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Protein
Submitted name:

Egf protein

Gene

Egf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Egf proteinImported
Gene namesi
Name:EgfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95290. Egf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029653.

Structurei

3D structure databases

ProteinModelPortaliQ8VD07.
SMRiQ8VD07. Positions 960-1012.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG003858.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
2.40.155.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR016317. Pro-epidermal_GF.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00058. Ldl_recept_b. 3 hits.
[Graphical view]
PIRSFiPIRSF001778. Pro-epidermal_growth_factor. 1 hit.
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00135. LY. 9 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS51120. LDLRB. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VD07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWGRRPTWL LLAFLLVFLK ISILSERSGT CAGPAPFLVF SQGKSISRID
60 70 80 90 100
PDGTNHQQLV VDAGISADMD IHYKKERLYW VDVERQVLLR VFLNGTGLEK
110 120 130 140 150
VCNVERKVSG LAIDWIDDEV LWVDQQNGVI TVTDMTGKNS RVLLSSLKHP
160 170 180 190 200
SNIAVDPIER LMFWSSEVTG SLHRAHLKGV DVKTLLETGG ISVLTLDVLD
210 220 230 240 250
KRLFWVQDSG EGSHAYIHSC DYEGGSVRLI RHQARHSLSS MAFFGDRIFY
260 270 280 290 300
SVLKSKAIWI ANKHTGKDTV RINLHPSFVT PGKLMVVHPR AQPRTEDAAK
310 320 330 340 350
DPDPELLKQR GRPCRFGLCE RDPKSHSSAC AEGYTLSRDR KYCEDVNECA
360 370 380 390 400
TQNHGCTLGC ENTPGSYHCT CPTGFVLLPD GKQCHELVSC PGNVSKCSHG
410 420 430 440 450
CVLTSDGPRC ICPAGSVLGR DGKTCTGCSS PDNGGCSQIC LPLRPGSWEC
460 470 480 490 500
DCFPGYDLQS DRKSCAASGP QPLLLFANSQ DIRHMHFDGT DYKVLLSRQM
510 520 530 540 550
GMVFALDYDP VESKIYFAQT ALKWIERANM DGSQRERLIT EGVDTLEGLA
560 570 580 590 600
LDWIGRRIYW TDSGKSVVGG SDLSGKHHRI IIQERISRPR GIAVHPRARR
610 620 630 640 650
LFWTDVGMSP RIESASLQGS DRVLIASSNL LEPSGITIDY LTDTLYWCDT
660 670 680 690 700
KRSVIEMANL DGSKRRRLIQ NDVGHPFSLA VFEDHLWVSD WAIPSVIRVN
710 720 730 740 750
KRTGQNRVRL QGSMLKPSSL VVVHPLAKPG ADPCLYRNGG CEHICQESLG
760 770 780 790 800
TARCLCREGF VKAWDGKMCL PQDYPILSGE NADLSKEVTS LSNSTQAEVP
810 820 830 840 850
DDDGTESSTL VAEIMVSGMN YEDDCGPGGC GSHARCVSDG ETAECQCLKG
860 870 880 890 900
FARDGNLCSD IDECVLARSD CPSTSSRCIN TEGGYVCRCS EGYEGDGISC
910 920 930 940 950
FDIDECQRGA HNCAENAACT NTEGGYNCTC AGRPSSPGRS CPDSTAPSLL
960 970 980 990 1000
GEDGHHLDRN SYPGCPSSYD GYCLNGGVCM HIESLDSYTC NCVIGYSGDR
1010 1020 1030 1040 1050
CQTRDLRWWE LRHAGYGQKH DIMVVAVCMV ALVLLLLLGM WGTYYYRTRK
1060 1070 1080 1090 1100
QLSNPPKNPC DEPSGSVSSS GPDSSSGAAV ASCPQPWFVV LEKHQDPKNG
1110 1120 1130 1140 1150
SLPADGTNGA VVDAGLSPSL QLGSVHLTSW RQKPHIDGMG TGQSCWIPPS
1160 1170 1180 1190 1200
SDRGPQEIEG NSHLPSYRPV GPEKLHSLQS ANGSCHERAP DLPRQTEPVQ
Length:1,200
Mass (Da):131,318
Last modified:March 1, 2002 - v1
Checksum:iB6A44F7294746476
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017681 mRNA. Translation: AAH17681.1.
UniGeneiMm.252481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017681 mRNA. Translation: AAH17681.1.
UniGeneiMm.252481.

3D structure databases

ProteinModelPortaliQ8VD07.
SMRiQ8VD07. Positions 960-1012.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029653.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:95290. Egf.

Phylogenomic databases

HOVERGENiHBG003858.

Miscellaneous databases

ChiTaRSiEgf. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
2.40.155.10. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR023413. GFP_like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000033. LDLR_classB_rpt.
IPR016317. Pro-epidermal_GF.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00058. Ldl_recept_b. 3 hits.
[Graphical view]
PIRSFiPIRSF001778. Pro-epidermal_growth_factor. 1 hit.
SMARTiSM00181. EGF. 5 hits.
SM00179. EGF_CA. 2 hits.
SM00135. LY. 9 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 6 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS51120. LDLRB. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ8VD07_MOUSE
AccessioniPrimary (citable) accession number: Q8VD07
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.