ID   ELF5_MOUSE              Reviewed;         253 AA.
AC   Q8VDK3; Q921H5; Q9Z2K6;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 2.
DT   24-JAN-2024, entry version 159.
DE   RecName: Full=ETS-related transcription factor Elf-5;
DE   AltName: Full=E74-like factor 5;
GN   Name=Elf5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Lung;
RX   PubMed=9840936; DOI=10.1038/sj.onc.1202198;
RA   Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S.,
RA   Kola I.;
RT   "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS
RT   genes and maps to human chromosome 11p13-15, a region subject to LOH and
RT   rearrangement in human carcinoma cell lines.";
RL   Oncogene 17:2719-2732(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, AND DOMAIN.
RX   PubMed=16704374; DOI=10.1042/bj20060375;
RA   Choi Y.S., Sinha S.;
RT   "Determination of the consensus DNA-binding sequence and a transcriptional
RT   activation domain for ESE-2.";
RL   Biochem. J. 398:497-507(2006).
CC   -!- FUNCTION: Transcriptionally activator that may play a role in
CC       regulating the later stages of keratinocytes terminal differentiation
CC       (By similarity). Binds to DNA sequences containing the consensus
CC       nucleotide core sequence GGA[AT]. Transcriptionally activates the TK
CC       promoter. {ECO:0000250, ECO:0000269|PubMed:16704374,
CC       ECO:0000269|PubMed:9840936}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
CC   -!- TISSUE SPECIFICITY: Expressed in lung, kidney, stomach, brain, ovaries,
CC       tongue, bladder and mammary glands. {ECO:0000269|PubMed:9840936}.
CC   -!- DEVELOPMENTAL STAGE: In the neonatal stage, and during embryogenesis on
CC       days 16, 17 and 19, an expression pattern similar to the adult was
CC       observed. In addition at stage 16, expression was detected in small
CC       intestine.
CC   -!- DOMAIN: The PNT domain acts as a transcriptional activator.
CC       {ECO:0000269|PubMed:16704374}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; AF049702; AAC79754.1; -; mRNA.
DR   EMBL; BC021629; AAH21629.1; -; mRNA.
DR   EMBL; BC012424; AAH12424.1; -; mRNA.
DR   CCDS; CCDS16477.1; -.
DR   RefSeq; NP_001139285.1; NM_001145813.1.
DR   RefSeq; NP_034255.2; NM_010125.3.
DR   RefSeq; XP_006498768.1; XM_006498705.1.
DR   AlphaFoldDB; Q8VDK3; -.
DR   SMR; Q8VDK3; -.
DR   BioGRID; 199428; 104.
DR   IntAct; Q8VDK3; 1.
DR   STRING; 10090.ENSMUSP00000126941; -.
DR   iPTMnet; Q8VDK3; -.
DR   PhosphoSitePlus; Q8VDK3; -.
DR   PaxDb; 10090-ENSMUSP00000028609; -.
DR   Antibodypedia; 25870; 294 antibodies from 29 providers.
DR   DNASU; 13711; -.
DR   Ensembl; ENSMUST00000028609.14; ENSMUSP00000028609.8; ENSMUSG00000027186.17.
DR   Ensembl; ENSMUST00000164172.8; ENSMUSP00000126941.2; ENSMUSG00000027186.17.
DR   GeneID; 13711; -.
DR   KEGG; mmu:13711; -.
DR   UCSC; uc008liv.2; mouse.
DR   AGR; MGI:1335079; -.
DR   CTD; 2001; -.
DR   MGI; MGI:1335079; Elf5.
DR   VEuPathDB; HostDB:ENSMUSG00000027186; -.
DR   eggNOG; KOG3804; Eukaryota.
DR   GeneTree; ENSGT00940000160980; -.
DR   HOGENOM; CLU_048172_1_0_1; -.
DR   InParanoid; Q8VDK3; -.
DR   OMA; MSWTELF; -.
DR   OrthoDB; 3686750at2759; -.
DR   PhylomeDB; Q8VDK3; -.
DR   TreeFam; TF318679; -.
DR   BioGRID-ORCS; 13711; 2 hits in 79 CRISPR screens.
DR   ChiTaRS; Elf5; mouse.
DR   PRO; PR:Q8VDK3; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8VDK3; Protein.
DR   Bgee; ENSMUSG00000027186; Expressed in seminal vesicle and 96 other cell types or tissues.
DR   ExpressionAtlas; Q8VDK3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:MGI.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR   GO; GO:0007398; P:ectoderm development; IMP:MGI.
DR   GO; GO:0001712; P:ectodermal cell fate commitment; IGI:MGI.
DR   GO; GO:0060644; P:mammary gland epithelial cell differentiation; IGI:MGI.
DR   GO; GO:0060806; P:negative regulation of cell differentiation involved in embryonic placenta development; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0035019; P:somatic stem cell population maintenance; IMP:MGI.
DR   GO; GO:0060707; P:trophoblast giant cell differentiation; IMP:MGI.
DR   CDD; cd08538; SAM_PNT-ESE-2-like; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF15; ETS-RELATED TRANSCRIPTION FACTOR ELF-5; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
DR   Genevisible; Q8VDK3; MM.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..253
FT                   /note="ETS-related transcription factor Elf-5"
FT                   /id="PRO_0000204093"
FT   DOMAIN          33..119
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        161..242
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   CONFLICT        31
FT                   /note="D -> E (in Ref. 2; AAH21629)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        228
FT                   /note="G -> R (in Ref. 1; AAC79754)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   253 AA;  29873 MW;  3FC4799F77AFCF48 CRC64;
     MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH PEYWTKRHVW
     EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA AGICGEYLYF ILQNIRSQGY
     SFFNDAEETK TGIKDYADSS CLKTSGIKSQ DCHSRTSLQS SHLWEFVRDL LLSPEENCGI
     LEWEDREQGI FRVVKSEALA KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK
     FGKNAHGWQE EKL
//