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Q8VD04

- GRAP1_MOUSE

UniProt

Q8VD04 - GRAP1_MOUSE

Protein

GRIP1-associated protein 1

Gene

Gripap1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei563 – 5642Cleavage; by caspase-3By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GRIP1-associated protein 1
    Short name:
    GRASP-1
    Alternative name(s):
    HCMV-interacting protein
    Gene namesi
    Name:Gripap1
    Synonyms:DXImx47e, Kiaa1167
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1859616. Gripap1.

    Subcellular locationi

    Early endosome By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 806805GRIP1-associated protein 1PRO_0000087582Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei620 – 6201PhosphoserineBy similarity
    Modified residuei631 – 6311Phosphoserine1 Publication
    Modified residuei634 – 6341Phosphoserine1 Publication
    Modified residuei655 – 6551PhosphoserineBy similarity
    Modified residuei657 – 6571PhosphoserineBy similarity

    Post-translational modificationi

    Proteolytically cleaved by caspase-3.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8VD04.
    PaxDbiQ8VD04.
    PRIDEiQ8VD04.

    PTM databases

    PhosphoSiteiQ8VD04.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VD04.
    BgeeiQ8VD04.
    CleanExiMM_GRIPAP1.
    GenevestigatoriQ8VD04.

    Interactioni

    Subunit structurei

    Interacts with GRIP1, GRIP2 and AMPA receptors.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Mapk8A3KBF52EBI-7585099,EBI-7585074

    Protein-protein interaction databases

    IntActiQ8VD04. 3 interactions.
    MINTiMINT-4609304.
    STRINGi10090.ENSMUSP00000111339.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VD04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili4 – 158155Sequence AnalysisAdd
    BLAST
    Coiled coili204 – 606403Sequence AnalysisAdd
    BLAST
    Coiled coili666 – 70035Sequence AnalysisAdd
    BLAST
    Coiled coili750 – 77930Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG135471.
    GeneTreeiENSGT00720000108868.
    HOGENOMiHOG000231369.
    HOVERGENiHBG080243.
    OrthoDBiEOG7BCNB6.
    PhylomeDBiQ8VD04.
    TreeFamiTF329006.

    Family and domain databases

    InterProiIPR026204. GRIPAP1.
    [Graphical view]
    PANTHERiPTHR18978. PTHR18978. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8VD04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQALSEEEF QRMQTQLLEL RTNNYQLSDE LRKNGVELSS LRQKVAYLDK    50
    EFSKAQKALS KSKKAQEVEV LLSENEMLQA KLHSQEEDFR LQNSTLMAEF 100
    SKLCSQLEQL ELENRQLKEG VPGAAGAHVD GELLRLQAEN TALQKNMAAL 150
    QERYGKEAVR PSAVGEGQGD PPGDVLPTPL APMPLAEVEL KWEMEREEKK 200
    LLWEQLQGLE SSKQAETSRL QEELAKLSEK LKKKQESFCR LQTEKETLFN 250
    DSRNKIEELQ QRKEADLKAQ LARTQKLQQE LEAANQSLAE LRDQRQGERL 300
    EHAAALRALQ DQIQTAKTQE LNMLREQTSE LASELQHRQA EYEELMGQKD 350
    DLNSQLQESL RANSRLLEQL QEIGQEKEQL TQDLQEARKS AEKRKVMLDE 400
    LAMETLQEKS QHKEELGAVR LRHEKELLGV RARYERELRE LHEDKKRQEE 450
    ELRGQIREEK ARTRELENLQ HTVEELQAQV HSMDGAKGWF ERRLKEAEES 500
    LQQQQQEQEE TLKLCREEHA AELKGKDEEL QNVREQLQQA QEERDGHVKT 550
    ISNLKQEVKD TVDGQRILEK KGSAVLKDLK RQLHLERKRA DKLQERLQEI 600
    LTNSKSRTGL EELVLSEMNS PSRTQTGDSS SVSSFSYREI LKEKESSAIP 650
    ARSLSSSPQA QPPRPAELSD EEVAELFQRL AETQQEKWML EEKVKHLEVS 700
    SASMAEDLCR KSAIIETYVM DSRIDVSVAA GHTDRSGLGS VLRDLVKPGD 750
    ENLREMNKKL QNMLEEQLTK NMHLHKDMEV LSQEIVRLSK ECVGSPDPDL 800
    EPGEAN 806
    Length:806
    Mass (Da):92,715
    Last modified:March 1, 2002 - v1
    Checksum:i766F7C5B44589020
    GO

    Sequence cautioni

    The sequence CAA66184.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41A → R in CAA66184. 1 PublicationCurated
    Sequence conflicti502 – 5021Q → L in BAE33608. (PubMed:16141072)Curated
    Sequence conflicti502 – 5021Q → L in BAE43101. (PubMed:16141072)Curated
    Sequence conflicti502 – 5021Q → L in BAE43133. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK156165 mRNA. Translation: BAE33608.1.
    AK172623 mRNA. Translation: BAE43101.1.
    AK172699 mRNA. Translation: BAE43133.1.
    AL671995 Genomic DNA. Translation: CAM13601.1.
    X97571 mRNA. Translation: CAA66184.1. Different initiation.
    AK173119 Transcribed RNA. Translation: BAD32397.1.
    CCDSiCCDS40844.1.
    RefSeqiNP_997553.1. NM_207670.2.
    UniGeneiMm.194811.

    Genome annotation databases

    EnsembliENSMUST00000065932; ENSMUSP00000068789; ENSMUSG00000031153.
    GeneIDi54645.
    KEGGimmu:54645.
    UCSCiuc009smo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK156165 mRNA. Translation: BAE33608.1 .
    AK172623 mRNA. Translation: BAE43101.1 .
    AK172699 mRNA. Translation: BAE43133.1 .
    AL671995 Genomic DNA. Translation: CAM13601.1 .
    X97571 mRNA. Translation: CAA66184.1 . Different initiation.
    AK173119 Transcribed RNA. Translation: BAD32397.1 .
    CCDSi CCDS40844.1.
    RefSeqi NP_997553.1. NM_207670.2.
    UniGenei Mm.194811.

    3D structure databases

    ProteinModelPortali Q8VD04.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8VD04. 3 interactions.
    MINTi MINT-4609304.
    STRINGi 10090.ENSMUSP00000111339.

    PTM databases

    PhosphoSitei Q8VD04.

    Proteomic databases

    MaxQBi Q8VD04.
    PaxDbi Q8VD04.
    PRIDEi Q8VD04.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000065932 ; ENSMUSP00000068789 ; ENSMUSG00000031153 .
    GeneIDi 54645.
    KEGGi mmu:54645.
    UCSCi uc009smo.1. mouse.

    Organism-specific databases

    CTDi 56850.
    MGIi MGI:1859616. Gripap1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG135471.
    GeneTreei ENSGT00720000108868.
    HOGENOMi HOG000231369.
    HOVERGENi HBG080243.
    OrthoDBi EOG7BCNB6.
    PhylomeDBi Q8VD04.
    TreeFami TF329006.

    Miscellaneous databases

    NextBioi 311492.
    PROi Q8VD04.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VD04.
    Bgeei Q8VD04.
    CleanExi MM_GRIPAP1.
    Genevestigatori Q8VD04.

    Family and domain databases

    InterProi IPR026204. GRIPAP1.
    [Graphical view ]
    PANTHERi PTHR18978. PTHR18978. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Spleen.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. Weber B.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-106.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-776.
      Tissue: Fetal brain.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-631 AND SER-634, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiGRAP1_MOUSE
    AccessioniPrimary (citable) accession number: Q8VD04
    Secondary accession number(s): A2AEW7
    , O35693, Q3T9C3, Q69ZP9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3