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Protein

Regulation of nuclear pre-mRNA domain-containing protein 1A

Gene

Rprd1a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 1A
Alternative name(s):
Cyclin-dependent kinase inhibitor 2B-related protein
p15INK4B-related protein
Gene namesi
Name:Rprd1a
Synonyms:Kiaa4077, P15rs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:2385066. Rprd1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 312311Regulation of nuclear pre-mRNA domain-containing protein 1APRO_0000311345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei153 – 1531PhosphoserineBy similarity
Modified residuei156 – 1561PhosphoserineBy similarity
Modified residuei285 – 2851PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8VDS4.
MaxQBiQ8VDS4.
PaxDbiQ8VDS4.
PeptideAtlasiQ8VDS4.
PRIDEiQ8VDS4.

PTM databases

iPTMnetiQ8VDS4.
PhosphoSiteiQ8VDS4.

Expressioni

Gene expression databases

BgeeiQ8VDS4.
GenevisibleiQ8VDS4. MM.

Interactioni

Subunit structurei

Associates with the RNA polymerase II complex.By similarity

Protein-protein interaction databases

IntActiQ8VDS4. 1 interaction.
MINTiMINT-4119951.
STRINGi10090.ENSMUSP00000043618.

Structurei

3D structure databases

ProteinModelPortaliQ8VDS4.
SMRiQ8VDS4. Positions 2-131, 163-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 133132CIDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili244 – 28643Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the UPF0400 (RTT103) family.Curated
Contains 1 CID domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2669. Eukaryota.
ENOG410XRAP. LUCA.
GeneTreeiENSGT00400000022016.
HOGENOMiHOG000007456.
HOVERGENiHBG051177.
InParanoidiQ8VDS4.
OMAiGEDGCKK.
OrthoDBiEOG7V1FRR.
PhylomeDBiQ8VDS4.
TreeFamiTF320926.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR032337. CREPT.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF16566. CREPT. 1 hit.
PF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFSEAALE KKLSELSNSQ QSVQTLSLWL IHHRKHSRPI VTVWERELRK
60 70 80 90 100
AKPNRKLTFL YLANDVIQNS KRKGPEFTKD FAPVIVEAFK HVSSETDESC
110 120 130 140 150
KKHLGRVLSI WEERSVYEND VLEQLKHALY GDKKARKRTY EQIKVDENEN
160 170 180 190 200
CSSLGSPSEP PQTLDLVRAL QDLENAASGD AAVHQRIASL PVEVQEVSLL
210 220 230 240 250
EKITDKESGE RLSKMVEDAC MLLADYNGRL AAEIDDRKQL TRMLADFLRC
260 270 280 290 300
QKEALAEKEH KLEEYKRKLA RVSLVRKELR ARIQSLPDLS RLPNVTGSHM
310
HLPFAGDIYS ED
Length:312
Mass (Da):35,701
Last modified:March 1, 2002 - v1
Checksum:iD7C90635A8992D27
GO

Sequence cautioni

The sequence BAD90282.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220475 mRNA. Translation: BAD90282.1. Different initiation.
BC021395 mRNA. Translation: AAH21395.1.
BC023084 mRNA. Translation: AAH23084.1.
CCDSiCCDS29102.1.
RefSeqiNP_659110.1. NM_144861.2.
XP_006525887.1. XM_006525824.2.
XP_006525888.1. XM_006525825.2.
UniGeneiMm.28427.

Genome annotation databases

EnsembliENSMUST00000046206; ENSMUSP00000043618; ENSMUSG00000040446.
GeneIDi225283.
KEGGimmu:225283.
UCSCiuc008egu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK220475 mRNA. Translation: BAD90282.1. Different initiation.
BC021395 mRNA. Translation: AAH21395.1.
BC023084 mRNA. Translation: AAH23084.1.
CCDSiCCDS29102.1.
RefSeqiNP_659110.1. NM_144861.2.
XP_006525887.1. XM_006525824.2.
XP_006525888.1. XM_006525825.2.
UniGeneiMm.28427.

3D structure databases

ProteinModelPortaliQ8VDS4.
SMRiQ8VDS4. Positions 2-131, 163-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VDS4. 1 interaction.
MINTiMINT-4119951.
STRINGi10090.ENSMUSP00000043618.

PTM databases

iPTMnetiQ8VDS4.
PhosphoSiteiQ8VDS4.

Proteomic databases

EPDiQ8VDS4.
MaxQBiQ8VDS4.
PaxDbiQ8VDS4.
PeptideAtlasiQ8VDS4.
PRIDEiQ8VDS4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046206; ENSMUSP00000043618; ENSMUSG00000040446.
GeneIDi225283.
KEGGimmu:225283.
UCSCiuc008egu.1. mouse.

Organism-specific databases

CTDi55197.
MGIiMGI:2385066. Rprd1a.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2669. Eukaryota.
ENOG410XRAP. LUCA.
GeneTreeiENSGT00400000022016.
HOGENOMiHOG000007456.
HOVERGENiHBG051177.
InParanoidiQ8VDS4.
OMAiGEDGCKK.
OrthoDBiEOG7V1FRR.
PhylomeDBiQ8VDS4.
TreeFamiTF320926.

Enzyme and pathway databases

ReactomeiR-MMU-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

PROiQ8VDS4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VDS4.
GenevisibleiQ8VDS4. MM.

Family and domain databases

Gene3Di1.25.40.90. 1 hit.
InterProiIPR006569. CID_dom.
IPR032337. CREPT.
IPR008942. ENTH_VHS.
IPR006903. RNA_pol_II-bd.
[Graphical view]
PfamiPF16566. CREPT. 1 hit.
PF04818. CTD_bind. 1 hit.
[Graphical view]
SMARTiSM00582. RPR. 1 hit.
[Graphical view]
SUPFAMiSSF48464. SSF48464. 1 hit.
PROSITEiPS51391. CID. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Fetal brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiRPR1A_MOUSE
AccessioniPrimary (citable) accession number: Q8VDS4
Secondary accession number(s): Q5DTP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.