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Protein

Vigilin

Gene

Hdlbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-194223. HDL-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Vigilin
Alternative name(s):
High density lipoprotein-binding protein
Short name:
HDL-binding protein
Gene namesi
Name:Hdlbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:99256. Hdlbp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, HDL, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000501322 – 1268VigilinAdd BLAST1267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei31PhosphoserineCombined sources1
Modified residuei295PhosphothreonineSequence analysis1
Modified residuei296PhosphothreonineSequence analysis1
Modified residuei317PhosphoserineBy similarity1
Modified residuei437PhosphotyrosineBy similarity1
Modified residuei645PhosphoserineBy similarity1
Modified residuei991N6-acetyllysineCombined sources1
Modified residuei1247PhosphoserineBy similarity1
Modified residuei1252PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8VDJ3.
MaxQBiQ8VDJ3.
PaxDbiQ8VDJ3.
PRIDEiQ8VDJ3.

PTM databases

iPTMnetiQ8VDJ3.
PhosphoSitePlusiQ8VDJ3.
SwissPalmiQ8VDJ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034088.
CleanExiMM_HDLBP.
ExpressionAtlasiQ8VDJ3. baseline and differential.
GenevisibleiQ8VDJ3. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi225750. 2 interactors.
IntActiQ8VDJ3. 5 interactors.
MINTiMINT-1858511.
STRINGi10090.ENSMUSP00000043047.

Structurei

3D structure databases

ProteinModelPortaliQ8VDJ3.
SMRiQ8VDJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 212KH 1PROSITE-ProRule annotationAdd BLAST63
Domaini222 – 284KH 2PROSITE-ProRule annotationAdd BLAST63
Domaini295 – 357KH 3PROSITE-ProRule annotationAdd BLAST63
Domaini364 – 424KH 4PROSITE-ProRule annotationAdd BLAST61
Domaini435 – 497KH 5PROSITE-ProRule annotationAdd BLAST63
Domaini507 – 570KH 6PROSITE-ProRule annotationAdd BLAST64
Domaini581 – 643KH 7PROSITE-ProRule annotationAdd BLAST63
Domaini653 – 716KH 8PROSITE-ProRule annotationAdd BLAST64
Domaini727 – 790KH 9PROSITE-ProRule annotationAdd BLAST64
Domaini800 – 863KH 10PROSITE-ProRule annotationAdd BLAST64
Domaini873 – 967KH 11PROSITE-ProRule annotationAdd BLAST95
Domaini972 – 1034KH 12PROSITE-ProRule annotationAdd BLAST63
Domaini1052 – 1117KH 13PROSITE-ProRule annotationAdd BLAST66
Domaini1127 – 1190KH 14PROSITE-ProRule annotationAdd BLAST64

Sequence similaritiesi

Contains 14 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2208. Eukaryota.
ENOG410XQFV. LUCA.
GeneTreeiENSGT00720000108747.
HOGENOMiHOG000007687.
HOVERGENiHBG054107.
InParanoidiQ8VDJ3.
OMAiVMISFPR.
OrthoDBiEOG091G00NZ.
PhylomeDBiQ8VDJ3.
TreeFamiTF323767.

Family and domain databases

Gene3Di3.30.1370.10. 15 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 14 hits.
[Graphical view]
SMARTiSM00322. KH. 14 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 15 hits.
PROSITEiPS50084. KH_TYPE_1. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK
60 70 80 90 100
AACLESAQEP AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ
110 120 130 140 150
AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ
160 170 180 190 200
ASATVPIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG
210 220 230 240 250
TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ
260 270 280 290 300
ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV
310 320 330 340 350
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL
360 370 380 390 400
GQALTEVYAK ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE
410 420 430 440 450
FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL
460 470 480 490 500
IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL
510 520 530 540 550
ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK
560 570 580 590 600
SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG
610 620 630 640 650
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL
660 670 680 690 700
ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV
710 720 730 740 750
VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI
760 770 780 790 800
RKVRDSTGAR IIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLENV
810 820 830 840 850
VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK
860 870 880 890 900
GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT
910 920 930 940 950
RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI
960 970 980 990 1000
IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD
1010 1020 1030 1040 1050
EFEVNIHVPA PELQSDTIAI TGLAANLDRA KAGLLDRVKE LQAEQEDRAL
1060 1070 1080 1090 1100
RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHEVNIQFPD KDDGNQPQDQ
1110 1120 1130 1140 1150
ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA RIIGARGKAI
1160 1170 1180 1190 1200
RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD
1210 1220 1230 1240 1250
VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF
1260
PSFGAQVAPK TLPWGPKR
Length:1,268
Mass (Da):141,743
Last modified:March 1, 2002 - v1
Checksum:i2502F3D4E9EE230C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021765 mRNA. Translation: AAH21765.1.
BC023806 mRNA. Translation: AAH23806.1.
BC025648 mRNA. Translation: AAH25648.1.
BC027779 mRNA. Translation: AAH27779.1.
BC027788 mRNA. Translation: AAH27788.1.
BC035301 mRNA. Translation: AAH35301.1.
CCDSiCCDS15189.1.
RefSeqiNP_001288293.1. NM_001301364.1.
NP_598569.1. NM_133808.5.
XP_006529137.1. XM_006529074.2.
XP_006529138.1. XM_006529075.2.
XP_006529139.1. XM_006529076.2.
XP_006529140.1. XM_006529077.3.
UniGeneiMm.30012.

Genome annotation databases

EnsembliENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088.
ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088.
GeneIDi110611.
KEGGimmu:110611.
UCSCiuc007cdx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021765 mRNA. Translation: AAH21765.1.
BC023806 mRNA. Translation: AAH23806.1.
BC025648 mRNA. Translation: AAH25648.1.
BC027779 mRNA. Translation: AAH27779.1.
BC027788 mRNA. Translation: AAH27788.1.
BC035301 mRNA. Translation: AAH35301.1.
CCDSiCCDS15189.1.
RefSeqiNP_001288293.1. NM_001301364.1.
NP_598569.1. NM_133808.5.
XP_006529137.1. XM_006529074.2.
XP_006529138.1. XM_006529075.2.
XP_006529139.1. XM_006529076.2.
XP_006529140.1. XM_006529077.3.
UniGeneiMm.30012.

3D structure databases

ProteinModelPortaliQ8VDJ3.
SMRiQ8VDJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi225750. 2 interactors.
IntActiQ8VDJ3. 5 interactors.
MINTiMINT-1858511.
STRINGi10090.ENSMUSP00000043047.

PTM databases

iPTMnetiQ8VDJ3.
PhosphoSitePlusiQ8VDJ3.
SwissPalmiQ8VDJ3.

Proteomic databases

EPDiQ8VDJ3.
MaxQBiQ8VDJ3.
PaxDbiQ8VDJ3.
PRIDEiQ8VDJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088.
ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088.
GeneIDi110611.
KEGGimmu:110611.
UCSCiuc007cdx.2. mouse.

Organism-specific databases

CTDi3069.
MGIiMGI:99256. Hdlbp.

Phylogenomic databases

eggNOGiKOG2208. Eukaryota.
ENOG410XQFV. LUCA.
GeneTreeiENSGT00720000108747.
HOGENOMiHOG000007687.
HOVERGENiHBG054107.
InParanoidiQ8VDJ3.
OMAiVMISFPR.
OrthoDBiEOG091G00NZ.
PhylomeDBiQ8VDJ3.
TreeFamiTF323767.

Enzyme and pathway databases

ReactomeiR-MMU-194223. HDL-mediated lipid transport.

Miscellaneous databases

ChiTaRSiHdlbp. mouse.
PROiQ8VDJ3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034088.
CleanExiMM_HDLBP.
ExpressionAtlasiQ8VDJ3. baseline and differential.
GenevisibleiQ8VDJ3. MM.

Family and domain databases

Gene3Di3.30.1370.10. 15 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 14 hits.
[Graphical view]
SMARTiSM00322. KH. 14 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 15 hits.
PROSITEiPS50084. KH_TYPE_1. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVIGLN_MOUSE
AccessioniPrimary (citable) accession number: Q8VDJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.