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Q8VDB9

- S620A_MOUSE

UniProt

Q8VDB9 - S620A_MOUSE

Protein

Sodium- and chloride-dependent transporter XTRP3A

Gene

Slc6a20a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids.1 Publication

    GO - Molecular functioni

    1. amino acid transmembrane transporter activity Source: UniProtKB
    2. neurotransmitter:sodium symporter activity Source: InterPro

    GO - Biological processi

    1. amino acid transport Source: UniProtKB
    2. glycine transport Source: Ensembl
    3. proline transport Source: Ensembl

    Keywords - Biological processi

    Amino-acid transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent transporter XTRP3A
    Alternative name(s):
    IMINO-B
    Solute carrier family 6 member 20A
    X transporter protein 3 similar 1
    Gene namesi
    Name:Slc6a20aImported
    Synonyms:Slc6a20Imported, Xt3s11 Publication, Xtm3s11 Publication, Xtrp3s1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:2143217. Slc6a20a.

    Subcellular locationi

    Apical cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi.1 Publication

    GO - Cellular componenti

    1. apical plasma membrane Source: UniProtKB
    2. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 592592Sodium- and chloride-dependent transporter XTRP3APRO_0000343522Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8VDB9.
    PRIDEiQ8VDB9.

    Expressioni

    Tissue specificityi

    Expressed in brain, kidney, small intestine, thymus, spleen and lung. In the brain, expressed in cerebellum, cortex and brain stem. Not detected in liver, muscle or heart.1 Publication

    Gene expression databases

    ArrayExpressiQ8VDB9.
    BgeeiQ8VDB9.
    GenevestigatoriQ8VDB9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VDB9.
    SMRiQ8VDB9. Positions 5-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini29 – 4214ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini64 – 7916CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini101 – 16565ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini187 – 1948CytoplasmicSequence Analysis
    Topological domaini216 – 24126ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27614CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini298 – 38992ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini411 – 43121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini453 – 46513ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini487 – 50418CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini526 – 55429ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini576 – 59217CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei390 – 41021Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei432 – 45221Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei466 – 48621Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei505 – 52521Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei555 – 57521Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    GeneTreeiENSGT00750000117424.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ8VDB9.
    KOiK05048.
    OMAiATNGLMY.
    OrthoDBiEOG793B71.
    PhylomeDBiQ8VDB9.
    TreeFamiTF343812.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR002438. Na/ntran_symport_orphan.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR00176. NANEUSMPORT.
    PR01206. ORPHTRNSPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VDB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKARPQWGH PLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM    50
    LIVEGMPLLY LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM 100
    YYNVINAWGF WYLFHSFQDP LPWSVCPLNS NHTGYDEECE KASSTQYFWY 150
    RKTLNISPSI QENGGVQWEP ALCLTLAWLM VYLCILRGTE STGKVVYFTA 200
    SMPYCVLIIY LVRGLTLHGA TNGLMYMFTP KMEQLANPKA WINAATQIFF 250
    SLGLGFGSLI AFASYNEPSN NCQKHAIIVS IINSSTSIFA SIVTFSIYGF 300
    KATFNYENCL NKVILLLTNS FDLEDGFLTV SNLEEVKNYL ASTYPNKYSE 350
    VFPHIRNCSL ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL 400
    MLGIGSMLGN TAAILTPLTD SKVISSYLPK EAISGLVCLI NCAVGMVFTM 450
    EAGNYWFDIF NDYAATLSLL LIVLVETIAV CYVYGLKRFE SDLRAMTGRT 500
    LSWYWKVMWA FVSPLLIVGL FIFYLSDYIL TGTLQYQAWD ATQGQLVTKD 550
    YPPHALAVIG LLVASSTMCI PLVALGTFIR NRLKRGGSAP VA 592
    Length:592
    Mass (Da):66,178
    Last modified:March 1, 2002 - v1
    Checksum:i547B9F8C0B7A99AA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti58 – 581L → P in BAE24391. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ428067 mRNA. Translation: CAD20989.1.
    AJ964961 mRNA. Translation: CAI80736.1.
    AK140445 mRNA. Translation: BAE24391.1.
    BC118933 mRNA. Translation: AAI18934.1.
    CCDSiCCDS40817.1.
    RefSeqiNP_631881.1. NM_139142.2.
    UniGeneiMm.440867.

    Genome annotation databases

    EnsembliENSMUST00000040960; ENSMUSP00000047690; ENSMUSG00000036814.
    GeneIDi102680.
    KEGGimmu:102680.
    UCSCiuc009sgk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ428067 mRNA. Translation: CAD20989.1 .
    AJ964961 mRNA. Translation: CAI80736.1 .
    AK140445 mRNA. Translation: BAE24391.1 .
    BC118933 mRNA. Translation: AAI18934.1 .
    CCDSi CCDS40817.1.
    RefSeqi NP_631881.1. NM_139142.2.
    UniGenei Mm.440867.

    3D structure databases

    ProteinModelPortali Q8VDB9.
    SMRi Q8VDB9. Positions 5-330.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8VDB9.
    PRIDEi Q8VDB9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040960 ; ENSMUSP00000047690 ; ENSMUSG00000036814 .
    GeneIDi 102680.
    KEGGi mmu:102680.
    UCSCi uc009sgk.1. mouse.

    Organism-specific databases

    CTDi 102680.
    MGIi MGI:2143217. Slc6a20a.

    Phylogenomic databases

    eggNOGi COG0733.
    GeneTreei ENSGT00750000117424.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q8VDB9.
    KOi K05048.
    OMAi ATNGLMY.
    OrthoDBi EOG793B71.
    PhylomeDBi Q8VDB9.
    TreeFami TF343812.

    Miscellaneous databases

    NextBioi 355610.
    PROi Q8VDB9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VDB9.
    Bgeei Q8VDB9.
    Genevestigatori Q8VDB9.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR002438. Na/ntran_symport_orphan.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR00176. NANEUSMPORT.
    PR01206. ORPHTRNSPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3."
      Kiss H., Darai E., Kiss C., Kost-Alimova M., Klein G., Dumanski J.P., Imreh S.
      Mamm. Genome 13:646-655(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/cImported.
    2. "Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter."
      Kowalczuk S., Broeer A., Munzinger M., Tietze N., Klingel K., Broeer S.
      Biochem. J. 386:417-422(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: C57BL/6JImported.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: Medulla oblongataImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus."
      Romeo E., Dave M.H., Bacic D., Ristic Z., Camargo S.M.R., Loffing J., Wagner C.A., Verrey F.
      Am. J. Physiol. 290:F376-F383(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiS620A_MOUSE
    AccessioniPrimary (citable) accession number: Q8VDB9
    Secondary accession number(s): Q3USE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3