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Protein

Sodium/glucose cotransporter 4

Gene

Slc5a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-428808. Na+-dependent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 4
Short name:
Na(+)/glucose cotransporter 4
Short name:
mSGLT4
Alternative name(s):
Solute carrier family 5 member 9
Gene namesi
Name:Slc5a9
Synonyms:Sglt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140201. Slc5a9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence analysisAdd
BLAST
Transmembranei33 – 5321HelicalSequence analysisAdd
BLAST
Topological domaini54 – 7118CytoplasmicSequence analysisAdd
BLAST
Transmembranei72 – 9423HelicalSequence analysisAdd
BLAST
Topological domaini95 – 11016ExtracellularSequence analysisAdd
BLAST
Transmembranei111 – 13121HelicalSequence analysisAdd
BLAST
Topological domaini132 – 15322CytoplasmicSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 18612ExtracellularSequence analysisAdd
BLAST
Transmembranei187 – 20721HelicalSequence analysisAdd
BLAST
Topological domaini208 – 2136CytoplasmicSequence analysis
Transmembranei214 – 23421HelicalSequence analysisAdd
BLAST
Topological domaini235 – 27137ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence analysisAdd
BLAST
Topological domaini293 – 31321CytoplasmicSequence analysisAdd
BLAST
Transmembranei314 – 33421HelicalSequence analysisAdd
BLAST
Topological domaini335 – 37945ExtracellularSequence analysisAdd
BLAST
Transmembranei380 – 40223HelicalSequence analysisAdd
BLAST
Topological domaini403 – 42321CytoplasmicSequence analysisAdd
BLAST
Transmembranei424 – 44421HelicalSequence analysisAdd
BLAST
Topological domaini445 – 45511ExtracellularSequence analysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence analysisAdd
BLAST
Topological domaini477 – 4837CytoplasmicSequence analysis
Transmembranei484 – 50421HelicalSequence analysisAdd
BLAST
Topological domaini505 – 52622ExtracellularSequence analysisAdd
BLAST
Transmembranei527 – 54721HelicalSequence analysisAdd
BLAST
Topological domaini548 – 664117CytoplasmicSequence analysisAdd
BLAST
Transmembranei665 – 68521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Sodium/glucose cotransporter 4PRO_0000333806Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi247 – 2471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDT1.
PRIDEiQ8VDT1.

PTM databases

iPTMnetiQ8VDT1.

Expressioni

Gene expression databases

BgeeiQ8VDT1.
ExpressionAtlasiQ8VDT1. baseline and differential.
GenevisibleiQ8VDT1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099780.

Structurei

3D structure databases

ProteinModelPortaliQ8VDT1.
SMRiQ8VDT1. Positions 33-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8VDT1.
KOiK14389.
OMAiQRIQIYM.
OrthoDBiEOG77126J.
PhylomeDBiQ8VDT1.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTELVAMEP GVSRNGVRTE TTTNPSLGLH TYDIVVVVIY FVFVLAVGIW
60 70 80 90 100
SSIRASRGTV GGYFLAGRSM TWWPIGASLM SSNVGSGLFI GLAGTGAAGG
110 120 130 140 150
LAVGGFEWNA TFLLLALGWI FVPVYIAAGV VTMPQYLKKR FGGQRIQVYM
160 170 180 190 200
SVLSLILYIF TKISTDIFSG ALFIQMALGW NLYLSTVILL VVTAVYTIAG
210 220 230 240 250
GLTAVIYTDA LQTVIMVGGA LVLMFLGFQE VGWYPGLQQL YRQAIPNTTV
260 270 280 290 300
PNTTCHLPRP DAFHMLRDPV NGDIPWPGLI FGLTVLATWC WCTDQVIVQR
310 320 330 340 350
SLAAKNLSHA KGGSVLGGYL KILPMFFIVM PGMISRALYP DEVACVDPDI
360 370 380 390 400
CQRVCGARVG CSNIAYPKLV MALMPVGLRG LMIAVIMAAL MSSLTSIFNS
410 420 430 440 450
SSTLFAIDVW QRFRRQASEQ ELMVVGRLFV VFLVVISILW IPIIQSSNSG
460 470 480 490 500
QLFDYIQSIT SYLAPPITAL FLLAIFCKRV NEPGAFWGLM FGLVVGILRM
510 520 530 540 550
ILEFSYSAPA CGEMDRRPAV LKDFHYLYFA LLLCGLTAII IVVISFFTEP
560 570 580 590 600
IPDDKLARLT WWTRNCAVSD LQKKTSVSVN NTEDDNSPGL AGRPVVEGPA
610 620 630 640 650
GDEEEANTTQ GPEQPGALHR SWGKWLWNWF CGLSGAPQQA LSPAEKAVLE
660 670 680
QKLTSIEEEP LWRRVCNINA IILLAINIFL WGYFA
Length:685
Mass (Da):75,065
Last modified:May 20, 2008 - v3
Checksum:i6D223B4EE896572C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1901L → V in AAH21357 (PubMed:15489334).Curated
Sequence conflicti203 – 2031T → A in BAC28283 (PubMed:16141072).Curated
Sequence conflicti584 – 5841D → G in AAH21357 (PubMed:15489334).Curated
Sequence conflicti685 – 6851A → S in AAH21357 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029158 mRNA. Translation: BAC26332.1.
AK033425 mRNA. Translation: BAC28283.1.
AK050696 mRNA. Translation: BAC34386.1.
BC021357 mRNA. Translation: AAH21357.2.
CCDSiCCDS18474.1.
RefSeqiNP_663526.3. NM_145551.4.
XP_006503063.1. XM_006503000.2.
UniGeneiMm.26630.

Genome annotation databases

EnsembliENSMUST00000102719; ENSMUSP00000099780; ENSMUSG00000028544.
ENSMUST00000102720; ENSMUSP00000099781; ENSMUSG00000028544.
ENSMUST00000102721; ENSMUSP00000099782; ENSMUSG00000028544.
GeneIDi230612.
KEGGimmu:230612.
UCSCiuc008udj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029158 mRNA. Translation: BAC26332.1.
AK033425 mRNA. Translation: BAC28283.1.
AK050696 mRNA. Translation: BAC34386.1.
BC021357 mRNA. Translation: AAH21357.2.
CCDSiCCDS18474.1.
RefSeqiNP_663526.3. NM_145551.4.
XP_006503063.1. XM_006503000.2.
UniGeneiMm.26630.

3D structure databases

ProteinModelPortaliQ8VDT1.
SMRiQ8VDT1. Positions 33-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099780.

PTM databases

iPTMnetiQ8VDT1.

Proteomic databases

PaxDbiQ8VDT1.
PRIDEiQ8VDT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102719; ENSMUSP00000099780; ENSMUSG00000028544.
ENSMUST00000102720; ENSMUSP00000099781; ENSMUSG00000028544.
ENSMUST00000102721; ENSMUSP00000099782; ENSMUSG00000028544.
GeneIDi230612.
KEGGimmu:230612.
UCSCiuc008udj.3. mouse.

Organism-specific databases

CTDi200010.
MGIiMGI:2140201. Slc5a9.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8VDT1.
KOiK14389.
OMAiQRIQIYM.
OrthoDBiEOG77126J.
PhylomeDBiQ8VDT1.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-MMU-428808. Na+-dependent glucose transporters.

Miscellaneous databases

PROiQ8VDT1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VDT1.
ExpressionAtlasiQ8VDT1. baseline and differential.
GenevisibleiQ8VDT1. MM.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Colon, Embryo and Skin.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney.

Entry informationi

Entry nameiSC5A9_MOUSE
AccessioniPrimary (citable) accession number: Q8VDT1
Secondary accession number(s): Q8BGU9, Q8BZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 8, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.