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Protein
Submitted name:

Transient receptor potential cation channel subfamily C member 5

Gene

Trpc5

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: RGD
  • actinin binding Source: RGD
  • ATPase binding Source: RGD
  • calcium channel activity Source: InterPro
  • clathrin binding Source: RGD

GO - Biological processi

  • negative regulation of dendrite morphogenesis Source: RGD
  • neuron differentiation Source: RGD
  • positive regulation of axon extension Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of neuron differentiation Source: RGD
  • positive regulation of peptidyl-threonine phosphorylation Source: RGD
  • regulation of membrane hyperpolarization Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel subfamily C member 5Imported
Submitted name:
Transient receptor potential cation channel, subfamily C, member 5Imported
Submitted name:
Transient receptor potential protein 5Imported
Gene namesi
Name:Trpc5Imported
ORF Names:rCG_23135Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi619787. Trpc5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei327 – 351HelicalSequence analysisAdd BLAST25
Transmembranei363 – 382HelicalSequence analysisAdd BLAST20
Transmembranei402 – 419HelicalSequence analysisAdd BLAST18
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Transmembranei480 – 499HelicalSequence analysisAdd BLAST20
Transmembranei520 – 542HelicalSequence analysisAdd BLAST23
Transmembranei599 – 621HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • growth cone Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: RGD
  • neuronal cell body Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSRNOG00000027233.

Interactioni

GO - Molecular functioni

  • actin binding Source: RGD
  • actinin binding Source: RGD
  • ATPase binding Source: RGD
  • clathrin binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009400.

Structurei

3D structure databases

ProteinModelPortaliQ8VD38.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 118ANK_REP_REGIONInterPro annotationAdd BLAST81
Domaini176 – 238TRP_2InterPro annotationAdd BLAST63
Domaini376 – 635Ion_transInterPro annotationAdd BLAST260

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation

Keywords - Domaini

ANK repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
KOiK04968.
PhylomeDBiQ8VD38.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VD38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQLYYKKVN YSPYRDRIPL QIVRAETELS AEEKAFLSAV EKGDYATVKQ
60 70 80 90 100
ALQEAEIYYN VNINCMDPLG RSALLIAIEN ENLEIMELLL NHSVYVGDAL
110 120 130 140 150
LYAIRKEVVG AVELLLSYRK PSGEKQVPTL MMDTQFSEFT PDITPIMLAA
160 170 180 190 200
HTNNYEIIKL LVQKRVTIPR PHQIRCNCVE CVSSSEVDSL RHSRSRLNIY
210 220 230 240 250
KALASPSLIA LSSEDPILTA FRLGWELKEL SKVENEFKAE YEELSQQCKL
260 270 280 290 300
FAKDLLDQAR SSRELEIILN HRDDHSEELD PQKYHDLAKL KVAIKYHQKE
310 320 330 340 350
FVAQPNCQQL LATLWYDGFP GWRRKHWVVK LLTCMTIGFL FPMLSIAYLI
360 370 380 390 400
SPRSNLGLFI KKPFIKFICH TASYLTFLFM LLLASQHIVR TDLHVQGPPP
410 420 430 440 450
TVVEWMILPW VLGFIWGEIK EMWDGGFTEY IHDWWNLMDF AMNSLYLATI
460 470 480 490 500
SLKIVAYVKY NGSRPREEWE MWHPTLIAEA LFAISNILSS LRLISLFTAN
510 520 530 540 550
SHLGPLQISL GRMLLDILKF LFIYCLVLLA FANGLNQLYF YYETRAIDEP
560 570 580 590 600
NNCKGIRCEK QNNAFSTLFE TLQSLFWSVF GLLNLYVTNV KARHEFTEFV
610 620 630 640 650
GATMFGTYNV ISLVVLLNML IAMMNNSYQL IADHADIEWK FARTKLWMSY
660 670 680 690 700
FDEGGTLPPP FNIIPSPKSF LYLGNWFNNT FCPKRDPDGR RRRHNLRSFT
710 720 730 740 750
ERHADSLIQN QHYQEVIRNL VKRYVAAMIR NSKTNEGLTE ENFKELKQDI
760 770 780 790 800
SSFRYEVLDL LGNRKHPRRS FSTSSAEFSQ RDDTNDGSGG ARAKSKSVSF
810 820 830 840 850
NLGCKKKACQ GAPLIRTMPR ASGAQGKPKA ESSGKRSFMG PSFKKLGLLF
860 870 880 890 900
SKFNGQTSEP TSEPMYTISD GIAQQHSMWQ DIRYSQMEKG KAEACSQSEM
910 920 930 940 950
NLSEVELGEI RGAARSSECP LACSSSLHCA SGICSSNSKL LDSSEDVFET
960 970
WGEACDLLMH KWGDGQEEQV TTRL
Length:974
Mass (Da):111,407
Last modified:March 1, 2002 - v1
Checksum:iBC9B37241E6A8E53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY064411 mRNA. Translation: AAL40872.1.
EF672039 mRNA. Translation: ABS00942.1.
CH474047 Genomic DNA. Translation: EDL85183.1.
RefSeqiNP_543174.1. NM_080898.2.
UniGeneiRn.212751.

Genome annotation databases

GeneIDi140933.
KEGGirno:140933.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY064411 mRNA. Translation: AAL40872.1.
EF672039 mRNA. Translation: ABS00942.1.
CH474047 Genomic DNA. Translation: EDL85183.1.
RefSeqiNP_543174.1. NM_080898.2.
UniGeneiRn.212751.

3D structure databases

ProteinModelPortaliQ8VD38.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009400.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi140933.
KEGGirno:140933.

Organism-specific databases

CTDi7224.
RGDi619787. Trpc5.

Phylogenomic databases

eggNOGiKOG3609. Eukaryota.
ENOG410XQ0Y. LUCA.
HOGENOMiHOG000020589.
HOVERGENiHBG068337.
KOiK04968.
PhylomeDBiQ8VD38.

Gene expression databases

BgeeiENSRNOG00000027233.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR013555. TRP_dom.
IPR005461. TRPC5_channel.
IPR002153. TRPC_channel.
[Graphical view]
PANTHERiPTHR10117. PTHR10117. 1 hit.
PTHR10117:SF24. PTHR10117:SF24. 1 hit.
PfamiPF12796. Ank_2. 1 hit.
PF00520. Ion_trans. 1 hit.
PF08344. TRP_2. 1 hit.
[Graphical view]
PRINTSiPR01097. TRNSRECEPTRP.
PR01646. TRPCHANNEL5.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8VD38_RAT
AccessioniPrimary (citable) accession number: Q8VD38
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.