Q8VDK3 (ELF5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ETS-related transcription factor Elf-5

Alternative name(s):
E74-like factor 5

Gene names

Name:

Elf5

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation By similarity. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter. Ref.1 Ref.3
Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands. Ref.1
Developmental stage	In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine.
Domain	The PNT domain acts as a transcriptional activator. Ref.3
Sequence similarities	Belongs to the ETS family. Contains 1 ETS DNA-binding domain. Contains 1 PNT (pointed) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ectoderm development Inferred from mutant phenotype PubMed 15829518. Source: MGI mammary gland epithelial cell differentiation Inferred from genetic interaction PubMed 16469767. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from direct assay PubMed 16469767. Source: MGI nucleus Inferred from direct assay PubMed 16469767. Source: MGI
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	ETS-related transcription factor Elf-5		PRO_0000204093
Regions
	Domain	33 – 119	87	PNT
	DNA binding	161 – 242	82	ETS
Experimental info
	Sequence conflict	31	1	D → E in AAH21629. Ref.2
	Sequence conflict	228	1	G → R in AAC79754. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8VDK3 [UniParc]. Last modified July 5, 2005. Version 2. Checksum: 3FC4799F77AFCF48	FASTA	253	29,873
	10 20 30 40 50 60 MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH PEYWTKRHVW 70 80 90 100 110 120 EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA AGICGEYLYF ILQNIRSQGY 130 140 150 160 170 180 SFFNDAEETK TGIKDYADSS CLKTSGIKSQ DCHSRTSLQS SHLWEFVRDL LLSPEENCGI 190 200 210 220 230 240 LEWEDREQGI FRVVKSEALA KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK 250 FGKNAHGWQE EKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines." Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I. Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Czech II. Tissue: Mammary gland.
[3]	"Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2." Choi Y.S., Sinha S. Biochem. J. 398:497-507(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DOMAIN.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF049702 mRNA. Translation: AAC79754.1. BC021629 mRNA. Translation: AAH21629.1. BC012424 mRNA. Translation: AAH12424.1.
IPI	IPI00131213.
RefSeq	NP_001139285.1. NM_001145813.1. NP_034255.2. NM_010125.3.
UniGene	Mm.20888.
3D structure databases
ProteinModelPortal	Q8VDK3.
SMR	Q8VDK3. Positions 162-253.
ModBase	Search...
Proteomic databases
PRIDE	Q8VDK3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186. ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186. ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186.
GeneID	13711.
KEGG	mmu:13711.
Organism-specific databases
CTD	2001.
MGI	MGI:1335079. Elf5.
Phylogenomic databases
eggNOG	NOG296414.
GeneTree	ENSGT00700000104115.
HOGENOM	HOG000232188.
HOVERGEN	HBG074143.
InParanoid	Q8VDK3.
KO	K09429.
OMA	SQGYSFF.
OrthoDB	EOG4V171B.
Gene expression databases
ArrayExpress	Q8VDK3.
Bgee	Q8VDK3.
CleanEx	MM_ELF5.
Genevestigator	Q8VDK3.
GermOnline	ENSMUSG00000027186. Mus musculus.
Family and domain databases
Gene3D	1.10.10.10. 1 hit. 1.10.150.50. 1 hit.
InterPro	IPR000418. Ets_dom. IPR003118. Pointed_dom. IPR013761. SAM/pointed. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00178. Ets. 1 hit. PF02198. SAM_PNT. 1 hit. [Graphical view]
PRINTS	PR00454. ETSDOMAIN.
SMART	SM00413. ETS. 1 hit. SM00251. SAM_PNT. 1 hit. [Graphical view]
SUPFAM	SSF47769. SAM_homology. 1 hit.
PROSITE	PS00345. ETS_DOMAIN_1. False negative. PS00346. ETS_DOMAIN_2. 1 hit. PS50061. ETS_DOMAIN_3. 1 hit. PS51433. PNT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ELF5. mouse.
NextBio	284478.
SOURCE	Search...

Entry information

Entry name

ELF5_MOUSE

Accession

Primary (citable) accession number: Q8VDK3
Secondary accession number(s): Q921H5, Q9Z2K6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	July 5, 2005
Last modified:	May 1, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program