SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8VD04

- GRAP1_MOUSE

UniProt

Q8VD04 - GRAP1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

GRIP1-associated protein 1

Gene
Gripap1, DXImx47e, Kiaa1167
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei563 – 5642Cleavage; by caspase-3 By similarity

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
GRIP1-associated protein 1
Short name:
GRASP-1
Alternative name(s):
HCMV-interacting protein
Gene namesi
Name:Gripap1
Synonyms:DXImx47e, Kiaa1167
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1859616. Gripap1.

Subcellular locationi

Early endosome By similarity

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 806805GRIP1-associated protein 1PRO_0000087582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity
Modified residuei620 – 6201Phosphoserine By similarity
Modified residuei631 – 6311Phosphoserine1 Publication
Modified residuei634 – 6341Phosphoserine1 Publication
Modified residuei655 – 6551Phosphoserine By similarity
Modified residuei657 – 6571Phosphoserine By similarity

Post-translational modificationi

Proteolytically cleaved by caspase-3 By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8VD04.
PaxDbiQ8VD04.
PRIDEiQ8VD04.

PTM databases

PhosphoSiteiQ8VD04.

Expressioni

Gene expression databases

ArrayExpressiQ8VD04.
BgeeiQ8VD04.
CleanExiMM_GRIPAP1.
GenevestigatoriQ8VD04.

Interactioni

Subunit structurei

Interacts with GRIP1, GRIP2 and AMPA receptors By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk8A3KBF52EBI-7585099,EBI-7585074

Protein-protein interaction databases

IntActiQ8VD04. 3 interactions.
MINTiMINT-4609304.
STRINGi10090.ENSMUSP00000111339.

Structurei

3D structure databases

ProteinModelPortaliQ8VD04.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili4 – 158155 Reviewed predictionAdd
BLAST
Coiled coili204 – 606403 Reviewed predictionAdd
BLAST
Coiled coili666 – 70035 Reviewed predictionAdd
BLAST
Coiled coili750 – 77930 Reviewed predictionAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG135471.
GeneTreeiENSGT00720000108868.
HOGENOMiHOG000231369.
HOVERGENiHBG080243.
OrthoDBiEOG7BCNB6.
PhylomeDBiQ8VD04.
TreeFamiTF329006.

Family and domain databases

InterProiIPR026204. GRIPAP1.
[Graphical view]
PANTHERiPTHR18978. PTHR18978. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VD04-1 [UniParc]FASTAAdd to Basket

« Hide

MAQALSEEEF QRMQTQLLEL RTNNYQLSDE LRKNGVELSS LRQKVAYLDK    50
EFSKAQKALS KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF 100
SKLCSQLEQL ELENRQLKEG VPGAAGAHVD GELLRLQAEN TALQKNMAAL 150
QERYGKEAVR PSAVGEGQGD PPGDVLPTPL APMPLAEVEL KWEMEREEKK 200
LLWEQLQGLE SSKQAETSRL QEELAKLSEK LKKKQESFCR LQTEKETLFN 250
DSRNKIEELQ QRKEADLKAQ LARTQKLQQE LEAANQSLAE LRDQRQGERL 300
EHAAALRALQ DQIQTAKTQE LNMLREQTSE LASELQHRQA EYEELMGQKD 350
DLNSQLQESL RANSRLLEQL QEIGQEKEQL TQDLQEARKS AEKRKVMLDE 400
LAMETLQEKS QHKEELGAVR LRHEKELLGV RARYERELRE LHEDKKRQEE 450
ELRGQIREEK ARTRELENLQ HTVEELQAQV HSMDGAKGWF ERRLKEAEES 500
LQQQQQEQEE TLKLCREEHA AELKGKDEEL QNVREQLQQA QEERDGHVKT 550
ISNLKQEVKD TVDGQRILEK KGSAVLKDLK RQLHLERKRA DKLQERLQEI 600
LTNSKSRTGL EELVLSEMNS PSRTQTGDSS SVSSFSYREI LKEKESSAIP 650
ARSLSSSPQA QPPRPAELSD EEVAELFQRL AETQQEKWML EEKVKHLEVS 700
SASMAEDLCR KSAIIETYVM DSRIDVSVAA GHTDRSGLGS VLRDLVKPGD 750
ENLREMNKKL QNMLEEQLTK NMHLHKDMEV LSQEIVRLSK ECVGSPDPDL 800
EPGEAN 806
Length:806
Mass (Da):92,715
Last modified:March 1, 2002 - v1
Checksum:i766F7C5B44589020
GO

Sequence cautioni

The sequence CAA66184.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41A → R in CAA66184. 1 Publication
Sequence conflicti502 – 5021Q → L in BAE33608. 1 Publication
Sequence conflicti502 – 5021Q → L in BAE43101. 1 Publication
Sequence conflicti502 – 5021Q → L in BAE43133. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK156165 mRNA. Translation: BAE33608.1.
AK172623 mRNA. Translation: BAE43101.1.
AK172699 mRNA. Translation: BAE43133.1.
AL671995 Genomic DNA. Translation: CAM13601.1.
X97571 mRNA. Translation: CAA66184.1. Different initiation.
AK173119 Transcribed RNA. Translation: BAD32397.1.
CCDSiCCDS40844.1.
RefSeqiNP_997553.1. NM_207670.2.
UniGeneiMm.194811.

Genome annotation databases

EnsembliENSMUST00000065932; ENSMUSP00000068789; ENSMUSG00000031153.
GeneIDi54645.
KEGGimmu:54645.
UCSCiuc009smo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK156165 mRNA. Translation: BAE33608.1 .
AK172623 mRNA. Translation: BAE43101.1 .
AK172699 mRNA. Translation: BAE43133.1 .
AL671995 Genomic DNA. Translation: CAM13601.1 .
X97571 mRNA. Translation: CAA66184.1 . Different initiation.
AK173119 Transcribed RNA. Translation: BAD32397.1 .
CCDSi CCDS40844.1.
RefSeqi NP_997553.1. NM_207670.2.
UniGenei Mm.194811.

3D structure databases

ProteinModelPortali Q8VD04.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VD04. 3 interactions.
MINTi MINT-4609304.
STRINGi 10090.ENSMUSP00000111339.

PTM databases

PhosphoSitei Q8VD04.

Proteomic databases

MaxQBi Q8VD04.
PaxDbi Q8VD04.
PRIDEi Q8VD04.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000065932 ; ENSMUSP00000068789 ; ENSMUSG00000031153 .
GeneIDi 54645.
KEGGi mmu:54645.
UCSCi uc009smo.1. mouse.

Organism-specific databases

CTDi 56850.
MGIi MGI:1859616. Gripap1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG135471.
GeneTreei ENSGT00720000108868.
HOGENOMi HOG000231369.
HOVERGENi HBG080243.
OrthoDBi EOG7BCNB6.
PhylomeDBi Q8VD04.
TreeFami TF329006.

Miscellaneous databases

NextBioi 311492.
PROi Q8VD04.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VD04.
Bgeei Q8VD04.
CleanExi MM_GRIPAP1.
Genevestigatori Q8VD04.

Family and domain databases

InterProi IPR026204. GRIPAP1.
[Graphical view ]
PANTHERi PTHR18978. PTHR18978. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Weber B.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-106.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-776.
    Tissue: Fetal brain.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631 AND SER-634, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiGRAP1_MOUSE
AccessioniPrimary (citable) accession number: Q8VD04
Secondary accession number(s): A2AEW7
, O35693, Q3T9C3, Q69ZP9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi