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Protein

Ubiquitin-associated domain-containing protein 1

Gene

Ubac1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle (By similarity).By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Protein family/group databases

MEROPSiC19.M01.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-associated domain-containing protein 1
Short name:
UBA domain-containing protein 1
Alternative name(s):
E3 ubiquitin-protein ligase subunit KPC2
Kip1 ubiquitination-promoting complex protein 2
Gene namesi
Name:Ubac1
Synonyms:Kpc2, Ubadc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1920995. Ubac1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002504501 – 409Ubiquitin-associated domain-containing protein 1Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VDI7.
MaxQBiQ8VDI7.
PaxDbiQ8VDI7.
PeptideAtlasiQ8VDI7.
PRIDEiQ8VDI7.

PTM databases

iPTMnetiQ8VDI7.
PhosphoSitePlusiQ8VDI7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036352.
CleanExiMM_UBAC1.
ExpressionAtlasiQ8VDI7. baseline and differential.
GenevisibleiQ8VDI7. MM.

Interactioni

Subunit structurei

Component of the KPC complex composed of RNF123/KPC1 and UBAC1/KPC2. Interacts with RNF123 via its N-terminal domain. Interacts with the proteasome via its N-terminal domain (By similarity).By similarity

Protein-protein interaction databases

BioGridi221128. 1 interactor.
STRINGi10090.ENSMUSP00000040220.

Structurei

3D structure databases

ProteinModelPortaliQ8VDI7.
SMRiQ8VDI7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 98Ubiquitin-likeAdd BLAST85
Domaini187 – 231UBA 1PROSITE-ProRule annotationAdd BLAST45
Domaini292 – 332UBA 2PROSITE-ProRule annotationAdd BLAST41
Domaini357 – 396STI1Add BLAST40

Sequence similaritiesi

Contains 1 STI1 domain.Curated
Contains 2 UBA domains.PROSITE-ProRule annotation
Contains 1 ubiquitin-like domain.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IHU5. Eukaryota.
ENOG410Y2UN. LUCA.
GeneTreeiENSGT00390000014658.
HOGENOMiHOG000231457.
HOVERGENiHBG053148.
InParanoidiQ8VDI7.
KOiK12174.
OMAiFQAILEN.
OrthoDBiEOG091G05QY.
PhylomeDBiQ8VDI7.
TreeFamiTF324579.

Family and domain databases

InterProiIPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 2 hits.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFVQEEKIFA GKVLRLHICA ADGAEWLEEA TEDTSVEKLK ESCLKHGAHG
60 70 80 90 100
SLEDPKNVTH HKLIHAASER VLSDSKTILE ENIQDQDVLL LIKKRVPSPL
110 120 130 140 150
PKMADVSAEE KKKQEQKAPD KDAILRATAN LPACSTDRTA VQTTMRDFQT
160 170 180 190 200
ELRKILVSLI EVAQKLLALN PDAVELFKKA NAMLDEDEDE RVDETALRQL
210 220 230 240 250
TEMGFPESRA SKALRLNHMS VPQAMEWLIE HSEDPAIDTP LPGHAAQAGA
260 270 280 290 300
SAAATTSSTS SEAAVGTSVE DEESRDELTE IFKKIRRKKE FRADARAVIS
310 320 330 340 350
LMEMGFDEKE VIDALRVNNN QQNAACEWLL GDRKPSPEEL DQGIDPNSPL
360 370 380 390 400
FQAILDNPVV QLGLTNPKTL LAFEDMLENP LNSTQWMNDP ETGPVMLQIS

RIFQTLNRT
Length:409
Mass (Da):45,531
Last modified:October 3, 2006 - v2
Checksum:i7CE7C9ACC5975231
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti252A → G in strain: Czech II. 1 Publication1
Natural varianti269V → A in strain: Czech II. 1 Publication1
Natural varianti274S → T in strain: Czech II. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157857 mRNA. Translation: BAE34235.1.
BC021811 mRNA. Translation: AAH21811.1.
CCDSiCCDS15795.1.
RefSeqiNP_598596.2. NM_133835.2.
UniGeneiMm.247824.

Genome annotation databases

EnsembliENSMUST00000036509; ENSMUSP00000040220; ENSMUSG00000036352.
GeneIDi98766.
KEGGimmu:98766.
UCSCiuc008itz.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK157857 mRNA. Translation: BAE34235.1.
BC021811 mRNA. Translation: AAH21811.1.
CCDSiCCDS15795.1.
RefSeqiNP_598596.2. NM_133835.2.
UniGeneiMm.247824.

3D structure databases

ProteinModelPortaliQ8VDI7.
SMRiQ8VDI7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi221128. 1 interactor.
STRINGi10090.ENSMUSP00000040220.

Protein family/group databases

MEROPSiC19.M01.

PTM databases

iPTMnetiQ8VDI7.
PhosphoSitePlusiQ8VDI7.

Proteomic databases

EPDiQ8VDI7.
MaxQBiQ8VDI7.
PaxDbiQ8VDI7.
PeptideAtlasiQ8VDI7.
PRIDEiQ8VDI7.

Protocols and materials databases

DNASUi98766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036509; ENSMUSP00000040220; ENSMUSG00000036352.
GeneIDi98766.
KEGGimmu:98766.
UCSCiuc008itz.2. mouse.

Organism-specific databases

CTDi10422.
MGIiMGI:1920995. Ubac1.

Phylogenomic databases

eggNOGiENOG410IHU5. Eukaryota.
ENOG410Y2UN. LUCA.
GeneTreeiENSGT00390000014658.
HOGENOMiHOG000231457.
HOVERGENiHBG053148.
InParanoidiQ8VDI7.
KOiK12174.
OMAiFQAILEN.
OrthoDBiEOG091G05QY.
PhylomeDBiQ8VDI7.
TreeFamiTF324579.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiUbac1. mouse.
PROiQ8VDI7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036352.
CleanExiMM_UBAC1.
ExpressionAtlasiQ8VDI7. baseline and differential.
GenevisibleiQ8VDI7. MM.

Family and domain databases

InterProiIPR006636. STI1_HS-bd.
IPR015940. UBA.
IPR009060. UBA-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00627. UBA. 2 hits.
[Graphical view]
SMARTiSM00727. STI1. 1 hit.
SM00165. UBA. 2 hits.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 2 hits.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50030. UBA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBAC1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDI7
Secondary accession number(s): Q3TZH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 3, 2006
Last modified: November 2, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.