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Q8VCZ6

- SGSM3_MOUSE

UniProt

Q8VCZ6 - SGSM3_MOUSE

Protein

Small G protein signaling modulator 3

Gene

Sgsm3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May play a cooperative role in NF2-mediated growth suppression of cells.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. Rab GTPase activator activity Source: MGI
    3. Rab GTPase binding Source: UniProtKB
    4. small GTPase regulator activity Source: UniProtKB

    GO - Biological processi

    1. cell cycle arrest Source: UniProtKB-KW
    2. positive regulation of protein catabolic process Source: UniProtKB
    3. positive regulation of Rab GTPase activity Source: GOC
    4. Rap protein signal transduction Source: UniProtKB
    5. regulation of Rab protein signal transduction Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Growth arrest

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Small G protein signaling modulator 3
    Alternative name(s):
    RUN and TBC1 domain-containing protein 3
    Gene namesi
    Name:Sgsm3By similarity
    Synonyms:Cip85Imported, Rutbc3Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1916329. Sgsm3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. gap junction Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 750750Small G protein signaling modulator 3PRO_0000307811Add
    BLAST

    Proteomic databases

    MaxQBiQ8VCZ6.
    PaxDbiQ8VCZ6.
    PRIDEiQ8VCZ6.

    PTM databases

    PhosphoSiteiQ8VCZ6.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ8VCZ6.
    BgeeiQ8VCZ6.
    CleanExiMM_SGSM3.
    GenevestigatoriQ8VCZ6.

    Interactioni

    Subunit structurei

    Interacts with GJA1. Interaction with GJA1 induces its degradation. Interacts via its RUN domain with the C-terminal region of NF2. Interacts with RAB3A, RAB4A, RAB5A, RAB8A, RAB11A, RAP1A, RAP1B, RAP2A, RAP2B and PDCD6I. No interaction with RAB27A By similarity.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Gja1P080504EBI-525155,EBI-476947From a different organism.

    Protein-protein interaction databases

    IntActiQ8VCZ6. 1 interaction.
    MINTiMINT-1326710.

    Structurei

    Secondary structure

    1
    750
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi483 – 4897
    Beta strandi506 – 5116
    Beta strandi514 – 5229
    Beta strandi525 – 5306
    Helixi531 – 5333
    Beta strandi534 – 5374

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YUONMR-A483-547[»]
    ProteinModelPortaliQ8VCZ6.
    SMRiQ8VCZ6. Positions 73-375, 480-551.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8VCZ6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini114 – 305192Rab-GAP TBCPROSITE-ProRule annotationAdd
    BLAST
    Domaini480 – 53960SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini555 – 718164RUNPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili415 – 43925Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Rab-GAP TBC domain.PROSITE-ProRule annotation
    Contains 1 RUN domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, SH3 domain

    Phylogenomic databases

    eggNOGiCOG5210.
    GeneTreeiENSGT00710000106533.
    HOGENOMiHOG000007875.
    HOVERGENiHBG108484.
    InParanoidiQ8VCZ6.
    OrthoDBiEOG70KGP2.
    PhylomeDBiQ8VCZ6.

    Family and domain databases

    InterProiIPR000195. Rab-GTPase-TBC_dom.
    IPR004012. Run.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00566. RabGAP-TBC. 1 hit.
    PF02759. RUN. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00593. RUN. 1 hit.
    SM00326. SH3. 1 hit.
    SM00164. TBC. 1 hit.
    [Graphical view]
    SUPFAMiSSF47923. SSF47923. 2 hits.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS50826. RUN. 1 hit.
    PS50002. SH3. 1 hit.
    PS50086. TBC_RABGAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VCZ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGNHTPSAS GPFSALTPSI WPQEILAKYS QKEESSEQPE LCYDEFGFRV    50
    DKEGSEPGCS QMTGSPLVED PPQRLRWQAH LEFTHNHDVG DLTWDKIAVS 100
    LPRSEKLRSL VLAGIPHGMR PQLWMRLSGA LQKKKNSELS YREIIKNSSN 150
    DETIAAKQIE KDLLRTMPSN ACFANVNSIG VPRLRRVLRA LAWLYPEIGY 200
    CQGTGMVAAC LLLFLEEEDA FWMMCAIIED LLPASYFSTT LLGVQTDQRV 250
    LRHLIVQYLP RLDKLLQEHD IELSLITLHW FLTAFASVVH IRLLLRIWDL 300
    FFYEGSLVLF QTTLGMLRLK EEELIQSENS ASIFNTLSDI PAQMDDAELL 350
    LGEAMRLAGS LTDVAVETQR RKHLAYLIAD QGQTLGTGTT TNLSQVVRRR 400
    TQRRKSGITS LLFGEDDLEA LKAKNIKQTE LVADLREAIL RVARHFQCTD 450
    PKNCSVELTP DYSMESHQRD HENYVACLRS HRRRAKALLD FERHDDDELG 500
    FRKNDIITII SQKDEHCWVG ELNGLRGWFP AKFVEVLDER SKEYSIAGDD 550
    SVTEGVTDLV RGTLCPALKA LFEHGLKKPS LLGGACHPWL FIEEAAGREV 600
    ERDFDSVYSR LVLCKTYRLD EDGKVLTPEE LLYRAVQSVN VTHDAAHAQM 650
    DVKLRSLICV GLNEQVLHLW LEVLCSSLPT VEKWYQPWSF LRSPGWVQIK 700
    CELRVLCCFA FSLSQDWELP ARREEEKQPL KEGVQDMLVK HHLFSWDIDG 750
    Length:750
    Mass (Da):85,490
    Last modified:March 1, 2002 - v1
    Checksum:iC0306BE346808B07
    GO

    Sequence cautioni

    The sequence BAE42041.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti622 – 6221D → G in BAE42041. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY382616 mRNA. Translation: AAR89983.1.
    AK170806 mRNA. Translation: BAE42041.1. Different initiation.
    BC018197 mRNA. Translation: AAH18197.1.
    BC024122 mRNA. Translation: AAH24122.1.
    BC025561 mRNA. Translation: AAH25561.1.
    RefSeqiNP_598852.2. NM_134091.2.
    UniGeneiMm.274943.

    Genome annotation databases

    EnsembliENSMUST00000139517; ENSMUSP00000122543; ENSMUSG00000042303.
    GeneIDi105835.
    KEGGimmu:105835.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY382616 mRNA. Translation: AAR89983.1 .
    AK170806 mRNA. Translation: BAE42041.1 . Different initiation.
    BC018197 mRNA. Translation: AAH18197.1 .
    BC024122 mRNA. Translation: AAH24122.1 .
    BC025561 mRNA. Translation: AAH25561.1 .
    RefSeqi NP_598852.2. NM_134091.2.
    UniGenei Mm.274943.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YUO NMR - A 483-547 [» ]
    ProteinModelPortali Q8VCZ6.
    SMRi Q8VCZ6. Positions 73-375, 480-551.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8VCZ6. 1 interaction.
    MINTi MINT-1326710.

    PTM databases

    PhosphoSitei Q8VCZ6.

    Proteomic databases

    MaxQBi Q8VCZ6.
    PaxDbi Q8VCZ6.
    PRIDEi Q8VCZ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000139517 ; ENSMUSP00000122543 ; ENSMUSG00000042303 .
    GeneIDi 105835.
    KEGGi mmu:105835.

    Organism-specific databases

    CTDi 27352.
    MGIi MGI:1916329. Sgsm3.

    Phylogenomic databases

    eggNOGi COG5210.
    GeneTreei ENSGT00710000106533.
    HOGENOMi HOG000007875.
    HOVERGENi HBG108484.
    InParanoidi Q8VCZ6.
    OrthoDBi EOG70KGP2.
    PhylomeDBi Q8VCZ6.

    Miscellaneous databases

    EvolutionaryTracei Q8VCZ6.
    NextBioi 357910.
    PROi Q8VCZ6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VCZ6.
    Bgeei Q8VCZ6.
    CleanExi MM_SGSM3.
    Genevestigatori Q8VCZ6.

    Family and domain databases

    InterProi IPR000195. Rab-GTPase-TBC_dom.
    IPR004012. Run.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00566. RabGAP-TBC. 1 hit.
    PF02759. RUN. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00593. RUN. 1 hit.
    SM00326. SH3. 1 hit.
    SM00164. TBC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47923. SSF47923. 2 hits.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS50826. RUN. 1 hit.
    PS50002. SH3. 1 hit.
    PS50086. TBC_RABGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation."
      Lan Z., Kurata W.E., Martyn K.D., Jin C., Lau A.F.
      Biochemistry 44:2385-2396(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH GJA1.
      Tissue: EmbryoImported.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NODImported.
      Tissue: Dendritic cellImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: LiverImported, Mammary tumorImported and Salivary glandImported.
    4. "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway."
      Yang H., Sasaki T., Minoshima S., Shimizu N.
      Genomics 90:249-260(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: LiverCurated.
    6. "Solution structure of the SH3 domain of mouse RUN and TBC1 domain containing 3."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 483-549.

    Entry informationi

    Entry nameiSGSM3_MOUSE
    AccessioniPrimary (citable) accession number: Q8VCZ6
    Secondary accession number(s): Q3TCB6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3