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Protein

Vigilin

Gene

Hdlbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-MMU-8964011 HDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Vigilin
Alternative name(s):
High density lipoprotein-binding protein
Short name:
HDL-binding protein
Gene namesi
Name:Hdlbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:99256 Hdlbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, HDL, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000501322 – 1268VigilinAdd BLAST1267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei8PhosphothreonineBy similarity1
Modified residuei11PhosphoserineBy similarity1
Modified residuei31PhosphoserineCombined sources1
Modified residuei295PhosphothreonineSequence analysis1
Modified residuei296PhosphothreonineSequence analysis1
Modified residuei317PhosphoserineBy similarity1
Modified residuei437PhosphotyrosineBy similarity1
Modified residuei645PhosphoserineBy similarity1
Modified residuei991N6-acetyllysineCombined sources1
Modified residuei1247PhosphoserineBy similarity1
Modified residuei1252PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8VDJ3
MaxQBiQ8VDJ3
PaxDbiQ8VDJ3
PRIDEiQ8VDJ3

PTM databases

iPTMnetiQ8VDJ3
PhosphoSitePlusiQ8VDJ3
SwissPalmiQ8VDJ3

Expressioni

Gene expression databases

BgeeiENSMUSG00000034088
CleanExiMM_HDLBP
ExpressionAtlasiQ8VDJ3 baseline and differential
GenevisibleiQ8VDJ3 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2257503 interactors.
IntActiQ8VDJ3 6 interactors.
MINTiQ8VDJ3
STRINGi10090.ENSMUSP00000043047

Structurei

3D structure databases

ProteinModelPortaliQ8VDJ3
SMRiQ8VDJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini150 – 212KH 1PROSITE-ProRule annotationAdd BLAST63
Domaini222 – 284KH 2PROSITE-ProRule annotationAdd BLAST63
Domaini295 – 357KH 3PROSITE-ProRule annotationAdd BLAST63
Domaini364 – 424KH 4PROSITE-ProRule annotationAdd BLAST61
Domaini435 – 497KH 5PROSITE-ProRule annotationAdd BLAST63
Domaini507 – 570KH 6PROSITE-ProRule annotationAdd BLAST64
Domaini581 – 643KH 7PROSITE-ProRule annotationAdd BLAST63
Domaini653 – 716KH 8PROSITE-ProRule annotationAdd BLAST64
Domaini727 – 790KH 9PROSITE-ProRule annotationAdd BLAST64
Domaini800 – 863KH 10PROSITE-ProRule annotationAdd BLAST64
Domaini873 – 967KH 11PROSITE-ProRule annotationAdd BLAST95
Domaini972 – 1034KH 12PROSITE-ProRule annotationAdd BLAST63
Domaini1052 – 1117KH 13PROSITE-ProRule annotationAdd BLAST66
Domaini1127 – 1190KH 14PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2208 Eukaryota
ENOG410XQFV LUCA
GeneTreeiENSGT00900000141059
HOGENOMiHOG000007687
HOVERGENiHBG054107
InParanoidiQ8VDJ3
OMAiYKHIIGK
OrthoDBiEOG091G00NZ
PhylomeDBiQ8VDJ3
TreeFamiTF323767

Family and domain databases

Gene3Di3.30.1370.1014 hits
InterProiView protein in InterPro
IPR004087 KH_dom
IPR004088 KH_dom_type_1
IPR036612 KH_dom_type_1_sf
PfamiView protein in Pfam
PF00013 KH_1, 14 hits
SMARTiView protein in SMART
SM00322 KH, 14 hits
SUPFAMiSSF54791 SSF54791, 15 hits
PROSITEiView protein in PROSITE
PS50084 KH_TYPE_1, 14 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK
60 70 80 90 100
AACLESAQEP AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ
110 120 130 140 150
AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ
160 170 180 190 200
ASATVPIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG
210 220 230 240 250
TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ
260 270 280 290 300
ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV
310 320 330 340 350
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL
360 370 380 390 400
GQALTEVYAK ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE
410 420 430 440 450
FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL
460 470 480 490 500
IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL
510 520 530 540 550
ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK
560 570 580 590 600
SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG
610 620 630 640 650
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL
660 670 680 690 700
ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV
710 720 730 740 750
VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI
760 770 780 790 800
RKVRDSTGAR IIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLENV
810 820 830 840 850
VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK
860 870 880 890 900
GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT
910 920 930 940 950
RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI
960 970 980 990 1000
IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD
1010 1020 1030 1040 1050
EFEVNIHVPA PELQSDTIAI TGLAANLDRA KAGLLDRVKE LQAEQEDRAL
1060 1070 1080 1090 1100
RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHEVNIQFPD KDDGNQPQDQ
1110 1120 1130 1140 1150
ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA RIIGARGKAI
1160 1170 1180 1190 1200
RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD
1210 1220 1230 1240 1250
VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF
1260
PSFGAQVAPK TLPWGPKR
Length:1,268
Mass (Da):141,743
Last modified:March 1, 2002 - v1
Checksum:i2502F3D4E9EE230C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021765 mRNA Translation: AAH21765.1
BC023806 mRNA Translation: AAH23806.1
BC025648 mRNA Translation: AAH25648.1
BC027779 mRNA Translation: AAH27779.1
BC027788 mRNA Translation: AAH27788.1
BC035301 mRNA Translation: AAH35301.1
CCDSiCCDS15189.1
RefSeqiNP_001288293.1, NM_001301364.1
NP_598569.1, NM_133808.5
XP_006529137.1, XM_006529074.2
XP_006529138.1, XM_006529075.2
XP_006529139.1, XM_006529076.2
XP_006529140.1, XM_006529077.3
UniGeneiMm.30012

Genome annotation databases

EnsembliENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088
ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088
GeneIDi110611
KEGGimmu:110611
UCSCiuc007cdx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVIGLN_MOUSE
AccessioniPrimary (citable) accession number: Q8VDJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: February 28, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome