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Protein

Syntaxin-18

Gene

Stx18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Syntaxin that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Molecular functioni

  • protein domain specific binding Source: AgBase
  • SNAP receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntaxin-18
Gene namesi
Name:Stx18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1918366. Stx18.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 308CytoplasmicSequence analysisAdd BLAST308
Transmembranei309 – 329Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST21
Topological domaini330 – 334LumenalSequence analysis5

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002102321 – 334Syntaxin-18Add BLAST334

Proteomic databases

PaxDbiQ8VDS8.
PeptideAtlasiQ8VDS8.
PRIDEiQ8VDS8.

PTM databases

iPTMnetiQ8VDS8.
PhosphoSitePlusiQ8VDS8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029125.
CleanExiMM_STX18.
ExpressionAtlasiQ8VDS8. baseline and differential.
GenevisibleiQ8VDS8. MM.

Interactioni

Subunit structurei

Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the complex through interaction with BNIP1/SEC20L. Interacts directly with USE1L and BNIP1/SEC20L (By similarity).By similarity

GO - Molecular functioni

  • protein domain specific binding Source: AgBase
  • SNAP receptor activity Source: InterPro

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109761.

Structurei

3D structure databases

ProteinModelPortaliQ8VDS8.
SMRiQ8VDS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini242 – 304t-SNARE coiled-coil homologyAdd BLAST63

Sequence similaritiesi

Belongs to the syntaxin family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3894. Eukaryota.
ENOG410XSGT. LUCA.
GeneTreeiENSGT00390000014853.
HOGENOMiHOG000007595.
HOVERGENiHBG054890.
InParanoidiQ8VDS8.
KOiK08492.
OMAiLQHRKDY.
OrthoDBiEOG091G0FVR.
PhylomeDBiQ8VDS8.
TreeFamiTF105868.

Family and domain databases

InterProiView protein in InterPro
IPR019529. Syntaxin-18_N.
IPR006012. Syntaxin/epimorphin_CS.
PfamiView protein in Pfam
PF10496. Syntaxin-18_N. 1 hit.
PROSITEiView protein in PROSITE
PS00914. SYNTAXIN. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VDS8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVDITLLFR ASVKTVKTRN KALGVAVGGG ADGSRDELFR RSPRPKGDFS
60 70 80 90 100
SRAREVISHI GKLRDFLLEH RKEYINAYSH TMSDYGRMTD TERDQIDQDA
110 120 130 140 150
QIFIRTCSEA IHQLRTEAHK EIHSQQVKEH RTAVLDFVDD YLKRVCKLYS
160 170 180 190 200
EQRAIRVKRV VDKKRLSKLE PEPHTKRKDS TSEKAPQNAS QDSEGKPAAE
210 220 230 240 250
ELPEKPLAES QPELGTWGDG KGEDELSPEE IQMFEQENQR LIGEMNSLFD
260 270 280 290 300
EVRQIEGKVV EISRLQEIFT EKVLQQETEI DSIHQLVVGA TENIKEGNED
310 320 330
IREAIKNNAG FRVWILFFLV MCSFSLLFLD WYDS
Length:334
Mass (Da):38,381
Last modified:April 18, 2006 - v2
Checksum:i17351A82343475F0
GO
Isoform 2 (identifier: Q8VDS8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     118-144: AHKEIHSQQVKEHRTAVLDFVDDYLKR → G

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):35,193
Checksum:i97EA948E98C85CAC
GO
Isoform 3 (identifier: Q8VDS8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     304-308: AIKNN → LAHQG
     309-334: Missing.

Note: No experimental confirmation available.
Show »
Length:308
Mass (Da):35,188
Checksum:iCD7FFCF57ED2B097
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti112H → Q in AAH21362 (PubMed:15489334).Curated1
Sequence conflicti189A → V in AAH21362 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017902118 – 144AHKEI…DYLKR → G in isoform 2. 1 PublicationAdd BLAST27
Alternative sequenceiVSP_017903304 – 308AIKNN → LAHQG in isoform 3. 1 Publication5
Alternative sequenceiVSP_017904309 – 334Missing in isoform 3. 1 PublicationAdd BLAST26

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007700 mRNA. Translation: BAB25198.1.
AK169273 mRNA. Translation: BAE41033.1.
AK170165 mRNA. Translation: BAE41611.1.
BC021362 mRNA. Translation: AAH21362.1.
CCDSiCCDS19250.1. [Q8VDS8-1]
CCDS71583.1. [Q8VDS8-3]
CCDS80270.1. [Q8VDS8-2]
RefSeqiNP_001276464.1. NM_001289535.1. [Q8VDS8-3]
NP_001276465.1. NM_001289536.1. [Q8VDS8-2]
NP_081235.2. NM_026959.3. [Q8VDS8-1]
UniGeneiMm.18959.

Genome annotation databases

EnsembliENSMUST00000031008; ENSMUSP00000031008; ENSMUSG00000029125. [Q8VDS8-3]
ENSMUST00000042146; ENSMUSP00000038205; ENSMUSG00000029125. [Q8VDS8-2]
ENSMUST00000114126; ENSMUSP00000109761; ENSMUSG00000029125. [Q8VDS8-1]
GeneIDi71116.
KEGGimmu:71116.
UCSCiuc008xfx.2. mouse. [Q8VDS8-3]
uc008xfy.2. mouse. [Q8VDS8-1]
uc008xfz.2. mouse. [Q8VDS8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSTX18_MOUSE
AccessioniPrimary (citable) accession number: Q8VDS8
Secondary accession number(s): Q3TDJ0, Q9D8T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: April 18, 2006
Last modified: June 7, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families