Reviewed, UniProtKB/Swiss-Prot Q8VCY8 (LPPR2_MOUSE)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphatase-related protein type 2
    EC=3.1.3.4
Alternative name(s):
    Plasticity-related gene 4 protein
      Short name=PRG-4

Gene names

Name:	Lppr2
Synonyms:	Prg4

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8VCY8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8VCY8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     317-343: NPRPAGRIRHRHGSPHPSRRTVPAVAT → LSVAQEPETC...YLFASRDHLL

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Lipid phosphate phosphatase-related protein type 2		PRO_0000317539
Regions
	Transmembrane	12 – 32	21	Potential
	Transmembrane	72 – 92	21	Potential
	Transmembrane	129 – 149	21	Potential
	Transmembrane	210 – 230	21	Potential
	Transmembrane	239 – 259	21	Potential
	Transmembrane	266 – 286	21	Potential
Amino acid modifications
	Glycosylation	165	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	317 – 343	27	NPRPA…PAVAT → LSVAQEPETCRPHSTPARLT PSKPQNCARRGHLIPSCVSS RAPAMCSSPRVPRPRLRSEP TPLPLPLPLPAPTPSQGPSP SSPGPGGPGGGGGRGRKLLL PTPLLRDLYTLSGLHPSPFH RDNFSPYLFASRDHLL in isoform 2.		VSP_031012

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: DE2F7F0F0F8215FD	FASTA	343	36,936
	10 20 30 40 50 60 MAGGRPHLKR SFSIIPCFVF VESVLLGIVV LLAYRLEFTD TFPVHTQGFF CYDSAYAKPY 70 80 90 100 110 120 PGPEAASRAP PALIYALVTA GPTLTILLGE LARAFFPAPP SSSPVSGEST IVSGACCRFS 130 140 150 160 170 180 PPLRRLVRFL GVYSFGLFTT TIFANAGQVV TGNPTPHFLS VCRPNYTALG CPPPSPDRPG 190 200 210 220 230 240 PDRFVTDQSA CAGSPSLVAA ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL 250 260 270 280 290 300 CLALLCPAFL VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPHSGRRLSP 310 320 330 340 WEDLSQAPTM DSPLEKNPRP AGRIRHRHGS PHPSRRTVPA VAT
	Isoform 2. Checksum: 7EE07C36C1EB352C	FASTA	452	48,408
	10 20 30 40 50 60 MAGGRPHLKR SFSIIPCFVF VESVLLGIVV LLAYRLEFTD TFPVHTQGFF CYDSAYAKPY 70 80 90 100 110 120 PGPEAASRAP PALIYALVTA GPTLTILLGE LARAFFPAPP SSSPVSGEST IVSGACCRFS 130 140 150 160 170 180 PPLRRLVRFL GVYSFGLFTT TIFANAGQVV TGNPTPHFLS VCRPNYTALG CPPPSPDRPG 190 200 210 220 230 240 PDRFVTDQSA CAGSPSLVAA ARRAFPCKDA ALCAYAVTYT AMYVTLVFRV KGSRLVKPSL 250 260 270 280 290 300 CLALLCPAFL VGVVRVAEYR NHWSDVLAGF LTGAAIATFL VTCVVHNFQS RPHSGRRLSP 310 320 330 340 350 360 WEDLSQAPTM DSPLEKLSVA QEPETCRPHS TPARLTPSKP QNCARRGHLI PSCVSSRAPA 370 380 390 400 410 420 MCSSPRVPRP RLRSEPTPLP LPLPLPAPTP SQGPSPSSPG PGGPGGGGGR GRKLLLPTPL 430 440 450 LRDLYTLSGL HPSPFHRDNF SPYLFASRDH LL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family." Savaskan N.E., Brauer A.U., Nitsch R. Eur. J. Neurosci. 19:212-220(2004) [PubMed: 14750979] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Brain.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Cerebellum.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Eye.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY438023 mRNA. Translation: AAR98841.1. AK082453 mRNA. Translation: BAC38494.1. BC018242 mRNA. Translation: AAH18242.1. BC023082 mRNA. Translation: AAH23082.1.
IPI	IPI00222105. IPI00885978.
RefSeq	NP_659184.1.
UniGene	Mm.277521
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8VCY8.
Genome annotation databases
Ensembl	ENSMUST00000046371; ENSMUSP00000038616; ENSMUSG00000040563; Mus musculus. [Genome view]
GeneID	235044.
KEGG	mmu:235044.
UCSC	uc009onb.1. mouse.
Organism-specific databases
MGI	MGI:2384575. BC018242.
Phylogenomic databases
eggNOG	roNOG13019.
HOGENOM	HBG445665.
HOVERGEN	Q8VCY8.
InParanoid	Q8VCY8.
OMA	MCSSPRV.
Enzyme and pathway databases
BRENDA	3.1.3.4. 244.
Gene expression databases
ArrayExpress	Q8VCY8.
Bgee	Q8VCY8.
CleanEx	MM_BC018242.
Genevestigator	Q8VCY8.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	382485.
SOURCE	Search...

Entry information

Entry name

LPPR2_MOUSE

Accession

Primary (citable) accession number: Q8VCY8
Secondary accession number(s): Q8BIE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 1, 2002
Last modified:	February 9, 2010
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)