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Q8VDC0 (SYLM_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable leucine--tRNA ligase, mitochondrial

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:Lars2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length902 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Subcellular location

Mitochondrion matrix By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 902Probable leucine--tRNA ligase, mitochondrialPRO_0000035807

Regions

Motif91 – 10111"HIGH" region
Motif638 – 6425"KMSKS" region

Sites

Binding site6411ATP By similarity

Amino acid modifications

Modified residue671N6-acetyllysine Ref.3
Modified residue2351N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8VDC0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F5ED21E130F3A5FC

FASTA902101,480
        10         20         30         40         50         60 
MASTCQRLSF YVSPLKRQLV SRPPVILWER LIPGCSRSIY SATGKWTKEY TLQTRKDVEK 

        70         80         90        100        110        120 
WWHQQIKEQA SRVSEEDKLK PKFYLLSMFP YPSGKLHMGH VRVYTLSDTI ARFQKMRGMQ 

       130        140        150        160        170        180 
VINPMGWDAF GLPAENAAIE RNLHPESWTQ SNIKHMRKQL DRLGLCFSWD REITTCLPDY 

       190        200        210        220        230        240 
YKWTQYLFIK LYEAGLAYQK EALVNWDPVD QTVLANEQVN EYGCSWRSGA KVEKKYLRQW 

       250        260        270        280        290        300 
FIKTTAYAKA MQDALADLPE WYGIKGMQAH WIGDCVGCHL DFTLKVDGED TGEKLTAYTA 

       310        320        330        340        350        360 
TPEAIYGISH VAISPSHGLL HGCSSVKKAL QKALVPGRDC LTPVMAVSML TLQEVPIVIM 

       370        380        390        400        410        420 
ANPDLEGSLD SKIGIPSTSS EDTRLAQALG LPYSEVIEAS PDGTERLSGS AEFTGMTRQD 

       430        440        450        460        470        480 
AFVALTRKAR GMRVGGHVTS NKLKDWLISR QRYWGTPIPI VHCPACGPVP VPLQDLPVIL 

       490        500        510        520        530        540 
PSIASLTGRG GSPLATALEW VNCSCPRCKG SAKRETDTMD TFVDSAWYYF RYTDPHNTQS 

       550        560        570        580        590        600 
PFGSALADFW MPVDLYIGGK EHAVMHLFYA RFLSHFCHDQ KMVKHREPFH KLLAQGLIKG 

       610        620        630        640        650        660 
QTFRLPSGQC LKKEDIDFTG PAPVCAKTKE KLEVTWEKMS KSKHNGVDPE EIVAQYGIDT 

       670        680        690        700        710        720 
IRLYILFAAP PEKDILWDVK TDALPGVLRW QQRLWSLTTR FIEARTSGTV PQPQLLNSKE 

       730        740        750        760        770        780 
KTKAQNLWEY KNAVIAQVTT HFTEDFALNS VVSQLMGLSS ALSQASQRVV LHSPEFEDAL 

       790        800        810        820        830        840 
CALLVMAAPL APHVTSELWA GLTLVPSKLC DHYAWDSGVM LQAWPTVDSQ FLQKPDMVQM 

       850        860        870        880        890        900 
AVLINNKACG KIPVPQHVAQ DQDKVHELVL QSELGMKLLQ GRSIKKAFLS PRTALINFLV 


QE 

« Hide

References

« Hide 'large scale' references
[1]"Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3."
Kiss H., Darai E., Kiss C., Kost-Alimova M., Klein G., Dumanski J.P., Imreh S.
Mamm. Genome 13:646-655(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-67, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ428066 mRNA. Translation: CAD20988.1.
BC080303 mRNA. Translation: AAH80303.1.
BC138206 mRNA. Translation: AAI38207.1.
BC145982 mRNA. Translation: AAI45983.1.
CCDSCCDS23659.1.
RefSeqNP_694808.1. NM_153168.2.
UniGeneMm.276076.

3D structure databases

ProteinModelPortalQ8VDC0.
SMRQ8VDC0. Positions 52-891.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8VDC0. 1 interaction.
MINTMINT-4136305.

PTM databases

PhosphoSiteQ8VDC0.

Proteomic databases

MaxQBQ8VDC0.
PaxDbQ8VDC0.
PRIDEQ8VDC0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038863; ENSMUSP00000036710; ENSMUSG00000035202.
GeneID102436.
KEGGmmu:102436.
UCSCuc009sgd.1. mouse.

Organism-specific databases

CTD23395.
MGIMGI:2142973. Lars2.

Phylogenomic databases

eggNOGCOG0495.
GeneTreeENSGT00390000015114.
HOGENOMHOG000200747.
HOVERGENHBG017877.
InParanoidA6H6S4.
KOK01869.
OMAHISHELW.
OrthoDBEOG754HNN.
PhylomeDBQ8VDC0.
TreeFamTF105662.

Gene expression databases

ArrayExpressQ8VDC0.
BgeeQ8VDC0.
CleanExMM_LARS2.
GenevestigatorQ8VDC0.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio355474.
PROQ8VDC0.
SOURCESearch...

Entry information

Entry nameSYLM_MOUSE
AccessionPrimary (citable) accession number: Q8VDC0
Secondary accession number(s): A6H6S4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries