Q8VDC3 (Q8VDC3_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytoplasmic aconitase EMBL CAD20353.1

Submitted name:
Uncharacterized protein Ensembl ENSMUSP00000030112

Gene names

Name:	Aco1 Ensembl ENSMUSP00000030112 MGI 87879
Synonyms:	aco1 EMBL CAD20353.1

Organism

Mus musculus (Mouse) EMBL CAD20353.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	899 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cellular iron ion homeostasis Inferred from mutant phenotype. Source: MGI intestinal absorption Inferred from genetic interaction. Source: MGI post-embryonic development Inferred from genetic interaction. Source: MGI regulation of translation Inferred from mutant phenotype. Source: MGI
Cellular component	cytosol Inferred from direct assay. Source: MGI mitochondrion Inferred from direct assay. Source: MGI
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: InterPro aconitate hydratase activity Inferred from direct assay. Source: MGI iron-responsive element binding Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8VDC3 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: B016E5BB5D4D64E8	FASTA	899	99,103
	10 20 30 40 50 60 MKNPFAHLAE PLDAAQPGKR FFNLNKLEDS RYGRLPFSIR VLLEAAVRNC DEFLVKKNDI 70 80 90 100 110 120 ENILNWNVMQ HKNIEVPFKP ARVILQDFTG VPAVVDFAAM RDAVKKLGGN PEKINPVCPA 130 140 150 160 170 180 DLVIDHSIQV DFNRRADSLQ KNQDLEFERN KERFEFLKWG SQAFCNMRII PPGSGIIHQV 190 200 210 220 230 240 NLEYLARVVF DQDGCYYPDS LVGTDSHTTM IDGLGVLGWE AFPCSAVTAG VGGIEAEAVM 250 260 270 280 290 300 LGQPISMVLP QVIGYKLMGK PHPLVTSTDI VLTITKHLRQ VGVVGKFVEF FGPGVAQLSI 310 320 330 340 350 360 ADRATIANMC PEYGATAAFF PVDEVSIAYL LQTGREEDKV KHIQKYLQAV GMFRDFNDTS 370 380 390 400 410 420 QDPDFTQVVE LDLKTVVPCC SGPKRPQDKV AVSEMKKDFE SCLGAKQGFK GFQVAPDRHN 430 440 450 460 470 480 DRKTFLYSNS EFTLAHGSVV IAAITSCTNT SNPSVMLGAG LLAKKAVEAG LSVKPYIKTS 490 500 510 520 530 540 LSPGSGVVTY YLRESGVMPY LSQLGFDVVG YGCMTCIGNS GPLPEPVVEA ITQGDLVAVG 550 560 570 580 590 600 VLSGNRNFEG RVHPNTRANY LASPPLVIAY AIAGTVRIDF EKEPLGVNAQ GRQVFLKDIW 610 620 630 640 650 660 PTRDEIQAVE RQHVIPGMFK EVYQKIETVN KSWNALAAPS EKLYAWNPKS TYIKSPPFFE 670 680 690 700 710 720 SLTLDLQPPK SIVDAYVLLN LGDSVTTDHI SPAGNIARNS PAARYLTNRG LTPREFNSYG 730 740 750 760 770 780 SRRGNDAIMA RGTFANIRLL NKFLNKQAPQ TVHLPSGETL DVFDAAERYQ QAGLPLIVLA 790 800 810 820 830 840 GKEYGSGSSR DWAAKGPFLL GIKAVLAESY ERIHRSNLVG MGVIPLEYLP GETADSLGLT 850 860 870 880 890 GRERYTINIP EDLKPRMTVQ IKLDTGKTFQ AVMRFDTDVE LTYFHNGGIL NYMIRKMAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo." Galy B., Ferring D., Benesova M., Benes V., Hentze M.W. RNA 10:1019-1025(2004) [PubMed: 15208438] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: 129/ola EMBL CAD20353.1.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Mouse Genome Sequencing Consortium Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6 Ensembl ENSMUSP00000030112.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000030112.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL831793 Genomic DNA. No translation available. AJ427344 Genomic DNA. Translation: CAD20353.1.
IPI	IPI00622780.
UniGene	Mm.331547.
3D structure databases
ProteinModelPortal	Q8VDC3.
SMR	Q8VDC3. Positions 3-899.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VDC3.
Proteomic databases
PRIDE	Q8VDC3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000030112; ENSMUSP00000030112; ENSMUSG00000028405.
Organism-specific databases
MGI	MGI:87879. Aco1.
Phylogenomic databases
GeneTree	ENSGT00530000063060.
HOGENOM	HBG289738.
HOVERGEN	HBG052147.
InParanoid	Q8VDC3.
OMA	IKYLVQT.
PhylomeDB	Q8VDC3.
Gene expression databases
ArrayExpress	Q8VDC3.
Bgee	Q8VDC3.
Genevestigator	Q8VDC3.
Family and domain databases
InterPro	IPR015931. Acnase/IPM_dHydase_lsu_aba_1/3. IPR015937. Acoase/IPM_deHydtase. IPR001030. Acoase/IPM_deHydtase_lsu_aba. IPR015928. Aconitase/3IPM_dehydase_swvl. IPR006249. Aconitase/Fe_reg_prot_2. IPR015934. Aconitase/Fe_reg_prot_2/AcnD. IPR015932. Aconitase/IPMdHydase_lsu_aba_2. IPR018136. Aconitase_4Fe-4S_BS. IPR000573. AconitaseA/IPMdHydase_ssu_swvl. [Graphical view]
Gene3D	G3DSA:3.30.499.10. Acnase/IPM_dHydase_lsu_aba_1/3. 3 hits. G3DSA:3.20.19.10. Aconitase/3IPM_dehydase_swvl. 1 hit. G3DSA:3.40.1060.10. Aconitase/IPMdHydase_lsu_aba_2. 1 hit.
PANTHER	PTHR11670. Aconitase-like_core. 1 hit. PTHR11670:SF1. Aconitase/Fe_reg_prot_2/AcnD. 1 hit.
Pfam	PF00330. Aconitase. 1 hit. PF00694. Aconitase_C. 1 hit. [Graphical view]
PRINTS	PR00415. ACONITASE.
SUPFAM	SSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit. SSF53732. Aconitase_N. 1 hit.
TIGRFAMs	TIGR01341. Aconitase_1. 1 hit.
PROSITE	PS00450. ACONITASE_1. 1 hit. PS01244. ACONITASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q8VDC3_MOUSE

Accession

Primary (citable) accession number: Q8VDC3

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	November 16, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)