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Protein

Platelet-activating factor acetylhydrolase 2, cytoplasmic

Gene

Pafah2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position. May share a common physiologic function with the plasma-type enzyme (By similarity).By similarity

Catalytic activityi

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei234 – 2341NucleophileBy similarity
Active sitei257 – 2571Charge relay systemPROSITE-ProRule annotation
Active sitei312 – 3121Charge relay systemPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.1.47. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase 2, cytoplasmic (EC:3.1.1.47)
Alternative name(s):
Serine-dependent phospholipase A2
Short name:
SD-PLA2
Gene namesi
Name:Pafah2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2140321. Pafah2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Platelet-activating factor acetylhydrolase 2, cytoplasmicPRO_0000090384Add
BLAST

Proteomic databases

MaxQBiQ8VDG7.
PaxDbiQ8VDG7.
PRIDEiQ8VDG7.

PTM databases

PhosphoSiteiQ8VDG7.

Expressioni

Gene expression databases

BgeeiQ8VDG7.
CleanExiMM_PAFAH2.
ExpressionAtlasiQ8VDG7. baseline and differential.
GenevestigatoriQ8VDG7.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101496.

Structurei

3D structure databases

ProteinModelPortaliQ8VDG7.
SMRiQ8VDG7. Positions 10-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serine esterase family.Curated

Phylogenomic databases

eggNOGiCOG4188.
GeneTreeiENSGT00390000005233.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiQ8VDG7.
KOiK01062.
OrthoDBiEOG7MSMQ5.
TreeFamiTF313831.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGQSVCFP PISGPHHIGC TDVMEGHSLE GSLFRLFYPC QASEKCEQPL
60 70 80 90 100
WIPRYEYSMG LADYLQYNKR WVGLLFNVGI GSCRLPVSWN GPFKAKESGY
110 120 130 140 150
PLIILSHGLG GFRASYSAFC MELASRGFVV AAVEHRDQSA AATYFCKPTS
160 170 180 190 200
QESSPAESLE EEWLPFRRIK EGEKEFHVRN PQVHQRVKEC VRVLRILQDA
210 220 230 240 250
SAGKTVVNVF PGGLDLMTLK GSIDRNRVAV MGHSFGGATA VLALTQEVQF
260 270 280 290 300
RCAIALDAWM FPLERDFYPK ARGPVFFINV EKFQTVESVN LMKKICAQHE
310 320 330 340 350
QSRIVTVLGA VHRSQTDFAF VTGNLIAKFF SSNSRGTLDP YESQEVMVRA
360 370 380 390
ILAFLQKHLD LKEDYDQWSS FIEGVGPSLI QGAPHYLSSL
Length:390
Mass (Da):43,562
Last modified:July 27, 2011 - v2
Checksum:i28AE6D00A25ED029
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2264IDRN → VDTS in AAH21890 (PubMed:15489334).Curated
Sequence conflicti223 – 2264IDRN → VDTS in AAH25495 (PubMed:15489334).Curated
Sequence conflicti223 – 2264IDRN → VDTS in AAH25938 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669982 Genomic DNA. No translation available.
BC021890 mRNA. Translation: AAH21890.1.
BC025495 mRNA. Translation: AAH25495.1.
BC025938 mRNA. Translation: AAH25938.1.
CCDSiCCDS18771.1.
RefSeqiNP_001272803.1. NM_001285874.1.
NP_598641.2. NM_133880.3.
XP_006538518.1. XM_006538455.2.
UniGeneiMm.22116.

Genome annotation databases

EnsembliENSMUST00000105869; ENSMUSP00000101495; ENSMUSG00000037366.
GeneIDi100163.
KEGGimmu:100163.
UCSCiuc008vey.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL669982 Genomic DNA. No translation available.
BC021890 mRNA. Translation: AAH21890.1.
BC025495 mRNA. Translation: AAH25495.1.
BC025938 mRNA. Translation: AAH25938.1.
CCDSiCCDS18771.1.
RefSeqiNP_001272803.1. NM_001285874.1.
NP_598641.2. NM_133880.3.
XP_006538518.1. XM_006538455.2.
UniGeneiMm.22116.

3D structure databases

ProteinModelPortaliQ8VDG7.
SMRiQ8VDG7. Positions 10-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101496.

Chemistry

ChEMBLiCHEMBL1795095.

PTM databases

PhosphoSiteiQ8VDG7.

Proteomic databases

MaxQBiQ8VDG7.
PaxDbiQ8VDG7.
PRIDEiQ8VDG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000105869; ENSMUSP00000101495; ENSMUSG00000037366.
GeneIDi100163.
KEGGimmu:100163.
UCSCiuc008vey.2. mouse.

Organism-specific databases

CTDi5051.
MGIiMGI:2140321. Pafah2.

Phylogenomic databases

eggNOGiCOG4188.
GeneTreeiENSGT00390000005233.
HOGENOMiHOG000008053.
HOVERGENiHBG001322.
InParanoidiQ8VDG7.
KOiK01062.
OrthoDBiEOG7MSMQ5.
TreeFamiTF313831.

Enzyme and pathway databases

BRENDAi3.1.1.47. 3474.

Miscellaneous databases

NextBioi354293.
PROiQ8VDG7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VDG7.
CleanExiMM_PAFAH2.
ExpressionAtlasiQ8VDG7. baseline and differential.
GenevestigatoriQ8VDG7.

Family and domain databases

Gene3Di3.40.50.1820. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR005065. PAF_acetylhydro.
IPR016715. PAF_acetylhydro_eukaryote.
[Graphical view]
PANTHERiPTHR10272. PTHR10272. 1 hit.
PfamiPF03403. PAF-AH_p_II. 1 hit.
[Graphical view]
PIRSFiPIRSF018169. PAF_acetylhydrolase. 1 hit.
SUPFAMiSSF53474. SSF53474. 2 hits.
PROSITEiPS00120. LIPASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver and Mammary gland.

Entry informationi

Entry nameiPAFA2_MOUSE
AccessioniPrimary (citable) accession number: Q8VDG7
Secondary accession number(s): E9QNW7, Q8R0Y7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 27, 2011
Last modified: April 1, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.