Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

General transcription factor IIH subunit 3

Gene

Gtf2h3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri269 – 28618C4-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-113418. Formation of the Early Elongation Complex.
R-MMU-5696395. Formation of Incision Complex in GG-NER.
R-MMU-5696400. Dual Incision in GG-NER.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-6782135. Dual incision in TC-NER.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-MMU-72086. mRNA Capping.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-73863. RNA Polymerase I Transcription Termination.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-75955. RNA Polymerase II Transcription Elongation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-MMU-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 3
Alternative name(s):
Basic transcription factor 2 34 kDa subunit
Short name:
BTF2 p34
General transcription factor IIH polypeptide 3
TFIIH basal transcription factor complex p34 subunit
Gene namesi
Name:Gtf2h3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1277143. Gtf2h3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309General transcription factor IIH subunit 3PRO_0000119252Add
BLAST

Proteomic databases

EPDiQ8VD76.
MaxQBiQ8VD76.
PaxDbiQ8VD76.
PRIDEiQ8VD76.

PTM databases

iPTMnetiQ8VD76.
PhosphoSiteiQ8VD76.

Expressioni

Gene expression databases

BgeeiQ8VD76.
CleanExiMM_GTF2H3.
ExpressionAtlasiQ8VD76. baseline and differential.
GenevisibleiQ8VD76. MM.

Interactioni

Subunit structurei

One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor (By similarity). Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229071. 2 interactions.
STRINGi10090.ENSMUSP00000031333.

Structurei

3D structure databases

ProteinModelPortaliQ8VD76.
SMRiQ8VD76. Positions 5-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB4 family.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri269 – 28618C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2487. Eukaryota.
COG5242. LUCA.
GeneTreeiENSGT00390000013143.
HOGENOMiHOG000175900.
HOVERGENiHBG054271.
InParanoidiQ8VD76.
KOiK03143.
OMAiMQKAQNK.
OrthoDBiEOG7MKW6M.
PhylomeDBiQ8VD76.
TreeFamiTF314336.

Family and domain databases

InterProiIPR004600. TFIIH_Tfb4/p34.
[Graphical view]
PANTHERiPTHR12831. PTHR12831. 1 hit.
PfamiPF03850. Tfb4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00627. tfb4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VD76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAADEDELNL LVIIVDTNPI WWGKQALKES QFTLSKCMDA VMVLANSHLF
60 70 80 90 100
MNRSNQLAVI ASHIQESRLL YPGKNGGLGD FFGDPGNALP DCNPSGSKDG
110 120 130 140 150
KYELLTVANE VIAEEIKDLM TKSDIKGQHT ETLLAGSLAK ALCYIHRVNK
160 170 180 190 200
AVKDNQEMKS RILVIKAAED SALQYMNFMN VIFAAQKQNI LIDACVLDSD
210 220 230 240 250
SGLLQQACDI TGGLYLKVPQ MPSLLQYLLW VFLPDQDQRS QLILPPPIHV
260 270 280 290 300
DYRAACFCHR SLIEIGYVCS VCLSIFCNFS PICTTCETAF KISLPPVLKA

KKKKQKVSL
Length:309
Mass (Da):34,244
Last modified:March 1, 2002 - v1
Checksum:i39CD6D1B8CD86E2D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017515 mRNA. Translation: AAH17515.1.
CCDSiCCDS19680.1.
RefSeqiNP_852075.1. NM_181410.3.
UniGeneiMm.185467.

Genome annotation databases

EnsembliENSMUST00000031333; ENSMUSP00000031333; ENSMUSG00000029387.
GeneIDi209357.
KEGGimmu:209357.
UCSCiuc012edo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017515 mRNA. Translation: AAH17515.1.
CCDSiCCDS19680.1.
RefSeqiNP_852075.1. NM_181410.3.
UniGeneiMm.185467.

3D structure databases

ProteinModelPortaliQ8VD76.
SMRiQ8VD76. Positions 5-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229071. 2 interactions.
STRINGi10090.ENSMUSP00000031333.

PTM databases

iPTMnetiQ8VD76.
PhosphoSiteiQ8VD76.

Proteomic databases

EPDiQ8VD76.
MaxQBiQ8VD76.
PaxDbiQ8VD76.
PRIDEiQ8VD76.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031333; ENSMUSP00000031333; ENSMUSG00000029387.
GeneIDi209357.
KEGGimmu:209357.
UCSCiuc012edo.1. mouse.

Organism-specific databases

CTDi2967.
MGIiMGI:1277143. Gtf2h3.

Phylogenomic databases

eggNOGiKOG2487. Eukaryota.
COG5242. LUCA.
GeneTreeiENSGT00390000013143.
HOGENOMiHOG000175900.
HOVERGENiHBG054271.
InParanoidiQ8VD76.
KOiK03143.
OMAiMQKAQNK.
OrthoDBiEOG7MKW6M.
PhylomeDBiQ8VD76.
TreeFamiTF314336.

Enzyme and pathway databases

ReactomeiR-MMU-112382. Formation of RNA Pol II elongation complex.
R-MMU-113418. Formation of the Early Elongation Complex.
R-MMU-5696395. Formation of Incision Complex in GG-NER.
R-MMU-5696400. Dual Incision in GG-NER.
R-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6781823. Formation of TC-NER Pre-Incision Complex.
R-MMU-6782135. Dual incision in TC-NER.
R-MMU-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.
R-MMU-72086. mRNA Capping.
R-MMU-73762. RNA Polymerase I Transcription Initiation.
R-MMU-73772. RNA Polymerase I Promoter Escape.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73777. RNA Polymerase I Chain Elongation.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-73863. RNA Polymerase I Transcription Termination.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-75955. RNA Polymerase II Transcription Elongation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.
R-MMU-77075. RNA Pol II CTD phosphorylation and interaction with CE.

Miscellaneous databases

NextBioi372643.
PROiQ8VD76.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VD76.
CleanExiMM_GTF2H3.
ExpressionAtlasiQ8VD76. baseline and differential.
GenevisibleiQ8VD76. MM.

Family and domain databases

InterProiIPR004600. TFIIH_Tfb4/p34.
[Graphical view]
PANTHERiPTHR12831. PTHR12831. 1 hit.
PfamiPF03850. Tfb4. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00627. tfb4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  2. "Stimulation of RAR alpha activation function AF-1 through binding to the general transcription factor TFIIH and phosphorylation by CDK7."
    Rochette-Egly C., Adam S., Rossignol M., Egly J.-M., Chambon P.
    Cell 90:97-107(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RARA.

Entry informationi

Entry nameiTF2H3_MOUSE
AccessioniPrimary (citable) accession number: Q8VD76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: March 1, 2002
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.