Vigilin - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Vigilin

Alternative name(s):
High density lipoprotein-binding protein
Short name=HDL-binding protein

Gene names

Name:

Hdlbp

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1268 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Contains 14 KH domains.

Ontologies

Keywords
Biological process	Cholesterol metabolism Lipid metabolism Lipid transport Steroid metabolism Sterol metabolism Transport
Cellular component	Cytoplasm HDL Nucleus
Domain	Repeat
Ligand	RNA-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cholesterol metabolic process Inferred from electronic annotation. Source: UniProtKB-KW lipid transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell high-density lipoprotein particle Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

2 – 1268

1267

Vigilin

PRO_0000050132

Regions

Domain

150 – 212

63

KH 1

Domain

222 – 284

63

KH 2

Domain

295 – 357

63

KH 3

Domain

364 – 424

61

KH 4

Domain

435 – 497

63

KH 5

Domain

507 – 570

64

KH 6

Domain

581 – 643

63

KH 7

Domain

653 – 716

64

KH 8

Domain

727 – 790

64

KH 9

Domain

800 – 863

64

KH 10

Domain

873 – 967

95

KH 11

Domain

972 – 1034

63

KH 12

Domain

1052 – 1117

66

KH 13

Domain

1127 – 1190

64

KH 14

Amino acid modifications

Modified residue

2

1

N-acetylserine By similarity

Modified residue

31

1

Phosphoserine Ref.2 Ref.3

Modified residue

295

1

Phosphothreonine Potential

Modified residue

296

1

Phosphothreonine Potential

Modified residue

437

1

Phosphotyrosine By similarity

Modified residue

944

1

Phosphoserine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q8VDJ3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2502F3D4E9EE230C
Show »

FASTA

1,268

141,743

        10         20         30         40         50         60 
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK AACLESAQEP 

        70         80         90        100        110        120 
AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ AKICLEIMQR TGAHLELSLA 

       130        140        150        160        170        180 
KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ ASATVPIPKE HHRFVIGKNG EKLQDLELKT 

       190        200        210        220        230        240 
ATKIQIPRPD DPSNQIKITG TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP 

       250        260        270        280        290        300 
YNRLVGEIMQ ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV 

       310        320        330        340        350        360 
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL GQALTEVYAK 

       370        380        390        400        410        420 
ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE FTEGEDKITL EGPTEDVNVA 

       430        440        450        460        470        480 
QEQIEGMVKD LINRMDYVEI NIDHKFHRHL IGKSGANINR IKDQYKVSVR IPPDSEKSNL 

       490        500        510        520        530        540 
IRIEGDPQGV QQAKRELLEL ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV 

       550        560        570        580        590        600 
IINFPDPAQK SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG 

       610        620        630        640        650        660 
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL ANIAEVEVSI 

       670        680        690        700        710        720 
PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV VIRGPSSDVE KAKKQLLHLA 

       730        740        750        760        770        780 
EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI RKVRDSTGAR IIFPAAEDKD QDLITIIGKE 

       790        800        810        820        830        840 
DAVREAQKEL EALIQNLENV VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS 

       850        860        870        880        890        900 
GTQSDKVTLK GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT 

       910        920        930        940        950        960 
RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI IIISGRKEKC 

       970        980        990       1000       1010       1020 
EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD EFEVNIHVPA PELQSDTIAI 

      1030       1040       1050       1060       1070       1080 
TGLAANLDRA KAGLLDRVKE LQAEQEDRAL RSFKLSVTVD PKYHPKIIGR KGAVITQIRL 

      1090       1100       1110       1120       1130       1140 
EHEVNIQFPD KDDGNQPQDQ ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA 

      1150       1160       1170       1180       1190       1200 
RIIGARGKAI RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD 

      1210       1220       1230       1240       1250       1260 
VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF PSFGAQVAPK 


TLPWGPKR

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References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N.
[2]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, MASS SPECTROMETRY. Tissue: Liver.
[3]	"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis." Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H. J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, MASS SPECTROMETRY. Tissue: Liver.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC021765 mRNA. Translation: AAH21765.1. BC023806 mRNA. Translation: AAH23806.1. BC025648 mRNA. Translation: AAH25648.1. BC027779 mRNA. Translation: AAH27779.1. BC027788 mRNA. Translation: AAH27788.1. BC035301 mRNA. Translation: AAH35301.1.
IPI	IPI00123379.
RefSeq	NP_598569.1. NM_133808.4.
UniGene	Mm.30012.
3D structure databases
ProteinModelPortal	Q8VDJ3.
SMR	Q8VDJ3. Positions 142-223, 345-502, 646-727, 795-873, 962-1200.
ModBase	Search...
PTM databases
PhosphoSite	Q8VDJ3.
Proteomic databases
PaxDb	Q8VDJ3.
PRIDE	Q8VDJ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088. ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088.
GeneID	110611.
KEGG	mmu:110611.
Organism-specific databases
CTD	3069.
MGI	MGI:99256. Hdlbp.
Phylogenomic databases
eggNOG	NOG313207.
GeneTree	ENSGT00690000102206.
HOGENOM	HOG000007687.
HOVERGEN	HBG054107.
InParanoid	Q8VDJ3.
OMA	YEKNTEA.
OrthoDB	EOG4M65GT.
Gene expression databases
ArrayExpress	Q8VDJ3.
Bgee	Q8VDJ3.
CleanEx	MM_HDLBP.
Genevestigator	Q8VDJ3.
GermOnline	ENSMUSG00000034088. Mus musculus.
Family and domain databases
InterPro	IPR004087. KH_dom. IPR004088. KH_dom_type_1. [Graphical view]
Pfam	PF00013. KH_1. 14 hits. [Graphical view]
SMART	SM00322. KH. 14 hits. [Graphical view]
PROSITE	PS50084. KH_TYPE_1. 14 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HDLBP. mouse.
NextBio	364327.
SOURCE	Search...

Entry information

Entry name

VIGLN_MOUSE

Accession

Primary (citable) accession number: Q8VDJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 13, 2004
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents