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Q8VDK3

- ELF5_MOUSE

UniProt

Q8VDK3 - ELF5_MOUSE

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Protein

ETS-related transcription factor Elf-5

Gene

Elf5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation (By similarity). Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi161 – 24282ETSPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II regulatory region sequence-specific DNA binding Source: NTNU_SB
  2. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  3. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: RefGenome

GO - Biological processi

  1. ectoderm development Source: MGI
  2. mammary gland epithelial cell differentiation Source: MGI
  3. positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  4. regulation of transcription from RNA polymerase II promoter Source: RefGenome
  5. transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ETS-related transcription factor Elf-5
Alternative name(s):
E74-like factor 5
Gene namesi
Name:Elf5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1335079. Elf5.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 253253ETS-related transcription factor Elf-5PRO_0000204093Add
BLAST

Proteomic databases

PRIDEiQ8VDK3.

Expressioni

Tissue specificityi

Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands.1 Publication

Developmental stagei

In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine.

Gene expression databases

BgeeiQ8VDK3.
CleanExiMM_ELF5.
ExpressionAtlasiQ8VDK3. baseline and differential.
GenevestigatoriQ8VDK3.

Interactioni

Protein-protein interaction databases

BioGridi199428. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8VDK3.
SMRiQ8VDK3. Positions 162-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 11987PNTPROSITE-ProRule annotationAdd
BLAST

Domaini

The PNT domain acts as a transcriptional activator.1 Publication

Sequence similaritiesi

Belongs to the ETS family.Curated
Contains 1 ETS DNA-binding domain.PROSITE-ProRule annotation
Contains 1 PNT (pointed) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG296414.
GeneTreeiENSGT00760000118996.
HOGENOMiHOG000232188.
HOVERGENiHBG074143.
InParanoidiQ8VDK3.
KOiK17101.
OMAiSQGYSFF.
OrthoDBiEOG7M0NRR.
PhylomeDBiQ8VDK3.
TreeFamiTF318679.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProiIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSiPR00454. ETSDOMAIN.
SMARTiSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
PROSITEiPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDK3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH
60 70 80 90 100
PEYWTKRHVW EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA
110 120 130 140 150
AGICGEYLYF ILQNIRSQGY SFFNDAEETK TGIKDYADSS CLKTSGIKSQ
160 170 180 190 200
DCHSRTSLQS SHLWEFVRDL LLSPEENCGI LEWEDREQGI FRVVKSEALA
210 220 230 240 250
KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK FGKNAHGWQE

EKL
Length:253
Mass (Da):29,873
Last modified:July 5, 2005 - v2
Checksum:i3FC4799F77AFCF48
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311D → E in AAH21629. (PubMed:15489334)Curated
Sequence conflicti228 – 2281G → R in AAC79754. (PubMed:9840936)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049702 mRNA. Translation: AAC79754.1.
BC021629 mRNA. Translation: AAH21629.1.
BC012424 mRNA. Translation: AAH12424.1.
CCDSiCCDS16477.1.
RefSeqiNP_001139285.1. NM_001145813.1.
NP_034255.2. NM_010125.3.
XP_006498768.1. XM_006498705.1.
UniGeneiMm.20888.

Genome annotation databases

EnsembliENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186.
ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186.
ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186.
GeneIDi13711.
KEGGimmu:13711.
UCSCiuc008liv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF049702 mRNA. Translation: AAC79754.1 .
BC021629 mRNA. Translation: AAH21629.1 .
BC012424 mRNA. Translation: AAH12424.1 .
CCDSi CCDS16477.1.
RefSeqi NP_001139285.1. NM_001145813.1.
NP_034255.2. NM_010125.3.
XP_006498768.1. XM_006498705.1.
UniGenei Mm.20888.

3D structure databases

ProteinModelPortali Q8VDK3.
SMRi Q8VDK3. Positions 162-253.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 199428. 1 interaction.

Proteomic databases

PRIDEi Q8VDK3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000028609 ; ENSMUSP00000028609 ; ENSMUSG00000027186 .
ENSMUST00000164172 ; ENSMUSP00000126941 ; ENSMUSG00000027186 .
ENSMUST00000171693 ; ENSMUSP00000131940 ; ENSMUSG00000027186 .
GeneIDi 13711.
KEGGi mmu:13711.
UCSCi uc008liv.2. mouse.

Organism-specific databases

CTDi 2001.
MGIi MGI:1335079. Elf5.

Phylogenomic databases

eggNOGi NOG296414.
GeneTreei ENSGT00760000118996.
HOGENOMi HOG000232188.
HOVERGENi HBG074143.
InParanoidi Q8VDK3.
KOi K17101.
OMAi SQGYSFF.
OrthoDBi EOG7M0NRR.
PhylomeDBi Q8VDK3.
TreeFami TF318679.

Miscellaneous databases

ChiTaRSi ELF5. mouse.
NextBioi 284478.
PROi Q8VDK3.
SOURCEi Search...

Gene expression databases

Bgeei Q8VDK3.
CleanExi MM_ELF5.
ExpressionAtlasi Q8VDK3. baseline and differential.
Genevestigatori Q8VDK3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProi IPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view ]
PRINTSi PR00454. ETSDOMAIN.
SMARTi SM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view ]
SUPFAMi SSF47769. SSF47769. 1 hit.
PROSITEi PS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines."
    Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I.
    Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary gland.
  3. "Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2."
    Choi Y.S., Sinha S.
    Biochem. J. 398:497-507(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN.

Entry informationi

Entry nameiELF5_MOUSE
AccessioniPrimary (citable) accession number: Q8VDK3
Secondary accession number(s): Q921H5, Q9Z2K6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3