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Q8VCZ6 (SGSM3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Small G protein signaling modulator 3
Alternative name(s):
RUN and TBC1 domain-containing protein 3
Gene names
Name:Sgsm3
Synonyms:Cip85, Rutbc3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a cooperative role in NF2-mediated growth suppression of cells By similarity. Ref.4 UniProtKB Q96HU1

Subunit structure

Interacts with GJA1. Interaction with GJA1 induces its degradation. Interacts via its RUN domain with the C-terminal region of NF2. Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A, RAP2B and PDCD6I. No interaction with RAB27A By similarity. Ref.1 UniProtKB Q96HU1

Subcellular location

Cytoplasm By similarity UniProtKB Q96HU1.

Tissue specificity

Widely expressed. Ref.4

Sequence similarities

Belongs to the small G protein signaling modulator family.

Contains 1 Rab-GAP TBC domain.

Contains 1 RUN domain.

Contains 1 SH3 domain.

Sequence caution

The sequence BAE42041.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Gja1P080504EBI-525155,EBI-476947From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 750750Small G protein signaling modulator 3
PRO_0000307811

Regions

Domain114 – 305192Rab-GAP TBC
Domain480 – 53960SH3
Domain555 – 718164RUN
Coiled coil415 – 43925 Potential

Experimental info

Sequence conflict6221D → G in BAE42041. Ref.2

Secondary structure

........... 750
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8VCZ6 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: C0306BE346808B07

FASTA75085,490
        10         20         30         40         50         60 
MSGNHTPSAS GPFSALTPSI WPQEILAKYS QKEESSEQPE LCYDEFGFRV DKEGSEPGCS 

        70         80         90        100        110        120 
QMTGSPLVED PPQRLRWQAH LEFTHNHDVG DLTWDKIAVS LPRSEKLRSL VLAGIPHGMR 

       130        140        150        160        170        180 
PQLWMRLSGA LQKKKNSELS YREIIKNSSN DETIAAKQIE KDLLRTMPSN ACFANVNSIG 

       190        200        210        220        230        240 
VPRLRRVLRA LAWLYPEIGY CQGTGMVAAC LLLFLEEEDA FWMMCAIIED LLPASYFSTT 

       250        260        270        280        290        300 
LLGVQTDQRV LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVH IRLLLRIWDL 

       310        320        330        340        350        360 
FFYEGSLVLF QTTLGMLRLK EEELIQSENS ASIFNTLSDI PAQMDDAELL LGEAMRLAGS 

       370        380        390        400        410        420 
LTDVAVETQR RKHLAYLIAD QGQTLGTGTT TNLSQVVRRR TQRRKSGITS LLFGEDDLEA 

       430        440        450        460        470        480 
LKAKNIKQTE LVADLREAIL RVARHFQCTD PKNCSVELTP DYSMESHQRD HENYVACLRS 

       490        500        510        520        530        540 
HRRRAKALLD FERHDDDELG FRKNDIITII SQKDEHCWVG ELNGLRGWFP AKFVEVLDER 

       550        560        570        580        590        600 
SKEYSIAGDD SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV 

       610        620        630        640        650        660 
ERDFDSVYSR LVLCKTYRLD EDGKVLTPEE LLYRAVQSVN VTHDAAHAQM DVKLRSLICV 

       670        680        690        700        710        720 
GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK CELRVLCCFA FSLSQDWELP 

       730        740        750 
ARREEEKQPL KEGVQDMLVK HHLFSWDIDG 

« Hide

References

« Hide 'large scale' references
[1]"Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation."
Lan Z., Kurata W.E., Martyn K.D., Jin C., Lau A.F.
Biochemistry 44:2385-2396(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GJA1.
Tissue: Embryo.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Dendritic cell.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver, Mammary tumor and Salivary gland.
[4]"Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway."
Yang H., Sasaki T., Minoshima S., Shimizu N.
Genomics 90:249-260(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3."
RIKEN structural genomics initiative (RSGI)
Submitted (OCT-2007) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 483-549.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY382616 mRNA. Translation: AAR89983.1.
AK170806 mRNA. Translation: BAE42041.1. Different initiation.
BC018197 mRNA. Translation: AAH18197.1.
BC024122 mRNA. Translation: AAH24122.1.
BC025561 mRNA. Translation: AAH25561.1.
RefSeqNP_598852.2. NM_134091.2.
UniGeneMm.274943.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YUONMR-A483-547[»]
ProteinModelPortalQ8VCZ6.
SMRQ8VCZ6. Positions 73-375, 480-551.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8VCZ6. 1 interaction.
MINTMINT-1326710.

PTM databases

PhosphoSiteQ8VCZ6.

Proteomic databases

MaxQBQ8VCZ6.
PaxDbQ8VCZ6.
PRIDEQ8VCZ6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000139517; ENSMUSP00000122543; ENSMUSG00000042303.
GeneID105835.
KEGGmmu:105835.

Organism-specific databases

CTD27352.
MGIMGI:1916329. Sgsm3.

Phylogenomic databases

eggNOGCOG5210.
GeneTreeENSGT00710000106533.
HOGENOMHOG000007875.
HOVERGENHBG108484.
InParanoidQ8VCZ6.
OrthoDBEOG70KGP2.
PhylomeDBQ8VCZ6.

Gene expression databases

ArrayExpressQ8VCZ6.
BgeeQ8VCZ6.
CleanExMM_SGSM3.
GenevestigatorQ8VCZ6.

Family and domain databases

InterProIPR000195. Rab-GTPase-TBC_dom.
IPR004012. Run.
IPR001452. SH3_domain.
[Graphical view]
PfamPF00566. RabGAP-TBC. 1 hit.
PF02759. RUN. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMSSF47923. SSF47923. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8VCZ6.
NextBio357910.
PROQ8VCZ6.
SOURCESearch...

Entry information

Entry nameSGSM3_MOUSE
AccessionPrimary (citable) accession number: Q8VCZ6
Secondary accession number(s): Q3TCB6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot