Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8VDG7 (PAFA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic

EC=3.1.1.47
Alternative name(s):
Serine-dependent phospholipase A2
Short name=SD-PLA2
Gene names
Name:Pafah2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length390 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme By similarity.

Catalytic activity

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the serine esterase family.

Ontologies

Keywords
   Biological processLipid degradation
Lipid metabolism
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processlipid catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function1-alkyl-2-acetylglycerophosphocholine esterase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 390390Platelet-activating factor acetylhydrolase 2, cytoplasmic
PRO_0000090384

Sites

Active site2341Nucleophile By similarity
Active site2571Charge relay system By similarity
Active site3121Charge relay system By similarity

Experimental info

Sequence conflict223 – 2264IDRN → VDTS in AAH21890. Ref.2
Sequence conflict223 – 2264IDRN → VDTS in AAH25495. Ref.2
Sequence conflict223 – 2264IDRN → VDTS in AAH25938. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8VDG7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 28AE6D00A25ED029

FASTA39043,562
        10         20         30         40         50         60 
MGAGQSVCFP PISGPHHIGC TDVMEGHSLE GSLFRLFYPC QASEKCEQPL WIPRYEYSMG 

        70         80         90        100        110        120 
LADYLQYNKR WVGLLFNVGI GSCRLPVSWN GPFKAKESGY PLIILSHGLG GFRASYSAFC 

       130        140        150        160        170        180 
MELASRGFVV AAVEHRDQSA AATYFCKPTS QESSPAESLE EEWLPFRRIK EGEKEFHVRN 

       190        200        210        220        230        240 
PQVHQRVKEC VRVLRILQDA SAGKTVVNVF PGGLDLMTLK GSIDRNRVAV MGHSFGGATA 

       250        260        270        280        290        300 
VLALTQEVQF RCAIALDAWM FPLERDFYPK ARGPVFFINV EKFQTVESVN LMKKICAQHE 

       310        320        330        340        350        360 
QSRIVTVLGA VHRSQTDFAF VTGNLIAKFF SSNSRGTLDP YESQEVMVRA ILAFLQKHLD 

       370        380        390 
LKEDYDQWSS FIEGVGPSLI QGAPHYLSSL 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver and Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL669982 Genomic DNA. No translation available.
BC021890 mRNA. Translation: AAH21890.1.
BC025495 mRNA. Translation: AAH25495.1.
BC025938 mRNA. Translation: AAH25938.1.
CCDSCCDS18771.1.
RefSeqNP_001272803.1. NM_001285874.1.
NP_598641.2. NM_133880.3.
XP_006538518.1. XM_006538455.1.
UniGeneMm.22116.

3D structure databases

ProteinModelPortalQ8VDG7.
SMRQ8VDG7. Positions 10-382.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000101496.

Chemistry

ChEMBLCHEMBL1795095.

PTM databases

PhosphoSiteQ8VDG7.

Proteomic databases

MaxQBQ8VDG7.
PaxDbQ8VDG7.
PRIDEQ8VDG7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000105869; ENSMUSP00000101495; ENSMUSG00000037366.
GeneID100163.
KEGGmmu:100163.
UCSCuc008vey.2. mouse.

Organism-specific databases

CTD5051.
MGIMGI:2140321. Pafah2.

Phylogenomic databases

eggNOGCOG4188.
GeneTreeENSGT00390000005233.
HOGENOMHOG000008053.
HOVERGENHBG001322.
InParanoidQ8VDG7.
KOK01062.
OrthoDBEOG7MSMQ5.
TreeFamTF313831.

Enzyme and pathway databases

BRENDA3.1.1.47. 3474.

Gene expression databases

ArrayExpressQ8VDG7.
BgeeQ8VDG7.
CleanExMM_PAFAH2.
GenevestigatorQ8VDG7.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERPTHR10272. PTHR10272. 1 hit.
PfamPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMSSF53474. SSF53474. 2 hits.
PROSITEPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio354293.
PROQ8VDG7.
SOURCESearch...

Entry information

Entry namePAFA2_MOUSE
AccessionPrimary (citable) accession number: Q8VDG7
Secondary accession number(s): E9QNW7, Q8R0Y7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot