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Q8VD07 (Q8VD07_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Egf MGI 95290
OrganismMus musculus (Mouse) EMBL AAH17681.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1200 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Cellular componentMembrane
   DomainEGF-like domain RuleBase RU000459 SAAS SAAS011042
Repeat SAAS SAAS011042
Transmembrane
Transmembrane helix SAAS SAAS000033
   PTMDisulfide bond SAAS SAAS011042
Gene Ontology (GO)
   Biological_processactivation of MAPKK activity

Inferred from direct assay PubMed 16339969. Source: MGI

branching morphogenesis of an epithelial tube

Inferred from direct assay PubMed 15831470. Source: MGI

epidermal growth factor receptor signaling pathway

Inferred from direct assay PubMed 15695332PubMed 6315706. Source: MGI

mammary gland alveolus development

Inferred from genetic interaction PubMed 10331984. Source: MGI

peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 14561752. Source: MGI

positive regulation of cell proliferation

Inferred from direct assay PubMed 14712229PubMed 15695332. Source: MGI

positive regulation of cerebellar granule cell precursor proliferation

Inferred from direct assay PubMed 10027293. Source: MGI

regulation of peptidyl-tyrosine phosphorylation

Inferred from direct assay PubMed 11940581. Source: MGI

regulation of protein transport

Inferred from sequence orthology PubMed 19723622. Source: MGI

   Cellular_componentextracellular space

Inferred from direct assay PubMed 7641815PubMed 8240367. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

epidermal growth factor receptor binding

Inferred from direct assay PubMed 6315706. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8VD07 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: B6A44F7294746476

FASTA1,200131,318
        10         20         30         40         50         60 
MPWGRRPTWL LLAFLLVFLK ISILSERSGT CAGPAPFLVF SQGKSISRID PDGTNHQQLV 

        70         80         90        100        110        120 
VDAGISADMD IHYKKERLYW VDVERQVLLR VFLNGTGLEK VCNVERKVSG LAIDWIDDEV 

       130        140        150        160        170        180 
LWVDQQNGVI TVTDMTGKNS RVLLSSLKHP SNIAVDPIER LMFWSSEVTG SLHRAHLKGV 

       190        200        210        220        230        240 
DVKTLLETGG ISVLTLDVLD KRLFWVQDSG EGSHAYIHSC DYEGGSVRLI RHQARHSLSS 

       250        260        270        280        290        300 
MAFFGDRIFY SVLKSKAIWI ANKHTGKDTV RINLHPSFVT PGKLMVVHPR AQPRTEDAAK 

       310        320        330        340        350        360 
DPDPELLKQR GRPCRFGLCE RDPKSHSSAC AEGYTLSRDR KYCEDVNECA TQNHGCTLGC 

       370        380        390        400        410        420 
ENTPGSYHCT CPTGFVLLPD GKQCHELVSC PGNVSKCSHG CVLTSDGPRC ICPAGSVLGR 

       430        440        450        460        470        480 
DGKTCTGCSS PDNGGCSQIC LPLRPGSWEC DCFPGYDLQS DRKSCAASGP QPLLLFANSQ 

       490        500        510        520        530        540 
DIRHMHFDGT DYKVLLSRQM GMVFALDYDP VESKIYFAQT ALKWIERANM DGSQRERLIT 

       550        560        570        580        590        600 
EGVDTLEGLA LDWIGRRIYW TDSGKSVVGG SDLSGKHHRI IIQERISRPR GIAVHPRARR 

       610        620        630        640        650        660 
LFWTDVGMSP RIESASLQGS DRVLIASSNL LEPSGITIDY LTDTLYWCDT KRSVIEMANL 

       670        680        690        700        710        720 
DGSKRRRLIQ NDVGHPFSLA VFEDHLWVSD WAIPSVIRVN KRTGQNRVRL QGSMLKPSSL 

       730        740        750        760        770        780 
VVVHPLAKPG ADPCLYRNGG CEHICQESLG TARCLCREGF VKAWDGKMCL PQDYPILSGE 

       790        800        810        820        830        840 
NADLSKEVTS LSNSTQAEVP DDDGTESSTL VAEIMVSGMN YEDDCGPGGC GSHARCVSDG 

       850        860        870        880        890        900 
ETAECQCLKG FARDGNLCSD IDECVLARSD CPSTSSRCIN TEGGYVCRCS EGYEGDGISC 

       910        920        930        940        950        960 
FDIDECQRGA HNCAENAACT NTEGGYNCTC AGRPSSPGRS CPDSTAPSLL GEDGHHLDRN 

       970        980        990       1000       1010       1020 
SYPGCPSSYD GYCLNGGVCM HIESLDSYTC NCVIGYSGDR CQTRDLRWWE LRHAGYGQKH 

      1030       1040       1050       1060       1070       1080 
DIMVVAVCMV ALVLLLLLGM WGTYYYRTRK QLSNPPKNPC DEPSGSVSSS GPDSSSGAAV 

      1090       1100       1110       1120       1130       1140 
ASCPQPWFVV LEKHQDPKNG SLPADGTNGA VVDAGLSPSL QLGSVHLTSW RQKPHIDGMG 

      1150       1160       1170       1180       1190       1200 
TGQSCWIPPS SDRGPQEIEG NSHLPSYRPV GPEKLHSLQS ANGSCHERAP DLPRQTEPVQ 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH17681.1.
Tissue: Kidney EMBL AAH17681.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC017681 mRNA. Translation: AAH17681.1.
UniGeneMm.252481.

3D structure databases

ProteinModelPortalQ8VD07.
SMRQ8VD07. Positions 960-1012.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029653.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:95290. Egf.

Phylogenomic databases

HOVERGENHBG003858.
InParanoidQ8VD07.

Gene expression databases

GenevestigatorQ8VD07.

Family and domain databases

Gene3D2.120.10.30. 2 hits.
2.40.155.10. 1 hit.
InterProIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR016317. Pro-epidermal_GF.
[Graphical view]
PfamPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00058. Ldl_recept_b. 3 hits.
[Graphical view]
PIRSFPIRSF001778. Pro-epidermal_growth_factor. 1 hit.
SMARTSM00181. EGF. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00135. LY. 9 hits.
[Graphical view]
SUPFAMSSF57184. SSF57184. 3 hits.
PROSITEPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS51120. LDLRB. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSEGF. mouse.
SOURCESearch...

Entry information

Entry nameQ8VD07_MOUSE
AccessionPrimary (citable) accession number: Q8VD07
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)