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Q8VDB9

- S620A_MOUSE

UniProt

Q8VDB9 - S620A_MOUSE

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Protein

Sodium- and chloride-dependent transporter XTRP3A

Gene

Slc6a20a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids.1 Publication

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: UniProtKB
  2. neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  1. amino acid transmembrane transport Source: GOC
  2. amino acid transport Source: UniProtKB
  3. glycine transport Source: Ensembl
  4. proline transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent transporter XTRP3A
Alternative name(s):
IMINO-B
Solute carrier family 6 member 20A
X transporter protein 3 similar 1
Gene namesi
Name:Slc6a20aImported
Synonyms:Slc6a20Imported, Xt3s11 Publication, Xtm3s11 Publication, Xtrp3s1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2143217. Slc6a20a.

Subcellular locationi

Apical cell membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi.1 Publication

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Sodium- and chloride-dependent transporter XTRP3APRO_0000343522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDB9.
PRIDEiQ8VDB9.

Expressioni

Tissue specificityi

Expressed in brain, kidney, small intestine, thymus, spleen and lung. In the brain, expressed in cerebellum, cortex and brain stem. Not detected in liver, muscle or heart.1 Publication

Gene expression databases

BgeeiQ8VDB9.
ExpressionAtlasiQ8VDB9. baseline and differential.
GenevestigatoriQ8VDB9.

Structurei

3D structure databases

ProteinModelPortaliQ8VDB9.
SMRiQ8VDB9. Positions 5-330.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77CytoplasmicSequence Analysis
Topological domaini29 – 4214ExtracellularSequence AnalysisAdd
BLAST
Topological domaini64 – 7916CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini101 – 16565ExtracellularSequence AnalysisAdd
BLAST
Topological domaini187 – 1948CytoplasmicSequence Analysis
Topological domaini216 – 24126ExtracellularSequence AnalysisAdd
BLAST
Topological domaini263 – 27614CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini298 – 38992ExtracellularSequence AnalysisAdd
BLAST
Topological domaini411 – 43121CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini453 – 46513ExtracellularSequence AnalysisAdd
BLAST
Topological domaini487 – 50418CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini526 – 55429ExtracellularSequence AnalysisAdd
BLAST
Topological domaini576 – 59217CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei8 – 2821Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei43 – 6321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei80 – 10021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei166 – 18621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei390 – 41021Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei432 – 45221Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei466 – 48621Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei505 – 52521Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei555 – 57521Helical; Name=12Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00760000119044.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8VDB9.
KOiK05048.
OMAiATNGLMY.
OrthoDBiEOG793B71.
PhylomeDBiQ8VDB9.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDB9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKARPQWGH PLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM
60 70 80 90 100
LIVEGMPLLY LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM
110 120 130 140 150
YYNVINAWGF WYLFHSFQDP LPWSVCPLNS NHTGYDEECE KASSTQYFWY
160 170 180 190 200
RKTLNISPSI QENGGVQWEP ALCLTLAWLM VYLCILRGTE STGKVVYFTA
210 220 230 240 250
SMPYCVLIIY LVRGLTLHGA TNGLMYMFTP KMEQLANPKA WINAATQIFF
260 270 280 290 300
SLGLGFGSLI AFASYNEPSN NCQKHAIIVS IINSSTSIFA SIVTFSIYGF
310 320 330 340 350
KATFNYENCL NKVILLLTNS FDLEDGFLTV SNLEEVKNYL ASTYPNKYSE
360 370 380 390 400
VFPHIRNCSL ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL
410 420 430 440 450
MLGIGSMLGN TAAILTPLTD SKVISSYLPK EAISGLVCLI NCAVGMVFTM
460 470 480 490 500
EAGNYWFDIF NDYAATLSLL LIVLVETIAV CYVYGLKRFE SDLRAMTGRT
510 520 530 540 550
LSWYWKVMWA FVSPLLIVGL FIFYLSDYIL TGTLQYQAWD ATQGQLVTKD
560 570 580 590
YPPHALAVIG LLVASSTMCI PLVALGTFIR NRLKRGGSAP VA
Length:592
Mass (Da):66,178
Last modified:March 1, 2002 - v1
Checksum:i547B9F8C0B7A99AA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581L → P in BAE24391. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ428067 mRNA. Translation: CAD20989.1.
AJ964961 mRNA. Translation: CAI80736.1.
AK140445 mRNA. Translation: BAE24391.1.
BC118933 mRNA. Translation: AAI18934.1.
CCDSiCCDS40817.1.
RefSeqiNP_631881.1. NM_139142.2.
UniGeneiMm.440867.

Genome annotation databases

EnsembliENSMUST00000040960; ENSMUSP00000047690; ENSMUSG00000036814.
GeneIDi102680.
KEGGimmu:102680.
UCSCiuc009sgk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ428067 mRNA. Translation: CAD20989.1 .
AJ964961 mRNA. Translation: CAI80736.1 .
AK140445 mRNA. Translation: BAE24391.1 .
BC118933 mRNA. Translation: AAI18934.1 .
CCDSi CCDS40817.1.
RefSeqi NP_631881.1. NM_139142.2.
UniGenei Mm.440867.

3D structure databases

ProteinModelPortali Q8VDB9.
SMRi Q8VDB9. Positions 5-330.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8VDB9.
PRIDEi Q8VDB9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040960 ; ENSMUSP00000047690 ; ENSMUSG00000036814 .
GeneIDi 102680.
KEGGi mmu:102680.
UCSCi uc009sgk.1. mouse.

Organism-specific databases

CTDi 102680.
MGIi MGI:2143217. Slc6a20a.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00760000119044.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q8VDB9.
KOi K05048.
OMAi ATNGLMY.
OrthoDBi EOG793B71.
PhylomeDBi Q8VDB9.
TreeFami TF343812.

Miscellaneous databases

NextBioi 355610.
PROi Q8VDB9.
SOURCEi Search...

Gene expression databases

Bgeei Q8VDB9.
ExpressionAtlasi Q8VDB9. baseline and differential.
Genevestigatori Q8VDB9.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3."
    Kiss H., Darai E., Kiss C., Kost-Alimova M., Klein G., Dumanski J.P., Imreh S.
    Mamm. Genome 13:646-655(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cImported.
  2. "Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter."
    Kowalczuk S., Broeer A., Munzinger M., Tietze N., Klingel K., Broeer S.
    Biochem. J. 386:417-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6JImported.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: Medulla oblongataImported.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus."
    Romeo E., Dave M.H., Bacic D., Ristic Z., Camargo S.M.R., Loffing J., Wagner C.A., Verrey F.
    Am. J. Physiol. 290:F376-F383(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS620A_MOUSE
AccessioniPrimary (citable) accession number: Q8VDB9
Secondary accession number(s): Q3USE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3