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Protein

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

Gene

Cdipt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the biosynthesis of phosphatidylinositol (PtdIns) as well as PtdIns:inositol exchange reaction. May thus act to reduce an excessive cellular PtdIns content. The exchange activity is due to the reverse reaction of PtdIns synthase and is dependent on CMP, which is tightly bound to the enzyme (By similarity).By similarity

Catalytic activityi

CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol.

Cofactori

Mn2+By similarity, Mg2+By similarityNote: Divalent metal cations; Mn2+ or Mg2+, but Mg2+ may be much less effective.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium, Manganese

Enzyme and pathway databases

ReactomeiR-MMU-1483226. Synthesis of PI.

Names & Taxonomyi

Protein namesi
Recommended name:
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC:2.7.8.11)
Alternative name(s):
Phosphatidylinositol synthase
Short name:
PI synthase
Short name:
PtdIns synthase
Gene namesi
Name:Cdipt
Synonyms:Pis1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:105491. Cdipt.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalSequence analysisAdd
BLAST
Transmembranei29 – 4921HelicalSequence analysisAdd
BLAST
Transmembranei74 – 9421HelicalSequence analysisAdd
BLAST
Transmembranei140 – 16021HelicalSequence analysisAdd
BLAST
Transmembranei175 – 19521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2176.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213CDP-diacylglycerol--inositol 3-phosphatidyltransferasePRO_0000056803Add
BLAST

Proteomic databases

EPDiQ8VDP6.
MaxQBiQ8VDP6.
PaxDbiQ8VDP6.
PeptideAtlasiQ8VDP6.
PRIDEiQ8VDP6.

PTM databases

iPTMnetiQ8VDP6.
PhosphoSiteiQ8VDP6.
SwissPalmiQ8VDP6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030682.
ExpressionAtlasiQ8VDP6. baseline and differential.
GenevisibleiQ8VDP6. MM.

Interactioni

Protein-protein interaction databases

BioGridi206858. 1 interaction.
STRINGi10090.ENSMUSP00000032920.

Structurei

3D structure databases

ProteinModelPortaliQ8VDP6.
SMRiQ8VDP6. Positions 9-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3240. Eukaryota.
COG0558. LUCA.
GeneTreeiENSGT00390000017279.
HOGENOMiHOG000204051.
HOVERGENiHBG050862.
InParanoidiQ8VDP6.
KOiK00999.
OMAiTDRCGTM.
OrthoDBiEOG091G0MDT.
PhylomeDBiQ8VDP6.
TreeFamiTF314603.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014387. CDP_diag_ino_3_P_euk.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000848. CDP_diag_ino_3_P. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPEENIFLFV PNLIGYARIV FAIISFYFMP CCPFTASSFY LLSGLLDAFD
60 70 80 90 100
GHAARALNQG TRFGAMLDML TDRCATMCLL VNLALLYPRA TLLFQLSMSL
110 120 130 140 150
DVASHWLHLH SSVVRGSESH KMIDLSGNPV LRIYYTSRPA LFTLCAGNEL
160 170 180 190 200
FYCLLYLFNF SEGPLVGSVG LFRMGLWVTA PIALLKSVIS VIHLITAARN
210
MAALDAADRA KKK
Length:213
Mass (Da):23,599
Last modified:March 1, 2002 - v1
Checksum:i93D9F4E60CD13BB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076974 mRNA. Translation: BAC36542.1.
AK079226 mRNA. Translation: BAC37580.1.
AK089109 mRNA. Translation: BAC40756.1.
BC021473 mRNA. Translation: AAH21473.1.
BC024413 mRNA. Translation: AAH24413.1.
CCDSiCCDS21853.1.
RefSeqiNP_080914.1. NM_026638.3.
UniGeneiMm.28219.

Genome annotation databases

EnsembliENSMUST00000032920; ENSMUSP00000032920; ENSMUSG00000030682.
GeneIDi52858.
KEGGimmu:52858.
UCSCiuc009jtv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK076974 mRNA. Translation: BAC36542.1.
AK079226 mRNA. Translation: BAC37580.1.
AK089109 mRNA. Translation: BAC40756.1.
BC021473 mRNA. Translation: AAH21473.1.
BC024413 mRNA. Translation: AAH24413.1.
CCDSiCCDS21853.1.
RefSeqiNP_080914.1. NM_026638.3.
UniGeneiMm.28219.

3D structure databases

ProteinModelPortaliQ8VDP6.
SMRiQ8VDP6. Positions 9-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi206858. 1 interaction.
STRINGi10090.ENSMUSP00000032920.

Chemistry

ChEMBLiCHEMBL2176.

PTM databases

iPTMnetiQ8VDP6.
PhosphoSiteiQ8VDP6.
SwissPalmiQ8VDP6.

Proteomic databases

EPDiQ8VDP6.
MaxQBiQ8VDP6.
PaxDbiQ8VDP6.
PeptideAtlasiQ8VDP6.
PRIDEiQ8VDP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032920; ENSMUSP00000032920; ENSMUSG00000030682.
GeneIDi52858.
KEGGimmu:52858.
UCSCiuc009jtv.2. mouse.

Organism-specific databases

CTDi10423.
MGIiMGI:105491. Cdipt.

Phylogenomic databases

eggNOGiKOG3240. Eukaryota.
COG0558. LUCA.
GeneTreeiENSGT00390000017279.
HOGENOMiHOG000204051.
HOVERGENiHBG050862.
InParanoidiQ8VDP6.
KOiK00999.
OMAiTDRCGTM.
OrthoDBiEOG091G0MDT.
PhylomeDBiQ8VDP6.
TreeFamiTF314603.

Enzyme and pathway databases

ReactomeiR-MMU-1483226. Synthesis of PI.

Miscellaneous databases

PROiQ8VDP6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030682.
ExpressionAtlasiQ8VDP6. baseline and differential.
GenevisibleiQ8VDP6. MM.

Family and domain databases

InterProiIPR000462. CDP-OH_P_trans.
IPR014387. CDP_diag_ino_3_P_euk.
[Graphical view]
PfamiPF01066. CDP-OH_P_transf. 1 hit.
[Graphical view]
PIRSFiPIRSF000848. CDP_diag_ino_3_P. 1 hit.
PROSITEiPS00379. CDP_ALCOHOL_P_TRANSF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDIPT_MOUSE
AccessioniPrimary (citable) accession number: Q8VDP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.