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Protein

UDP-glucuronosyltransferase

Gene

Ugt1a5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotation, Transferase

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronosyltransferaseUniRule annotation (EC:2.4.1.17UniRule annotation)
Gene namesi
Name:Ugt1a5Imported
Synonyms:Ugt1a1Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1583689. Ugt1a5.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei481 – 50525HelicalUniRule annotationAdd
BLAST

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525UniRule annotationAdd
BLAST
Chaini26 – 531506UDP-glucuronosyltransferaseUniRule annotationPRO_5001420483Add
BLAST

Proteomic databases

PRIDEiQ8VD45.

Structurei

3D structure databases

ProteinModelPortaliQ8VD45.
SMRiQ8VD45. Positions 282-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

HOVERGENiHBG004033.
PhylomeDBiQ8VD45.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VD45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLHVTLQGL AGLLLLLYAL PWAEGGKVLV FPMEGSHWLS MRDVVRELHA
60 70 80 90 100
RGHQAVVLAP EVTVHIKEED FFTLQTYPVP YTRQGFRQQM MRNIKVVFET
110 120 130 140 150
GNYVKTFFET SEILKNISTV LLRSCMNLLH NGSLLQHLNS SSFDMVLTDP
160 170 180 190 200
VIPCGQVLAK YLGIPTVFFL RYIPCGIDSE ATQCPKPSSY IPNLLTMLSD
210 220 230 240 250
HMTFLQRVKN MLYPLALKYI CHFSFTRYES LASELLQREV SLVEVLSHAS
260 270 280 290 300
VWLFRGDFVF DYPRPVMPNM VFIGGINCVI KKPLSQEFEA YVNASGEHGI
310 320 330 340 350
VVFSLGSMVS EIPEKKAMEI AEALGRIPQT VLWRYTGTRP SNLAKNTILV
360 370 380 390 400
KWLPQNDLLG HPKARAFITH SGSHGIYEGI CNGVPMVMMP LFGDQMDNAK
410 420 430 440 450
RMETRGAGVT LNVLEMTADD LENALKTVIN NKSYKENIMR LSSLHKDRPI
460 470 480 490 500
EPLDLAVFWV EYVMRHKGAP HLRPAAHDLT WYQYHSLDVI GFLLAIVLTV
510 520 530
VFIVYKSCAY GCRKCFGGKG RVKKSHKSKT H
Length:531
Mass (Da):60,013
Last modified:March 1, 2002 - v1
Checksum:iA18E5C6AEB5B07FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461734 mRNA. Translation: AAL67850.1.
UniGeneiRn.26489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF461734 mRNA. Translation: AAL67850.1.
UniGeneiRn.26489.

3D structure databases

ProteinModelPortaliQ8VD45.
SMRiQ8VD45. Positions 282-442.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT1. Glycosyltransferase Family 1.

Proteomic databases

PRIDEiQ8VD45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi1583689. Ugt1a5.

Phylogenomic databases

HOVERGENiHBG004033.
PhylomeDBiQ8VD45.

Family and domain databases

InterProiIPR002213. UDP_glucos_trans.
[Graphical view]
PANTHERiPTHR11926. PTHR11926. 1 hit.
PfamiPF00201. UDPGT. 1 hit.
[Graphical view]
PROSITEiPS00375. UDPGT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Glucuronidation of acetaminophen catalyzed by multiple rat phenol UDP-glucuronosyltransferases."
    Kessler F.K., Kessler M.R., Auyeung D.J., Ritter J.K.
    Drug Metab. Dispos. 30:324-330(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.
    Tissue: Oltipraz-pretreated liverImported.

Entry informationi

Entry nameiQ8VD45_RAT
AccessioniPrimary (citable) accession number: Q8VD45
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.