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Protein

F-box only protein 21

Gene

Fbxo21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 21
Gene namesi
Name:Fbxo21
Synonyms:Fbx21, Kiaa0875
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1924223. Fbxo21.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627F-box only protein 21PRO_0000119904Add
BLAST

Proteomic databases

EPDiQ8VDH1.
MaxQBiQ8VDH1.
PaxDbiQ8VDH1.
PRIDEiQ8VDH1.

PTM databases

iPTMnetiQ8VDH1.
PhosphoSiteiQ8VDH1.

Expressioni

Gene expression databases

BgeeiQ8VDH1.
CleanExiMM_FBXO21.
ExpressionAtlasiQ8VDH1. baseline and differential.
GenevisibleiQ8VDH1. MM.

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

BioGridi231154. 26 interactions.
IntActiQ8VDH1. 26 interactions.
STRINGi10090.ENSMUSP00000035506.

Structurei

3D structure databases

ProteinModelPortaliQ8VDH1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 7650F-boxPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410II53. Eukaryota.
COG2912. LUCA.
GeneTreeiENSGT00390000005653.
HOGENOMiHOG000065670.
HOVERGENiHBG051569.
InParanoidiQ8VDH1.
KOiK10301.
OMAiSHEKHRD.
OrthoDBiEOG73V6JS.
PhylomeDBiQ8VDH1.
TreeFamiTF313177.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR011722. Hemimethylated_DNA-bd_dom.
IPR032698. SirB1_N.
[Graphical view]
PfamiPF13369. Transglut_core2. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF141255. SSF141255. 1 hit.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR02097. yccV. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8VDH1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASVAGDSAM EVVPALAEEA AAEATGPSCL VQLPGEVLEY ILCSGSLTAL
60 70 80 90 100
DIGRVSSTCR RLREVCQSSG QVWKEQFRVR WPSLMKHYSP TDYVNWLEEY
110 120 130 140 150
KVRQKAGLEA RKIVASFSKR FFSEHVPCNG FSDIENLEGP EIFFEDELVC
160 170 180 190 200
ILNMEGRKAL TWKYYAKKIL YYLRQQKILN NLKAFLQQPD DYESYLEGAV
210 220 230 240 250
YIDQYCNPLS DISFRDIQAQ IHSIVELVCK TLRGINSRHP SLTFRAGESS
260 270 280 290 300
MIMEIELQSQ VLDAINYVLY DQLKFKGNRM DYYNALNLYM HQVLTRRTGI
310 320 330 340 350
PISMSLLYLT VARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID
360 370 380 390 400
AFGKGKQLTV KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG
410 420 430 440 450
IDQSYQLLRD SLDLYLAMYP DQVQLLLLQA RLYFHLGIWP EKSFCLVLKV
460 470 480 490 500
LDILQHIQTL DPGQHGAVGY LVQHTLEHIE RKKEEVGVEV KLRSEEKHRD
510 520 530 540 550
VCYSIGLVMK HKRYGYNCVI YGWDPTCMMG HEWIRNMNVH SLPHGHHQPF
560 570 580 590 600
YNVLVEDGSC RYAAQENLEY NVEPQEISHP DVGRYFSEFT GTHYIPNAEL
610 620
EIRYPEDLEF VYETVQNIYS AKEDTAE
Length:627
Mass (Da):72,173
Last modified:March 1, 2002 - v1
Checksum:iA62939DCC7482112
GO
Isoform 2 (identifier: Q8VDH1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     443-449: Missing.

Show »
Length:620
Mass (Da):71,382
Checksum:i9582F6DE5CF39E4D
GO

Sequence cautioni

The sequence BAC41454.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti396 – 3961G → S in BAC33252 (PubMed:16141072).Curated
Sequence conflicti396 – 3961G → S in BAC33369 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei443 – 4497Missing in isoform 2. 2 PublicationsVSP_011350

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048131 mRNA. Translation: BAC33252.1.
AK048542 mRNA. Translation: BAC33369.1.
AK049723 mRNA. Translation: BAC33894.1.
AB093270 mRNA. Translation: BAC41454.1. Different initiation.
BC021871 mRNA. Translation: AAH21871.1.
CCDSiCCDS19607.1. [Q8VDH1-1]
RefSeqiNP_663539.1. NM_145564.3. [Q8VDH1-1]
XP_006530360.1. XM_006530297.1. [Q8VDH1-2]
UniGeneiMm.21912.

Genome annotation databases

EnsembliENSMUST00000035579; ENSMUSP00000035506; ENSMUSG00000032898. [Q8VDH1-2]
ENSMUST00000202447; ENSMUSP00000143873; ENSMUSG00000032898. [Q8VDH1-1]
GeneIDi231670.
KEGGimmu:231670.
UCSCiuc008zga.1. mouse. [Q8VDH1-1]
uc008zgb.1. mouse. [Q8VDH1-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK048131 mRNA. Translation: BAC33252.1.
AK048542 mRNA. Translation: BAC33369.1.
AK049723 mRNA. Translation: BAC33894.1.
AB093270 mRNA. Translation: BAC41454.1. Different initiation.
BC021871 mRNA. Translation: AAH21871.1.
CCDSiCCDS19607.1. [Q8VDH1-1]
RefSeqiNP_663539.1. NM_145564.3. [Q8VDH1-1]
XP_006530360.1. XM_006530297.1. [Q8VDH1-2]
UniGeneiMm.21912.

3D structure databases

ProteinModelPortaliQ8VDH1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231154. 26 interactions.
IntActiQ8VDH1. 26 interactions.
STRINGi10090.ENSMUSP00000035506.

PTM databases

iPTMnetiQ8VDH1.
PhosphoSiteiQ8VDH1.

Proteomic databases

EPDiQ8VDH1.
MaxQBiQ8VDH1.
PaxDbiQ8VDH1.
PRIDEiQ8VDH1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035579; ENSMUSP00000035506; ENSMUSG00000032898. [Q8VDH1-2]
ENSMUST00000202447; ENSMUSP00000143873; ENSMUSG00000032898. [Q8VDH1-1]
GeneIDi231670.
KEGGimmu:231670.
UCSCiuc008zga.1. mouse. [Q8VDH1-1]
uc008zgb.1. mouse. [Q8VDH1-2]

Organism-specific databases

CTDi23014.
MGIiMGI:1924223. Fbxo21.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410II53. Eukaryota.
COG2912. LUCA.
GeneTreeiENSGT00390000005653.
HOGENOMiHOG000065670.
HOVERGENiHBG051569.
InParanoidiQ8VDH1.
KOiK10301.
OMAiSHEKHRD.
OrthoDBiEOG73V6JS.
PhylomeDBiQ8VDH1.
TreeFamiTF313177.

Miscellaneous databases

PROiQ8VDH1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VDH1.
CleanExiMM_FBXO21.
ExpressionAtlasiQ8VDH1. baseline and differential.
GenevisibleiQ8VDH1. MM.

Family and domain databases

InterProiIPR001810. F-box_dom.
IPR011722. Hemimethylated_DNA-bd_dom.
IPR032698. SirB1_N.
[Graphical view]
PfamiPF13369. Transglut_core2. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF141255. SSF141255. 1 hit.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR02097. yccV. 1 hit.
PROSITEiPS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Head and Spinal cord.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H.
    DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver and Testis.

Entry informationi

Entry nameiFBX21_MOUSE
AccessioniPrimary (citable) accession number: Q8VDH1
Secondary accession number(s): Q8BHA5, Q8CHC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.