Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8VDB9 (S620A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent transporter XTRP3A
Alternative name(s):
IMINO-B
Solute carrier family 6 member 20A
X transporter protein 3 similar 1
Gene names
Name:Slc6a20a
Synonyms:Slc6a20, Xt3s1, Xtm3s1, Xtrp3s1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Ref.2

Subcellular location

Apical cell membrane; Multi-pass membrane protein. Note: Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. Ref.5

Tissue specificity

Expressed in brain, kidney, small intestine, thymus, spleen and lung. In the brain, expressed in cerebellum, cortex and brain stem. Not detected in liver, muscle or heart. Ref.2

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A20 subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 592592Sodium- and chloride-dependent transporter XTRP3A
PRO_0000343522

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2821Helical; Name=1; Potential
Topological domain29 – 4214Extracellular Potential
Transmembrane43 – 6321Helical; Name=2; Potential
Topological domain64 – 7916Cytoplasmic Potential
Transmembrane80 – 10021Helical; Name=3; Potential
Topological domain101 – 16565Extracellular Potential
Transmembrane166 – 18621Helical; Name=4; Potential
Topological domain187 – 1948Cytoplasmic Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Topological domain216 – 24126Extracellular Potential
Transmembrane242 – 26221Helical; Name=6; Potential
Topological domain263 – 27614Cytoplasmic Potential
Transmembrane277 – 29721Helical; Name=7; Potential
Topological domain298 – 38992Extracellular Potential
Transmembrane390 – 41021Helical; Name=8; Potential
Topological domain411 – 43121Cytoplasmic Potential
Transmembrane432 – 45221Helical; Name=9; Potential
Topological domain453 – 46513Extracellular Potential
Transmembrane466 – 48621Helical; Name=10; Potential
Topological domain487 – 50418Cytoplasmic Potential
Transmembrane505 – 52521Helical; Name=11; Potential
Topological domain526 – 55429Extracellular Potential
Transmembrane555 – 57521Helical; Name=12; Potential
Topological domain576 – 59217Cytoplasmic Potential

Amino acid modifications

Glycosylation1311N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict581L → P in BAE24391. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8VDB9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 547B9F8C0B7A99AA

FASTA59266,178
        10         20         30         40         50         60 
MEKARPQWGH PLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM LIVEGMPLLY 

        70         80         90        100        110        120 
LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM YYNVINAWGF WYLFHSFQDP 

       130        140        150        160        170        180 
LPWSVCPLNS NHTGYDEECE KASSTQYFWY RKTLNISPSI QENGGVQWEP ALCLTLAWLM 

       190        200        210        220        230        240 
VYLCILRGTE STGKVVYFTA SMPYCVLIIY LVRGLTLHGA TNGLMYMFTP KMEQLANPKA 

       250        260        270        280        290        300 
WINAATQIFF SLGLGFGSLI AFASYNEPSN NCQKHAIIVS IINSSTSIFA SIVTFSIYGF 

       310        320        330        340        350        360 
KATFNYENCL NKVILLLTNS FDLEDGFLTV SNLEEVKNYL ASTYPNKYSE VFPHIRNCSL 

       370        380        390        400        410        420 
ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL MLGIGSMLGN TAAILTPLTD 

       430        440        450        460        470        480 
SKVISSYLPK EAISGLVCLI NCAVGMVFTM EAGNYWFDIF NDYAATLSLL LIVLVETIAV 

       490        500        510        520        530        540 
CYVYGLKRFE SDLRAMTGRT LSWYWKVMWA FVSPLLIVGL FIFYLSDYIL TGTLQYQAWD 

       550        560        570        580        590 
ATQGQLVTKD YPPHALAVIG LLVASSTMCI PLVALGTFIR NRLKRGGSAP VA 

« Hide

References

« Hide 'large scale' references
[1]"Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3."
Kiss H., Darai E., Kiss C., Kost-Alimova M., Klein G., Dumanski J.P., Imreh S.
Mamm. Genome 13:646-655(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter."
Kowalczuk S., Broeer A., Munzinger M., Tietze N., Klingel K., Broeer S.
Biochem. J. 386:417-422(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Medulla oblongata.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus."
Romeo E., Dave M.H., Bacic D., Ristic Z., Camargo S.M.R., Loffing J., Wagner C.A., Verrey F.
Am. J. Physiol. 290:F376-F383(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ428067 mRNA. Translation: CAD20989.1.
AJ964961 mRNA. Translation: CAI80736.1.
AK140445 mRNA. Translation: BAE24391.1.
BC118933 mRNA. Translation: AAI18934.1.
CCDSCCDS40817.1.
RefSeqNP_631881.1. NM_139142.2.
UniGeneMm.440867.

3D structure databases

ProteinModelPortalQ8VDB9.
SMRQ8VDB9. Positions 5-330.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ8VDB9.
PRIDEQ8VDB9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040960; ENSMUSP00000047690; ENSMUSG00000036814.
GeneID102680.
KEGGmmu:102680.
UCSCuc009sgk.1. mouse.

Organism-specific databases

CTD102680.
MGIMGI:2143217. Slc6a20a.

Phylogenomic databases

eggNOGCOG0733.
GeneTreeENSGT00750000117424.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ8VDB9.
KOK05048.
OMAATNGLMY.
OrthoDBEOG793B71.
PhylomeDBQ8VDB9.
TreeFamTF343812.

Gene expression databases

ArrayExpressQ8VDB9.
BgeeQ8VDB9.
GenevestigatorQ8VDB9.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio355610.
PROQ8VDB9.
SOURCESearch...

Entry information

Entry nameS620A_MOUSE
AccessionPrimary (citable) accession number: Q8VDB9
Secondary accession number(s): Q3USE2
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot