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Q8VD07

- Q8VD07_MOUSE

UniProt

Q8VD07 - Q8VD07_MOUSE

Protein
Submitted name:

Egf protein

Gene

Egf

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. epidermal growth factor receptor binding Source: MGI

    GO - Biological processi

    1. activation of MAPKK activity Source: MGI
    2. branching morphogenesis of an epithelial tube Source: MGI
    3. epidermal growth factor receptor signaling pathway Source: MGI
    4. mammary gland alveolus development Source: MGI
    5. peptidyl-tyrosine phosphorylation Source: MGI
    6. positive regulation of cell proliferation Source: MGI
    7. positive regulation of cerebellar granule cell precursor proliferation Source: MGI
    8. regulation of peptidyl-tyrosine phosphorylation Source: MGI
    9. regulation of protein transport Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Egf proteinImported
    Gene namesi
    Name:EgfImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95290. Egf.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Expressioni

    Gene expression databases

    GenevestigatoriQ8VD07.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029653.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VD07.
    SMRiQ8VD07. Positions 960-1012.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG003858.
    InParanoidiQ8VD07.

    Family and domain databases

    Gene3Di2.120.10.30. 2 hits.
    2.40.155.10. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR023413. GFP_like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000033. LDLR_classB_rpt.
    IPR016317. Pro-epidermal_GF.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF00058. Ldl_recept_b. 3 hits.
    [Graphical view]
    PIRSFiPIRSF001778. Pro-epidermal_growth_factor. 1 hit.
    SMARTiSM00181. EGF. 5 hits.
    SM00179. EGF_CA. 2 hits.
    SM00135. LY. 9 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 3 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 6 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS51120. LDLRB. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VD07-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPWGRRPTWL LLAFLLVFLK ISILSERSGT CAGPAPFLVF SQGKSISRID     50
    PDGTNHQQLV VDAGISADMD IHYKKERLYW VDVERQVLLR VFLNGTGLEK 100
    VCNVERKVSG LAIDWIDDEV LWVDQQNGVI TVTDMTGKNS RVLLSSLKHP 150
    SNIAVDPIER LMFWSSEVTG SLHRAHLKGV DVKTLLETGG ISVLTLDVLD 200
    KRLFWVQDSG EGSHAYIHSC DYEGGSVRLI RHQARHSLSS MAFFGDRIFY 250
    SVLKSKAIWI ANKHTGKDTV RINLHPSFVT PGKLMVVHPR AQPRTEDAAK 300
    DPDPELLKQR GRPCRFGLCE RDPKSHSSAC AEGYTLSRDR KYCEDVNECA 350
    TQNHGCTLGC ENTPGSYHCT CPTGFVLLPD GKQCHELVSC PGNVSKCSHG 400
    CVLTSDGPRC ICPAGSVLGR DGKTCTGCSS PDNGGCSQIC LPLRPGSWEC 450
    DCFPGYDLQS DRKSCAASGP QPLLLFANSQ DIRHMHFDGT DYKVLLSRQM 500
    GMVFALDYDP VESKIYFAQT ALKWIERANM DGSQRERLIT EGVDTLEGLA 550
    LDWIGRRIYW TDSGKSVVGG SDLSGKHHRI IIQERISRPR GIAVHPRARR 600
    LFWTDVGMSP RIESASLQGS DRVLIASSNL LEPSGITIDY LTDTLYWCDT 650
    KRSVIEMANL DGSKRRRLIQ NDVGHPFSLA VFEDHLWVSD WAIPSVIRVN 700
    KRTGQNRVRL QGSMLKPSSL VVVHPLAKPG ADPCLYRNGG CEHICQESLG 750
    TARCLCREGF VKAWDGKMCL PQDYPILSGE NADLSKEVTS LSNSTQAEVP 800
    DDDGTESSTL VAEIMVSGMN YEDDCGPGGC GSHARCVSDG ETAECQCLKG 850
    FARDGNLCSD IDECVLARSD CPSTSSRCIN TEGGYVCRCS EGYEGDGISC 900
    FDIDECQRGA HNCAENAACT NTEGGYNCTC AGRPSSPGRS CPDSTAPSLL 950
    GEDGHHLDRN SYPGCPSSYD GYCLNGGVCM HIESLDSYTC NCVIGYSGDR 1000
    CQTRDLRWWE LRHAGYGQKH DIMVVAVCMV ALVLLLLLGM WGTYYYRTRK 1050
    QLSNPPKNPC DEPSGSVSSS GPDSSSGAAV ASCPQPWFVV LEKHQDPKNG 1100
    SLPADGTNGA VVDAGLSPSL QLGSVHLTSW RQKPHIDGMG TGQSCWIPPS 1150
    SDRGPQEIEG NSHLPSYRPV GPEKLHSLQS ANGSCHERAP DLPRQTEPVQ 1200
    Length:1,200
    Mass (Da):131,318
    Last modified:March 1, 2002 - v1
    Checksum:iB6A44F7294746476
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC017681 mRNA. Translation: AAH17681.1.
    UniGeneiMm.252481.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC017681 mRNA. Translation: AAH17681.1 .
    UniGenei Mm.252481.

    3D structure databases

    ProteinModelPortali Q8VD07.
    SMRi Q8VD07. Positions 960-1012.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029653.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:95290. Egf.

    Phylogenomic databases

    HOVERGENi HBG003858.
    InParanoidi Q8VD07.

    Miscellaneous databases

    ChiTaRSi EGF. mouse.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8VD07.

    Family and domain databases

    Gene3Di 2.120.10.30. 2 hits.
    2.40.155.10. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR023413. GFP_like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000033. LDLR_classB_rpt.
    IPR016317. Pro-epidermal_GF.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF07645. EGF_CA. 2 hits.
    PF00058. Ldl_recept_b. 3 hits.
    [Graphical view ]
    PIRSFi PIRSF001778. Pro-epidermal_growth_factor. 1 hit.
    SMARTi SM00181. EGF. 5 hits.
    SM00179. EGF_CA. 2 hits.
    SM00135. LY. 9 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 3 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 6 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS51120. LDLRB. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: KidneyImported.

    Entry informationi

    Entry nameiQ8VD07_MOUSE
    AccessioniPrimary (citable) accession number: Q8VD07
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)