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Protein

ETS-related transcription factor Elf-5

Gene

Elf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi161 – 242ETSPROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

GO - Biological processi

  • ectodermal cell fate commitment Source: MGI
  • ectoderm development Source: MGI
  • mammary gland epithelial cell differentiation Source: MGI
  • negative regulation of cell differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: NTNU_SB
  • somatic stem cell population maintenance Source: MGI

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-5
Alternative name(s):
E74-like factor 5
Gene namesi
Name:Elf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1335079 Elf5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002040931 – 253ETS-related transcription factor Elf-5Add BLAST253

Proteomic databases

PaxDbiQ8VDK3
PRIDEiQ8VDK3

PTM databases

iPTMnetiQ8VDK3
PhosphoSitePlusiQ8VDK3

Expressioni

Tissue specificityi

Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands.1 Publication

Developmental stagei

In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine.

Gene expression databases

BgeeiENSMUSG00000027186
CleanExiMM_ELF5
ExpressionAtlasiQ8VDK3 baseline and differential
GenevisibleiQ8VDK3 MM

Interactioni

Protein-protein interaction databases

BioGridi199428, 104 interactors
STRINGi10090.ENSMUSP00000028609

Structurei

3D structure databases

ProteinModelPortaliQ8VDK3
SMRiQ8VDK3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 119PNTPROSITE-ProRule annotationAdd BLAST87

Domaini

The PNT domain acts as a transcriptional activator.1 Publication

Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGiKOG3804 Eukaryota
ENOG4111K4J LUCA
GeneTreeiENSGT00760000118996
HOGENOMiHOG000232188
HOVERGENiHBG074143
InParanoidiQ8VDK3
KOiK17101
OMAiAHGWQEE
OrthoDBiEOG091G0BE6
PhylomeDBiQ8VDK3
TreeFamiTF318679

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR033069 Elf5
IPR000418 Ets_dom
IPR003118 Pointed_dom
IPR013761 SAM/pointed_sf
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11849:SF15 PTHR11849:SF15, 1 hit
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF02198 SAM_PNT, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SM00251 SAM_PNT, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit
PS51433 PNT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VDK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH
60 70 80 90 100
PEYWTKRHVW EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA
110 120 130 140 150
AGICGEYLYF ILQNIRSQGY SFFNDAEETK TGIKDYADSS CLKTSGIKSQ
160 170 180 190 200
DCHSRTSLQS SHLWEFVRDL LLSPEENCGI LEWEDREQGI FRVVKSEALA
210 220 230 240 250
KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK FGKNAHGWQE

EKL
Length:253
Mass (Da):29,873
Last modified:July 5, 2005 - v2
Checksum:i3FC4799F77AFCF48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31D → E in AAH21629 (PubMed:15489334).Curated1
Sequence conflicti228G → R in AAC79754 (PubMed:9840936).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049702 mRNA Translation: AAC79754.1
BC021629 mRNA Translation: AAH21629.1
BC012424 mRNA Translation: AAH12424.1
CCDSiCCDS16477.1
RefSeqiNP_001139285.1, NM_001145813.1
NP_034255.2, NM_010125.3
XP_006498768.1, XM_006498705.1
UniGeneiMm.20888

Genome annotation databases

EnsembliENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186
ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186
ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186
GeneIDi13711
KEGGimmu:13711
UCSCiuc008liv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiELF5_MOUSE
AccessioniPrimary (citable) accession number: Q8VDK3
Secondary accession number(s): Q921H5, Q9Z2K6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: March 28, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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