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Protein

Zinc finger CCCH-type with G patch domain-containing protein

Gene

Zgpat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. Represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. Negatively regulates expression of EGFR, a gene involved in cell proliferation, survival and migration. Its ability to repress genes of the EGFR pathway suggest it may act as a tumor suppressor (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 200C3H1-typePROSITE-ProRule annotationAdd BLAST27

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH-type with G patch domain-containing protein
Gene namesi
Name:Zgpat
Synonyms:Kiaa1847
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2449939. Zgpat.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138951 – 511Zinc finger CCCH-type with G patch domain-containing proteinAdd BLAST511

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei70PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei280PhosphothreonineCombined sources1
Modified residuei353PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8VDM1.
MaxQBiQ8VDM1.
PaxDbiQ8VDM1.
PeptideAtlasiQ8VDM1.
PRIDEiQ8VDM1.

PTM databases

iPTMnetiQ8VDM1.
PhosphoSitePlusiQ8VDM1.
SwissPalmiQ8VDM1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027582.
CleanExiMM_ZGPAT.
ExpressionAtlasiQ8VDM1. baseline and differential.
GenevisibleiQ8VDM1. MM.

Interactioni

Subunit structurei

Interacts with CHD4/Mi-2; the interaction is direct.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029105.

Structurei

3D structure databases

ProteinModelPortaliQ8VDM1.
SMRiQ8VDM1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 359G-patchPROSITE-ProRule annotationAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi117 – 121Poly-Glu5

Sequence similaritiesi

Contains 1 C3H1-type zinc finger.PROSITE-ProRule annotation
Contains 1 G-patch domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri174 – 200C3H1-typePROSITE-ProRule annotationAdd BLAST27

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2185. Eukaryota.
ENOG410Z4ZI. LUCA.
GeneTreeiENSGT00390000000732.
HOGENOMiHOG000231955.
HOVERGENiHBG056371.
InParanoidiQ8VDM1.
OMAiRFKENCR.
OrthoDBiEOG091G0FZN.
PhylomeDBiQ8VDM1.
TreeFamiTF105970.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDM1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDNLETAL QTYRAQLQQV ELALGAGLDA SEQADLRQLQ GDLKELIELT
60 70 80 90 100
EASLLSVRKS KLLSTVDQES PAQEDAEYLA FQKAIAEEVE APGAPCNDSE
110 120 130 140 150
TAPGSEVQPG STSSALEEEE EDPDLEELSG AKVNAPYYSA WGTLEYHNAM
160 170 180 190 200
VVGAEEAEDG SACVRVLYLY PTHKSLKPCP FFLEGKCRFK ENCRFSHGQV
210 220 230 240 250
VSVDELRPFQ DPDLSLLQTG SACLAKHQDG LWHPARITDV DNGYYTVKFD
260 270 280 290 300
SLLLKEAVVE GDSILPPLRT EATESSDSDT GDASDSSYAR VVEPSTVDTG
310 320 330 340 350
TCSSAFAGWE VHTRGIGSKL LVKMGYEFGK GLGRHAEGRV EPIHAVVLPR
360 370 380 390 400
GKSLDQCAEI LQKKTKRGQA GSNRPPKCRR SGSRPEGRPP PRNVFDFLNE
410 420 430 440 450
KLQSQVPGTP DAGVDTPERR NKDMYHASKS AKQALSLQLF QTEEKIERTQ
460 470 480 490 500
RDIRGIQEAL TRNTGRHNMT TAHLQEKLEG AQRQLGQLRA QEADLQRKQR
510
KADTHRKMTE F
Length:511
Mass (Da):56,411
Last modified:March 1, 2002 - v1
Checksum:i13B7C46AB107F918
GO

Sequence cautioni

The sequence BAD32554 differs from that shown. The sequence differs from that shown because it seems to be derived from a pre-mRNA.Curated
The sequence CAM26425 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236R → Q in BAC33909 (PubMed:16141072).Curated1
Sequence conflicti264I → T in BAE35381 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173276 Transcribed RNA. Translation: BAD32554.1. Sequence problems.
AK041491 mRNA. Translation: BAC30962.1.
AK049764 mRNA. Translation: BAC33909.1.
AK052236 mRNA. Translation: BAC34894.1.
AK159801 mRNA. Translation: BAE35381.1.
AL928965 Genomic DNA. Translation: CAM26424.1.
AL928965 Genomic DNA. Translation: CAM26425.1. Sequence problems.
CH466626 Genomic DNA. Translation: EDL07412.1.
BC021513 mRNA. Translation: AAH21513.1.
BC027218 mRNA. Translation: AAH27218.1.
CCDSiCCDS17210.1.
RefSeqiNP_001041613.1. NM_001048148.1.
NP_659143.1. NM_144894.3.
UniGeneiMm.272712.
Mm.87720.

Genome annotation databases

EnsembliENSMUST00000029105; ENSMUSP00000029105; ENSMUSG00000027582.
ENSMUST00000108807; ENSMUSP00000104435; ENSMUSG00000027582.
ENSMUST00000116366; ENSMUSP00000112067; ENSMUSG00000027582.
GeneIDi229007.
KEGGimmu:229007.
UCSCiuc008omb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173276 Transcribed RNA. Translation: BAD32554.1. Sequence problems.
AK041491 mRNA. Translation: BAC30962.1.
AK049764 mRNA. Translation: BAC33909.1.
AK052236 mRNA. Translation: BAC34894.1.
AK159801 mRNA. Translation: BAE35381.1.
AL928965 Genomic DNA. Translation: CAM26424.1.
AL928965 Genomic DNA. Translation: CAM26425.1. Sequence problems.
CH466626 Genomic DNA. Translation: EDL07412.1.
BC021513 mRNA. Translation: AAH21513.1.
BC027218 mRNA. Translation: AAH27218.1.
CCDSiCCDS17210.1.
RefSeqiNP_001041613.1. NM_001048148.1.
NP_659143.1. NM_144894.3.
UniGeneiMm.272712.
Mm.87720.

3D structure databases

ProteinModelPortaliQ8VDM1.
SMRiQ8VDM1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029105.

PTM databases

iPTMnetiQ8VDM1.
PhosphoSitePlusiQ8VDM1.
SwissPalmiQ8VDM1.

Proteomic databases

EPDiQ8VDM1.
MaxQBiQ8VDM1.
PaxDbiQ8VDM1.
PeptideAtlasiQ8VDM1.
PRIDEiQ8VDM1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029105; ENSMUSP00000029105; ENSMUSG00000027582.
ENSMUST00000108807; ENSMUSP00000104435; ENSMUSG00000027582.
ENSMUST00000116366; ENSMUSP00000112067; ENSMUSG00000027582.
GeneIDi229007.
KEGGimmu:229007.
UCSCiuc008omb.1. mouse.

Organism-specific databases

CTDi84619.
MGIiMGI:2449939. Zgpat.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2185. Eukaryota.
ENOG410Z4ZI. LUCA.
GeneTreeiENSGT00390000000732.
HOGENOMiHOG000231955.
HOVERGENiHBG056371.
InParanoidiQ8VDM1.
OMAiRFKENCR.
OrthoDBiEOG091G0FZN.
PhylomeDBiQ8VDM1.
TreeFamiTF105970.

Miscellaneous databases

PROiQ8VDM1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027582.
CleanExiMM_ZGPAT.
ExpressionAtlasiQ8VDM1. baseline and differential.
GenevisibleiQ8VDM1. MM.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR000467. G_patch_dom.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF01585. G-patch. 1 hit.
[Graphical view]
SMARTiSM00443. G_patch. 1 hit.
SM00356. ZnF_C3H1. 1 hit.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50174. G_PATCH. 1 hit.
PS50103. ZF_C3H1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZGPAT_MOUSE
AccessioniPrimary (citable) accession number: Q8VDM1
Secondary accession number(s): A2AU20
, A2AU21, Q3TW85, Q69Z90, Q8BWW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.