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Q8VDJ3

- VIGLN_MOUSE

UniProt

Q8VDJ3 - VIGLN_MOUSE

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Protein
Vigilin
Gene
Hdlbp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol By similarity.

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cholesterol metabolic process Source: UniProtKB-KW
  2. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vigilin
Alternative name(s):
High density lipoprotein-binding protein
Short name:
HDL-binding protein
Gene namesi
Name:Hdlbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:99256. Hdlbp.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. high-density lipoprotein particle Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, HDL, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 12681267Vigilin
PRO_0000050132Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine By similarity
Modified residuei31 – 311Phosphoserine2 Publications
Modified residuei295 – 2951Phosphothreonine Reviewed prediction
Modified residuei296 – 2961Phosphothreonine Reviewed prediction
Modified residuei437 – 4371Phosphotyrosine By similarity
Modified residuei991 – 9911N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8VDJ3.
PaxDbiQ8VDJ3.
PRIDEiQ8VDJ3.

PTM databases

PhosphoSiteiQ8VDJ3.

Expressioni

Gene expression databases

ArrayExpressiQ8VDJ3.
BgeeiQ8VDJ3.
CleanExiMM_HDLBP.
GenevestigatoriQ8VDJ3.

Interactioni

Protein-protein interaction databases

BioGridi225750. 2 interactions.
IntActiQ8VDJ3. 5 interactions.
MINTiMINT-1858511.

Structurei

3D structure databases

ProteinModelPortaliQ8VDJ3.
SMRiQ8VDJ3. Positions 142-223, 345-502, 646-727, 795-873, 962-1200.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 21263KH 1
Add
BLAST
Domaini222 – 28463KH 2
Add
BLAST
Domaini295 – 35763KH 3
Add
BLAST
Domaini364 – 42461KH 4
Add
BLAST
Domaini435 – 49763KH 5
Add
BLAST
Domaini507 – 57064KH 6
Add
BLAST
Domaini581 – 64363KH 7
Add
BLAST
Domaini653 – 71664KH 8
Add
BLAST
Domaini727 – 79064KH 9
Add
BLAST
Domaini800 – 86364KH 10
Add
BLAST
Domaini873 – 96795KH 11
Add
BLAST
Domaini972 – 103463KH 12
Add
BLAST
Domaini1052 – 111766KH 13
Add
BLAST
Domaini1127 – 119064KH 14
Add
BLAST

Sequence similaritiesi

Contains 14 KH domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG313207.
GeneTreeiENSGT00720000108747.
HOGENOMiHOG000007687.
HOVERGENiHBG054107.
InParanoidiQ8VDJ3.
OMAiQHHKFLI.
OrthoDBiEOG7KH9HW.
PhylomeDBiQ8VDJ3.
TreeFamiTF323767.

Family and domain databases

Gene3Di3.30.1370.10. 15 hits.
InterProiIPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view]
PfamiPF00013. KH_1. 14 hits.
[Graphical view]
SMARTiSM00322. KH. 14 hits.
[Graphical view]
SUPFAMiSSF54791. SSF54791. 15 hits.
PROSITEiPS50084. KH_TYPE_1. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDJ3-1 [UniParc]FASTAAdd to Basket

« Hide

MSSVAVLTQE SFAEHRSGLV PQQIKVATLN SEEENDPPTY KDAFPPLPEK     50
AACLESAQEP AGAWSNKIRP IKASVITQVF HVPLEERKYK DMNQFGEGEQ 100
AKICLEIMQR TGAHLELSLA KDQGLSIMVS GKLDAVMKAR KDIVARLQTQ 150
ASATVPIPKE HHRFVIGKNG EKLQDLELKT ATKIQIPRPD DPSNQIKITG 200
TKEGIEKARH EVLLISAEQD KRAVERLEVE KAFHPFIAGP YNRLVGEIMQ 250
ETGTRINIPP PSVNRTEIVF TGEKEQLAQA VARIKKIYEE KKKKTTTIAV 300
EVKKSQHKYV IGPKGNSLQE ILERTGVSVE IPPSDSISET VILRGEPEKL 350
GQALTEVYAK ANSFTVSSVS APSWLHRFII GKKGQNLAKI TQQMPKVHIE 400
FTEGEDKITL EGPTEDVNVA QEQIEGMVKD LINRMDYVEI NIDHKFHRHL 450
IGKSGANINR IKDQYKVSVR IPPDSEKSNL IRIEGDPQGV QQAKRELLEL 500
ASRMENERTK DLIIEQRFHR TIIGQKGERI REIRDKFPEV IINFPDPAQK 550
SDIVQLRGPK NEVEKCTKYM QKMVADLVEN SYSISVPIFK QFHKNIIGKG 600
GANIKKIREE SNTKIDLPAE NSNSETIIIT GKRANCEAAR SRILSIQKDL 650
ANIAEVEVSI PAKLHNSLIG TKGRLIRSIM EECGGVHIHF PVEGSGSDTV 700
VIRGPSSDVE KAKKQLLHLA EEKQTKSFTV DIRAKPEYHK FLIGKGGGKI 750
RKVRDSTGAR IIFPAAEDKD QDLITIIGKE DAVREAQKEL EALIQNLENV 800
VEDYMLVDPK HHRHFVIRRG QVLREIAEEY GGVMVSFPRS GTQSDKVTLK 850
GAKDCVEAAK KRIQEIIEDL EAQVTVECAI PQKFHRSVMG PKGSRIQQIT 900
RDYNVQIKFP DREENPVHSV EPSIQENGDE AGEGREAKET DPGSPRRCDI 950
IIISGRKEKC EAAKEALEAL VPVTIEVEVP FDLHRYIIGQ KGSGIRKMMD 1000
EFEVNIHVPA PELQSDTIAI TGLAANLDRA KAGLLDRVKE LQAEQEDRAL 1050
RSFKLSVTVD PKYHPKIIGR KGAVITQIRL EHEVNIQFPD KDDGNQPQDQ 1100
ITITGYEKNT EAARDAILKI VGELEQMVSE DVPLDHRVHA RIIGARGKAI 1150
RKIMDEFKVD IRFPQSGAPD PNCVTVTGLP ENVEEAIDHI LNLEEEYLAD 1200
VVDSEALQVY MKPPAHEESR APSKGFVVRD APWTSNSSEK APDMSSSEEF 1250
PSFGAQVAPK TLPWGPKR 1268
Length:1,268
Mass (Da):141,743
Last modified:March 1, 2002 - v1
Checksum:i2502F3D4E9EE230C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC021765 mRNA. Translation: AAH21765.1.
BC023806 mRNA. Translation: AAH23806.1.
BC025648 mRNA. Translation: AAH25648.1.
BC027779 mRNA. Translation: AAH27779.1.
BC027788 mRNA. Translation: AAH27788.1.
BC035301 mRNA. Translation: AAH35301.1.
CCDSiCCDS15189.1.
RefSeqiNP_598569.1. NM_133808.4.
XP_006529136.1. XM_006529073.1.
XP_006529137.1. XM_006529074.1.
XP_006529138.1. XM_006529075.1.
XP_006529139.1. XM_006529076.1.
XP_006529140.1. XM_006529077.1.
UniGeneiMm.30012.

Genome annotation databases

EnsembliENSMUST00000042498; ENSMUSP00000043047; ENSMUSG00000034088.
ENSMUST00000170883; ENSMUSP00000127903; ENSMUSG00000034088.
GeneIDi110611.
KEGGimmu:110611.
UCSCiuc007cdx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC021765 mRNA. Translation: AAH21765.1 .
BC023806 mRNA. Translation: AAH23806.1 .
BC025648 mRNA. Translation: AAH25648.1 .
BC027779 mRNA. Translation: AAH27779.1 .
BC027788 mRNA. Translation: AAH27788.1 .
BC035301 mRNA. Translation: AAH35301.1 .
CCDSi CCDS15189.1.
RefSeqi NP_598569.1. NM_133808.4.
XP_006529136.1. XM_006529073.1.
XP_006529137.1. XM_006529074.1.
XP_006529138.1. XM_006529075.1.
XP_006529139.1. XM_006529076.1.
XP_006529140.1. XM_006529077.1.
UniGenei Mm.30012.

3D structure databases

ProteinModelPortali Q8VDJ3.
SMRi Q8VDJ3. Positions 142-223, 345-502, 646-727, 795-873, 962-1200.
ModBasei Search...

Protein-protein interaction databases

BioGridi 225750. 2 interactions.
IntActi Q8VDJ3. 5 interactions.
MINTi MINT-1858511.

PTM databases

PhosphoSitei Q8VDJ3.

Proteomic databases

MaxQBi Q8VDJ3.
PaxDbi Q8VDJ3.
PRIDEi Q8VDJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000042498 ; ENSMUSP00000043047 ; ENSMUSG00000034088 .
ENSMUST00000170883 ; ENSMUSP00000127903 ; ENSMUSG00000034088 .
GeneIDi 110611.
KEGGi mmu:110611.
UCSCi uc007cdx.1. mouse.

Organism-specific databases

CTDi 3069.
MGIi MGI:99256. Hdlbp.

Phylogenomic databases

eggNOGi NOG313207.
GeneTreei ENSGT00720000108747.
HOGENOMi HOG000007687.
HOVERGENi HBG054107.
InParanoidi Q8VDJ3.
OMAi QHHKFLI.
OrthoDBi EOG7KH9HW.
PhylomeDBi Q8VDJ3.
TreeFami TF323767.

Miscellaneous databases

ChiTaRSi HDLBP. mouse.
NextBioi 364327.
PROi Q8VDJ3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VDJ3.
Bgeei Q8VDJ3.
CleanExi MM_HDLBP.
Genevestigatori Q8VDJ3.

Family and domain databases

Gene3Di 3.30.1370.10. 15 hits.
InterProi IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
[Graphical view ]
Pfami PF00013. KH_1. 14 hits.
[Graphical view ]
SMARTi SM00322. KH. 14 hits.
[Graphical view ]
SUPFAMi SSF54791. SSF54791. 15 hits.
PROSITEi PS50084. KH_TYPE_1. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
  2. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-991, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiVIGLN_MOUSE
AccessioniPrimary (citable) accession number: Q8VDJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi