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Q8VDI9

- ALG9_MOUSE

UniProt

Q8VDI9 - ALG9_MOUSE

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Protein
Alpha-1,2-mannosyltransferase ALG9
Gene
Alg9, Dibd1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides By similarity.

Catalytic activityi

Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

Pathwayi

GO - Molecular functioni

  1. dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC
  2. dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT22. Glycosyltransferase Family 22.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,2-mannosyltransferase ALG9 (EC:2.4.1.259, EC:2.4.1.261)
Alternative name(s):
Asparagine-linked glycosylation protein 9 homolog
Disrupted in bipolar disorder protein 1 homolog
Dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
Gene namesi
Name:Alg9
Synonyms:Dibd1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1924753. Alg9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 135135Lumenal Reviewed prediction
Add
BLAST
Transmembranei136 – 15621Helical; Reviewed prediction
Add
BLAST
Topological domaini157 – 17115Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei172 – 19221Helical; Reviewed prediction
Add
BLAST
Topological domaini193 – 21321Lumenal Reviewed prediction
Add
BLAST
Transmembranei214 – 23421Helical; Reviewed prediction
Add
BLAST
Topological domaini235 – 24915Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei250 – 27021Helical; Reviewed prediction
Add
BLAST
Topological domaini271 – 31040Lumenal Reviewed prediction
Add
BLAST
Transmembranei311 – 33121Helical; Reviewed prediction
Add
BLAST
Topological domaini332 – 34211Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei343 – 36321Helical; Reviewed prediction
Add
BLAST
Topological domaini364 – 3707Lumenal Reviewed prediction
Transmembranei371 – 39121Helical; Reviewed prediction
Add
BLAST
Topological domaini392 – 40514Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei406 – 42621Helical; Reviewed prediction
Add
BLAST
Topological domaini427 – 611185Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Alpha-1,2-mannosyltransferase ALG9
PRO_0000215788Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi550 – 5501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi593 – 5931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDI9.
PRIDEiQ8VDI9.

PTM databases

PhosphoSiteiQ8VDI9.

Expressioni

Gene expression databases

ArrayExpressiQ8VDI9.
BgeeiQ8VDI9.
GenevestigatoriQ8VDI9.

Structurei

3D structure databases

ProteinModelPortaliQ8VDI9.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 2110Poly-Gly

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278599.
GeneTreeiENSGT00390000004731.
HOGENOMiHOG000205434.
HOVERGENiHBG062906.
InParanoidiQ8VDI9.
KOiK03846.
OMAiISPLYIW.
OrthoDBiEOG74TWZM.
PhylomeDBiQ8VDI9.

Family and domain databases

InterProiIPR005599. GPI_mannosylTrfase.
[Graphical view]
PANTHERiPTHR22760. PTHR22760. 1 hit.
PfamiPF03901. Glyco_transf_22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDI9-1 [UniParc]FASTAAdd to Basket

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MASRRARQRL KGGGGGGGGG GDAGPAAEKL EQLGSREAGA EPRPESGNKA    50
GQVWAPEGST AFKCLLSARL CAALLSNISD CDETFNYWEP THYLIYGKGF 100
QTWEYSPVYA IRSYAYLLLH AWPAAFHARI LQTNKILVFY FLRCLLAFVS 150
CVCELYFYKA VCKKFGLHVS RMMLAFLVLS TGMFCSSSAF LPSSFCMYTT 200
LIAMTGWYMD KTPIAVLGVA AGAILGWPFS AALGLPIAFD LLARKHRWKS 250
FLLWSLVALA LFLVPVVVID SYYYGKLVVA PLNIVLYNVF TSHGPDLYGT 300
EPWYFYLING FLNFNVAFAL ALLVLPLTFL MEYLLQRFHV QNLGHPYWLT 350
LAPMYIWFII FFIQPHKEER FLFPVYPLIC LCGAVALSAL QKCYHFVFQR 400
YRLEHYTVTS NWLALGTVFL FGLLSFSRSV ALFRGYHGPL DLYPEFYRIA 450
TDPTIHTVPE GRPVNVCVGK EWYRFPSSFL LPDNWQLQFI PSEFRGQLPK 500
PFAEGPLATR TVPTHMNDQN REEPSRYIDI SKCHYLVDLD TMRETPREPN 550
YSSHREEWVS LAHRPFLDAS RSSKLLRAFY VPFLSDQYTV YVNYTILKPR 600
KAKPSRKKSG G 611
Length:611
Mass (Da):69,561
Last modified:March 1, 2002 - v1
Checksum:i3C96FFC7854F0133
GO

Sequence cautioni

The sequence BAC39717.1 differs from that shown. Reason: Frameshift at position 546.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti8 – 81Q → R in BAC34195. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK020231 mRNA. Translation: BAC25619.1.
AK050335 mRNA. Translation: BAC34195.1.
AK054293 mRNA. Translation: BAC35720.1.
AK086674 mRNA. Translation: BAC39717.1. Frameshift.
BC021791 mRNA. Translation: AAH21791.1.
CCDSiCCDS23175.1.
RefSeqiNP_598742.1. NM_133981.2.
UniGeneiMm.160035.

Genome annotation databases

EnsembliENSMUST00000034561; ENSMUSP00000034561; ENSMUSG00000032059.
GeneIDi102580.
KEGGimmu:102580.
UCSCiuc009pkt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK020231 mRNA. Translation: BAC25619.1 .
AK050335 mRNA. Translation: BAC34195.1 .
AK054293 mRNA. Translation: BAC35720.1 .
AK086674 mRNA. Translation: BAC39717.1 . Frameshift.
BC021791 mRNA. Translation: AAH21791.1 .
CCDSi CCDS23175.1.
RefSeqi NP_598742.1. NM_133981.2.
UniGenei Mm.160035.

3D structure databases

ProteinModelPortali Q8VDI9.
ModBasei Search...

Protein family/group databases

CAZyi GT22. Glycosyltransferase Family 22.

PTM databases

PhosphoSitei Q8VDI9.

Proteomic databases

PaxDbi Q8VDI9.
PRIDEi Q8VDI9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034561 ; ENSMUSP00000034561 ; ENSMUSG00000032059 .
GeneIDi 102580.
KEGGi mmu:102580.
UCSCi uc009pkt.2. mouse.

Organism-specific databases

CTDi 79796.
MGIi MGI:1924753. Alg9.

Phylogenomic databases

eggNOGi NOG278599.
GeneTreei ENSGT00390000004731.
HOGENOMi HOG000205434.
HOVERGENi HBG062906.
InParanoidi Q8VDI9.
KOi K03846.
OMAi ISPLYIW.
OrthoDBi EOG74TWZM.
PhylomeDBi Q8VDI9.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 355542.
PROi Q8VDI9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VDI9.
Bgeei Q8VDI9.
Genevestigatori Q8VDI9.

Family and domain databases

InterProi IPR005599. GPI_mannosylTrfase.
[Graphical view ]
PANTHERi PTHR22760. PTHR22760. 1 hit.
Pfami PF03901. Glyco_transf_22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Head, Liver and Ovary.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiALG9_MOUSE
AccessioniPrimary (citable) accession number: Q8VDI9
Secondary accession number(s): Q8BT44, Q8C378, Q8C7G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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