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Protein

FYVE and coiled-coil domain-containing protein 1

Gene

Fyco1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May mediate microtubule plus end-directed vesicle transport.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1132 – 119059FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
FYVE and coiled-coil domain-containing protein 1
Gene namesi
Name:Fyco1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107277. Fyco1.

Subcellular locationi

  • Cytoplasmic vesicleautophagosome By similarity
  • Endosome By similarity
  • Lysosome By similarity

  • Note: Localizes to the external but not to the internal membrane of autophagosomes, and upon autophagosome/late endosome/lysosome fusion, it stays on the external surface of autolysosomes.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 14371436FYVE and coiled-coil domain-containing protein 1PRO_0000245838Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei196 – 1961PhosphoserineBy similarity
Modified residuei372 – 3721PhosphothreonineCombined sources
Modified residuei837 – 8371PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8VDC1.
MaxQBiQ8VDC1.
PaxDbiQ8VDC1.
PeptideAtlasiQ8VDC1.
PRIDEiQ8VDC1.

PTM databases

iPTMnetiQ8VDC1.
PhosphoSiteiQ8VDC1.
SwissPalmiQ8VDC1.

Expressioni

Tissue specificityi

Expressed in heart and testis. Expressed in the eye lens.2 Publications

Gene expression databases

BgeeiENSMUSG00000025241.
CleanExiMM_FYCO1.
GenevisibleiQ8VDC1. MM.

Interactioni

Subunit structurei

Can form homodimers. Interacts (via C-terminus) with MAP1LC3B. Interacts with RAB7A; the interaction with RAB7A induces FYCO1 recruitment to late endosomal/lysosomal compartments.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081764.

Structurei

3D structure databases

ProteinModelPortaliQ8VDC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 169134RUNPROSITE-ProRule annotationAdd
BLAST
Domaini1296 – 1425130GOLDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 3027Sequence analysisAdd
BLAST
Coiled coili223 – 27048Sequence analysisAdd
BLAST
Coiled coili305 – 846542Sequence analysisAdd
BLAST
Coiled coili873 – 1110238Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation
Contains 1 GOLD domain.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1132 – 119059FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00730000110715.
HOGENOMiHOG000168295.
HOVERGENiHBG063805.
InParanoidiQ8VDC1.
OMAiNNEALEG.
OrthoDBiEOG091G00LS.
PhylomeDBiQ8VDC1.
TreeFamiTF341788.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR009038. GOLD_dom.
IPR004012. Run_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSTETQL QRIIRDLQDA ATELSHEFKE GGEPITDDST SLHKFSYKLE
60 70 80 90 100
YLLQFDQKEK ASLLGSKKDY WDYFCACLAK VKGANDGIRF VRSISELRTS
110 120 130 140 150
LGKGRAFIRY SLVHQRLADT LQQCFMNTKV TSDWYYARSP FLKPKLSSDI
160 170 180 190 200
VGQLYELTEV QFDLAPRGYD LDAAWPTFAR RTLATSTSAY MWKPPSRSSS
210 220 230 240 250
MSSLVSNYLQ TQEMASSLDL NCSLNNEALE SFDEMRLELD QLEVREKQLQ
260 270 280 290 300
ERVQQLDREN QALRMLVSRQ GGQLQVEKEM GYLAVEDSIG LVSLVAELQK
310 320 330 340 350
QGDVSQATVK KLQSCLQALE LNVDKKEYSP SALQLENMAK ELDTVRGSLG
360 370 380 390 400
RENQLLASLS ERLARAEKGE KTPPDTELHQ EPVPADLVLK FQELKGKLQA
410 420 430 440 450
LEGENTEAQE LNRQQSIKLE QLAKELQLKE EARASLAHLV KDVVPLQEEL
460 470 480 490 500
SGKKQESAQL RRQLQESLAH LSSVEEELAE ARQQEKQHRE EKQLLEQEAT
510 520 530 540 550
SLTWQLQLLE TQLGQVSQLV SDLEEQKKQL MQERDHLSQR VGTLEQLAEV
560 570 580 590 600
HGPPQSAEMP EKRQQCLREE QVNNSTVSEA EQEELQKELQ NMVDRNQLLE
610 620 630 640 650
GKLQALQTDY KALQQREAAI QGSLASLEAE QASIRHLGNQ MEASLLAVKK
660 670 680 690 700
AKETMKAQVA EKEAALQSKE SECQRLQEEA DQCRLQAEAQ AQELRALENQ
710 720 730 740 750
CQQQIQLIEV LSAEKGQQGL SLPQVNTDQL ALSQAQLEIH QGEAQRLQNE
760 770 780 790 800
VVDLQAKLQV ALGDRDKLQS QLGVAETVLR EHKTLVQQLK EQNEALNRAH
810 820 830 840 850
VQELLQCSER EGILQEESIY KAQKQEQELR ALQAELSQVR CSSEGAHLEH
860 870 880 890 900
AELQDQLHRA NTDTAELGIQ VCALTAEKDR MEEALASLAQ ELQDSKEAAL
910 920 930 940 950
QERKGLELQV MQLQQEKEKL QEKVKAAEEA ASSFSGLQAQ LAQAEQLAQS
960 970 980 990 1000
LQETAHQEQD ALKFQLSAEI MDHQNRLKTA NEECGHLRAQ LEEQGQQLQM
1010 1020 1030 1040 1050
TKEAVQELEI TKAAMEEKLN CTSSHLAECQ ATLLRKDEES TMLQTSLERT
1060 1070 1080 1090 1100
QKELEKATSK IQEYYNKLCQ EVTNRERNDQ KMLADLDDLN RTKKYLEERL
1110 1120 1130 1140 1150
IELLRDKDAL WQKSDALEFQ QKLSAEEKCL GDMEVNHCHD CKREFSWIVR
1160 1170 1180 1190 1200
RHHCRICGRI FCYYCCNNYV VTKPSGKKER CCRACFQKFG EGSGSNDSSG
1210 1220 1230 1240 1250
SGTSQGEPSP MVSPAEASPQ SIGSQGINSV CRPPDDAVFD IITDEELCQI
1260 1270 1280 1290 1300
QESGSSLPET PTETDSMDPN TAEQDTTSNS LTPEDTEDVP MGQDAEICLL
1310 1320 1330 1340 1350
KSGELMIKLP LTVEEVASFG EGSRELFVRS STYSLITITV AEPGLTISWV
1360 1370 1380 1390 1400
FSSDPKSISF SVVFQETEDT PLDQCKVLIP TTRCNSHKEN IRGQLKVRIP
1410 1420 1430
GIYLLIFDNT FSRFISKKVL YHLTVDRPVI YDGSDFP
Length:1,437
Mass (Da):162,336
Last modified:March 1, 2002 - v1
Checksum:i2AD12D8E10C54F61
GO

Sequence cautioni

The sequence AAH53712 differs from that shown.Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191D → V in AAH53712 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428065 mRNA. Translation: CAD20987.1.
BC053712 mRNA. Translation: AAH53712.1. Sequence problems.
AK081259 mRNA. Translation: BAC38178.2.
AK044587 mRNA. Translation: BAE43322.1.
CCDSiCCDS40819.1.
RefSeqiNP_001103723.2. NM_001110253.2.
NP_683727.3. NM_148925.3.
UniGeneiMm.252941.

Genome annotation databases

EnsembliENSMUST00000084715; ENSMUSP00000081764; ENSMUSG00000025241.
ENSMUST00000167595; ENSMUSP00000133222; ENSMUSG00000025241.
GeneIDi17281.
KEGGimmu:17281.
UCSCiuc029xgt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428065 mRNA. Translation: CAD20987.1.
BC053712 mRNA. Translation: AAH53712.1. Sequence problems.
AK081259 mRNA. Translation: BAC38178.2.
AK044587 mRNA. Translation: BAE43322.1.
CCDSiCCDS40819.1.
RefSeqiNP_001103723.2. NM_001110253.2.
NP_683727.3. NM_148925.3.
UniGeneiMm.252941.

3D structure databases

ProteinModelPortaliQ8VDC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081764.

PTM databases

iPTMnetiQ8VDC1.
PhosphoSiteiQ8VDC1.
SwissPalmiQ8VDC1.

Proteomic databases

EPDiQ8VDC1.
MaxQBiQ8VDC1.
PaxDbiQ8VDC1.
PeptideAtlasiQ8VDC1.
PRIDEiQ8VDC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084715; ENSMUSP00000081764; ENSMUSG00000025241.
ENSMUST00000167595; ENSMUSP00000133222; ENSMUSG00000025241.
GeneIDi17281.
KEGGimmu:17281.
UCSCiuc029xgt.2. mouse.

Organism-specific databases

CTDi79443.
MGIiMGI:107277. Fyco1.

Phylogenomic databases

eggNOGiKOG1729. Eukaryota.
ENOG410XPJK. LUCA.
GeneTreeiENSGT00730000110715.
HOGENOMiHOG000168295.
HOVERGENiHBG063805.
InParanoidiQ8VDC1.
OMAiNNEALEG.
OrthoDBiEOG091G00LS.
PhylomeDBiQ8VDC1.
TreeFamiTF341788.

Miscellaneous databases

PROiQ8VDC1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025241.
CleanExiMM_FYCO1.
GenevisibleiQ8VDC1. MM.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR009038. GOLD_dom.
IPR004012. Run_dom.
IPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
PF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF101576. SSF101576. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50866. GOLD. 1 hit.
PS50826. RUN. 1 hit.
PS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFYCO1_MOUSE
AccessioniPrimary (citable) accession number: Q8VDC1
Secondary accession number(s): Q3V385, Q7TMT0, Q8BJN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.