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Protein

Chromobox protein homolog 7

Gene

Cbx7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded RNA. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.2 Publications

GO - Molecular functioni

  • chromatin binding Source: MGI
  • methylated histone binding Source: UniProtKB
  • single-stranded RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromobox protein homolog 7
Gene namesi
Name:Cbx7
Synonyms:D15Ertd417e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1196439. Cbx7.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • heterochromatin Source: UniProtKB
  • nuclear chromatin Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: UniProtKB
  • PcG protein complex Source: UniProtKB
  • PRC1 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi11 – 111F → A: Abolishes binding to trimethylated histone H3. 1 Publication
Mutagenesisi17 – 171R → A or Q: Strongly reduced RNA binding. Prevents cellular senescence and promotes continued cell division. 1 Publication
Mutagenesisi31 – 311K → A: Strongly reduced RNA binding. 1 Publication
Mutagenesisi35 – 351W → A: Strongly reduced binding to methylated histone H3 (H3K27me3). Causes premature cellular senescence. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 158158Chromobox protein homolog 7PRO_0000080213Add
BLAST

Proteomic databases

MaxQBiQ8VDS3.
PaxDbiQ8VDS3.
PRIDEiQ8VDS3.

PTM databases

iPTMnetiQ8VDS3.
PhosphoSiteiQ8VDS3.

Expressioni

Developmental stagei

In embryonic fibroblast cultured in vitro, expression gradually decreases with passage number and totally disappears in senescent cells.

Gene expression databases

BgeeiENSMUSG00000053411.
CleanExiMM_CBX7.
ExpressionAtlasiQ8VDS3. baseline and differential.
GenevisibleiQ8VDS3. MM.

Interactioni

Subunit structurei

Component of a PRC1-like complex (By similarity). Interacts with RING1. Interacts with RNF2/RING1B. Interacts with PCGF1, PCGF2, PCGF3, PCGF5 and PCGF6 (By similarity).By similarity

GO - Molecular functioni

  • methylated histone binding Source: UniProtKB

Protein-protein interaction databases

BioGridi206690. 26 interactions.
DIPiDIP-38616N.
IntActiQ8VDS3. 23 interactions.
STRINGi10090.ENSMUSP00000105244.

Structurei

Secondary structure

1
158
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 53Combined sources
Beta strandi10 – 2213Combined sources
Beta strandi25 – 328Combined sources
Helixi37 – 393Combined sources
Beta strandi41 – 444Combined sources
Helixi45 – 473Combined sources
Helixi51 – 6515Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KVMNMR-A1-71[»]
4X3KX-ray1.45A/B7-66[»]
4X3SX-ray1.60A/B7-66[»]
4X3TX-ray2.14A/B/C/D/E/F7-66[»]
4X3UX-ray1.63A/B7-66[»]
5EJWX-ray2.60A1-71[»]
ProteinModelPortaliQ8VDS3.
SMRiQ8VDS3. Positions 7-62, 126-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VDS3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 6959ChromoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 chromo domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG410ZMH7. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000233642.
HOVERGENiHBG019320.
InParanoidiQ8VDS3.
KOiK11454.
PhylomeDBiQ8VDS3.
TreeFamiTF106456.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDS3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSAIGEQV FAVESIRKKR VRKGKVEYLV KWKGWPPKYS TWEPEEHILD
60 70 80 90 100
PRLVMAYEEK EERDRASGYR KRGPKPRRLL LQESAAPDVV QTPGDWEPME
110 120 130 140 150
QAPEEEAEAD LTNGPPPWTP TLPSSEVTVT DITANSVTVT FREAQAAEGF

FRDRNEKL
Length:158
Mass (Da):18,109
Last modified:March 1, 2002 - v1
Checksum:iA40021F05B16BEAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453793 mRNA. Translation: AAR26721.1.
BC021398 mRNA. Translation: AAH21398.1.
CCDSiCCDS37143.1.
RefSeqiNP_659060.1. NM_144811.3.
UniGeneiMm.323442.

Genome annotation databases

EnsembliENSMUST00000109615; ENSMUSP00000105244; ENSMUSG00000053411.
ENSMUST00000109616; ENSMUSP00000105245; ENSMUSG00000053411.
GeneIDi52609.
KEGGimmu:52609.
UCSCiuc007wuv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY453793 mRNA. Translation: AAR26721.1.
BC021398 mRNA. Translation: AAH21398.1.
CCDSiCCDS37143.1.
RefSeqiNP_659060.1. NM_144811.3.
UniGeneiMm.323442.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2KVMNMR-A1-71[»]
4X3KX-ray1.45A/B7-66[»]
4X3SX-ray1.60A/B7-66[»]
4X3TX-ray2.14A/B/C/D/E/F7-66[»]
4X3UX-ray1.63A/B7-66[»]
5EJWX-ray2.60A1-71[»]
ProteinModelPortaliQ8VDS3.
SMRiQ8VDS3. Positions 7-62, 126-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206690. 26 interactions.
DIPiDIP-38616N.
IntActiQ8VDS3. 23 interactions.
STRINGi10090.ENSMUSP00000105244.

PTM databases

iPTMnetiQ8VDS3.
PhosphoSiteiQ8VDS3.

Proteomic databases

MaxQBiQ8VDS3.
PaxDbiQ8VDS3.
PRIDEiQ8VDS3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109615; ENSMUSP00000105244; ENSMUSG00000053411.
ENSMUST00000109616; ENSMUSP00000105245; ENSMUSG00000053411.
GeneIDi52609.
KEGGimmu:52609.
UCSCiuc007wuv.1. mouse.

Organism-specific databases

CTDi23492.
MGIiMGI:1196439. Cbx7.

Phylogenomic databases

eggNOGiKOG2748. Eukaryota.
ENOG410ZMH7. LUCA.
GeneTreeiENSGT00530000063056.
HOGENOMiHOG000233642.
HOVERGENiHBG019320.
InParanoidiQ8VDS3.
KOiK11454.
PhylomeDBiQ8VDS3.
TreeFamiTF106456.

Miscellaneous databases

ChiTaRSiCbx7. mouse.
EvolutionaryTraceiQ8VDS3.
PROiQ8VDS3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053411.
CleanExiMM_CBX7.
ExpressionAtlasiQ8VDS3. baseline and differential.
GenevisibleiQ8VDS3. MM.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR017984. Chromo_dom_subgr.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
[Graphical view]
PRINTSiPR00504. CHROMODOMAIN.
SMARTiSM00298. CHROMO. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBX7_MOUSE
AccessioniPrimary (citable) accession number: Q8VDS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.