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Protein

Small G protein signaling modulator 3

Gene

Sgsm3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a cooperative role in NF2-mediated growth suppression of cells.By similarity

GO - Molecular functioni

  • GTPase activator activity Source: MGI
  • GTPase regulator activity Source: UniProtKB
  • Rab GTPase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Small G protein signaling modulator 3
Alternative name(s):
RUN and TBC1 domain-containing protein 3
Gene namesi
Name:Sgsm3By similarity
Synonyms:Cip85Imported, Rutbc3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1916329. Sgsm3.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytosol Source: MGI
  • endomembrane system Source: GO_Central
  • gap junction Source: UniProtKB
  • intracellular Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078111 – 750Small G protein signaling modulator 3Add BLAST750

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei406PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VCZ6.
PaxDbiQ8VCZ6.
PRIDEiQ8VCZ6.

PTM databases

iPTMnetiQ8VCZ6.
PhosphoSitePlusiQ8VCZ6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000042303.
CleanExiMM_SGSM3.
ExpressionAtlasiQ8VCZ6. baseline and differential.
GenevisibleiQ8VCZ6. MM.

Interactioni

Subunit structurei

Interacts with GJA1. Interaction with GJA1 induces its degradation. Interacts via its RUN domain with the C-terminal region of NF2. Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A, RAP2B and PDCD6I. No interaction with RAB27A (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gja1P080504EBI-525155,EBI-476947From a different organism.

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VCZ6. 1 interactor.
MINTiMINT-1326710.
STRINGi10090.ENSMUSP00000043311.

Structurei

Secondary structure

1750
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi483 – 489Combined sources7
Beta strandi506 – 511Combined sources6
Beta strandi514 – 522Combined sources9
Beta strandi525 – 530Combined sources6
Helixi531 – 533Combined sources3
Beta strandi534 – 537Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUONMR-A483-547[»]
ProteinModelPortaliQ8VCZ6.
SMRiQ8VCZ6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VCZ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini114 – 305Rab-GAP TBCPROSITE-ProRule annotationAdd BLAST192
Domaini480 – 539SH3PROSITE-ProRule annotationAdd BLAST60
Domaini555 – 718RUNPROSITE-ProRule annotationAdd BLAST164

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili415 – 439Sequence analysisAdd BLAST25

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiKOG2222. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000007875.
HOVERGENiHBG108484.
InParanoidiQ8VCZ6.
KOiK20176.
OrthoDBiEOG091G02H8.
PhylomeDBiQ8VCZ6.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR004012. Run_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
PF02759. RUN. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGNHTPSAS GPFSALTPSI WPQEILAKYS QKEESSEQPE LCYDEFGFRV
60 70 80 90 100
DKEGSEPGCS QMTGSPLVED PPQRLRWQAH LEFTHNHDVG DLTWDKIAVS
110 120 130 140 150
LPRSEKLRSL VLAGIPHGMR PQLWMRLSGA LQKKKNSELS YREIIKNSSN
160 170 180 190 200
DETIAAKQIE KDLLRTMPSN ACFANVNSIG VPRLRRVLRA LAWLYPEIGY
210 220 230 240 250
CQGTGMVAAC LLLFLEEEDA FWMMCAIIED LLPASYFSTT LLGVQTDQRV
260 270 280 290 300
LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVH IRLLLRIWDL
310 320 330 340 350
FFYEGSLVLF QTTLGMLRLK EEELIQSENS ASIFNTLSDI PAQMDDAELL
360 370 380 390 400
LGEAMRLAGS LTDVAVETQR RKHLAYLIAD QGQTLGTGTT TNLSQVVRRR
410 420 430 440 450
TQRRKSGITS LLFGEDDLEA LKAKNIKQTE LVADLREAIL RVARHFQCTD
460 470 480 490 500
PKNCSVELTP DYSMESHQRD HENYVACLRS HRRRAKALLD FERHDDDELG
510 520 530 540 550
FRKNDIITII SQKDEHCWVG ELNGLRGWFP AKFVEVLDER SKEYSIAGDD
560 570 580 590 600
SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV
610 620 630 640 650
ERDFDSVYSR LVLCKTYRLD EDGKVLTPEE LLYRAVQSVN VTHDAAHAQM
660 670 680 690 700
DVKLRSLICV GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK
710 720 730 740 750
CELRVLCCFA FSLSQDWELP ARREEEKQPL KEGVQDMLVK HHLFSWDIDG
Length:750
Mass (Da):85,490
Last modified:March 1, 2002 - v1
Checksum:iC0306BE346808B07
GO

Sequence cautioni

The sequence BAE42041 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti622D → G in BAE42041 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382616 mRNA. Translation: AAR89983.1.
AK170806 mRNA. Translation: BAE42041.1. Different initiation.
BC018197 mRNA. Translation: AAH18197.1.
BC024122 mRNA. Translation: AAH24122.1.
BC025561 mRNA. Translation: AAH25561.1.
CCDSiCCDS49673.1.
RefSeqiNP_598852.3. NM_134091.2.
UniGeneiMm.274943.

Genome annotation databases

EnsembliENSMUST00000139517; ENSMUSP00000122543; ENSMUSG00000042303.
GeneIDi105835.
KEGGimmu:105835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382616 mRNA. Translation: AAR89983.1.
AK170806 mRNA. Translation: BAE42041.1. Different initiation.
BC018197 mRNA. Translation: AAH18197.1.
BC024122 mRNA. Translation: AAH24122.1.
BC025561 mRNA. Translation: AAH25561.1.
CCDSiCCDS49673.1.
RefSeqiNP_598852.3. NM_134091.2.
UniGeneiMm.274943.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2YUONMR-A483-547[»]
ProteinModelPortaliQ8VCZ6.
SMRiQ8VCZ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCZ6. 1 interactor.
MINTiMINT-1326710.
STRINGi10090.ENSMUSP00000043311.

PTM databases

iPTMnetiQ8VCZ6.
PhosphoSitePlusiQ8VCZ6.

Proteomic databases

MaxQBiQ8VCZ6.
PaxDbiQ8VCZ6.
PRIDEiQ8VCZ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000139517; ENSMUSP00000122543; ENSMUSG00000042303.
GeneIDi105835.
KEGGimmu:105835.

Organism-specific databases

CTDi27352.
MGIiMGI:1916329. Sgsm3.

Phylogenomic databases

eggNOGiKOG2222. Eukaryota.
COG5210. LUCA.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000007875.
HOVERGENiHBG108484.
InParanoidiQ8VCZ6.
KOiK20176.
OrthoDBiEOG091G02H8.
PhylomeDBiQ8VCZ6.

Miscellaneous databases

EvolutionaryTraceiQ8VCZ6.
PROiQ8VCZ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042303.
CleanExiMM_SGSM3.
ExpressionAtlasiQ8VCZ6. baseline and differential.
GenevisibleiQ8VCZ6. MM.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR004012. Run_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
PF02759. RUN. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSGSM3_MOUSE
AccessioniPrimary (citable) accession number: Q8VCZ6
Secondary accession number(s): Q3TCB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.