Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8VCZ9 (PROD2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable proline dehydrogenase 2
EC=1.5.99.8
Alternative name(s):
Kidney and liver proline oxidase 1
MmPOX1
Probable proline oxidase 2
Proline oxidase-like protein
Short name=PO
Short name=Proline oxidase
Gene names
Name:Prodh2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts proline to delta-1-pyrroline-5-carboxylate Probable.

Catalytic activity

L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.

Cofactor

FAD By similarity.

Pathway

Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.

Developmental stage

Expressed in liver at E14. Expression level increases at P5 and decreases after P21. Ref.5

Induction

In liver, by TCF1 and HNF4A. Ref.5

Sequence similarities

Belongs to the proline oxidase family.

Sequence caution

The sequence AAF21466.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAQ13907.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProline metabolism
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processglutamate biosynthetic process

Inferred from electronic annotation. Source: InterPro

proline catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentmitochondrial inner membrane

Inferred from direct assay. Source: MGI

   Molecular functionproline dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 456456Probable proline dehydrogenase 2
PRO_0000308624

Experimental info

Sequence conflict3371R → H in AAF21466. Ref.1
Sequence conflict4161E → K in AAF21466. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8VCZ9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: CD02C1474AADBD56

FASTA45650,723
        10         20         30         40         50         60 
MIWTRLPLYG PSKPSTGGWQ PLRFDGGAFH VKGTAELARA LLVLRLCAWP PLVTHGLAFQ 

        70         80         90        100        110        120 
AWSQRLLGSR LSGALLRASI YGQFVAGETA EEVRNCVGQL QALGLQPLLA VPTEEEPDST 

       130        140        150        160        170        180 
AKTSEVWYEE NLSAMLRCVD LSRALVDAHG PARNSLMQLK VTALASTRLC KELSAWIQRP 

       190        200        210        220        230        240 
RGSSELSPER LAEAMDSGRN LQLSCLSTEQ NQHLQASLSR LHRVAQHARA KCVRLLVDAE 

       250        260        270        280        290        300 
YTFINPALSL LVAALAVRWN SPEEGGPWVW NTYQAYLKDT HQRLEQDAEA AHKAGLAFGV 

       310        320        330        340        350        360 
KLVRGAYLDK ERSMTQLQGK EDCTQPDYEA TSRSYSRCLE LMLRCVSNHG PPCHLMVASH 

       370        380        390        400        410        420 
NEESVRQATK RMWELGIPLD GPVCFGQLLG MCDHVSLALG QAGYMVYKSI PYGCLEEVIP 

       430        440        450 
YLIRRAQENR SVLQGARREQ ALLSQELWRR LLGRTA

« Hide

References

« Hide 'large scale' references
[1]Lin W.-W., Hu C.A., Valle D.
Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Yang Q., Tian Y., Wallner E.I., Kanwar Y.S.
Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Liver.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
[5]"Hepatocyte nuclear factors 1alpha and 4alpha control expression of proline oxidase in adult liver."
Kamiya A., Inoue Y., Kodama T., Gonzalez F.J.
FEBS Lett. 578:63-68(2004) [PubMed: 15581617] [Abstract]
Cited for: INDUCTION BY TCF1 AND HNF4A, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U80019 mRNA. Translation: AAF21466.1. Different initiation.
AF222851 mRNA. Translation: AAQ13907.1. Different initiation.
AK050141 mRNA. Translation: BAC34090.1.
BC018182 mRNA. Translation: AAH18182.1.
IPIIPI00134509.
RefSeqNP_062419.2. NM_019546.5.
UniGeneMm.270525.

3D structure databases

ProteinModelPortalQ8VCZ9.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ8VCZ9.

PTM databases

PhosphoSiteQ8VCZ9.

Proteomic databases

PRIDEQ8VCZ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000058280; ENSMUSP00000062214; ENSMUSG00000036892.
GeneID56189.
KEGGmmu:56189.
NMPDRfig|10090.3.peg.16137.
UCSCuc009geo.1. mouse.

Organism-specific databases

CTD58510.
MGIMGI:1929093. Prodh2.

Phylogenomic databases

eggNOGmaNOG08806.
GeneTreeENSGT00390000006265.
HOGENOMHBG714012.
HOVERGENHBG108294.
InParanoidQ8VCZ9.
OMASAMLRCV.
OrthoDBEOG4BK541.

Gene expression databases

ArrayExpressQ8VCZ9.
BgeeQ8VCZ9.
CleanExMM_PRODH2.
GenevestigatorQ8VCZ9.

Family and domain databases

InterProIPR002872. Proline_DH.
IPR015659. Proline_oxidase.
[Graphical view]
KOK11394.
PANTHERPTHR13914. Proline_oxidase. 1 hit.
PfamPF01619. Pro_dh. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311988.
SOURCESearch...

Entry information

Entry namePROD2_MOUSE
AccessionPrimary (citable) accession number: Q8VCZ9
Secondary accession number(s): Q2V058, Q9QX62
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2002
Last modified: December 14, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents