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Q8VD04 (GRAP1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GRIP1-associated protein 1

Short name=GRASP-1
Alternative name(s):
HCMV-interacting protein
Gene names
Name:Gripap1
Synonyms:DXImx47e, Kiaa1167
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length806 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with GRIP1, GRIP2 and AMPA receptors By similarity.

Subcellular location

Early endosome By similarity.

Post-translational modification

Proteolytically cleaved by caspase-3 By similarity.

Sequence caution

The sequence CAA66184.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentEndosome
   DomainCoiled coil
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentearly endosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 17761173. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Mapk8A3KBF52EBI-7585099,EBI-7585074

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 806805GRIP1-associated protein 1
PRO_0000087582

Regions

Coiled coil4 – 158155 Potential
Coiled coil204 – 606403 Potential
Coiled coil666 – 70035 Potential
Coiled coil750 – 77930 Potential

Sites

Site563 – 5642Cleavage; by caspase-3 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue6201Phosphoserine By similarity
Modified residue6311Phosphoserine Ref.5
Modified residue6341Phosphoserine Ref.5
Modified residue6551Phosphoserine By similarity
Modified residue6571Phosphoserine By similarity

Experimental info

Sequence conflict41A → R in CAA66184. Ref.3
Sequence conflict5021Q → L in BAE33608. Ref.1
Sequence conflict5021Q → L in BAE43101. Ref.1
Sequence conflict5021Q → L in BAE43133. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8VD04 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 766F7C5B44589020

FASTA80692,715
        10         20         30         40         50         60 
MAQALSEEEF QRMQTQLLEL RTNNYQLSDE LRKNGVELSS LRQKVAYLDK EFSKAQKALS 

        70         80         90        100        110        120 
KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF SKLCSQLEQL ELENRQLKEG 

       130        140        150        160        170        180 
VPGAAGAHVD GELLRLQAEN TALQKNMAAL QERYGKEAVR PSAVGEGQGD PPGDVLPTPL 

       190        200        210        220        230        240 
APMPLAEVEL KWEMEREEKK LLWEQLQGLE SSKQAETSRL QEELAKLSEK LKKKQESFCR 

       250        260        270        280        290        300 
LQTEKETLFN DSRNKIEELQ QRKEADLKAQ LARTQKLQQE LEAANQSLAE LRDQRQGERL 

       310        320        330        340        350        360 
EHAAALRALQ DQIQTAKTQE LNMLREQTSE LASELQHRQA EYEELMGQKD DLNSQLQESL 

       370        380        390        400        410        420 
RANSRLLEQL QEIGQEKEQL TQDLQEARKS AEKRKVMLDE LAMETLQEKS QHKEELGAVR 

       430        440        450        460        470        480 
LRHEKELLGV RARYERELRE LHEDKKRQEE ELRGQIREEK ARTRELENLQ HTVEELQAQV 

       490        500        510        520        530        540 
HSMDGAKGWF ERRLKEAEES LQQQQQEQEE TLKLCREEHA AELKGKDEEL QNVREQLQQA 

       550        560        570        580        590        600 
QEERDGHVKT ISNLKQEVKD TVDGQRILEK KGSAVLKDLK RQLHLERKRA DKLQERLQEI 

       610        620        630        640        650        660 
LTNSKSRTGL EELVLSEMNS PSRTQTGDSS SVSSFSYREI LKEKESSAIP ARSLSSSPQA 

       670        680        690        700        710        720 
QPPRPAELSD EEVAELFQRL AETQQEKWML EEKVKHLEVS SASMAEDLCR KSAIIETYVM 

       730        740        750        760        770        780 
DSRIDVSVAA GHTDRSGLGS VLRDLVKPGD ENLREMNKKL QNMLEEQLTK NMHLHKDMEV 

       790        800 
LSQEIVRLSK ECVGSPDPDL EPGEAN 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Spleen.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Weber B.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-106.
[4]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-776.
Tissue: Fetal brain.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631 AND SER-634, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK156165 mRNA. Translation: BAE33608.1.
AK172623 mRNA. Translation: BAE43101.1.
AK172699 mRNA. Translation: BAE43133.1.
AL671995 Genomic DNA. Translation: CAM13601.1.
X97571 mRNA. Translation: CAA66184.1. Different initiation.
AK173119 Transcribed RNA. Translation: BAD32397.1.
CCDSCCDS40844.1.
RefSeqNP_997553.1. NM_207670.2.
UniGeneMm.194811.

3D structure databases

ProteinModelPortalQ8VD04.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8VD04. 3 interactions.
MINTMINT-4609304.
STRING10090.ENSMUSP00000111339.

PTM databases

PhosphoSiteQ8VD04.

Proteomic databases

MaxQBQ8VD04.
PaxDbQ8VD04.
PRIDEQ8VD04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000065932; ENSMUSP00000068789; ENSMUSG00000031153.
GeneID54645.
KEGGmmu:54645.
UCSCuc009smo.1. mouse.

Organism-specific databases

CTD56850.
MGIMGI:1859616. Gripap1.
RougeSearch...

Phylogenomic databases

eggNOGNOG135471.
GeneTreeENSGT00720000108868.
HOGENOMHOG000231369.
HOVERGENHBG080243.
OrthoDBEOG7BCNB6.
PhylomeDBQ8VD04.
TreeFamTF329006.

Gene expression databases

ArrayExpressQ8VD04.
BgeeQ8VD04.
CleanExMM_GRIPAP1.
GenevestigatorQ8VD04.

Family and domain databases

InterProIPR026204. GRIPAP1.
[Graphical view]
PANTHERPTHR18978. PTHR18978. 1 hit.
ProtoNetSearch...

Other

NextBio311492.
PROQ8VD04.
SOURCESearch...

Entry information

Entry nameGRAP1_MOUSE
AccessionPrimary (citable) accession number: Q8VD04
Secondary accession number(s): A2AEW7 expand/collapse secondary AC list , O35693, Q3T9C3, Q69ZP9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot