPR002219. Prot_Kinase_C-like_PE/DAG_bd. IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain. IPR020473. SH3_region. IPR003096. SM22_calponin. [Graphical view]
Gene3D	G3DSA:1.10.418.10. Calponin-homology. 1 hit. G3DSA:1.20.900.10. RhoGEF. 1 hit. G3DSA:3.30.505.10. SH2. 1 hit.
Pfam	PF00130. C1_1. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00018. SH3_1. 1 hit. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00452. SH3DOMAIN. PR00888. SM22CALPONIN.
SMART	SM00109. C1. 1 hit. SM00033. CH. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 2 hits. [Graphical view]
PROSITE	PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 2 hits. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

Q8VDU4_MOUSE

Accession

Primary (citable) accession number: Q8VDU4

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 19, 2010
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)