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Q8VDU0

- GPSM2_MOUSE

UniProt

Q8VDU0 - GPSM2_MOUSE

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Protein

G-protein-signaling modulator 2

Gene

Gpsm2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays an important role in spindle pole orientation By similarity. Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.By similarity

GO - Molecular functioni

  1. GTPase regulator activity Source: InterPro

GO - Biological processi

  1. establishment of mitotic spindle orientation Source: MGI
  2. lung epithelial cell differentiation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein-signaling modulator 2
Alternative name(s):
Pins homolog
Gene namesi
Name:Gpsm2
Synonyms:Lgn, Pins
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1923373. Gpsm2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcell cortex By similarity
Note: Localizes in the cytoplasm in the interphase and at cell periphery in the metaphase.By similarity

GO - Cellular componenti

  1. apical part of cell Source: MGI
  2. cytoplasm Source: UniProtKB-KW
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 679679G-protein-signaling modulator 2PRO_0000106359Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei408 – 4081Phosphoserine1 Publication
Modified residuei484 – 4841PhosphoserineBy similarity
Modified residuei487 – 4871PhosphothreonineBy similarity
Modified residuei540 – 5401PhosphoserineBy similarity
Modified residuei564 – 5641Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VDU0.
PaxDbiQ8VDU0.
PRIDEiQ8VDU0.

PTM databases

PhosphoSiteiQ8VDU0.

Expressioni

Tissue specificityi

Expressed in many tissues, but its expression is enriched in the ventricular zone of the developing central nervous systems.

Gene expression databases

BgeeiQ8VDU0.
ExpressionAtlasiQ8VDU0. baseline and differential.
GenevestigatoriQ8VDU0.

Interactioni

Subunit structurei

Interacts with LLGL2 By similarity. Interacts with INSC/inscuteable and F2RL2.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg1Q626967EBI-7575403,EBI-389325From a different organism.
DLG4P783527EBI-7575403,EBI-80389From a different organism.

Protein-protein interaction databases

BioGridi217976. 1 interaction.
DIPiDIP-60164N.
IntActiQ8VDU0. 3 interactions.
MINTiMINT-4096561.

Structurei

Secondary structure

1
679
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 3615
Helixi40 – 5314
Helixi58 – 7417
Helixi78 – 9518
Helixi98 – 11417
Helixi118 – 13417
Helixi138 – 15720
Beta strandi159 – 1635
Helixi172 – 19524
Helixi198 – 21417
Helixi218 – 23518
Helixi238 – 25417
Helixi258 – 27417
Helixi278 – 29417
Helixi298 – 31417
Helixi318 – 33518
Helixi338 – 35215
Helixi598 – 6014
Turni617 – 6193
Helixi632 – 64615

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RO2X-ray2.30A22-357[»]
3RO3X-ray1.10A198-357[»]
4G2VX-ray2.40A22-357[»]
4G5OX-ray2.90E/F/G/H628-653[»]
4G5QX-ray2.90E/F/G/H628-652[»]
4G5RX-ray3.48E/F/G/Z628-652[»]
4G5SX-ray3.62E/F/G/Z594-618[»]
4JHRX-ray2.80A/B96-357[»]
A/B593-651[»]
ProteinModelPortaliQ8VDU0.
SMRiQ8VDU0. Positions 20-648.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 5734TPR 1Add
BLAST
Repeati62 – 9534TPR 2Add
BLAST
Repeati102 – 13534TPR 3Add
BLAST
Repeati142 – 18443TPR 4Add
BLAST
Repeati202 – 23534TPR 5Add
BLAST
Repeati242 – 27534TPR 6Add
BLAST
Repeati282 – 31534TPR 7Add
BLAST
Repeati322 – 35534TPR 8Add
BLAST
Domaini490 – 51223GoLoco 1PROSITE-ProRule annotationAdd
BLAST
Domaini543 – 56523GoLoco 2PROSITE-ProRule annotationAdd
BLAST
Domaini594 – 61623GoLoco 3PROSITE-ProRule annotationAdd
BLAST
Domaini628 – 65023GoLoco 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the GPSM family.Curated
Contains 4 GoLoco domains.PROSITE-ProRule annotation
Contains 8 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiCOG0457.
GeneTreeiENSGT00530000063126.
HOGENOMiHOG000231543.
HOVERGENiHBG051823.
InParanoidiQ8VDU0.
KOiK15837.
OMAiEYYEANL.
OrthoDBiEOG7WHH8W.
PhylomeDBiQ8VDU0.
TreeFamiTF328344.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR003109. GoLoco_motif.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF02188. GoLoco. 4 hits.
PF00515. TPR_1. 2 hits.
PF13176. TPR_7. 1 hit.
[Graphical view]
SMARTiSM00390. GoLoco. 4 hits.
SM00028. TPR. 6 hits.
[Graphical view]
PROSITEiPS50877. GOLOCO. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDU0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGNLISMRE DHSFHVRYRM EASCLELALE GERLCKSGDC RAGVSFFEAA
60 70 80 90 100
VQVGTEDLKT LSAIYSQLGN AYFYLHDYAK ALEYHHHDLT LARTIGDQLG
110 120 130 140 150
EAKASGNLGN TLKVLGNFDE AIVCCQRHLD ISRELNDKVG EARALYNLGN
160 170 180 190 200
VYHAKGKSFG CPGPQDTGEF PEDVRNALQA AVDLYEENLS LVTALGDRAA
210 220 230 240 250
QGRAFGNLGN THYLLGNFRD AVIAHEQRLL IAKEFGDKAA ERRAYSNLGN
260 270 280 290 300
AYIFLGEFET ASEYYKKTLL LARQLKDRAV EAQSCYSLGN TYTLLQDYEK
310 320 330 340 350
AIDYHLKHLA IAQELKDRIG EGRACWSLGN AYTALGNHDQ AMHFAEKHLE
360 370 380 390 400
ISREVGDKSG ELTARLNLSD LQMVLGLSYS TNNSMMSENI EIDGSLHGAG
410 420 430 440 450
AKLGRRHSME NLELMKLTPE KVPNWNSEIL AKQKPLIAKP SAKLLFVNRL
460 470 480 490 500
KGKKYKSGSA CTKVLQDASN SVDHRAPRSQ KKISSDTIGD EGFFDLLRRF
510 520 530 540 550
QSNRMDDQRC HLQGNCRTTS TAAASATPKL MKAPSVSVVS PNTDEFLDLL
560 570 580 590 600
ASSQSRRLDD QRASFSNLPG LRLTKGNSPS VLERLMTNDK KEPDEDFFDI
610 620 630 640 650
LVKCQGSRLD DQRCAPPSAA TKGPTVPDED FFSLILRSQA KRMDEQRVLL
660 670
QRDPNRDSEF GLKELLQNNA LLEFKHSGK
Length:679
Mass (Da):75,591
Last modified:April 20, 2010 - v2
Checksum:i8005F2A52FE66D77
GO

Sequence cautioni

The sequence AAH21308.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence AAL87447.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY081187 mRNA. Translation: AAL87447.1. Different initiation.
BC021308 mRNA. Translation: AAH21308.1. Different initiation.
AK040996 mRNA. Translation: BAC30775.1.
CCDSiCCDS51048.1.
RefSeqiNP_083798.2. NM_029522.2.
UniGeneiMm.226941.

Genome annotation databases

EnsembliENSMUST00000029482; ENSMUSP00000029482; ENSMUSG00000027883.
GeneIDi76123.
KEGGimmu:76123.
UCSCiuc008qzo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY081187 mRNA. Translation: AAL87447.1 . Different initiation.
BC021308 mRNA. Translation: AAH21308.1 . Different initiation.
AK040996 mRNA. Translation: BAC30775.1 .
CCDSi CCDS51048.1.
RefSeqi NP_083798.2. NM_029522.2.
UniGenei Mm.226941.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RO2 X-ray 2.30 A 22-357 [» ]
3RO3 X-ray 1.10 A 198-357 [» ]
4G2V X-ray 2.40 A 22-357 [» ]
4G5O X-ray 2.90 E/F/G/H 628-653 [» ]
4G5Q X-ray 2.90 E/F/G/H 628-652 [» ]
4G5R X-ray 3.48 E/F/G/Z 628-652 [» ]
4G5S X-ray 3.62 E/F/G/Z 594-618 [» ]
4JHR X-ray 2.80 A/B 96-357 [» ]
A/B 593-651 [» ]
ProteinModelPortali Q8VDU0.
SMRi Q8VDU0. Positions 20-648.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 217976. 1 interaction.
DIPi DIP-60164N.
IntActi Q8VDU0. 3 interactions.
MINTi MINT-4096561.

PTM databases

PhosphoSitei Q8VDU0.

Proteomic databases

MaxQBi Q8VDU0.
PaxDbi Q8VDU0.
PRIDEi Q8VDU0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029482 ; ENSMUSP00000029482 ; ENSMUSG00000027883 .
GeneIDi 76123.
KEGGi mmu:76123.
UCSCi uc008qzo.2. mouse.

Organism-specific databases

CTDi 29899.
MGIi MGI:1923373. Gpsm2.

Phylogenomic databases

eggNOGi COG0457.
GeneTreei ENSGT00530000063126.
HOGENOMi HOG000231543.
HOVERGENi HBG051823.
InParanoidi Q8VDU0.
KOi K15837.
OMAi EYYEANL.
OrthoDBi EOG7WHH8W.
PhylomeDBi Q8VDU0.
TreeFami TF328344.

Miscellaneous databases

NextBioi 344635.
PROi Q8VDU0.
SOURCEi Search...

Gene expression databases

Bgeei Q8VDU0.
ExpressionAtlasi Q8VDU0. baseline and differential.
Genevestigatori Q8VDU0.

Family and domain databases

Gene3Di 1.25.40.10. 2 hits.
InterProi IPR003109. GoLoco_motif.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view ]
Pfami PF02188. GoLoco. 4 hits.
PF00515. TPR_1. 2 hits.
PF13176. TPR_7. 1 hit.
[Graphical view ]
SMARTi SM00390. GoLoco. 4 hits.
SM00028. TPR. 6 hits.
[Graphical view ]
PROSITEi PS50877. GOLOCO. 4 hits.
PS50005. TPR. 6 hits.
PS50293. TPR_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts."
    Yu F., Morin X., Kaushik R., Bahri S., Yang X., Chia W.
    J. Cell Sci. 116:887-896(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary tumor.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-640.
    Strain: C57BL/6J.
    Tissue: Aorta and Vein.
  4. "Asymmetric cell divisions promote stratification and differentiation of mammalian skin."
    Lechler T., Fuchs E.
    Nature 437:275-280(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH INSC AND F2RL2.
    Strain: CD-1.
    Tissue: Epidermis.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-408 AND SER-564, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPSM2_MOUSE
AccessioniPrimary (citable) accession number: Q8VDU0
Secondary accession number(s): Q8BLX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-8 is the initiator.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3