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Protein

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Gene

Pafah2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme (By similarity).By similarity

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei234NucleophileBy similarity1
Active sitei257Charge relay systemPROSITE-ProRule annotation1
Active sitei312Charge relay systemPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.47. 3474.
ReactomeiR-MMU-418346. Platelet homeostasis.

Protein family/group databases

ESTHERimouse-paf2. PAF-Acetylhydrolase.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC:3.1.1.47)
Alternative name(s):
Serine-dependent phospholipase A2
Short name:
SD-PLA2
Gene namesi
Name:Pafah2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140321. Pafah2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000903841 – 390Platelet-activating factor acetylhydrolase 2, cytoplasmicAdd BLAST390

Proteomic databases

EPDiQ8VDG7.
MaxQBiQ8VDG7.
PaxDbiQ8VDG7.
PRIDEiQ8VDG7.

PTM databases

PhosphoSitePlusiQ8VDG7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037366.
CleanExiMM_PAFAH2.
ExpressionAtlasiQ8VDG7. baseline and differential.
GenevisibleiQ8VDG7. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101495.

Structurei

3D structure databases

ProteinModelPortaliQ8VDG7.
SMRiQ8VDG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Phylogenomic databases

eggNOGiKOG3847. Eukaryota.
ENOG4111FH0. LUCA.
GeneTreeiENSGT00390000005233.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiQ8VDG7.
KOiK01062.
TreeFamiTF313831.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGQSVCFP PISGPHHIGC TDVMEGHSLE GSLFRLFYPC QASEKCEQPL
60 70 80 90 100
WIPRYEYSMG LADYLQYNKR WVGLLFNVGI GSCRLPVSWN GPFKAKESGY
110 120 130 140 150
PLIILSHGLG GFRASYSAFC MELASRGFVV AAVEHRDQSA AATYFCKPTS
160 170 180 190 200
QESSPAESLE EEWLPFRRIK EGEKEFHVRN PQVHQRVKEC VRVLRILQDA
210 220 230 240 250
SAGKTVVNVF PGGLDLMTLK GSIDRNRVAV MGHSFGGATA VLALTQEVQF
260 270 280 290 300
RCAIALDAWM FPLERDFYPK ARGPVFFINV EKFQTVESVN LMKKICAQHE
310 320 330 340 350
QSRIVTVLGA VHRSQTDFAF VTGNLIAKFF SSNSRGTLDP YESQEVMVRA
360 370 380 390
ILAFLQKHLD LKEDYDQWSS FIEGVGPSLI QGAPHYLSSL
Length:390
Mass (Da):43,562
Last modified:July 27, 2011 - v2
Checksum:i28AE6D00A25ED029
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223 – 226IDRN → VDTS in AAH21890 (PubMed:15489334).Curated4
Sequence conflicti223 – 226IDRN → VDTS in AAH25495 (PubMed:15489334).Curated4
Sequence conflicti223 – 226IDRN → VDTS in AAH25938 (PubMed:15489334).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669982 Genomic DNA. No translation available.
BC021890 mRNA. Translation: AAH21890.1.
BC025495 mRNA. Translation: AAH25495.1.
BC025938 mRNA. Translation: AAH25938.1.
CCDSiCCDS18771.1.
RefSeqiNP_001272803.1. NM_001285874.1.
NP_598641.2. NM_133880.3.
XP_006538518.1. XM_006538455.2.
XP_011248473.1. XM_011250171.2.
XP_017175376.1. XM_017319887.1.
UniGeneiMm.22116.

Genome annotation databases

EnsembliENSMUST00000105869; ENSMUSP00000101495; ENSMUSG00000037366.
GeneIDi100163.
KEGGimmu:100163.
UCSCiuc008vey.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669982 Genomic DNA. No translation available.
BC021890 mRNA. Translation: AAH21890.1.
BC025495 mRNA. Translation: AAH25495.1.
BC025938 mRNA. Translation: AAH25938.1.
CCDSiCCDS18771.1.
RefSeqiNP_001272803.1. NM_001285874.1.
NP_598641.2. NM_133880.3.
XP_006538518.1. XM_006538455.2.
XP_011248473.1. XM_011250171.2.
XP_017175376.1. XM_017319887.1.
UniGeneiMm.22116.

3D structure databases

ProteinModelPortaliQ8VDG7.
SMRiQ8VDG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101495.

Chemistry databases

ChEMBLiCHEMBL1795095.

Protein family/group databases

ESTHERimouse-paf2. PAF-Acetylhydrolase.

PTM databases

PhosphoSitePlusiQ8VDG7.

Proteomic databases

EPDiQ8VDG7.
MaxQBiQ8VDG7.
PaxDbiQ8VDG7.
PRIDEiQ8VDG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105869; ENSMUSP00000101495; ENSMUSG00000037366.
GeneIDi100163.
KEGGimmu:100163.
UCSCiuc008vey.3. mouse.

Organism-specific databases

CTDi5051.
MGIiMGI:2140321. Pafah2.

Phylogenomic databases

eggNOGiKOG3847. Eukaryota.
ENOG4111FH0. LUCA.
GeneTreeiENSGT00390000005233.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiQ8VDG7.
KOiK01062.
TreeFamiTF313831.

Enzyme and pathway databases

BRENDAi3.1.1.47. 3474.
ReactomeiR-MMU-418346. Platelet homeostasis.

Miscellaneous databases

PROiQ8VDG7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037366.
CleanExiMM_PAFAH2.
ExpressionAtlasiQ8VDG7. baseline and differential.
GenevisibleiQ8VDG7. MM.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAFA2_MOUSE
AccessioniPrimary (citable) accession number: Q8VDG7
Secondary accession number(s): E9QNW7, Q8R0Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.