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Q8VDG7

- PAFA2_MOUSE

UniProt

Q8VDG7 - PAFA2_MOUSE

Protein

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Gene

Pafah2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme By similarity.By similarity

    Catalytic activityi

    1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei234 – 2341NucleophileBy similarity
    Active sitei257 – 2571Charge relay systemPROSITE-ProRule annotation
    Active sitei312 – 3121Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. 1-alkyl-2-acetylglycerophosphocholine esterase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. negative regulation of apoptotic process Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    BRENDAi3.1.1.47. 3474.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC:3.1.1.47)
    Alternative name(s):
    Serine-dependent phospholipase A2
    Short name:
    SD-PLA2
    Gene namesi
    Name:Pafah2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2140321. Pafah2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Platelet-activating factor acetylhydrolase 2, cytoplasmicPRO_0000090384Add
    BLAST

    Proteomic databases

    MaxQBiQ8VDG7.
    PaxDbiQ8VDG7.
    PRIDEiQ8VDG7.

    PTM databases

    PhosphoSiteiQ8VDG7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VDG7.
    BgeeiQ8VDG7.
    CleanExiMM_PAFAH2.
    GenevestigatoriQ8VDG7.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000101496.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VDG7.
    SMRiQ8VDG7. Positions 10-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serine esterase family.Curated

    Phylogenomic databases

    eggNOGiCOG4188.
    GeneTreeiENSGT00390000005233.
    HOGENOMiHOG000008053.
    HOVERGENiHBG001322.
    InParanoidiQ8VDG7.
    KOiK01062.
    OrthoDBiEOG7MSMQ5.
    TreeFamiTF313831.

    Family and domain databases

    Gene3Di3.40.50.1820. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view]
    PANTHERiPTHR10272. PTHR10272. 1 hit.
    PfamiPF03403. PAF-AH_p_II. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMiSSF53474. SSF53474. 2 hits.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VDG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAGQSVCFP PISGPHHIGC TDVMEGHSLE GSLFRLFYPC QASEKCEQPL    50
    WIPRYEYSMG LADYLQYNKR WVGLLFNVGI GSCRLPVSWN GPFKAKESGY 100
    PLIILSHGLG GFRASYSAFC MELASRGFVV AAVEHRDQSA AATYFCKPTS 150
    QESSPAESLE EEWLPFRRIK EGEKEFHVRN PQVHQRVKEC VRVLRILQDA 200
    SAGKTVVNVF PGGLDLMTLK GSIDRNRVAV MGHSFGGATA VLALTQEVQF 250
    RCAIALDAWM FPLERDFYPK ARGPVFFINV EKFQTVESVN LMKKICAQHE 300
    QSRIVTVLGA VHRSQTDFAF VTGNLIAKFF SSNSRGTLDP YESQEVMVRA 350
    ILAFLQKHLD LKEDYDQWSS FIEGVGPSLI QGAPHYLSSL 390
    Length:390
    Mass (Da):43,562
    Last modified:July 27, 2011 - v2
    Checksum:i28AE6D00A25ED029
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti223 – 2264IDRN → VDTS in AAH21890. (PubMed:15489334)Curated
    Sequence conflicti223 – 2264IDRN → VDTS in AAH25495. (PubMed:15489334)Curated
    Sequence conflicti223 – 2264IDRN → VDTS in AAH25938. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL669982 Genomic DNA. No translation available.
    BC021890 mRNA. Translation: AAH21890.1.
    BC025495 mRNA. Translation: AAH25495.1.
    BC025938 mRNA. Translation: AAH25938.1.
    CCDSiCCDS18771.1.
    RefSeqiNP_001272803.1. NM_001285874.1.
    NP_598641.2. NM_133880.3.
    XP_006538518.1. XM_006538455.1.
    UniGeneiMm.22116.

    Genome annotation databases

    EnsembliENSMUST00000105869; ENSMUSP00000101495; ENSMUSG00000037366.
    GeneIDi100163.
    KEGGimmu:100163.
    UCSCiuc008vey.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL669982 Genomic DNA. No translation available.
    BC021890 mRNA. Translation: AAH21890.1 .
    BC025495 mRNA. Translation: AAH25495.1 .
    BC025938 mRNA. Translation: AAH25938.1 .
    CCDSi CCDS18771.1.
    RefSeqi NP_001272803.1. NM_001285874.1.
    NP_598641.2. NM_133880.3.
    XP_006538518.1. XM_006538455.1.
    UniGenei Mm.22116.

    3D structure databases

    ProteinModelPortali Q8VDG7.
    SMRi Q8VDG7. Positions 10-382.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000101496.

    Chemistry

    ChEMBLi CHEMBL1795095.

    PTM databases

    PhosphoSitei Q8VDG7.

    Proteomic databases

    MaxQBi Q8VDG7.
    PaxDbi Q8VDG7.
    PRIDEi Q8VDG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000105869 ; ENSMUSP00000101495 ; ENSMUSG00000037366 .
    GeneIDi 100163.
    KEGGi mmu:100163.
    UCSCi uc008vey.2. mouse.

    Organism-specific databases

    CTDi 5051.
    MGIi MGI:2140321. Pafah2.

    Phylogenomic databases

    eggNOGi COG4188.
    GeneTreei ENSGT00390000005233.
    HOGENOMi HOG000008053.
    HOVERGENi HBG001322.
    InParanoidi Q8VDG7.
    KOi K01062.
    OrthoDBi EOG7MSMQ5.
    TreeFami TF313831.

    Enzyme and pathway databases

    BRENDAi 3.1.1.47. 3474.

    Miscellaneous databases

    NextBioi 354293.
    PROi Q8VDG7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VDG7.
    Bgeei Q8VDG7.
    CleanExi MM_PAFAH2.
    Genevestigatori Q8VDG7.

    Family and domain databases

    Gene3Di 3.40.50.1820. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR005065. PAF_acetylhydro.
    IPR016715. PAF_acetylhydro_eukaryote.
    [Graphical view ]
    PANTHERi PTHR10272. PTHR10272. 1 hit.
    Pfami PF03403. PAF-AH_p_II. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018169. PAF_acetylhydrolase. 1 hit.
    SUPFAMi SSF53474. SSF53474. 2 hits.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver and Mammary gland.

    Entry informationi

    Entry nameiPAFA2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VDG7
    Secondary accession number(s): E9QNW7, Q8R0Y7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3