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Protein

Pro-epidermal growth factor

Gene

Egf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factorUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-epidermal growth factorUniRule annotation
Gene namesi
Name:EgfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95290. Egf.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1022 – 1046HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500431456826 – 1200Pro-epidermal growth factorSequence analysisAdd BLAST1175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi973 ↔ 990PROSITE-ProRule annotation
Disulfide bondi992 ↔ 1001PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

PaxDbiQ8VD07.
PRIDEiQ8VD07.

Interactioni

Subunit structurei

Interacts with EGFR and promotes EGFR dimerization.UniRule annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8VD07.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 117LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati118 – 159LDL-receptor class BPROSITE-ProRule annotationAdd BLAST42
Repeati160 – 202LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini345 – 385EGF-likeInterPro annotationAdd BLAST41
Repeati472 – 512LDL-receptor class BPROSITE-ProRule annotationAdd BLAST41
Repeati513 – 555LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati556 – 598LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati599 – 642LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati643 – 685LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini821 – 859EGF-likeInterPro annotationAdd BLAST39
Domaini860 – 901EGF-likeInterPro annotationAdd BLAST42
Domaini902 – 942EGF-likeInterPro annotationAdd BLAST41
Domaini961 – 1002EGF-likeInterPro annotationAdd BLAST42

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPSY. Eukaryota.
ENOG410ZVIM. LUCA.
HOVERGENiHBG003858.

Family and domain databases

Gene3Di2.120.10.30. 2 hits.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_cys_sf.
IPR000033. LDLR_classB_rpt.
IPR016317. Pro-epidermal_GF.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 3 hits.
PF00058. Ldl_recept_b. 3 hits.
PIRSFiPIRSF001778. Pro-epidermal_growth_factor. 1 hit.
SMARTiView protein in SMART
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 8 hits.
SM00135. LY. 9 hits.
SUPFAMiSSF57184. SSF57184. 3 hits.
PROSITEiView protein in PROSITE
PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 4 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 2 hits.
PS51120. LDLRB. 8 hits.

Sequencei

Sequence statusi: Complete.

Q8VD07-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWGRRPTWL LLAFLLVFLK ISILSERSGT CAGPAPFLVF SQGKSISRID
60 70 80 90 100
PDGTNHQQLV VDAGISADMD IHYKKERLYW VDVERQVLLR VFLNGTGLEK
110 120 130 140 150
VCNVERKVSG LAIDWIDDEV LWVDQQNGVI TVTDMTGKNS RVLLSSLKHP
160 170 180 190 200
SNIAVDPIER LMFWSSEVTG SLHRAHLKGV DVKTLLETGG ISVLTLDVLD
210 220 230 240 250
KRLFWVQDSG EGSHAYIHSC DYEGGSVRLI RHQARHSLSS MAFFGDRIFY
260 270 280 290 300
SVLKSKAIWI ANKHTGKDTV RINLHPSFVT PGKLMVVHPR AQPRTEDAAK
310 320 330 340 350
DPDPELLKQR GRPCRFGLCE RDPKSHSSAC AEGYTLSRDR KYCEDVNECA
360 370 380 390 400
TQNHGCTLGC ENTPGSYHCT CPTGFVLLPD GKQCHELVSC PGNVSKCSHG
410 420 430 440 450
CVLTSDGPRC ICPAGSVLGR DGKTCTGCSS PDNGGCSQIC LPLRPGSWEC
460 470 480 490 500
DCFPGYDLQS DRKSCAASGP QPLLLFANSQ DIRHMHFDGT DYKVLLSRQM
510 520 530 540 550
GMVFALDYDP VESKIYFAQT ALKWIERANM DGSQRERLIT EGVDTLEGLA
560 570 580 590 600
LDWIGRRIYW TDSGKSVVGG SDLSGKHHRI IIQERISRPR GIAVHPRARR
610 620 630 640 650
LFWTDVGMSP RIESASLQGS DRVLIASSNL LEPSGITIDY LTDTLYWCDT
660 670 680 690 700
KRSVIEMANL DGSKRRRLIQ NDVGHPFSLA VFEDHLWVSD WAIPSVIRVN
710 720 730 740 750
KRTGQNRVRL QGSMLKPSSL VVVHPLAKPG ADPCLYRNGG CEHICQESLG
760 770 780 790 800
TARCLCREGF VKAWDGKMCL PQDYPILSGE NADLSKEVTS LSNSTQAEVP
810 820 830 840 850
DDDGTESSTL VAEIMVSGMN YEDDCGPGGC GSHARCVSDG ETAECQCLKG
860 870 880 890 900
FARDGNLCSD IDECVLARSD CPSTSSRCIN TEGGYVCRCS EGYEGDGISC
910 920 930 940 950
FDIDECQRGA HNCAENAACT NTEGGYNCTC AGRPSSPGRS CPDSTAPSLL
960 970 980 990 1000
GEDGHHLDRN SYPGCPSSYD GYCLNGGVCM HIESLDSYTC NCVIGYSGDR
1010 1020 1030 1040 1050
CQTRDLRWWE LRHAGYGQKH DIMVVAVCMV ALVLLLLLGM WGTYYYRTRK
1060 1070 1080 1090 1100
QLSNPPKNPC DEPSGSVSSS GPDSSSGAAV ASCPQPWFVV LEKHQDPKNG
1110 1120 1130 1140 1150
SLPADGTNGA VVDAGLSPSL QLGSVHLTSW RQKPHIDGMG TGQSCWIPPS
1160 1170 1180 1190 1200
SDRGPQEIEG NSHLPSYRPV GPEKLHSLQS ANGSCHERAP DLPRQTEPVQ
Length:1,200
Mass (Da):131,318
Last modified:March 1, 2002 - v1
Checksum:iB6A44F7294746476
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC017681 mRNA. Translation: AAH17681.1.
UniGeneiMm.252481.

Similar proteinsi

Entry informationi

Entry nameiQ8VD07_MOUSE
AccessioniPrimary (citable) accession number: Q8VD07
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 22, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation