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Protein

Sodium- and chloride-dependent transporter XTRP3A

Gene

Slc6a20a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids.1 Publication

GO - Molecular functioni

GO - Biological processi

  • amino-acid betaine transport Source: MGI
  • amino acid transport Source: UniProtKB
  • glycine import Source: GO_Central
  • glycine transport Source: MGI
  • proline transmembrane transport Source: MGI
  • proline transport Source: MGI
  • synaptic transmission, glycinergic Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent transporter XTRP3A
Alternative name(s):
IMINO-B
Solute carrier family 6 member 20A
X transporter protein 3 similar 1
Gene namesi
Name:Slc6a20aImported
Synonyms:Slc6a20Imported, Xt3s11 Publication, Xtm3s11 Publication, Xtrp3s1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2143217. Slc6a20a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 42ExtracellularSequence analysisAdd BLAST14
Transmembranei43 – 63Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini64 – 79CytoplasmicSequence analysisAdd BLAST16
Transmembranei80 – 100Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini101 – 165ExtracellularSequence analysisAdd BLAST65
Transmembranei166 – 186Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini187 – 194CytoplasmicSequence analysis8
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 241ExtracellularSequence analysisAdd BLAST26
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 276CytoplasmicSequence analysisAdd BLAST14
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 389ExtracellularSequence analysisAdd BLAST92
Transmembranei390 – 410Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini411 – 431CytoplasmicSequence analysisAdd BLAST21
Transmembranei432 – 452Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini453 – 465ExtracellularSequence analysisAdd BLAST13
Transmembranei466 – 486Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini487 – 504CytoplasmicSequence analysisAdd BLAST18
Transmembranei505 – 525Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini526 – 554ExtracellularSequence analysisAdd BLAST29
Transmembranei555 – 575Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini576 – 592CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003435221 – 592Sodium- and chloride-dependent transporter XTRP3AAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi131N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8VDB9.
PaxDbiQ8VDB9.
PRIDEiQ8VDB9.

PTM databases

iPTMnetiQ8VDB9.
PhosphoSitePlusiQ8VDB9.

Expressioni

Tissue specificityi

Expressed in brain, kidney, small intestine, thymus, spleen and lung. In the brain, expressed in cerebellum, cortex and brain stem. Not detected in liver, muscle or heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000036814.
ExpressionAtlasiQ8VDB9. baseline and differential.
GenevisibleiQ8VDB9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047690.

Structurei

3D structure databases

ProteinModelPortaliQ8VDB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8VDB9.
KOiK05048.
OMAiLVCLVNC.
OrthoDBiEOG091G08PX.
PhylomeDBiQ8VDB9.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDB9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKARPQWGH PLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM
60 70 80 90 100
LIVEGMPLLY LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM
110 120 130 140 150
YYNVINAWGF WYLFHSFQDP LPWSVCPLNS NHTGYDEECE KASSTQYFWY
160 170 180 190 200
RKTLNISPSI QENGGVQWEP ALCLTLAWLM VYLCILRGTE STGKVVYFTA
210 220 230 240 250
SMPYCVLIIY LVRGLTLHGA TNGLMYMFTP KMEQLANPKA WINAATQIFF
260 270 280 290 300
SLGLGFGSLI AFASYNEPSN NCQKHAIIVS IINSSTSIFA SIVTFSIYGF
310 320 330 340 350
KATFNYENCL NKVILLLTNS FDLEDGFLTV SNLEEVKNYL ASTYPNKYSE
360 370 380 390 400
VFPHIRNCSL ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL
410 420 430 440 450
MLGIGSMLGN TAAILTPLTD SKVISSYLPK EAISGLVCLI NCAVGMVFTM
460 470 480 490 500
EAGNYWFDIF NDYAATLSLL LIVLVETIAV CYVYGLKRFE SDLRAMTGRT
510 520 530 540 550
LSWYWKVMWA FVSPLLIVGL FIFYLSDYIL TGTLQYQAWD ATQGQLVTKD
560 570 580 590
YPPHALAVIG LLVASSTMCI PLVALGTFIR NRLKRGGSAP VA
Length:592
Mass (Da):66,178
Last modified:March 1, 2002 - v1
Checksum:i547B9F8C0B7A99AA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58L → P in BAE24391 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428067 mRNA. Translation: CAD20989.1.
AJ964961 mRNA. Translation: CAI80736.1.
AK140445 mRNA. Translation: BAE24391.1.
BC118933 mRNA. Translation: AAI18934.1.
CCDSiCCDS40817.1.
RefSeqiNP_631881.1. NM_139142.2.
UniGeneiMm.440867.

Genome annotation databases

EnsembliENSMUST00000040960; ENSMUSP00000047690; ENSMUSG00000036814.
GeneIDi102680.
KEGGimmu:102680.
UCSCiuc009sgk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ428067 mRNA. Translation: CAD20989.1.
AJ964961 mRNA. Translation: CAI80736.1.
AK140445 mRNA. Translation: BAE24391.1.
BC118933 mRNA. Translation: AAI18934.1.
CCDSiCCDS40817.1.
RefSeqiNP_631881.1. NM_139142.2.
UniGeneiMm.440867.

3D structure databases

ProteinModelPortaliQ8VDB9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047690.

PTM databases

iPTMnetiQ8VDB9.
PhosphoSitePlusiQ8VDB9.

Proteomic databases

MaxQBiQ8VDB9.
PaxDbiQ8VDB9.
PRIDEiQ8VDB9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040960; ENSMUSP00000047690; ENSMUSG00000036814.
GeneIDi102680.
KEGGimmu:102680.
UCSCiuc009sgk.1. mouse.

Organism-specific databases

CTDi102680.
MGIiMGI:2143217. Slc6a20a.

Phylogenomic databases

eggNOGiKOG3659. Eukaryota.
COG0733. LUCA.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8VDB9.
KOiK05048.
OMAiLVCLVNC.
OrthoDBiEOG091G08PX.
PhylomeDBiQ8VDB9.
TreeFamiTF343812.

Enzyme and pathway databases

ReactomeiR-MMU-352230. Amino acid transport across the plasma membrane.
R-MMU-442660. Na+/Cl- dependent neurotransmitter transporters.

Miscellaneous databases

PROiQ8VDB9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036814.
ExpressionAtlasiQ8VDB9. baseline and differential.
GenevisibleiQ8VDB9. MM.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 2 hits.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS620A_MOUSE
AccessioniPrimary (citable) accession number: Q8VDB9
Secondary accession number(s): Q3USE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.