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Q8VDK3

- ELF5_MOUSE

UniProt

Q8VDK3 - ELF5_MOUSE

Protein

ETS-related transcription factor Elf-5

Gene

Elf5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (05 Jul 2005)
      Previous versions | rss
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    Functioni

    Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation By similarity. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi161 – 24282ETSPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
    2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
    3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

    GO - Biological processi

    1. ectoderm development Source: MGI
    2. mammary gland epithelial cell differentiation Source: MGI
    3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
    4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
    5. transcription from RNA polymerase II promoter Source: GOC

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ETS-related transcription factor Elf-5
    Alternative name(s):
    E74-like factor 5
    Gene namesi
    Name:Elf5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1335079. Elf5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 253253ETS-related transcription factor Elf-5PRO_0000204093Add
    BLAST

    Proteomic databases

    PRIDEiQ8VDK3.

    Expressioni

    Tissue specificityi

    Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands.1 Publication

    Developmental stagei

    In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine.

    Gene expression databases

    ArrayExpressiQ8VDK3.
    BgeeiQ8VDK3.
    CleanExiMM_ELF5.
    GenevestigatoriQ8VDK3.

    Interactioni

    Protein-protein interaction databases

    BioGridi199428. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VDK3.
    SMRiQ8VDK3. Positions 162-253.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 11987PNTPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PNT domain acts as a transcriptional activator.1 Publication

    Sequence similaritiesi

    Belongs to the ETS family.Curated
    Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG296414.
    GeneTreeiENSGT00750000117299.
    HOGENOMiHOG000232188.
    HOVERGENiHBG074143.
    InParanoidiQ8VDK3.
    KOiK17101.
    OMAiSQGYSFF.
    OrthoDBiEOG7M0NRR.
    PhylomeDBiQ8VDK3.
    TreeFamiTF318679.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProiIPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view]
    PRINTSiPR00454. ETSDOMAIN.
    SMARTiSM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF47769. SSF47769. 1 hit.
    PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VDK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH    50
    PEYWTKRHVW EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA 100
    AGICGEYLYF ILQNIRSQGY SFFNDAEETK TGIKDYADSS CLKTSGIKSQ 150
    DCHSRTSLQS SHLWEFVRDL LLSPEENCGI LEWEDREQGI FRVVKSEALA 200
    KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK FGKNAHGWQE 250
    EKL 253
    Length:253
    Mass (Da):29,873
    Last modified:July 5, 2005 - v2
    Checksum:i3FC4799F77AFCF48
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti31 – 311D → E in AAH21629. (PubMed:15489334)Curated
    Sequence conflicti228 – 2281G → R in AAC79754. (PubMed:9840936)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049702 mRNA. Translation: AAC79754.1.
    BC021629 mRNA. Translation: AAH21629.1.
    BC012424 mRNA. Translation: AAH12424.1.
    CCDSiCCDS16477.1.
    RefSeqiNP_001139285.1. NM_001145813.1.
    NP_034255.2. NM_010125.3.
    XP_006498768.1. XM_006498705.1.
    UniGeneiMm.20888.

    Genome annotation databases

    EnsembliENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186.
    ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186.
    ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186.
    GeneIDi13711.
    KEGGimmu:13711.
    UCSCiuc008liv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF049702 mRNA. Translation: AAC79754.1 .
    BC021629 mRNA. Translation: AAH21629.1 .
    BC012424 mRNA. Translation: AAH12424.1 .
    CCDSi CCDS16477.1.
    RefSeqi NP_001139285.1. NM_001145813.1.
    NP_034255.2. NM_010125.3.
    XP_006498768.1. XM_006498705.1.
    UniGenei Mm.20888.

    3D structure databases

    ProteinModelPortali Q8VDK3.
    SMRi Q8VDK3. Positions 162-253.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199428. 1 interaction.

    Proteomic databases

    PRIDEi Q8VDK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000028609 ; ENSMUSP00000028609 ; ENSMUSG00000027186 .
    ENSMUST00000164172 ; ENSMUSP00000126941 ; ENSMUSG00000027186 .
    ENSMUST00000171693 ; ENSMUSP00000131940 ; ENSMUSG00000027186 .
    GeneIDi 13711.
    KEGGi mmu:13711.
    UCSCi uc008liv.2. mouse.

    Organism-specific databases

    CTDi 2001.
    MGIi MGI:1335079. Elf5.

    Phylogenomic databases

    eggNOGi NOG296414.
    GeneTreei ENSGT00750000117299.
    HOGENOMi HOG000232188.
    HOVERGENi HBG074143.
    InParanoidi Q8VDK3.
    KOi K17101.
    OMAi SQGYSFF.
    OrthoDBi EOG7M0NRR.
    PhylomeDBi Q8VDK3.
    TreeFami TF318679.

    Miscellaneous databases

    ChiTaRSi ELF5. mouse.
    NextBioi 284478.
    PROi Q8VDK3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VDK3.
    Bgeei Q8VDK3.
    CleanExi MM_ELF5.
    Genevestigatori Q8VDK3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    1.10.150.50. 1 hit.
    InterProi IPR000418. Ets_dom.
    IPR003118. Pointed_dom.
    IPR013761. SAM/pointed.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00178. Ets. 1 hit.
    PF02198. SAM_PNT. 1 hit.
    [Graphical view ]
    PRINTSi PR00454. ETSDOMAIN.
    SMARTi SM00413. ETS. 1 hit.
    SM00251. SAM_PNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47769. SSF47769. 1 hit.
    PROSITEi PS00346. ETS_DOMAIN_2. 1 hit.
    PS50061. ETS_DOMAIN_3. 1 hit.
    PS51433. PNT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines."
      Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I.
      Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Lung.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary gland.
    3. "Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2."
      Choi Y.S., Sinha S.
      Biochem. J. 398:497-507(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DOMAIN.

    Entry informationi

    Entry nameiELF5_MOUSE
    AccessioniPrimary (citable) accession number: Q8VDK3
    Secondary accession number(s): Q921H5, Q9Z2K6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2005
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3