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Q8VDN2

- AT1A1_MOUSE

UniProt

Q8VDN2 - AT1A1_MOUSE

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Protein
Sodium/potassium-transporting ATPase subunit alpha-1
Gene
Atp1a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients By similarity.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei376 – 37614-aspartylphosphate intermediate By similarity
Binding sitei487 – 4871ATP By similarity
Metal bindingi717 – 7171Magnesium By similarity
Metal bindingi721 – 7211Magnesium By similarity

GO - Molecular functioni

  1. ADP binding Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. phosphatase activity Source: MGI
  4. potassium ion binding Source: Ensembl
  5. protein binding Source: BHF-UCL
  6. sodium ion binding Source: Ensembl
  7. sodium:potassium-exchanging ATPase activity Source: MGI

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
  2. cellular response to mechanical stimulus Source: Ensembl
  3. dephosphorylation Source: GOC
  4. membrane hyperpolarization Source: Ensembl
  5. negative regulation of glucocorticoid biosynthetic process Source: MGI
  6. negative regulation of heart contraction Source: MGI
  7. positive regulation of heart contraction Source: MGI
  8. positive regulation of striated muscle contraction Source: MGI
  9. potassium ion import Source: Ensembl
  10. regulation of blood pressure Source: MGI
  11. regulation of cardiac muscle cell contraction Source: Ensembl
  12. regulation of sodium ion transport Source: UniProtKB
  13. regulation of the force of heart contraction Source: MGI
  14. response to drug Source: MGI
  15. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha-1 (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha-1 subunit
Alternative name(s):
Sodium pump subunit alpha-1
Gene namesi
Name:Atp1a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:88105. Atp1a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini6 – 9691Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei97 – 11721Helical; Reviewed prediction
Add
BLAST
Topological domaini118 – 12912Extracellular Reviewed prediction
Add
BLAST
Transmembranei130 – 15021Helical; Reviewed prediction
Add
BLAST
Topological domaini151 – 291141Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei292 – 31221Helical; Reviewed prediction
Add
BLAST
Topological domaini313 – 3197Extracellular Reviewed prediction
Transmembranei320 – 34021Helical; Reviewed prediction
Add
BLAST
Topological domaini341 – 789449Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei790 – 81021Helical; Reviewed prediction
Add
BLAST
Topological domaini811 – 86555Extracellular Reviewed prediction
Add
BLAST
Transmembranei866 – 88621Helical; Reviewed prediction
Add
BLAST
Topological domaini887 – 91529Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei916 – 93621Helical; Reviewed prediction
Add
BLAST
Topological domaini937 – 95216Extracellular Reviewed prediction
Add
BLAST
Transmembranei953 – 97321Helical; Reviewed prediction
Add
BLAST
Topological domaini974 – 9796Cytoplasmic Reviewed prediction
Transmembranei980 – 100021Helical; Reviewed prediction
Add
BLAST
Topological domaini1001 – 102323Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. T-tubule Source: BHF-UCL
  3. apical plasma membrane Source: MGI
  4. basolateral plasma membrane Source: MGI
  5. caveola Source: Ensembl
  6. endoplasmic reticulum Source: Ensembl
  7. endosome Source: Ensembl
  8. integral component of membrane Source: UniProtKB
  9. melanosome Source: UniProtKB-SubCell
  10. plasma membrane Source: MGI
  11. protein complex Source: MGI
  12. sarcolemma Source: BHF-UCL
  13. sodium:potassium-exchanging ATPase complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 55 By similarity
PRO_0000002485
Chaini6 – 10231018Sodium/potassium-transporting ATPase subunit alpha-1
PRO_0000002486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91N6-acetyllysine1 Publication
Modified residuei10 – 101Phosphotyrosine By similarity
Modified residuei16 – 161Phosphoserine By similarity
Modified residuei21 – 211N6-acetyllysine1 Publication
Modified residuei260 – 2601Phosphotyrosine1 Publication
Modified residuei542 – 5421Phosphotyrosine By similarity
Modified residuei661 – 6611N6-succinyllysine1 Publication
Modified residuei943 – 9431Phosphoserine; by PKA By similarity

Post-translational modificationi

Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8VDN2.
PaxDbiQ8VDN2.
PRIDEiQ8VDN2.

PTM databases

PhosphoSiteiQ8VDN2.

Expressioni

Gene expression databases

ArrayExpressiQ8VDN2.
BgeeiQ8VDN2.
CleanExiMM_ATP1A1.
GenevestigatoriQ8VDN2.

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma. Interacts with SIK1 By similarity.

Protein-protein interaction databases

BioGridi198243. 8 interactions.
DIPiDIP-31885N.
IntActiQ8VDN2. 22 interactions.
MINTiMINT-1797662.

Structurei

3D structure databases

ProteinModelPortaliQ8VDN2.
SMRiQ8VDN2. Positions 30-1023.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni82 – 843Phosphoinositide-3 kinase binding By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0474.
GeneTreeiENSGT00560000076866.
HOGENOMiHOG000265622.
HOVERGENiHBG004298.
InParanoidiQ8VDN2.
KOiK01539.
OMAiFLPTHLL.
OrthoDBiEOG7327N0.
PhylomeDBiQ8VDN2.
TreeFamiTF312838.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDN2-1 [UniParc]FASTAAdd to Basket

« Hide

MGKGVGRDKY EPAAVSEHGD KKGKKAKKER DMDELKKEVS MDDHKLSLDE     50
LHRKYGTDLS RGLTPARAAE ILARDGPNAL TPPPTTPEWV KFCRQLFGGF 100
SMLLWIGAIL CFLAYGIRSA TEEEPPNDDL YLGVVLSAVV IITGCFSYYQ 150
EAKSSKIMES FKNMVPQQAL VIRNGEKMSI NAEDVVVGDL VEVKGGDRIP 200
ADLRIISANG CKVDNSSLTG ESEPQTRSPD FTNENPLETR NIAFFSTNCV 250
EGTARGIVVY TGDRTVMGRI ATLASGLEGG QTPIAEEIEH FIHLITGVAV 300
FLGVSFFILS LILEYTWLEA VIFLIGIIVA NVPEGLLATV TVCLTLTAKR 350
MARKNCLVKN LEAVETLGST STICSDKTGT LTQNRMTVAH MWFDNQIHEA 400
DTTENQSGVS FDKTSATWFA LSRIAGLCNR AVFQANQENL PILKRAVAGD 450
ASESALLKCI EVCCGSVMEM REKYSKIVEI PFNSTNKYQL SIHKNPNASE 500
PKHLLVMKGA PERILDRCSS ILLHGKEQPL DEELKDAFQN AYLELGGLGE 550
RVLGFCHLLL PDEQFPEGFQ FDTDDVNFPV DNLCFVGLIS MIDPPRAAVP 600
DAVGKCRSAG IKVIMVTGDH PITAKAIAKG VGIISEGNET VEDIAARLNI 650
PVNQVNPRDA KACVVHGSDL KDMTSEELDD ILRYHTEIVF ARTSPQQKLI 700
IVEGCQRQGA IVAVTGDGVN DSPALKKADI GVAMGIVGSD VSKQAADMIL 750
LDDNFASIVT GVEEGRLIFD NLKKSIAYTL TSNIPEITPF LIFIIANIPL 800
PLGTVTILCI DLGTDMVPAI SLAYEQAESD IMKRQPRNPK TDKLVNERLI 850
SMAYGQIGMI QALGGFFTYF VILAENGFLP FHLLGIRETW DDRWVNDVED 900
SYGQQWTYEQ RKIVEFTCHT AFFVSIVVVQ WADLVICKTR RNSVFQQGMK 950
NKILIFGLFE ETALAAFLSY CPGMGAALRM YPLKPTWWFC AFPYSLLIFV 1000
YDEVRKLIIR RRPGGWVEKE TYY 1023
Length:1,023
Mass (Da):112,982
Last modified:March 1, 2002 - v1
Checksum:i1E806D3FDFC5AD80
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC010319 mRNA. Translation: AAH10319.1.
BC021496 mRNA. Translation: AAH21496.1.
BC023794 mRNA. Translation: AAH23794.1.
BC025618 mRNA. Translation: AAH25618.1.
BC025627 mRNA. Translation: AAH25627.1.
BC025811 mRNA. Translation: AAH25811.1.
BC032187 mRNA. Translation: AAH32187.1.
BC033435 mRNA. Translation: AAH33435.1.
BC033471 mRNA. Translation: AAH33471.1.
BC042435 mRNA. Translation: AAH42435.1.
CCDSiCCDS17683.1.
RefSeqiNP_659149.1. NM_144900.2.
UniGeneiMm.280103.

Genome annotation databases

EnsembliENSMUST00000036493; ENSMUSP00000039657; ENSMUSG00000033161.
GeneIDi11928.
KEGGimmu:11928.
UCSCiuc008qrj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC010319 mRNA. Translation: AAH10319.1 .
BC021496 mRNA. Translation: AAH21496.1 .
BC023794 mRNA. Translation: AAH23794.1 .
BC025618 mRNA. Translation: AAH25618.1 .
BC025627 mRNA. Translation: AAH25627.1 .
BC025811 mRNA. Translation: AAH25811.1 .
BC032187 mRNA. Translation: AAH32187.1 .
BC033435 mRNA. Translation: AAH33435.1 .
BC033471 mRNA. Translation: AAH33471.1 .
BC042435 mRNA. Translation: AAH42435.1 .
CCDSi CCDS17683.1.
RefSeqi NP_659149.1. NM_144900.2.
UniGenei Mm.280103.

3D structure databases

ProteinModelPortali Q8VDN2.
SMRi Q8VDN2. Positions 30-1023.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198243. 8 interactions.
DIPi DIP-31885N.
IntActi Q8VDN2. 22 interactions.
MINTi MINT-1797662.

PTM databases

PhosphoSitei Q8VDN2.

Proteomic databases

MaxQBi Q8VDN2.
PaxDbi Q8VDN2.
PRIDEi Q8VDN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000036493 ; ENSMUSP00000039657 ; ENSMUSG00000033161 .
GeneIDi 11928.
KEGGi mmu:11928.
UCSCi uc008qrj.2. mouse.

Organism-specific databases

CTDi 476.
MGIi MGI:88105. Atp1a1.

Phylogenomic databases

eggNOGi COG0474.
GeneTreei ENSGT00560000076866.
HOGENOMi HOG000265622.
HOVERGENi HBG004298.
InParanoidi Q8VDN2.
KOi K01539.
OMAi FLPTHLL.
OrthoDBi EOG7327N0.
PhylomeDBi Q8VDN2.
TreeFami TF312838.

Miscellaneous databases

ChiTaRSi ATP1A1. mouse.
NextBioi 280013.
PROi Q8VDN2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VDN2.
Bgeei Q8VDN2.
CleanExi MM_ATP1A1.
Genevestigatori Q8VDN2.

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver and Mammary gland.
  2. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  3. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  4. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-260, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-9 AND LYS-21, SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-661, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiAT1A1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDN2
Secondary accession number(s): Q91Z09
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi