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Protein

Probable leucine--tRNA ligase, mitochondrial

Gene

Lars2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei641ATPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable leucine--tRNA ligase, mitochondrial (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:Lars2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2142973 Lars2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000035807? – 902Probable leucine--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei67N6-acetyllysineCombined sources1
Modified residuei235N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VDC0
MaxQBiQ8VDC0
PaxDbiQ8VDC0
PRIDEiQ8VDC0

PTM databases

iPTMnetiQ8VDC0
PhosphoSitePlusiQ8VDC0

Expressioni

Gene expression databases

BgeeiENSMUSG00000035202
CleanExiMM_LARS2
ExpressionAtlasiQ8VDC0 baseline and differential
GenevisibleiQ8VDC0 MM

Interactioni

Protein-protein interaction databases

IntActiQ8VDC0, 1 interactor
MINTiQ8VDC0
STRINGi10090.ENSMUSP00000036710

Structurei

3D structure databases

ProteinModelPortaliQ8VDC0
SMRiQ8VDC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi91 – 101"HIGH" regionAdd BLAST11
Motifi638 – 642"KMSKS" region5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0435 Eukaryota
COG0495 LUCA
GeneTreeiENSGT00390000015114
HOGENOMiHOG000200747
HOVERGENiHBG017877
InParanoidiQ8VDC0
KOiK01869
OMAiTFMVLAP
OrthoDBiEOG091G01P6
PhylomeDBiQ8VDC0
TreeFamiTF105662

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 3 hits
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VDC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTCQRLSF YVSPLKRQLV SRPPVILWER LIPGCSRSIY SATGKWTKEY
60 70 80 90 100
TLQTRKDVEK WWHQQIKEQA SRVSEEDKLK PKFYLLSMFP YPSGKLHMGH
110 120 130 140 150
VRVYTLSDTI ARFQKMRGMQ VINPMGWDAF GLPAENAAIE RNLHPESWTQ
160 170 180 190 200
SNIKHMRKQL DRLGLCFSWD REITTCLPDY YKWTQYLFIK LYEAGLAYQK
210 220 230 240 250
EALVNWDPVD QTVLANEQVN EYGCSWRSGA KVEKKYLRQW FIKTTAYAKA
260 270 280 290 300
MQDALADLPE WYGIKGMQAH WIGDCVGCHL DFTLKVDGED TGEKLTAYTA
310 320 330 340 350
TPEAIYGISH VAISPSHGLL HGCSSVKKAL QKALVPGRDC LTPVMAVSML
360 370 380 390 400
TLQEVPIVIM ANPDLEGSLD SKIGIPSTSS EDTRLAQALG LPYSEVIEAS
410 420 430 440 450
PDGTERLSGS AEFTGMTRQD AFVALTRKAR GMRVGGHVTS NKLKDWLISR
460 470 480 490 500
QRYWGTPIPI VHCPACGPVP VPLQDLPVIL PSIASLTGRG GSPLATALEW
510 520 530 540 550
VNCSCPRCKG SAKRETDTMD TFVDSAWYYF RYTDPHNTQS PFGSALADFW
560 570 580 590 600
MPVDLYIGGK EHAVMHLFYA RFLSHFCHDQ KMVKHREPFH KLLAQGLIKG
610 620 630 640 650
QTFRLPSGQC LKKEDIDFTG PAPVCAKTKE KLEVTWEKMS KSKHNGVDPE
660 670 680 690 700
EIVAQYGIDT IRLYILFAAP PEKDILWDVK TDALPGVLRW QQRLWSLTTR
710 720 730 740 750
FIEARTSGTV PQPQLLNSKE KTKAQNLWEY KNAVIAQVTT HFTEDFALNS
760 770 780 790 800
VVSQLMGLSS ALSQASQRVV LHSPEFEDAL CALLVMAAPL APHVTSELWA
810 820 830 840 850
GLTLVPSKLC DHYAWDSGVM LQAWPTVDSQ FLQKPDMVQM AVLINNKACG
860 870 880 890 900
KIPVPQHVAQ DQDKVHELVL QSELGMKLLQ GRSIKKAFLS PRTALINFLV

QE
Length:902
Mass (Da):101,480
Last modified:March 1, 2002 - v1
Checksum:iF5ED21E130F3A5FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428066 mRNA Translation: CAD20988.1
BC080303 mRNA Translation: AAH80303.1
BC138206 mRNA Translation: AAI38207.1
BC145982 mRNA Translation: AAI45983.1
CCDSiCCDS23659.1
RefSeqiNP_001335096.1, NM_001348167.1
NP_001335097.1, NM_001348168.1
NP_694808.1, NM_153168.3
UniGeneiMm.276076

Genome annotation databases

EnsembliENSMUST00000038863; ENSMUSP00000036710; ENSMUSG00000035202
GeneIDi102436
KEGGimmu:102436
UCSCiuc009sgd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSYLM_MOUSE
AccessioniPrimary (citable) accession number: Q8VDC0
Secondary accession number(s): A6H6S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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