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Q8VDJ3 (VIGLN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Vigilin
Alternative name(s):
High density lipoprotein-binding protein
Short name=HDL-binding protein
Gene names
Name:Hdlbp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1268 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Contains 14 KH domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 12681267Vigilin
PRO_0000050132

Regions

Domain150 – 21263KH 1
Domain222 – 28463KH 2
Domain295 – 35763KH 3
Domain364 – 42461KH 4
Domain435 – 49763KH 5
Domain507 – 57064KH 6
Domain581 – 64363KH 7
Domain653 – 71664KH 8
Domain727 – 79064KH 9
Domain800 – 86364KH 10
Domain873 – 96795KH 11
Domain972 – 103463KH 12
Domain1052 – 111766KH 13
Domain1127 – 119064KH 14

Amino acid modifications

Modified residue21N-acetylserine By similarity
Modified residue311Phosphoserine Ref.3 Ref.4
Modified residue2951Phosphothreonine Potential
Modified residue2961Phosphothreonine Potential
Modified residue4371Phosphotyrosine By similarity
Modified residue9911N6-acetyllysine Ref.5

Sequences

Sequence LengthMass (Da)Tools
Q8VDJ3 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2502F3D4E9EE230C

FASTA1,268141,743
        10         20         30         40         50         60 
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK AACLESAQEP 

        70         80         90        100        110        120 
AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ AKICLEIMQR TGAHLELSLA 

       130        140        150        160        170        180 
KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ ASATVPIPKE HHRFVIGKNG EKLQDLELKT 

       190        200        210        220        230        240 
ATKIQIPRPD DPSNQIKITG TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP 

       250        260        270        280        290        300 
YNRLVGEIMQ ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV 

       310        320        330        340        350        360 
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL GQALTEVYAK 

       370        380        390        400        410        420 
ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE FTEGEDKITL EGPTEDVNVA 

       430        440        450        460        470        480 
QEQIEGMVKD LINRMDYVEI NIDHKFHRHL IGKSGANINR IKDQYKVSVR IPPDSEKSNL 

       490        500        510        520        530        540 
IRIEGDPQGV QQAKRELLEL ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV 

       550        560        570        580        590        600 
IINFPDPAQK SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG 

       610        620        630        640        650        660 
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL ANIAEVEVSI 

       670        680        690        700        710        720 
PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV VIRGPSSDVE KAKKQLLHLA 

       730        740        750        760        770        780 
EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI RKVRDSTGAR IIFPAAEDKD QDLITIIGKE 

       790        800        810        820        830        840 
DAVREAQKEL EALIQNLENV VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS 

       850        860        870        880        890        900 
GTQSDKVTLK GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT 

       910        920        930        940        950        960 
RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI IIISGRKEKC 

       970        980        990       1000       1010       1020 
EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD EFEVNIHVPA PELQSDTIAI 

      1030       1040       1050       1060       1070       1080 
TGLAANLDRA KAGLLDRVKE LQAEQEDRAL RSFKLSVTVD PKYHPKIIGR KGAVITQIRL 

      1090       1100       1110       1120       1130       1140 
EHEVNIQFPD KDDGNQPQDQ ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA 

      1150       1160       1170       1180       1190       1200 
RIIGARGKAI RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD 

      1210       1220       1230       1240       1250       1260 
VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF PSFGAQVAPK 


TLPWGPKR 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
[2]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[5]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-991, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC021765 mRNA. Translation: AAH21765.1.
BC023806 mRNA. Translation: AAH23806.1.
BC025648 mRNA. Translation: AAH25648.1.
BC027779 mRNA. Translation: AAH27779.1.
BC027788 mRNA. Translation: AAH27788.1.
BC035301 mRNA. Translation: AAH35301.1.
RefSeqNP_598569.1. NM_133808.4.
XP_006529136.1. XM_006529073.1.
XP_006529137.1. XM_006529074.1.
XP_006529138.1. XM_006529075.1.
XP_006529139.1. XM_006529076.1.
XP_006529140.1. XM_006529077.1.
UniGeneMm.30012.

3D structure databases

ProteinModelPortalQ8VDJ3.
SMRQ8VDJ3. Positions 142-290, 345-580, 582-910, 962-1200.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid225750. 1 interaction.
IntActQ8VDJ3. 5 interactions.
MINTMINT-1858511.

PTM databases

PhosphoSiteQ8VDJ3.

Proteomic databases

PaxDbQ8VDJ3.
PRIDEQ8VDJ3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088.
ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088.
GeneID110611.
KEGGmmu:110611.
UCSCuc007cdx.1. mouse.

Organism-specific databases

CTD3069.
MGIMGI:99256. Hdlbp.

Phylogenomic databases

eggNOGNOG313207.
GeneTreeENSGT00720000108747.
HOGENOMHOG000007687.
HOVERGENHBG054107.
InParanoidQ8VDJ3.
OMAQHHKFLI.
OrthoDBEOG7KH9HW.
PhylomeDBQ8VDJ3.
TreeFamTF323767.

Gene expression databases

ArrayExpressQ8VDJ3.
BgeeQ8VDJ3.
CleanExMM_HDLBP.
GenevestigatorQ8VDJ3.

Family and domain databases

Gene3D3.30.1370.10. 15 hits.
InterProIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamPF00013. KH_1. 14 hits.
[Graphical view]
SMARTSM00322. KH. 14 hits.
[Graphical view]
SUPFAMSSF54791. SSF54791. 15 hits.
PROSITEPS50084. KH_TYPE_1. 14 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHDLBP. mouse.
NextBio364327.
PROQ8VDJ3.
SOURCESearch...

Entry information

Entry nameVIGLN_MOUSE
AccessionPrimary (citable) accession number: Q8VDJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot