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Q8VCZ6

- SGSM3_MOUSE

UniProt

Q8VCZ6 - SGSM3_MOUSE

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Protein

Small G protein signaling modulator 3

Gene

Sgsm3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a cooperative role in NF2-mediated growth suppression of cells.By similarity

GO - Molecular functioni

  1. Rab GTPase activator activity Source: MGI
  2. Rab GTPase binding Source: UniProtKB
  3. small GTPase regulator activity Source: UniProtKB

GO - Biological processi

  1. cell cycle arrest Source: UniProtKB-KW
  2. positive regulation of protein catabolic process Source: UniProtKB
  3. positive regulation of Rab GTPase activity Source: GOC
  4. Rap protein signal transduction Source: UniProtKB
  5. regulation of Rab protein signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Growth arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Small G protein signaling modulator 3
Alternative name(s):
RUN and TBC1 domain-containing protein 3
Gene namesi
Name:Sgsm3By similarity
Synonyms:Cip85Imported, Rutbc3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1916329. Sgsm3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. gap junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 750750Small G protein signaling modulator 3PRO_0000307811Add
BLAST

Proteomic databases

MaxQBiQ8VCZ6.
PaxDbiQ8VCZ6.
PRIDEiQ8VCZ6.

PTM databases

PhosphoSiteiQ8VCZ6.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ8VCZ6.
CleanExiMM_SGSM3.
ExpressionAtlasiQ8VCZ6. baseline and differential.
GenevestigatoriQ8VCZ6.

Interactioni

Subunit structurei

Interacts with GJA1. Interaction with GJA1 induces its degradation. Interacts via its RUN domain with the C-terminal region of NF2. Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A, RAP2B and PDCD6I. No interaction with RAB27A (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Gja1P080504EBI-525155,EBI-476947From a different organism.

Protein-protein interaction databases

IntActiQ8VCZ6. 1 interaction.
MINTiMINT-1326710.

Structurei

Secondary structure

1
750
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi483 – 4897
Beta strandi506 – 5116
Beta strandi514 – 5229
Beta strandi525 – 5306
Helixi531 – 5333
Beta strandi534 – 5374

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YUONMR-A483-547[»]
ProteinModelPortaliQ8VCZ6.
SMRiQ8VCZ6. Positions 94-360, 480-551.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8VCZ6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 305192Rab-GAP TBCPROSITE-ProRule annotationAdd
BLAST
Domaini480 – 53960SH3PROSITE-ProRule annotationAdd
BLAST
Domaini555 – 718164RUNPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili415 – 43925Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation
Contains 1 RUN domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, SH3 domain

Phylogenomic databases

eggNOGiCOG5210.
GeneTreeiENSGT00760000119137.
HOGENOMiHOG000007875.
HOVERGENiHBG108484.
InParanoidiQ8VCZ6.
OrthoDBiEOG70KGP2.
PhylomeDBiQ8VCZ6.

Family and domain databases

InterProiIPR000195. Rab-GTPase-TBC_dom.
IPR004012. Run.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00566. RabGAP-TBC. 1 hit.
PF02759. RUN. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view]
SUPFAMiSSF47923. SSF47923. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCZ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGNHTPSAS GPFSALTPSI WPQEILAKYS QKEESSEQPE LCYDEFGFRV
60 70 80 90 100
DKEGSEPGCS QMTGSPLVED PPQRLRWQAH LEFTHNHDVG DLTWDKIAVS
110 120 130 140 150
LPRSEKLRSL VLAGIPHGMR PQLWMRLSGA LQKKKNSELS YREIIKNSSN
160 170 180 190 200
DETIAAKQIE KDLLRTMPSN ACFANVNSIG VPRLRRVLRA LAWLYPEIGY
210 220 230 240 250
CQGTGMVAAC LLLFLEEEDA FWMMCAIIED LLPASYFSTT LLGVQTDQRV
260 270 280 290 300
LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVH IRLLLRIWDL
310 320 330 340 350
FFYEGSLVLF QTTLGMLRLK EEELIQSENS ASIFNTLSDI PAQMDDAELL
360 370 380 390 400
LGEAMRLAGS LTDVAVETQR RKHLAYLIAD QGQTLGTGTT TNLSQVVRRR
410 420 430 440 450
TQRRKSGITS LLFGEDDLEA LKAKNIKQTE LVADLREAIL RVARHFQCTD
460 470 480 490 500
PKNCSVELTP DYSMESHQRD HENYVACLRS HRRRAKALLD FERHDDDELG
510 520 530 540 550
FRKNDIITII SQKDEHCWVG ELNGLRGWFP AKFVEVLDER SKEYSIAGDD
560 570 580 590 600
SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV
610 620 630 640 650
ERDFDSVYSR LVLCKTYRLD EDGKVLTPEE LLYRAVQSVN VTHDAAHAQM
660 670 680 690 700
DVKLRSLICV GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK
710 720 730 740 750
CELRVLCCFA FSLSQDWELP ARREEEKQPL KEGVQDMLVK HHLFSWDIDG
Length:750
Mass (Da):85,490
Last modified:March 1, 2002 - v1
Checksum:iC0306BE346808B07
GO

Sequence cautioni

The sequence BAE42041.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti622 – 6221D → G in BAE42041. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY382616 mRNA. Translation: AAR89983.1.
AK170806 mRNA. Translation: BAE42041.1. Different initiation.
BC018197 mRNA. Translation: AAH18197.1.
BC024122 mRNA. Translation: AAH24122.1.
BC025561 mRNA. Translation: AAH25561.1.
RefSeqiNP_598852.2. NM_134091.2.
UniGeneiMm.274943.

Genome annotation databases

EnsembliENSMUST00000139517; ENSMUSP00000122543; ENSMUSG00000042303.
GeneIDi105835.
KEGGimmu:105835.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY382616 mRNA. Translation: AAR89983.1 .
AK170806 mRNA. Translation: BAE42041.1 . Different initiation.
BC018197 mRNA. Translation: AAH18197.1 .
BC024122 mRNA. Translation: AAH24122.1 .
BC025561 mRNA. Translation: AAH25561.1 .
RefSeqi NP_598852.2. NM_134091.2.
UniGenei Mm.274943.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YUO NMR - A 483-547 [» ]
ProteinModelPortali Q8VCZ6.
SMRi Q8VCZ6. Positions 94-360, 480-551.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8VCZ6. 1 interaction.
MINTi MINT-1326710.

PTM databases

PhosphoSitei Q8VCZ6.

Proteomic databases

MaxQBi Q8VCZ6.
PaxDbi Q8VCZ6.
PRIDEi Q8VCZ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000139517 ; ENSMUSP00000122543 ; ENSMUSG00000042303 .
GeneIDi 105835.
KEGGi mmu:105835.

Organism-specific databases

CTDi 27352.
MGIi MGI:1916329. Sgsm3.

Phylogenomic databases

eggNOGi COG5210.
GeneTreei ENSGT00760000119137.
HOGENOMi HOG000007875.
HOVERGENi HBG108484.
InParanoidi Q8VCZ6.
OrthoDBi EOG70KGP2.
PhylomeDBi Q8VCZ6.

Miscellaneous databases

EvolutionaryTracei Q8VCZ6.
NextBioi 357910.
PROi Q8VCZ6.
SOURCEi Search...

Gene expression databases

Bgeei Q8VCZ6.
CleanExi MM_SGSM3.
ExpressionAtlasi Q8VCZ6. baseline and differential.
Genevestigatori Q8VCZ6.

Family and domain databases

InterProi IPR000195. Rab-GTPase-TBC_dom.
IPR004012. Run.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00566. RabGAP-TBC. 1 hit.
PF02759. RUN. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00593. RUN. 1 hit.
SM00326. SH3. 1 hit.
SM00164. TBC. 1 hit.
[Graphical view ]
SUPFAMi SSF47923. SSF47923. 2 hits.
SSF50044. SSF50044. 1 hit.
PROSITEi PS50826. RUN. 1 hit.
PS50002. SH3. 1 hit.
PS50086. TBC_RABGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation."
    Lan Z., Kurata W.E., Martyn K.D., Jin C., Lau A.F.
    Biochemistry 44:2385-2396(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GJA1.
    Tissue: EmbryoImported.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NODImported.
    Tissue: Dendritic cellImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported, Mammary tumorImported and Salivary glandImported.
  4. "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway."
    Yang H., Sasaki T., Minoshima S., Shimizu N.
    Genomics 90:249-260(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: LiverCurated.
  6. "Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 483-549.

Entry informationi

Entry nameiSGSM3_MOUSE
AccessioniPrimary (citable) accession number: Q8VCZ6
Secondary accession number(s): Q3TCB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3