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Protein

Sodium/glucose cotransporter 4

Gene

Slc5a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in sodium-dependent transport of D-mannose, D-glucose and D-fructose.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-428808. Na+-dependent glucose transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/glucose cotransporter 4
Short name:
Na(+)/glucose cotransporter 4
Short name:
mSGLT4
Alternative name(s):
Solute carrier family 5 member 9
Gene namesi
Name:Slc5a9
Synonyms:Sglt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140201. Slc5a9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 71CytoplasmicSequence analysisAdd BLAST18
Transmembranei72 – 94HelicalSequence analysisAdd BLAST23
Topological domaini95 – 110ExtracellularSequence analysisAdd BLAST16
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 153CytoplasmicSequence analysisAdd BLAST22
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 186ExtracellularSequence analysisAdd BLAST12
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Topological domaini208 – 213CytoplasmicSequence analysis6
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 271ExtracellularSequence analysisAdd BLAST37
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293 – 313CytoplasmicSequence analysisAdd BLAST21
Transmembranei314 – 334HelicalSequence analysisAdd BLAST21
Topological domaini335 – 379ExtracellularSequence analysisAdd BLAST45
Transmembranei380 – 402HelicalSequence analysisAdd BLAST23
Topological domaini403 – 423CytoplasmicSequence analysisAdd BLAST21
Transmembranei424 – 444HelicalSequence analysisAdd BLAST21
Topological domaini445 – 455ExtracellularSequence analysisAdd BLAST11
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21
Topological domaini477 – 483CytoplasmicSequence analysis7
Transmembranei484 – 504HelicalSequence analysisAdd BLAST21
Topological domaini505 – 526ExtracellularSequence analysisAdd BLAST22
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 664CytoplasmicSequence analysisAdd BLAST117
Transmembranei665 – 685HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003338061 – 685Sodium/glucose cotransporter 4Add BLAST685

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi247N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDT1.
PRIDEiQ8VDT1.

PTM databases

iPTMnetiQ8VDT1.
PhosphoSitePlusiQ8VDT1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000028544.
ExpressionAtlasiQ8VDT1. baseline and differential.
GenevisibleiQ8VDT1. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099780.

Structurei

3D structure databases

ProteinModelPortaliQ8VDT1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8VDT1.
KOiK14389.
OMAiQRIQIYM.
OrthoDBiEOG091G077U.
PhylomeDBiQ8VDT1.
TreeFamiTF352855.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDT1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTELVAMEP GVSRNGVRTE TTTNPSLGLH TYDIVVVVIY FVFVLAVGIW
60 70 80 90 100
SSIRASRGTV GGYFLAGRSM TWWPIGASLM SSNVGSGLFI GLAGTGAAGG
110 120 130 140 150
LAVGGFEWNA TFLLLALGWI FVPVYIAAGV VTMPQYLKKR FGGQRIQVYM
160 170 180 190 200
SVLSLILYIF TKISTDIFSG ALFIQMALGW NLYLSTVILL VVTAVYTIAG
210 220 230 240 250
GLTAVIYTDA LQTVIMVGGA LVLMFLGFQE VGWYPGLQQL YRQAIPNTTV
260 270 280 290 300
PNTTCHLPRP DAFHMLRDPV NGDIPWPGLI FGLTVLATWC WCTDQVIVQR
310 320 330 340 350
SLAAKNLSHA KGGSVLGGYL KILPMFFIVM PGMISRALYP DEVACVDPDI
360 370 380 390 400
CQRVCGARVG CSNIAYPKLV MALMPVGLRG LMIAVIMAAL MSSLTSIFNS
410 420 430 440 450
SSTLFAIDVW QRFRRQASEQ ELMVVGRLFV VFLVVISILW IPIIQSSNSG
460 470 480 490 500
QLFDYIQSIT SYLAPPITAL FLLAIFCKRV NEPGAFWGLM FGLVVGILRM
510 520 530 540 550
ILEFSYSAPA CGEMDRRPAV LKDFHYLYFA LLLCGLTAII IVVISFFTEP
560 570 580 590 600
IPDDKLARLT WWTRNCAVSD LQKKTSVSVN NTEDDNSPGL AGRPVVEGPA
610 620 630 640 650
GDEEEANTTQ GPEQPGALHR SWGKWLWNWF CGLSGAPQQA LSPAEKAVLE
660 670 680
QKLTSIEEEP LWRRVCNINA IILLAINIFL WGYFA
Length:685
Mass (Da):75,065
Last modified:May 20, 2008 - v3
Checksum:i6D223B4EE896572C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190L → V in AAH21357 (PubMed:15489334).Curated1
Sequence conflicti203T → A in BAC28283 (PubMed:16141072).Curated1
Sequence conflicti584D → G in AAH21357 (PubMed:15489334).Curated1
Sequence conflicti685A → S in AAH21357 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029158 mRNA. Translation: BAC26332.1.
AK033425 mRNA. Translation: BAC28283.1.
AK050696 mRNA. Translation: BAC34386.1.
BC021357 mRNA. Translation: AAH21357.2.
CCDSiCCDS18474.1.
RefSeqiNP_663526.3. NM_145551.4.
XP_006503063.1. XM_006503000.2.
UniGeneiMm.26630.

Genome annotation databases

EnsembliENSMUST00000102719; ENSMUSP00000099780; ENSMUSG00000028544.
ENSMUST00000102720; ENSMUSP00000099781; ENSMUSG00000028544.
ENSMUST00000102721; ENSMUSP00000099782; ENSMUSG00000028544.
GeneIDi230612.
KEGGimmu:230612.
UCSCiuc008udj.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029158 mRNA. Translation: BAC26332.1.
AK033425 mRNA. Translation: BAC28283.1.
AK050696 mRNA. Translation: BAC34386.1.
BC021357 mRNA. Translation: AAH21357.2.
CCDSiCCDS18474.1.
RefSeqiNP_663526.3. NM_145551.4.
XP_006503063.1. XM_006503000.2.
UniGeneiMm.26630.

3D structure databases

ProteinModelPortaliQ8VDT1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099780.

PTM databases

iPTMnetiQ8VDT1.
PhosphoSitePlusiQ8VDT1.

Proteomic databases

PaxDbiQ8VDT1.
PRIDEiQ8VDT1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102719; ENSMUSP00000099780; ENSMUSG00000028544.
ENSMUST00000102720; ENSMUSP00000099781; ENSMUSG00000028544.
ENSMUST00000102721; ENSMUSP00000099782; ENSMUSG00000028544.
GeneIDi230612.
KEGGimmu:230612.
UCSCiuc008udj.3. mouse.

Organism-specific databases

CTDi200010.
MGIiMGI:2140201. Slc5a9.

Phylogenomic databases

eggNOGiENOG410IP49. Eukaryota.
COG4146. LUCA.
GeneTreeiENSGT00760000118955.
HOGENOMiHOG000025422.
HOVERGENiHBG052859.
InParanoidiQ8VDT1.
KOiK14389.
OMAiQRIQIYM.
OrthoDBiEOG091G077U.
PhylomeDBiQ8VDT1.
TreeFamiTF352855.

Enzyme and pathway databases

ReactomeiR-MMU-428808. Na+-dependent glucose transporters.

Miscellaneous databases

PROiQ8VDT1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028544.
ExpressionAtlasiQ8VDT1. baseline and differential.
GenevisibleiQ8VDT1. MM.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSC5A9_MOUSE
AccessioniPrimary (citable) accession number: Q8VDT1
Secondary accession number(s): Q8BGU9, Q8BZW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 2, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.