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Protein

Dehydrogenase/reductase SDR family member 9

Gene

Dhrs9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83NADBy similarity1
Binding sitei164SubstrateBy similarity1
Active sitei176Proton acceptorBy similarity1
Binding sitei180NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi34 – 58NADBy similarityAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

ReactomeiR-RNO-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 9 (EC:1.1.-.-)
Alternative name(s):
3-alpha hydroxysteroid dehydrogenase
Short name:
3-alpha-HSD
Short-chain dehydrogenase/reductase retSDR8
Gene namesi
Name:Dhrs9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620655. Dhrs9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075220.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004261921 – 319Dehydrogenase/reductase SDR family member 9Add BLAST299

Proteomic databases

PaxDbiQ8VD48.
PRIDEiQ8VD48.

PTM databases

iPTMnetiQ8VD48.
PhosphoSitePlusiQ8VD48.

Expressioni

Tissue specificityi

Highly expressed in epithelium of estrus uterus.1 Publication

Gene expression databases

BgeeiENSRNOG00000006773.
GenevisibleiQ8VD48. RN.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008921.

Chemistry databases

BindingDBiQ8VD48.

Structurei

3D structure databases

ProteinModelPortaliQ8VD48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG005482.
InParanoidiQ8VD48.
KOiK11149.
OMAiFLCAFLW.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ8VD48.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VD48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLWVLALLF LCAFLWNYKG QLKIADIADK YIFITGCDSG FGNLAARTFD
60 70 80 90 100
RKGFRVIAAC LTESGSEALK AKTSERLHTV LLDVTNPENV KETAQWVKSH
110 120 130 140 150
VGEKGLWGLI NNAGVLGVLA PTDWLTVDDY REPIEVNLFG LINVTLNMLP
160 170 180 190 200
LVKKARGRVI NVSSIGGRLA FGGGGYTPSK YAVEGFNDSL RRDMKAFGVH
210 220 230 240 250
VSCIEPGLFK TGLADPIKTT EKKLAIWKHL SPDIKQQYGE GYIEKSLHRL
260 270 280 290 300
KSSTSSVNLD LSLVVECMDH ALTSLFPKTR YTAGKDAKTF WIPLSHMPAA
310
LQDFLLLKEK VELANPQAV
Length:319
Mass (Da):35,214
Last modified:March 1, 2002 - v1
Checksum:i2EA1B82D3F170B9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337953 mRNA. Translation: AAL73225.1.
RefSeqiNP_570832.1. NM_130819.1.
UniGeneiRn.81185.

Genome annotation databases

EnsembliENSRNOT00000080525; ENSRNOP00000069708; ENSRNOG00000058568.
GeneIDi170635.
KEGGirno:170635.
UCSCiRGD:620655. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF337953 mRNA. Translation: AAL73225.1.
RefSeqiNP_570832.1. NM_130819.1.
UniGeneiRn.81185.

3D structure databases

ProteinModelPortaliQ8VD48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000008921.

Chemistry databases

BindingDBiQ8VD48.
ChEMBLiCHEMBL1075220.

PTM databases

iPTMnetiQ8VD48.
PhosphoSitePlusiQ8VD48.

Proteomic databases

PaxDbiQ8VD48.
PRIDEiQ8VD48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000080525; ENSRNOP00000069708; ENSRNOG00000058568.
GeneIDi170635.
KEGGirno:170635.
UCSCiRGD:620655. rat.

Organism-specific databases

CTDi10170.
RGDi620655. Dhrs9.

Phylogenomic databases

eggNOGiKOG1610. Eukaryota.
ENOG410Y7FK. LUCA.
GeneTreeiENSGT00860000133667.
HOVERGENiHBG005482.
InParanoidiQ8VD48.
KOiK11149.
OMAiFLCAFLW.
OrthoDBiEOG091G0LMI.
PhylomeDBiQ8VD48.

Enzyme and pathway databases

ReactomeiR-RNO-5365859. RA biosynthesis pathway.

Miscellaneous databases

PROiQ8VD48.

Gene expression databases

BgeeiENSRNOG00000006773.
GenevisibleiQ8VD48. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHRS9_RAT
AccessioniPrimary (citable) accession number: Q8VD48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.