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Protein
Submitted name:

Homeobox protein OTX2

Gene

Otx2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein OTX2Imported
Submitted name:
Orthodenticle homolog 2 (Drosophila), isoform CRA_aImported
Submitted name:
Otx2 proteinImported
Gene namesi
Name:Otx2Imported
ORF Names:mCG_12117Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:97451. Otx2.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000021848.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113690.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMSNMR-A39-105[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 9661Homeobox DNA-bindingInterPro annotationAdd
BLAST

Keywords - Domaini

HomeoboxUniRule annotation

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00820000126963.
HOVERGENiHBG004028.
KOiK18490.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VD35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSYLKQPPY AVNGLSLTTS GMDLLHPSVG YPATPRKQRR ERTTFTRAQL
60 70 80 90 100
DVLEALFAKT RYPDIFMREE VALKINLPES RVQVWFKNRR AKCRQQQQQQ
110 120 130 140 150
QNGGQNKVRP AKKKSSPARE VSSESGTSGQ FSPPSSTSVP TIASSSAPVS
160 170 180 190 200
IWSPASISPL SDPLSTSSSC MQRSYPMTYT QASGYSQGYA GSTSYFGGMD
210 220 230 240 250
CGSYLTPMHH QLPGPGATLS PMGTNAVTSH LNQSPASLST QGYGASSLGF
260 270 280
NSTTDCLDYK DQTASWKLNF NADCLDYKDQ TSSWKFQVL
Length:289
Mass (Da):31,608
Last modified:March 1, 2002 - v1
Checksum:iEEAF2A5FA9781CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166574 Genomic DNA. No translation available.
BC017609 mRNA. Translation: AAH17609.1.
AK053741 mRNA. Translation: BAC35500.1.
AK081535 mRNA. Translation: BAC38249.1.
AK087527 mRNA. Translation: BAC39913.1.
CH466605 Genomic DNA. Translation: EDL20772.1.
CH466605 Genomic DNA. Translation: EDL20774.1.
RefSeqiNP_001273410.1. NM_001286481.1.
NP_001273411.1. NM_001286482.1.
NP_001273412.1. NM_001286483.1.
NP_659090.1. NM_144841.4.
XP_011243291.1. XM_011244989.1.
UniGeneiMm.134516.
Mm.487292.

Genome annotation databases

EnsembliENSMUST00000118578; ENSMUSP00000113690; ENSMUSG00000021848.
ENSMUST00000122009; ENSMUSP00000113930; ENSMUSG00000021848.
GeneIDi18424.
KEGGimmu:18424.
UCSCiuc007tjq.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC166574 Genomic DNA. No translation available.
BC017609 mRNA. Translation: AAH17609.1.
AK053741 mRNA. Translation: BAC35500.1.
AK081535 mRNA. Translation: BAC38249.1.
AK087527 mRNA. Translation: BAC39913.1.
CH466605 Genomic DNA. Translation: EDL20772.1.
CH466605 Genomic DNA. Translation: EDL20774.1.
RefSeqiNP_001273410.1. NM_001286481.1.
NP_001273411.1. NM_001286482.1.
NP_001273412.1. NM_001286483.1.
NP_659090.1. NM_144841.4.
XP_011243291.1. XM_011244989.1.
UniGeneiMm.134516.
Mm.487292.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DMSNMR-A39-105[»]
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000113690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118578; ENSMUSP00000113690; ENSMUSG00000021848.
ENSMUST00000122009; ENSMUSP00000113930; ENSMUSG00000021848.
GeneIDi18424.
KEGGimmu:18424.
UCSCiuc007tjq.3. mouse.

Organism-specific databases

CTDi5015.
MGIiMGI:97451. Otx2.

Phylogenomic databases

eggNOGiKOG2251. Eukaryota.
ENOG4111XIJ. LUCA.
GeneTreeiENSGT00820000126963.
HOVERGENiHBG004028.
KOiK18490.

Miscellaneous databases

ChiTaRSiOtx2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021848.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR003022. Otx2_TF.
IPR003025. Otx_TF.
IPR013851. Otx_TF_C.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF03529. TF_Otx. 1 hit.
[Graphical view]
PRINTSiPR01257. OTX2HOMEOBOX.
PR01255. OTXHOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ8VD35_MOUSE
AccessioniPrimary (citable) accession number: Q8VD35
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.