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Q8VDJ3

- VIGLN_MOUSE

UniProt

Q8VDJ3 - VIGLN_MOUSE

Protein

Vigilin

Gene

Hdlbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol By similarity.By similarity

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. cholesterol metabolic process Source: UniProtKB-KW
    2. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vigilin
    Alternative name(s):
    High density lipoprotein-binding protein
    Short name:
    HDL-binding protein
    Gene namesi
    Name:Hdlbp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:99256. Hdlbp.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. high-density lipoprotein particle Source: UniProtKB-KW
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, HDL, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 12681267VigilinPRO_0000050132Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserineBy similarity
    Modified residuei31 – 311Phosphoserine2 Publications
    Modified residuei295 – 2951PhosphothreonineSequence Analysis
    Modified residuei296 – 2961PhosphothreonineSequence Analysis
    Modified residuei437 – 4371PhosphotyrosineBy similarity
    Modified residuei991 – 9911N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8VDJ3.
    PaxDbiQ8VDJ3.
    PRIDEiQ8VDJ3.

    PTM databases

    PhosphoSiteiQ8VDJ3.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VDJ3.
    BgeeiQ8VDJ3.
    CleanExiMM_HDLBP.
    GenevestigatoriQ8VDJ3.

    Interactioni

    Protein-protein interaction databases

    BioGridi225750. 2 interactions.
    IntActiQ8VDJ3. 5 interactions.
    MINTiMINT-1858511.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VDJ3.
    SMRiQ8VDJ3. Positions 142-223, 345-502, 646-727, 795-873, 962-1200.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini150 – 21263KH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini222 – 28463KH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini295 – 35763KH 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini364 – 42461KH 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini435 – 49763KH 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini507 – 57064KH 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini581 – 64363KH 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini653 – 71664KH 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini727 – 79064KH 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini800 – 86364KH 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini873 – 96795KH 11PROSITE-ProRule annotationAdd
    BLAST
    Domaini972 – 103463KH 12PROSITE-ProRule annotationAdd
    BLAST
    Domaini1052 – 111766KH 13PROSITE-ProRule annotationAdd
    BLAST
    Domaini1127 – 119064KH 14PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 14 KH domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG313207.
    GeneTreeiENSGT00720000108747.
    HOGENOMiHOG000007687.
    HOVERGENiHBG054107.
    InParanoidiQ8VDJ3.
    OMAiQHHKFLI.
    OrthoDBiEOG7KH9HW.
    PhylomeDBiQ8VDJ3.
    TreeFamiTF323767.

    Family and domain databases

    Gene3Di3.30.1370.10. 15 hits.
    InterProiIPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view]
    PfamiPF00013. KH_1. 14 hits.
    [Graphical view]
    SMARTiSM00322. KH. 14 hits.
    [Graphical view]
    SUPFAMiSSF54791. SSF54791. 15 hits.
    PROSITEiPS50084. KH_TYPE_1. 14 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VDJ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK     50
    AACLESAQEP AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ 100
    AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ 150
    ASATVPIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG 200
    TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ 250
    ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV 300
    EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL 350
    GQALTEVYAK ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE 400
    FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL 450
    IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL 500
    ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK 550
    SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG 600
    GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL 650
    ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV 700
    VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI 750
    RKVRDSTGAR IIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLENV 800
    VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK 850
    GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT 900
    RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI 950
    IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD 1000
    EFEVNIHVPA PELQSDTIAI TGLAANLDRA KAGLLDRVKE LQAEQEDRAL 1050
    RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHEVNIQFPD KDDGNQPQDQ 1100
    ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA RIIGARGKAI 1150
    RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD 1200
    VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF 1250
    PSFGAQVAPK TLPWGPKR 1268
    Length:1,268
    Mass (Da):141,743
    Last modified:March 1, 2002 - v1
    Checksum:i2502F3D4E9EE230C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC021765 mRNA. Translation: AAH21765.1.
    BC023806 mRNA. Translation: AAH23806.1.
    BC025648 mRNA. Translation: AAH25648.1.
    BC027779 mRNA. Translation: AAH27779.1.
    BC027788 mRNA. Translation: AAH27788.1.
    BC035301 mRNA. Translation: AAH35301.1.
    CCDSiCCDS15189.1.
    RefSeqiNP_598569.1. NM_133808.4.
    XP_006529136.1. XM_006529073.1.
    XP_006529137.1. XM_006529074.1.
    XP_006529138.1. XM_006529075.1.
    XP_006529139.1. XM_006529076.1.
    XP_006529140.1. XM_006529077.1.
    UniGeneiMm.30012.

    Genome annotation databases

    EnsembliENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088.
    ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088.
    GeneIDi110611.
    KEGGimmu:110611.
    UCSCiuc007cdx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC021765 mRNA. Translation: AAH21765.1 .
    BC023806 mRNA. Translation: AAH23806.1 .
    BC025648 mRNA. Translation: AAH25648.1 .
    BC027779 mRNA. Translation: AAH27779.1 .
    BC027788 mRNA. Translation: AAH27788.1 .
    BC035301 mRNA. Translation: AAH35301.1 .
    CCDSi CCDS15189.1.
    RefSeqi NP_598569.1. NM_133808.4.
    XP_006529136.1. XM_006529073.1.
    XP_006529137.1. XM_006529074.1.
    XP_006529138.1. XM_006529075.1.
    XP_006529139.1. XM_006529076.1.
    XP_006529140.1. XM_006529077.1.
    UniGenei Mm.30012.

    3D structure databases

    ProteinModelPortali Q8VDJ3.
    SMRi Q8VDJ3. Positions 142-223, 345-502, 646-727, 795-873, 962-1200.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 225750. 2 interactions.
    IntActi Q8VDJ3. 5 interactions.
    MINTi MINT-1858511.

    PTM databases

    PhosphoSitei Q8VDJ3.

    Proteomic databases

    MaxQBi Q8VDJ3.
    PaxDbi Q8VDJ3.
    PRIDEi Q8VDJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000042498 ; ENSMUSP00000043047 ; ENSMUSG00000034088 .
    ENSMUST00000170883 ; ENSMUSP00000127903 ; ENSMUSG00000034088 .
    GeneIDi 110611.
    KEGGi mmu:110611.
    UCSCi uc007cdx.1. mouse.

    Organism-specific databases

    CTDi 3069.
    MGIi MGI:99256. Hdlbp.

    Phylogenomic databases

    eggNOGi NOG313207.
    GeneTreei ENSGT00720000108747.
    HOGENOMi HOG000007687.
    HOVERGENi HBG054107.
    InParanoidi Q8VDJ3.
    OMAi QHHKFLI.
    OrthoDBi EOG7KH9HW.
    PhylomeDBi Q8VDJ3.
    TreeFami TF323767.

    Miscellaneous databases

    ChiTaRSi HDLBP. mouse.
    NextBioi 364327.
    PROi Q8VDJ3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VDJ3.
    Bgeei Q8VDJ3.
    CleanExi MM_HDLBP.
    Genevestigatori Q8VDJ3.

    Family and domain databases

    Gene3Di 3.30.1370.10. 15 hits.
    InterProi IPR004087. KH_dom.
    IPR004088. KH_dom_type_1.
    [Graphical view ]
    Pfami PF00013. KH_1. 14 hits.
    [Graphical view ]
    SMARTi SM00322. KH. 14 hits.
    [Graphical view ]
    SUPFAMi SSF54791. SSF54791. 15 hits.
    PROSITEi PS50084. KH_TYPE_1. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
    2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
      J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-991, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiVIGLN_MOUSE
    AccessioniPrimary (citable) accession number: Q8VDJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3