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Protein

ETS-related transcription factor Elf-5

Gene

Elf5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi161 – 24282ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: GO_Central

GO - Biological processi

  1. ectoderm development Source: MGI
  2. mammary gland epithelial cell differentiation Source: MGI
  3. negative regulation of cell differentiation Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  5. regulation of transcription from RNA polymerase II promoter Source: GO_Central
  6. somatic stem cell maintenance Source: MGI
  7. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-5
Alternative name(s):
E74-like factor 5
Gene namesi
Name:Elf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1335079. Elf5.

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253ETS-related transcription factor Elf-5PRO_0000204093Add
BLAST

Proteomic databases

PRIDEiQ8VDK3.

Expressioni

Tissue specificityi

Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands.1 Publication

Developmental stagei

In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine.

Gene expression databases

BgeeiQ8VDK3.
CleanExiMM_ELF5.
ExpressionAtlasiQ8VDK3. baseline and differential.
GenevestigatoriQ8VDK3.

Interactioni

Protein-protein interaction databases

BioGridi199428. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8VDK3.
SMRiQ8VDK3. Positions 162-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 11987PNTPROSITE-ProRule annotationAdd
BLAST

Domaini

The PNT domain acts as a transcriptional activator.1 Publication

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG296414.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiQ8VDK3.
KOiK17101.
OMAiSQGYSFF.
OrthoDBiEOG7M0NRR.
PhylomeDBiQ8VDK3.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH
60 70 80 90 100
PEYWTKRHVW EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA
110 120 130 140 150
AGICGEYLYF ILQNIRSQGY SFFNDAEETK TGIKDYADSS CLKTSGIKSQ
160 170 180 190 200
DCHSRTSLQS SHLWEFVRDL LLSPEENCGI LEWEDREQGI FRVVKSEALA
210 220 230 240 250
KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK FGKNAHGWQE

EKL
Length:253
Mass (Da):29,873
Last modified:July 5, 2005 - v2
Checksum:i3FC4799F77AFCF48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311D → E in AAH21629 (PubMed:15489334).Curated
Sequence conflicti228 – 2281G → R in AAC79754 (PubMed:9840936).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049702 mRNA. Translation: AAC79754.1.
BC021629 mRNA. Translation: AAH21629.1.
BC012424 mRNA. Translation: AAH12424.1.
CCDSiCCDS16477.1.
RefSeqiNP_001139285.1. NM_001145813.1.
NP_034255.2. NM_010125.3.
XP_006498768.1. XM_006498705.1.
UniGeneiMm.20888.

Genome annotation databases

EnsembliENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186.
ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186.
ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186.
GeneIDi13711.
KEGGimmu:13711.
UCSCiuc008liv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF049702 mRNA. Translation: AAC79754.1.
BC021629 mRNA. Translation: AAH21629.1.
BC012424 mRNA. Translation: AAH12424.1.
CCDSiCCDS16477.1.
RefSeqiNP_001139285.1. NM_001145813.1.
NP_034255.2. NM_010125.3.
XP_006498768.1. XM_006498705.1.
UniGeneiMm.20888.

3D structure databases

ProteinModelPortaliQ8VDK3.
SMRiQ8VDK3. Positions 162-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199428. 1 interaction.

Proteomic databases

PRIDEiQ8VDK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186.
ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186.
ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186.
GeneIDi13711.
KEGGimmu:13711.
UCSCiuc008liv.2. mouse.

Organism-specific databases

CTDi2001.
MGIiMGI:1335079. Elf5.

Phylogenomic databases

eggNOGiNOG296414.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiQ8VDK3.
KOiK17101.
OMAiSQGYSFF.
OrthoDBiEOG7M0NRR.
PhylomeDBiQ8VDK3.
TreeFamiTF318679.

Miscellaneous databases

ChiTaRSiElf5. mouse.
NextBioi284478.
PROiQ8VDK3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VDK3.
CleanExiMM_ELF5.
ExpressionAtlasiQ8VDK3. baseline and differential.
GenevestigatoriQ8VDK3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines."
    Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I.
    Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. "Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2."
    Choi Y.S., Sinha S.
    Biochem. J. 398:497-507(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN.

Entry informationi

Entry nameiELF5_MOUSE
AccessioniPrimary (citable) accession number: Q8VDK3
Secondary accession number(s): Q921H5, Q9Z2K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 1, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.