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Q8VCY8 (LPPR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid phosphate phosphatase-related protein type 2
EC=3.1.3.4
Alternative name(s):
Plasticity-related gene 4 protein
Short name=PRG-4
Gene names
Name:Lppr2
Synonyms:Prg4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionHydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionphosphatidate phosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8VCY8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8VCY8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     317-343: NPRPAGRIRHRHGSPHPSRRTVPAVAT → LSVAQEPETC...YLFASRDHLL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 343343Lipid phosphate phosphatase-related protein type 2
PRO_0000317539

Regions

Transmembrane12 – 3221Helical; Potential
Transmembrane72 – 9221Helical; Potential
Transmembrane129 – 14921Helical; Potential
Transmembrane210 – 23021Helical; Potential
Transmembrane239 – 25921Helical; Potential
Transmembrane266 – 28621Helical; Potential

Amino acid modifications

Glycosylation1651N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence317 – 34327NPRPA…PAVAT → LSVAQEPETCRPHSTPARLT PSKPQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLHPSPFH RDNFSPYLFASRDHLL in isoform 2.
VSP_031012

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: DE2F7F0F0F8215FD

FASTA34336,936
        10         20         30         40         50         60 
MAGGRPHLKR SFSIIPCFVF VESVLLGIVV LLAYRLEFTD TFPVHTQGFF CYDSAYAKPY 

        70         80         90        100        110        120 
PGPEAASRAP PALIYALVTA GPTLTILLGE LARAFFPAPP SSSPVSGEST IVSGACCRFS 

       130        140        150        160        170        180 
PPLRRLVRFL GVYSFGLFTT TIFANAGQVV TGNPTPHFLS VCRPNYTALG CPPPSPDRPG 

       190        200        210        220        230        240 
PDRFVTDQSA CAGSPSLVAA ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL 

       250        260        270        280        290        300 
CLALLCPAFL VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPHSGRRLSP 

       310        320        330        340 
WEDLSQAPTM DSPLEKNPRP AGRIRHRHGS PHPSRRTVPA VAT

« Hide

Isoform 2 [UniParc].

Checksum: 7EE07C36C1EB352C
Show »

FASTA45248,408

References

« Hide 'large scale' references
[1]"Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family."
Savaskan N.E., Brauer A.U., Nitsch R.
Eur. J. Neurosci. 19:212-220(2004) [PubMed: 14750979] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Cerebellum.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Eye.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY438023 mRNA. Translation: AAR98841.1.
AK082453 mRNA. Translation: BAC38494.1.
BC018242 mRNA. Translation: AAH18242.1.
BC023082 mRNA. Translation: AAH23082.1.
IPIIPI00222105.
IPI00885978.
RefSeqNP_659184.1. NM_144935.1.
UniGeneMm.277521.

3D structure databases

ProteinModelPortalQ8VCY8.
ModBaseSearch...

PTM databases

PhosphoSiteQ8VCY8.

Proteomic databases

PRIDEQ8VCY8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046371; ENSMUSP00000038616; ENSMUSG00000040563.
GeneID235044.
KEGGmmu:235044.
UCSCuc009ona.1. mouse.
uc009onb.1. mouse.

Organism-specific databases

MGIMGI:2384575. BC018242.

Phylogenomic databases

eggNOGroNOG13019.
GeneTreeENSGT00550000074203.
HOGENOMHBG445665.
HOVERGENHBG108093.
InParanoidQ8VCY8.
OMADSAYAKP.
OrthoDBEOG4SF96H.

Gene expression databases

ArrayExpressQ8VCY8.
BgeeQ8VCY8.
CleanExMM_BC018242.
GenevestigatorQ8VCY8.

Family and domain databases

InterProIPR016118. P_Acid_Pase/Cl_peroxidase_N.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
Gene3DG3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
PfamPF01569. PAP2. 1 hit.
[Graphical view]
SMARTSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMSSF48317. AcPase_VanPerase. 1 hit.
ProtoNetSearch...

Other

NextBio382485.
SOURCESearch...

Entry information

Entry nameLPPR2_MOUSE
AccessionPrimary (citable) accession number: Q8VCY8
Secondary accession number(s): Q8BIE4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2002
Last modified: September 21, 2011
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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