Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8VD00 (TMM97_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protein 97
Gene names
Name:Tmem97
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length176 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a role as a regulator of cellular cholesterol homeostasis By similarity.

Subunit structure

Interacts with NPC1 By similarity.

Subcellular location

Nucleus membrane By similarity. Rough endoplasmic reticulum By similarity. Cell membrane By similarity. Lysosome By similarity. Membrane; Multi-pass membrane protein Potential. Note: Localized in sterol-depleted cells at cell membrane and in lysosomes By similarity.

Sequence similarities

Belongs to the TMEM97 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 176176Transmembrane protein 97
PRO_0000254569

Regions

Topological domain1 – 99Cytoplasmic Potential
Transmembrane10 – 3021Helical; Potential
Topological domain31 – 6838Extracellular Potential
Transmembrane69 – 8921Helical; Potential
Topological domain90 – 9910Cytoplasmic Potential
Transmembrane100 – 12021Helical; Potential
Topological domain121 – 14020Extracellular Potential
Transmembrane141 – 16121Helical; Potential
Topological domain162 – 17615Cytoplasmic Potential

Sequences

Sequence LengthMass (Da)Tools
Q8VD00 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 245D2427FC03AE2E

FASTA17620,811
        10         20         30         40         50         60 
MGALAARRCV EWLLGLYFVS HIPITLFIDL QAVLPPELYP QEFSNLLRWY SKEFKDPLMQ 

        70         80         90        100        110        120 
EPPVWFKSFL LCELVFQLPF FPIAAYAFFK GSCRWIRIPA IIYAAHTITT LIPILYTLLF 

       130        140        150        160        170 
EDFSKAVAFK GQRPESFRER LTLVGVYAPY LIIPLILLLF MLRNPYYKYE EKRKKK

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Dendritic cell and Spleen.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver and Salivary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK155107 mRNA. Translation: BAE33052.1.
AK171954 mRNA. Translation: BAE42746.1.
AL591177 Genomic DNA. Translation: CAI25555.1.
BC018156 mRNA. Translation: AAH18156.1.
BC093511 mRNA. Translation: AAH93511.1.
IPIIPI00122430.
RefSeqNP_598467.1. NM_133706.2.
UniGeneMm.29431.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000099532.

PTM databases

PhosphoSiteQ8VD00.

Proteomic databases

PaxDbQ8VD00.
PRIDEQ8VD00.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000103242; ENSMUSP00000099532; ENSMUSG00000037278.
GeneID69071.
KEGGmmu:69071.
UCSCuc007kjv.1. mouse.

Organism-specific databases

CTD27346.
MGIMGI:1916321. Tmem97.

Phylogenomic databases

eggNOGNOG16760.
GeneTreeENSGT00390000007149.
HOGENOMHOG000031140.
HOVERGENHBG079913.
InParanoidQ8VD00.
OMACKWIRTP.
OrthoDBEOG44TP90.

Gene expression databases

BgeeQ8VD00.
CleanExMM_TMEM97.
GenevestigatorQ8VD00.
GermOnlineENSMUSG00000037278. Mus musculus.

Family and domain databases

InterProIPR016964. Transmembrane_6/97.
[Graphical view]
PfamPF10914. DUF2781. 1 hit.
[Graphical view]
PIRSFPIRSF031032. TMP_97_prd. 1 hit.
ProtoNetSearch...

Other

NextBio328532.
SOURCESearch...

Entry information

Entry nameTMM97_MOUSE
AccessionPrimary (citable) accession number: Q8VD00
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: March 1, 2002
Last modified: April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents