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Q8VDB9

- S620A_MOUSE

UniProt

Q8VDB9 - S620A_MOUSE

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Protein

Sodium- and chloride-dependent transporter XTRP3A

Gene
Slc6a20a, Slc6a20, Xt3s1, Xtm3s1, Xtrp3s1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the calcium-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids.1 Publication

GO - Molecular functioni

  1. amino acid transmembrane transporter activity Source: UniProtKB
  2. neurotransmitter:sodium symporter activity Source: InterPro

GO - Biological processi

  1. amino acid transport Source: UniProtKB
  2. glycine transport Source: Ensembl
  3. proline transport Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent transporter XTRP3A
Alternative name(s):
IMINO-B
Solute carrier family 6 member 20A
X transporter protein 3 similar 1
Gene namesi
Name:Slc6a20a
Synonyms:Slc6a20, Xt3s1, Xtm3s1, Xtrp3s1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:2143217. Slc6a20a.

Subcellular locationi

Apical cell membrane; Multi-pass membrane protein
Note: Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2821Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini29 – 4214Extracellular Reviewed predictionAdd
BLAST
Transmembranei43 – 6321Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini64 – 7916Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei80 – 10021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini101 – 16565Extracellular Reviewed predictionAdd
BLAST
Transmembranei166 – 18621Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini187 – 1948Cytoplasmic Reviewed prediction
Transmembranei195 – 21521Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini216 – 24126Extracellular Reviewed predictionAdd
BLAST
Transmembranei242 – 26221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini263 – 27614Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei277 – 29721Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini298 – 38992Extracellular Reviewed predictionAdd
BLAST
Transmembranei390 – 41021Helical; Name=8; Reviewed predictionAdd
BLAST
Topological domaini411 – 43121Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei432 – 45221Helical; Name=9; Reviewed predictionAdd
BLAST
Topological domaini453 – 46513Extracellular Reviewed predictionAdd
BLAST
Transmembranei466 – 48621Helical; Name=10; Reviewed predictionAdd
BLAST
Topological domaini487 – 50418Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei505 – 52521Helical; Name=11; Reviewed predictionAdd
BLAST
Topological domaini526 – 55429Extracellular Reviewed predictionAdd
BLAST
Transmembranei555 – 57521Helical; Name=12; Reviewed predictionAdd
BLAST
Topological domaini576 – 59217Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: UniProtKB
  2. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 592592Sodium- and chloride-dependent transporter XTRP3APRO_0000343522Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi131 – 1311N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8VDB9.
PRIDEiQ8VDB9.

Expressioni

Tissue specificityi

Expressed in brain, kidney, small intestine, thymus, spleen and lung. In the brain, expressed in cerebellum, cortex and brain stem. Not detected in liver, muscle or heart.1 Publication

Gene expression databases

ArrayExpressiQ8VDB9.
BgeeiQ8VDB9.
GenevestigatoriQ8VDB9.

Structurei

3D structure databases

ProteinModelPortaliQ8VDB9.
SMRiQ8VDB9. Positions 5-330.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
GeneTreeiENSGT00750000117424.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ8VDB9.
KOiK05048.
OMAiATNGLMY.
OrthoDBiEOG793B71.
PhylomeDBiQ8VDB9.
TreeFamiTF343812.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VDB9-1 [UniParc]FASTAAdd to Basket

« Hide

MEKARPQWGH PLQFVFACIS YAVGLGNVWR FPYLCQMYGG GSFLVPYIIM    50
LIVEGMPLLY LELAVGQRMR QGSIGAWRTI SPYLSGVGVA SVVVSFFLSM 100
YYNVINAWGF WYLFHSFQDP LPWSVCPLNS NHTGYDEECE KASSTQYFWY 150
RKTLNISPSI QENGGVQWEP ALCLTLAWLM VYLCILRGTE STGKVVYFTA 200
SMPYCVLIIY LVRGLTLHGA TNGLMYMFTP KMEQLANPKA WINAATQIFF 250
SLGLGFGSLI AFASYNEPSN NCQKHAIIVS IINSSTSIFA SIVTFSIYGF 300
KATFNYENCL NKVILLLTNS FDLEDGFLTV SNLEEVKNYL ASTYPNKYSE 350
VFPHIRNCSL ESELDTAVQG TGLAFIVYTE AIKNMEVSQL WSVLYFFMLL 400
MLGIGSMLGN TAAILTPLTD SKVISSYLPK EAISGLVCLI NCAVGMVFTM 450
EAGNYWFDIF NDYAATLSLL LIVLVETIAV CYVYGLKRFE SDLRAMTGRT 500
LSWYWKVMWA FVSPLLIVGL FIFYLSDYIL TGTLQYQAWD ATQGQLVTKD 550
YPPHALAVIG LLVASSTMCI PLVALGTFIR NRLKRGGSAP VA 592
Length:592
Mass (Da):66,178
Last modified:March 1, 2002 - v1
Checksum:i547B9F8C0B7A99AA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581L → P in BAE24391. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ428067 mRNA. Translation: CAD20989.1.
AJ964961 mRNA. Translation: CAI80736.1.
AK140445 mRNA. Translation: BAE24391.1.
BC118933 mRNA. Translation: AAI18934.1.
CCDSiCCDS40817.1.
RefSeqiNP_631881.1. NM_139142.2.
UniGeneiMm.440867.

Genome annotation databases

EnsembliENSMUST00000040960; ENSMUSP00000047690; ENSMUSG00000036814.
GeneIDi102680.
KEGGimmu:102680.
UCSCiuc009sgk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ428067 mRNA. Translation: CAD20989.1 .
AJ964961 mRNA. Translation: CAI80736.1 .
AK140445 mRNA. Translation: BAE24391.1 .
BC118933 mRNA. Translation: AAI18934.1 .
CCDSi CCDS40817.1.
RefSeqi NP_631881.1. NM_139142.2.
UniGenei Mm.440867.

3D structure databases

ProteinModelPortali Q8VDB9.
SMRi Q8VDB9. Positions 5-330.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8VDB9.
PRIDEi Q8VDB9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040960 ; ENSMUSP00000047690 ; ENSMUSG00000036814 .
GeneIDi 102680.
KEGGi mmu:102680.
UCSCi uc009sgk.1. mouse.

Organism-specific databases

CTDi 102680.
MGIi MGI:2143217. Slc6a20a.

Phylogenomic databases

eggNOGi COG0733.
GeneTreei ENSGT00750000117424.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q8VDB9.
KOi K05048.
OMAi ATNGLMY.
OrthoDBi EOG793B71.
PhylomeDBi Q8VDB9.
TreeFami TF343812.

Miscellaneous databases

NextBioi 355610.
PROi Q8VDB9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VDB9.
Bgeei Q8VDB9.
Genevestigatori Q8VDB9.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR002438. Na/ntran_symport_orphan.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR00176. NANEUSMPORT.
PR01206. ORPHTRNSPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3."
    Kiss H., Darai E., Kiss C., Kost-Alimova M., Klein G., Dumanski J.P., Imreh S.
    Mamm. Genome 13:646-655(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Molecular cloning of the mouse IMINO system: an Na+- and Cl--dependent proline transporter."
    Kowalczuk S., Broeer A., Munzinger M., Tietze N., Klingel K., Broeer S.
    Biochem. J. 386:417-422(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Medulla oblongata.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Luminal kidney and intestine SLC6 amino acid transporters of B0AT-cluster and their tissue distribution in Mus musculus."
    Romeo E., Dave M.H., Bacic D., Ristic Z., Camargo S.M.R., Loffing J., Wagner C.A., Verrey F.
    Am. J. Physiol. 290:F376-F383(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS620A_MOUSE
AccessioniPrimary (citable) accession number: Q8VDB9
Secondary accession number(s): Q3USE2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi