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Q8VDK3 (ELF5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ETS-related transcription factor Elf-5
Alternative name(s):
E74-like factor 5
Gene names
Name:Elf5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length253 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation By similarity. Binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates the TK promoter. Ref.1 Ref.3

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in lung, kidney, stomach, brain, ovaries, tongue, bladder and mammary glands. Ref.1

Developmental stage

In the neonatal stage, and during embryogenesis on days 16, 17 and 19, an expression pattern similar to the adult was observed. In addition at stage 16, expression was detected in small intestine.

Domain

The PNT domain acts as a transcriptional activator. Ref.3

Sequence similarities

Belongs to the ETS family.

Contains 1 ETS DNA-binding domain.

Contains 1 PNT (pointed) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253ETS-related transcription factor Elf-5
PRO_0000204093

Regions

Domain33 – 11987PNT
DNA binding161 – 24282ETS

Experimental info

Sequence conflict311D → E in AAH21629. Ref.2
Sequence conflict2281G → R in AAC79754. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8VDK3 [UniParc].

Last modified July 5, 2005. Version 2.
Checksum: 3FC4799F77AFCF48

FASTA25329,873
        10         20         30         40         50         60 
MLDSVTHSTF LPNASFCDPL MPWTDLFSNE DYYPAFEHQT ACDSYWTSVH PEYWTKRHVW 

        70         80         90        100        110        120 
EWLQFCCDQY KLDANCISFC HFNISGLQLC SMTQEEFIEA AGICGEYLYF ILQNIRSQGY 

       130        140        150        160        170        180 
SFFNDAEETK TGIKDYADSS CLKTSGIKSQ DCHSRTSLQS SHLWEFVRDL LLSPEENCGI 

       190        200        210        220        230        240 
LEWEDREQGI FRVVKSEALA KMWGQRKKND RMTYEKLSRA LRYYYKTGIL ERVDRRLVYK 

       250 
FGKNAHGWQE EKL 

« Hide

References

« Hide 'large scale' references
[1]"A novel transcription factor, ELF5, belongs to the ELF subfamily of ETS genes and maps to human chromosome 11p13-15, a region subject to LOH and rearrangement in human carcinoma cell lines."
Zhou J., Ng A.Y., Tymms M.J., Jermiin L.S., Seth A.K., Thomas R.S., Kola I.
Oncogene 17:2719-2732(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Lung.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: Czech II.
Tissue: Mammary gland.
[3]"Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2."
Choi Y.S., Sinha S.
Biochem. J. 398:497-507(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, DOMAIN.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF049702 mRNA. Translation: AAC79754.1.
BC021629 mRNA. Translation: AAH21629.1.
BC012424 mRNA. Translation: AAH12424.1.
RefSeqNP_001139285.1. NM_001145813.1.
NP_034255.2. NM_010125.3.
XP_006498768.1. XM_006498705.1.
UniGeneMm.20888.

3D structure databases

ProteinModelPortalQ8VDK3.
SMRQ8VDK3. Positions 21-122, 162-253.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid199428. 1 interaction.

Proteomic databases

PRIDEQ8VDK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000028609; ENSMUSP00000028609; ENSMUSG00000027186.
ENSMUST00000164172; ENSMUSP00000126941; ENSMUSG00000027186.
ENSMUST00000171693; ENSMUSP00000131940; ENSMUSG00000027186.
GeneID13711.
KEGGmmu:13711.
UCSCuc008liv.2. mouse.

Organism-specific databases

CTD2001.
MGIMGI:1335079. Elf5.

Phylogenomic databases

eggNOGNOG296414.
GeneTreeENSGT00750000117299.
HOGENOMHOG000232188.
HOVERGENHBG074143.
InParanoidQ8VDK3.
KOK17101.
OMASQGYSFF.
OrthoDBEOG7M0NRR.
PhylomeDBQ8VDK3.
TreeFamTF318679.

Gene expression databases

ArrayExpressQ8VDK3.
BgeeQ8VDK3.
CleanExMM_ELF5.
GenevestigatorQ8VDK3.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
1.10.150.50. 1 hit.
InterProIPR000418. Ets_dom.
IPR003118. Pointed_dom.
IPR013761. SAM/pointed.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00178. Ets. 1 hit.
PF02198. SAM_PNT. 1 hit.
[Graphical view]
PRINTSPR00454. ETSDOMAIN.
SMARTSM00413. ETS. 1 hit.
SM00251. SAM_PNT. 1 hit.
[Graphical view]
SUPFAMSSF47769. SSF47769. 1 hit.
PROSITEPS00346. ETS_DOMAIN_2. 1 hit.
PS50061. ETS_DOMAIN_3. 1 hit.
PS51433. PNT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSELF5. mouse.
NextBio284478.
PROQ8VDK3.
SOURCESearch...

Entry information

Entry nameELF5_MOUSE
AccessionPrimary (citable) accession number: Q8VDK3
Secondary accession number(s): Q921H5, Q9Z2K6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2005
Last modified: April 16, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot