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Protein

Heterogeneous nuclear ribonucleoprotein U-like protein 1

Gene

Hnrnpul1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a basic transcriptional regulator. Represses basic transcription driven by several virus and cellular promoters. When associated with BRD7, activates transcription of glucocorticoid-responsive promoter in the absence of ligand-stimulation. Plays also a role in mRNA processing and transport. Binds avidly to poly(G) and poly(C) RNA homopolymers in vitro (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor, Ribonucleoprotein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein U-like protein 1
Gene namesi
Name:Hnrnpul1
Synonyms:Hnrpul1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2443517. Hnrnpul1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002275561 – 859Heterogeneous nuclear ribonucleoprotein U-like protein 1Add BLAST859

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki117Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki143Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei195PhosphoserineCombined sources1
Modified residuei210PhosphothreonineCombined sources1
Modified residuei513PhosphoserineBy similarity1
Modified residuei639Asymmetric dimethylarginineCombined sources1
Modified residuei645Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei645Omega-N-methylarginine; alternateCombined sources1
Modified residuei659Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei659Omega-N-methylarginine; alternateCombined sources1
Modified residuei664Omega-N-methylarginineCombined sources1
Modified residuei674Omega-N-methylarginineBy similarity1
Modified residuei721PhosphoserineBy similarity1

Post-translational modificationi

Methylated.By similarity

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8VDM6.
PaxDbiQ8VDM6.
PeptideAtlasiQ8VDM6.
PRIDEiQ8VDM6.

PTM databases

iPTMnetiQ8VDM6.
PhosphoSitePlusiQ8VDM6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040725.
GenevisibleiQ8VDM6. MM.

Interactioni

Subunit structurei

Interacts with BRD7, PRMT2, TP53 and NXF1. Associates with histones and BRD7 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231344. 2 interactors.
IntActiQ8VDM6. 3 interactors.
MINTiMINT-4119866.
STRINGi10090.ENSMUSP00000037268.

Structurei

3D structure databases

ProteinModelPortaliQ8VDM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 37SAPPROSITE-ProRule annotationAdd BLAST35
Domaini192 – 389B30.2/SPRYPROSITE-ProRule annotationAdd BLAST198
Repeati613 – 6151-13
Repeati620 – 6221-23
Repeati639 – 6411-33
Repeati645 – 6471-43
Repeati659 – 6611-53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 103Necessary for interaction with HRMT1L1By similarityAdd BLAST103
Regioni214 – 859Necessary for interaction with TP53By similarityAdd BLAST646
Regioni457 – 595Necessary for interaction with BRD7 and transcriptional activationBy similarityAdd BLAST139
Regioni613 – 6615 X 3 AA repeats of R-G-GAdd BLAST49
Regioni613 – 661Necessary for transcription repressionBy similarityAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi614 – 669Gly-richAdd BLAST56
Compositional biasi671 – 692Asn-richAdd BLAST22
Compositional biasi695 – 814Pro-richAdd BLAST120
Compositional biasi760 – 848Tyr-richAdd BLAST89
Compositional biasi809 – 835Gln-richAdd BLAST27

Domaini

The RGG-box domain is methylated.By similarity

Sequence similaritiesi

Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 SAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2242. Eukaryota.
ENOG410XSBV. LUCA.
GeneTreeiENSGT00390000020210.
HOGENOMiHOG000253920.
HOVERGENiHBG061101.
InParanoidiQ8VDM6.
KOiK15047.
OMAiHYVMDNI.
OrthoDBiEOG091G041T.
PhylomeDBiQ8VDM6.
TreeFamiTF317301.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR027025. hnRNP_U-like_1.
IPR027417. P-loop_NTPase.
IPR003034. SAP_dom.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR12381:SF41. PTHR12381:SF41. 2 hits.
PfamiPF02037. SAP. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VDM6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDVRRLKVNE LREELQRRGL DTRGLKAELA ERLLAALEAE EPEDERELEA
60 70 80 90 100
DDDPGLPGHN NEEVETEGGS ELEGTAQPPP PGLQPHPEPG GYSGPDGHYV
110 120 130 140 150
MDNITRQNQF YETPVIKQEN ESSYDRRPLD MEPQQQVYHP ELKTEMKQEA
160 170 180 190 200
PPSFLPPEAS QLKTDRPQFQ NRKRPFEENR GRGYFEHRED RRGRSPQPPA
210 220 230 240 250
EEDEDDFDDT LVAIDTYNCD LHFKVARDRS SGYPLTIEGF AYLWSGARAS
260 270 280 290 300
YGVRRGRVCF EMKINEEISV KHLPSTEPDP HVVRIGWSLD SCSTQLGEEP
310 320 330 340 350
FSYGYGGTGK KSTNSRFENY GDKFAENDVI GCFADFECGN DVELSFTKNG
360 370 380 390 400
KWMGIAFRIQ KEALGGQALY PHVLVKNCAV EFNFGQRAEP YCSVLPGFTF
410 420 430 440 450
IQHLPLSERI RGTIGPKSKA ECEILMMVGL PAAGKTTWAI KHAASNPSKK
460 470 480 490 500
YNILGTNAIM DKMRVMGLRR QRNYAGRWDV LIQQATQCLN RLIQIAARKK
510 520 530 540 550
RNYILDQTNV YGSAQRRKMR PFEGFQRKAI VICPTDEDLK DRTVKRTDEE
560 570 580 590 600
GKDVPDHAVL EMKANFTLPD VGDFLDEVLF IELQREEADK LVRQYNEEGR
610 620 630 640 650
KAGPPPEKRF DSRGGGFRGR GGGGGFQRYD NRGPPGGNRG GFQNRGGGGG
660 670 680 690 700
SGGGGGNYRG GFNRSGGGGY NQNRWGNNNR DNNNSNNRGN YNRAPQQQPP
710 720 730 740 750
PQQPPPPQPP PQQPPPPPSY SPARNPPGAS SYNKNSNIPG SSANTSTPTV
760 770 780 790 800
SSYTPPQPSY SQPPYNQGGY TQGYTAPPPP PPPPPAYNYG SYGPYNPAPY
810 820 830 840 850
TPPPPPTAQT YPQPSYNQYQ QYAQQWSQYY QNQSQWPPYY GNYDYGGYSG

STQGGTSTQ
Length:859
Mass (Da):96,002
Last modified:March 1, 2002 - v1
Checksum:i197328B681DF260E
GO
Isoform 2 (identifier: Q8VDM6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: Missing.

Show »
Length:759
Mass (Da):85,046
Checksum:i7DB36055FFEE4BF0
GO
Isoform 3 (identifier: Q8VDM6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     335-340: DFECGN → VLELQV
     341-859: Missing.

Show »
Length:340
Mass (Da):38,733
Checksum:i78013360382D09E2
GO

Sequence cautioni

The sequence AAH27844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti657N → Y in BAE33342 (PubMed:16141072).Curated1
Sequence conflicti665S → T in BAE33342 (PubMed:16141072).Curated1
Sequence conflicti672Q → L in BAE33342 (PubMed:16141072).Curated1
Sequence conflicti686N → Y in BAE33342 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0175531 – 100Missing in isoform 2. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_017554335 – 340DFECGN → VLELQV in isoform 3. 1 Publication6
Alternative sequenceiVSP_017555341 – 859Missing in isoform 3. 1 PublicationAdd BLAST519

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042090 mRNA. Translation: BAC31161.1.
AK143666 mRNA. Translation: BAE25486.1.
AK155604 mRNA. Translation: BAE33342.1.
BC021506 mRNA. Translation: AAH21506.1.
BC027844 mRNA. Translation: AAH27844.1. Different initiation.
BC078642 mRNA. Translation: AAH78642.1.
CCDSiCCDS20995.1. [Q8VDM6-1]
CCDS39841.1. [Q8VDM6-3]
RefSeqiNP_659171.1. NM_144922.2. [Q8VDM6-1]
NP_835190.1. NM_178089.2. [Q8VDM6-3]
XP_006539918.1. XM_006539855.3. [Q8VDM6-2]
XP_006539919.1. XM_006539856.2. [Q8VDM6-2]
UniGeneiMm.254223.

Genome annotation databases

EnsembliENSMUST00000043765; ENSMUSP00000037268; ENSMUSG00000040725. [Q8VDM6-2]
ENSMUST00000108401; ENSMUSP00000104038; ENSMUSG00000040725. [Q8VDM6-3]
ENSMUST00000206832; ENSMUSP00000146263; ENSMUSG00000040725. [Q8VDM6-1]
GeneIDi232989.
KEGGimmu:232989.
UCSCiuc009ftu.1. mouse. [Q8VDM6-1]
uc009ftw.1. mouse. [Q8VDM6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK042090 mRNA. Translation: BAC31161.1.
AK143666 mRNA. Translation: BAE25486.1.
AK155604 mRNA. Translation: BAE33342.1.
BC021506 mRNA. Translation: AAH21506.1.
BC027844 mRNA. Translation: AAH27844.1. Different initiation.
BC078642 mRNA. Translation: AAH78642.1.
CCDSiCCDS20995.1. [Q8VDM6-1]
CCDS39841.1. [Q8VDM6-3]
RefSeqiNP_659171.1. NM_144922.2. [Q8VDM6-1]
NP_835190.1. NM_178089.2. [Q8VDM6-3]
XP_006539918.1. XM_006539855.3. [Q8VDM6-2]
XP_006539919.1. XM_006539856.2. [Q8VDM6-2]
UniGeneiMm.254223.

3D structure databases

ProteinModelPortaliQ8VDM6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231344. 2 interactors.
IntActiQ8VDM6. 3 interactors.
MINTiMINT-4119866.
STRINGi10090.ENSMUSP00000037268.

PTM databases

iPTMnetiQ8VDM6.
PhosphoSitePlusiQ8VDM6.

Proteomic databases

EPDiQ8VDM6.
PaxDbiQ8VDM6.
PeptideAtlasiQ8VDM6.
PRIDEiQ8VDM6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043765; ENSMUSP00000037268; ENSMUSG00000040725. [Q8VDM6-2]
ENSMUST00000108401; ENSMUSP00000104038; ENSMUSG00000040725. [Q8VDM6-3]
ENSMUST00000206832; ENSMUSP00000146263; ENSMUSG00000040725. [Q8VDM6-1]
GeneIDi232989.
KEGGimmu:232989.
UCSCiuc009ftu.1. mouse. [Q8VDM6-1]
uc009ftw.1. mouse. [Q8VDM6-3]

Organism-specific databases

CTDi11100.
MGIiMGI:2443517. Hnrnpul1.

Phylogenomic databases

eggNOGiKOG2242. Eukaryota.
ENOG410XSBV. LUCA.
GeneTreeiENSGT00390000020210.
HOGENOMiHOG000253920.
HOVERGENiHBG061101.
InParanoidiQ8VDM6.
KOiK15047.
OMAiHYVMDNI.
OrthoDBiEOG091G041T.
PhylomeDBiQ8VDM6.
TreeFamiTF317301.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

PROiQ8VDM6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040725.
GenevisibleiQ8VDM6. MM.

Family and domain databases

Gene3Di1.10.720.30. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR027025. hnRNP_U-like_1.
IPR027417. P-loop_NTPase.
IPR003034. SAP_dom.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR12381:SF41. PTHR12381:SF41. 2 hits.
PfamiPF02037. SAP. 1 hit.
PF00622. SPRY. 1 hit.
[Graphical view]
SMARTiSM00513. SAP. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50800. SAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRL1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDM6
Secondary accession number(s): Q3U201
, Q3UPB0, Q6AZA7, Q8BY45, Q8K365
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.