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Q8VDJ3

- VIGLN_MOUSE

UniProt

Q8VDJ3 - VIGLN_MOUSE

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Protein

Vigilin

Gene

Hdlbp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity).By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. cholesterol metabolic process Source: UniProtKB-KW
  2. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vigilin
Alternative name(s):
High density lipoprotein-binding protein
Short name:
HDL-binding protein
Gene namesi
Name:Hdlbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:99256. Hdlbp.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. high-density lipoprotein particle Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, HDL, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 12681267VigilinPRO_0000050132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei31 – 311Phosphoserine2 Publications
Modified residuei295 – 2951PhosphothreonineSequence Analysis
Modified residuei296 – 2961PhosphothreonineSequence Analysis
Modified residuei437 – 4371PhosphotyrosineBy similarity
Modified residuei991 – 9911N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8VDJ3.
PaxDbiQ8VDJ3.
PRIDEiQ8VDJ3.

PTM databases

PhosphoSiteiQ8VDJ3.

Expressioni

Gene expression databases

BgeeiQ8VDJ3.
CleanExiMM_HDLBP.
ExpressionAtlasiQ8VDJ3. baseline and differential.
GenevestigatoriQ8VDJ3.

Interactioni

Protein-protein interaction databases

BioGridi225750. 2 interactions.
IntActiQ8VDJ3. 5 interactions.
MINTiMINT-1858511.

Structurei

3D structure databases

ProteinModelPortaliQ8VDJ3.
SMRiQ8VDJ3. Positions 142-223, 345-502, 646-727, 795-873, 962-1200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 21263KH 1PROSITE-ProRule annotationAdd
BLAST
Domaini222 – 28463KH 2PROSITE-ProRule annotationAdd
BLAST
Domaini295 – 35763KH 3PROSITE-ProRule annotationAdd
BLAST
Domaini364 – 42461KH 4PROSITE-ProRule annotationAdd
BLAST
Domaini435 – 49763KH 5PROSITE-ProRule annotationAdd
BLAST
Domaini507 – 57064KH 6PROSITE-ProRule annotationAdd
BLAST
Domaini581 – 64363KH 7PROSITE-ProRule annotationAdd
BLAST
Domaini653 – 71664KH 8PROSITE-ProRule annotationAdd
BLAST
Domaini727 – 79064KH 9PROSITE-ProRule annotationAdd
BLAST
Domaini800 – 86364KH 10PROSITE-ProRule annotationAdd
BLAST
Domaini873 – 96795KH 11PROSITE-ProRule annotationAdd
BLAST
Domaini972 – 103463KH 12PROSITE-ProRule annotationAdd
BLAST
Domaini1052 – 111766KH 13PROSITE-ProRule annotationAdd
BLAST
Domaini1127 – 119064KH 14PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 14 KH domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG313207.
GeneTreeiENSGT00720000108747.
HOGENOMiHOG000007687.
HOVERGENiHBG054107.
InParanoidiQ8VDJ3.
OMAiQHHKFLI.
OrthoDBiEOG7KH9HW.
PhylomeDBiQ8VDJ3.
TreeFamiTF323767.

Family and domain databases

Gene3Di3.30.1370.10. 15 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 14 hits.
[Graphical view]
SMARTiSM00322. KH. 14 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 15 hits.
PROSITEiPS50084. KH_TYPE_1. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDJ3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK
60 70 80 90 100
AACLESAQEP AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ
110 120 130 140 150
AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ
160 170 180 190 200
ASATVPIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG
210 220 230 240 250
TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ
260 270 280 290 300
ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV
310 320 330 340 350
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL
360 370 380 390 400
GQALTEVYAK ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE
410 420 430 440 450
FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL
460 470 480 490 500
IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL
510 520 530 540 550
ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK
560 570 580 590 600
SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG
610 620 630 640 650
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL
660 670 680 690 700
ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV
710 720 730 740 750
VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI
760 770 780 790 800
RKVRDSTGAR IIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLENV
810 820 830 840 850
VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK
860 870 880 890 900
GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT
910 920 930 940 950
RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI
960 970 980 990 1000
IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD
1010 1020 1030 1040 1050
EFEVNIHVPA PELQSDTIAI TGLAANLDRA KAGLLDRVKE LQAEQEDRAL
1060 1070 1080 1090 1100
RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHEVNIQFPD KDDGNQPQDQ
1110 1120 1130 1140 1150
ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA RIIGARGKAI
1160 1170 1180 1190 1200
RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD
1210 1220 1230 1240 1250
VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF
1260
PSFGAQVAPK TLPWGPKR
Length:1,268
Mass (Da):141,743
Last modified:March 1, 2002 - v1
Checksum:i2502F3D4E9EE230C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC021765 mRNA. Translation: AAH21765.1.
BC023806 mRNA. Translation: AAH23806.1.
BC025648 mRNA. Translation: AAH25648.1.
BC027779 mRNA. Translation: AAH27779.1.
BC027788 mRNA. Translation: AAH27788.1.
BC035301 mRNA. Translation: AAH35301.1.
CCDSiCCDS15189.1.
RefSeqiNP_598569.1. NM_133808.5.
XP_006529137.1. XM_006529074.1.
XP_006529138.1. XM_006529075.1.
XP_006529139.1. XM_006529076.1.
XP_006529140.1. XM_006529077.1.
UniGeneiMm.30012.

Genome annotation databases

EnsembliENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088.
ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088.
GeneIDi110611.
KEGGimmu:110611.
UCSCiuc007cdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC021765 mRNA. Translation: AAH21765.1 .
BC023806 mRNA. Translation: AAH23806.1 .
BC025648 mRNA. Translation: AAH25648.1 .
BC027779 mRNA. Translation: AAH27779.1 .
BC027788 mRNA. Translation: AAH27788.1 .
BC035301 mRNA. Translation: AAH35301.1 .
CCDSi CCDS15189.1.
RefSeqi NP_598569.1. NM_133808.5.
XP_006529137.1. XM_006529074.1.
XP_006529138.1. XM_006529075.1.
XP_006529139.1. XM_006529076.1.
XP_006529140.1. XM_006529077.1.
UniGenei Mm.30012.

3D structure databases

ProteinModelPortali Q8VDJ3.
SMRi Q8VDJ3. Positions 142-223, 345-502, 646-727, 795-873, 962-1200.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 225750. 2 interactions.
IntActi Q8VDJ3. 5 interactions.
MINTi MINT-1858511.

PTM databases

PhosphoSitei Q8VDJ3.

Proteomic databases

MaxQBi Q8VDJ3.
PaxDbi Q8VDJ3.
PRIDEi Q8VDJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042498 ; ENSMUSP00000043047 ; ENSMUSG00000034088 .
ENSMUST00000170883 ; ENSMUSP00000127903 ; ENSMUSG00000034088 .
GeneIDi 110611.
KEGGi mmu:110611.
UCSCi uc007cdx.1. mouse.

Organism-specific databases

CTDi 3069.
MGIi MGI:99256. Hdlbp.

Phylogenomic databases

eggNOGi NOG313207.
GeneTreei ENSGT00720000108747.
HOGENOMi HOG000007687.
HOVERGENi HBG054107.
InParanoidi Q8VDJ3.
OMAi QHHKFLI.
OrthoDBi EOG7KH9HW.
PhylomeDBi Q8VDJ3.
TreeFami TF323767.

Miscellaneous databases

ChiTaRSi HDLBP. mouse.
NextBioi 364327.
PROi Q8VDJ3.
SOURCEi Search...

Gene expression databases

Bgeei Q8VDJ3.
CleanExi MM_HDLBP.
ExpressionAtlasi Q8VDJ3. baseline and differential.
Genevestigatori Q8VDJ3.

Family and domain databases

Gene3Di 3.30.1370.10. 15 hits.
InterProi IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view ]
Pfami PF00013. KH_1. 14 hits.
[Graphical view ]
SMARTi SM00322. KH. 14 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 15 hits.
PROSITEi PS50084. KH_TYPE_1. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-991, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiVIGLN_MOUSE
AccessioniPrimary (citable) accession number: Q8VDJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3