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Q8VD07

- Q8VD07_MOUSE

UniProt

Q8VD07 - Q8VD07_MOUSE

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Protein
Submitted name:

Egf protein

Gene

Egf

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. epidermal growth factor receptor binding Source: MGI

GO - Biological processi

  1. activation of MAPKK activity Source: MGI
  2. branching morphogenesis of an epithelial tube Source: MGI
  3. epidermal growth factor receptor signaling pathway Source: MGI
  4. mammary gland alveolus development Source: MGI
  5. peptidyl-tyrosine phosphorylation Source: MGI
  6. positive regulation of cell proliferation Source: MGI
  7. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
  8. regulation of peptidyl-tyrosine phosphorylation Source: MGI
  9. regulation of protein transport Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Egf proteinImported
Gene namesi
Name:EgfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95290. Egf.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ8VD07.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029653.

Structurei

3D structure databases

ProteinModelPortaliQ8VD07.
SMRiQ8VD07. Positions 960-1012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG003858.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
2.40.155.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR016317. Pro-epidermal_GF.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00058. Ldl_recept_b. 3 hits.
[Graphical view]
PIRSFiPIRSF001778. Pro-epidermal_growth_factor. 1 hit.
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00135. LY. 9 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS51120. LDLRB. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VD07-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPWGRRPTWL LLAFLLVFLK ISILSERSGT CAGPAPFLVF SQGKSISRID
60 70 80 90 100
PDGTNHQQLV VDAGISADMD IHYKKERLYW VDVERQVLLR VFLNGTGLEK
110 120 130 140 150
VCNVERKVSG LAIDWIDDEV LWVDQQNGVI TVTDMTGKNS RVLLSSLKHP
160 170 180 190 200
SNIAVDPIER LMFWSSEVTG SLHRAHLKGV DVKTLLETGG ISVLTLDVLD
210 220 230 240 250
KRLFWVQDSG EGSHAYIHSC DYEGGSVRLI RHQARHSLSS MAFFGDRIFY
260 270 280 290 300
SVLKSKAIWI ANKHTGKDTV RINLHPSFVT PGKLMVVHPR AQPRTEDAAK
310 320 330 340 350
DPDPELLKQR GRPCRFGLCE RDPKSHSSAC AEGYTLSRDR KYCEDVNECA
360 370 380 390 400
TQNHGCTLGC ENTPGSYHCT CPTGFVLLPD GKQCHELVSC PGNVSKCSHG
410 420 430 440 450
CVLTSDGPRC ICPAGSVLGR DGKTCTGCSS PDNGGCSQIC LPLRPGSWEC
460 470 480 490 500
DCFPGYDLQS DRKSCAASGP QPLLLFANSQ DIRHMHFDGT DYKVLLSRQM
510 520 530 540 550
GMVFALDYDP VESKIYFAQT ALKWIERANM DGSQRERLIT EGVDTLEGLA
560 570 580 590 600
LDWIGRRIYW TDSGKSVVGG SDLSGKHHRI IIQERISRPR GIAVHPRARR
610 620 630 640 650
LFWTDVGMSP RIESASLQGS DRVLIASSNL LEPSGITIDY LTDTLYWCDT
660 670 680 690 700
KRSVIEMANL DGSKRRRLIQ NDVGHPFSLA VFEDHLWVSD WAIPSVIRVN
710 720 730 740 750
KRTGQNRVRL QGSMLKPSSL VVVHPLAKPG ADPCLYRNGG CEHICQESLG
760 770 780 790 800
TARCLCREGF VKAWDGKMCL PQDYPILSGE NADLSKEVTS LSNSTQAEVP
810 820 830 840 850
DDDGTESSTL VAEIMVSGMN YEDDCGPGGC GSHARCVSDG ETAECQCLKG
860 870 880 890 900
FARDGNLCSD IDECVLARSD CPSTSSRCIN TEGGYVCRCS EGYEGDGISC
910 920 930 940 950
FDIDECQRGA HNCAENAACT NTEGGYNCTC AGRPSSPGRS CPDSTAPSLL
960 970 980 990 1000
GEDGHHLDRN SYPGCPSSYD GYCLNGGVCM HIESLDSYTC NCVIGYSGDR
1010 1020 1030 1040 1050
CQTRDLRWWE LRHAGYGQKH DIMVVAVCMV ALVLLLLLGM WGTYYYRTRK
1060 1070 1080 1090 1100
QLSNPPKNPC DEPSGSVSSS GPDSSSGAAV ASCPQPWFVV LEKHQDPKNG
1110 1120 1130 1140 1150
SLPADGTNGA VVDAGLSPSL QLGSVHLTSW RQKPHIDGMG TGQSCWIPPS
1160 1170 1180 1190 1200
SDRGPQEIEG NSHLPSYRPV GPEKLHSLQS ANGSCHERAP DLPRQTEPVQ
Length:1,200
Mass (Da):131,318
Last modified:March 1, 2002 - v1
Checksum:iB6A44F7294746476
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC017681 mRNA. Translation: AAH17681.1.
UniGeneiMm.252481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC017681 mRNA. Translation: AAH17681.1 .
UniGenei Mm.252481.

3D structure databases

ProteinModelPortali Q8VD07.
SMRi Q8VD07. Positions 960-1012.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029653.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:95290. Egf.

Phylogenomic databases

HOVERGENi HBG003858.

Miscellaneous databases

ChiTaRSi EGF. mouse.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8VD07.

Family and domain databases

Gene3Di 2.120.10.30. 2 hits.
2.40.155.10. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR016317. Pro-epidermal_GF.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00058. Ldl_recept_b. 3 hits.
[Graphical view ]
PIRSFi PIRSF001778. Pro-epidermal_growth_factor. 1 hit.
SMARTi SM00181. EGF. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00135. LY. 9 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 3 hits.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS51120. LDLRB. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ8VD07_MOUSE
AccessioniPrimary (citable) accession number: Q8VD07
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)