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Protein

GRIP1-associated protein 1

Gene

Gripap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP1-associated protein 1
Short name:
GRASP-1
Alternative name(s):
HCMV-interacting protein
Gene namesi
Name:Gripap1
Synonyms:DXImx47e, Kiaa1167
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859616. Gripap1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000875822 – 806GRIP1-associated protein 1Add BLAST805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei620PhosphoserineCombined sources1
Modified residuei631PhosphoserineCombined sources1
Modified residuei633PhosphoserineCombined sources1
Modified residuei634PhosphoserineCombined sources1
Modified residuei653PhosphoserineBy similarity1
Modified residuei655PhosphoserineBy similarity1
Modified residuei656PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei795PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved by caspase-3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei563 – 564Cleavage; by caspase-3By similarity2

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8VD04.
MaxQBiQ8VD04.
PaxDbiQ8VD04.
PeptideAtlasiQ8VD04.
PRIDEiQ8VD04.

PTM databases

iPTMnetiQ8VD04.
PhosphoSitePlusiQ8VD04.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031153.
CleanExiMM_GRIPAP1.
ExpressionAtlasiQ8VD04. baseline and differential.
GenevisibleiQ8VD04. MM.

Interactioni

Subunit structurei

Interacts with GRIP1, GRIP2 and AMPA receptors.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk8A3KBF52EBI-7585099,EBI-7585074

Protein-protein interaction databases

IntActiQ8VD04. 3 interactors.
MINTiMINT-4609304.
STRINGi10090.ENSMUSP00000068789.

Structurei

3D structure databases

ProteinModelPortaliQ8VD04.
SMRiQ8VD04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili4 – 158Sequence analysisAdd BLAST155
Coiled coili204 – 606Sequence analysisAdd BLAST403
Coiled coili666 – 700Sequence analysisAdd BLAST35
Coiled coili750 – 779Sequence analysisAdd BLAST30

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKP9. Eukaryota.
ENOG410YB89. LUCA.
GeneTreeiENSGT00720000108868.
HOGENOMiHOG000231369.
HOVERGENiHBG080243.
InParanoidiQ8VD04.
PhylomeDBiQ8VD04.
TreeFamiTF329006.

Family and domain databases

InterProiIPR026204. GRIPAP1.
[Graphical view]
PANTHERiPTHR18978. PTHR18978. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VD04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQALSEEEF QRMQTQLLEL RTNNYQLSDE LRKNGVELSS LRQKVAYLDK
60 70 80 90 100
EFSKAQKALS KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF
110 120 130 140 150
SKLCSQLEQL ELENRQLKEG VPGAAGAHVD GELLRLQAEN TALQKNMAAL
160 170 180 190 200
QERYGKEAVR PSAVGEGQGD PPGDVLPTPL APMPLAEVEL KWEMEREEKK
210 220 230 240 250
LLWEQLQGLE SSKQAETSRL QEELAKLSEK LKKKQESFCR LQTEKETLFN
260 270 280 290 300
DSRNKIEELQ QRKEADLKAQ LARTQKLQQE LEAANQSLAE LRDQRQGERL
310 320 330 340 350
EHAAALRALQ DQIQTAKTQE LNMLREQTSE LASELQHRQA EYEELMGQKD
360 370 380 390 400
DLNSQLQESL RANSRLLEQL QEIGQEKEQL TQDLQEARKS AEKRKVMLDE
410 420 430 440 450
LAMETLQEKS QHKEELGAVR LRHEKELLGV RARYERELRE LHEDKKRQEE
460 470 480 490 500
ELRGQIREEK ARTRELENLQ HTVEELQAQV HSMDGAKGWF ERRLKEAEES
510 520 530 540 550
LQQQQQEQEE TLKLCREEHA AELKGKDEEL QNVREQLQQA QEERDGHVKT
560 570 580 590 600
ISNLKQEVKD TVDGQRILEK KGSAVLKDLK RQLHLERKRA DKLQERLQEI
610 620 630 640 650
LTNSKSRTGL EELVLSEMNS PSRTQTGDSS SVSSFSYREI LKEKESSAIP
660 670 680 690 700
ARSLSSSPQA QPPRPAELSD EEVAELFQRL AETQQEKWML EEKVKHLEVS
710 720 730 740 750
SASMAEDLCR KSAIIETYVM DSRIDVSVAA GHTDRSGLGS VLRDLVKPGD
760 770 780 790 800
ENLREMNKKL QNMLEEQLTK NMHLHKDMEV LSQEIVRLSK ECVGSPDPDL

EPGEAN
Length:806
Mass (Da):92,715
Last modified:March 1, 2002 - v1
Checksum:i766F7C5B44589020
GO

Sequence cautioni

The sequence CAA66184 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4A → R in CAA66184 (Ref. 3) Curated1
Sequence conflicti502Q → L in BAE33608 (PubMed:16141072).Curated1
Sequence conflicti502Q → L in BAE43101 (PubMed:16141072).Curated1
Sequence conflicti502Q → L in BAE43133 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156165 mRNA. Translation: BAE33608.1.
AK172623 mRNA. Translation: BAE43101.1.
AK172699 mRNA. Translation: BAE43133.1.
AL671995 Genomic DNA. Translation: CAM13601.1.
X97571 mRNA. Translation: CAA66184.1. Different initiation.
AK173119 Transcribed RNA. Translation: BAD32397.1.
CCDSiCCDS40844.1.
RefSeqiNP_997553.1. NM_207670.2.
UniGeneiMm.194811.

Genome annotation databases

EnsembliENSMUST00000065932; ENSMUSP00000068789; ENSMUSG00000031153.
GeneIDi54645.
KEGGimmu:54645.
UCSCiuc009smo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156165 mRNA. Translation: BAE33608.1.
AK172623 mRNA. Translation: BAE43101.1.
AK172699 mRNA. Translation: BAE43133.1.
AL671995 Genomic DNA. Translation: CAM13601.1.
X97571 mRNA. Translation: CAA66184.1. Different initiation.
AK173119 Transcribed RNA. Translation: BAD32397.1.
CCDSiCCDS40844.1.
RefSeqiNP_997553.1. NM_207670.2.
UniGeneiMm.194811.

3D structure databases

ProteinModelPortaliQ8VD04.
SMRiQ8VD04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VD04. 3 interactors.
MINTiMINT-4609304.
STRINGi10090.ENSMUSP00000068789.

PTM databases

iPTMnetiQ8VD04.
PhosphoSitePlusiQ8VD04.

Proteomic databases

EPDiQ8VD04.
MaxQBiQ8VD04.
PaxDbiQ8VD04.
PeptideAtlasiQ8VD04.
PRIDEiQ8VD04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065932; ENSMUSP00000068789; ENSMUSG00000031153.
GeneIDi54645.
KEGGimmu:54645.
UCSCiuc009smo.2. mouse.

Organism-specific databases

CTDi56850.
MGIiMGI:1859616. Gripap1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IKP9. Eukaryota.
ENOG410YB89. LUCA.
GeneTreeiENSGT00720000108868.
HOGENOMiHOG000231369.
HOVERGENiHBG080243.
InParanoidiQ8VD04.
PhylomeDBiQ8VD04.
TreeFamiTF329006.

Miscellaneous databases

PROiQ8VD04.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031153.
CleanExiMM_GRIPAP1.
ExpressionAtlasiQ8VD04. baseline and differential.
GenevisibleiQ8VD04. MM.

Family and domain databases

InterProiIPR026204. GRIPAP1.
[Graphical view]
PANTHERiPTHR18978. PTHR18978. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGRAP1_MOUSE
AccessioniPrimary (citable) accession number: Q8VD04
Secondary accession number(s): A2AEW7
, O35693, Q3T9C3, Q69ZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.