Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

KICSTOR complex protein kaptin

Gene

Kptn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
KICSTOR complex protein kaptinCurated
Gene namesi
Name:KptnImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1890380. Kptn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392351 – 430KICSTOR complex protein kaptinAdd BLAST430

Proteomic databases

EPDiQ8VCX6.
MaxQBiQ8VCX6.
PaxDbiQ8VCX6.
PRIDEiQ8VCX6.

PTM databases

PhosphoSitePlusiQ8VCX6.

Expressioni

Gene expression databases

CleanExiMM_KPTN.

Interactioni

Subunit structurei

Part of the KICSTOR complex composed of KPTN, ITFG2, C12orf66 and SZT2. SZT2 probably serves as a link between the other three proteins in the KICSTOR complex and mediates the direct interaction with the GATOR1 complex. May associate with F-actin filaments.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006178.

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IJRR. Eukaryota.
ENOG41100KB. LUCA.
HOGENOMiHOG000008052.
HOVERGENiHBG061148.
InParanoidiQ8VCX6.
PhylomeDBiQ8VCX6.

Family and domain databases

InterProiView protein in InterPro
IPR029982. Kptn.
PANTHERiPTHR15435. PTHR15435. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VCX6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEAAVAEGP CPLLEDSFTR FSSQSNVYGL AGGADGRGEL LAATLKGKVL
60 70 80 90 100
GFRYQDLRQK IRPVAKELQF NYIPVDAEIV SIDTFNKSPP KRGLVVGITF
110 120 130 140 150
IKDSGDKGSP FLNIYCDYEP GSEYNLDSIA ESCLNLELQF TPFQLCHAEV
160 170 180 190 200
QVGDQLETVF LLSGNDPAIH LYKENEGLHQ FEEQPVENLF PELTNLTSSV
210 220 230 240 250
LWLDVHNLPG SSQRLSALGC QSGYVRVAHV DQKNQEILQT WTIQQDGPIS
260 270 280 290 300
RVIVFSLSAS EATQDSPQQE GYSLLVASML EPAVVYWDLL NKGLDDQLLL
310 320 330 340 350
PGSDQFDSVL CGLVTDVDLD GQLEVLVATY GQELLCYKYR GLPEDSRGFR
360 370 380 390 400
LLWRRSFASP LLAMAHVDLT GDGLRELAVI SLKGVHILQH SLIQASELVL
410 420 430
TRLRHQVEQR KHQQGLGDRV GPRPVEHPAS
Length:430
Mass (Da):47,545
Last modified:March 1, 2002 - v1
Checksum:i9A4A897DCFF8C2CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018316 mRNA. Translation: AAH18316.1.
CCDSiCCDS20844.1.
UniGeneiMm.41101.

Similar proteinsi

Entry informationi

Entry nameiKPTN_MOUSE
AccessioniPrimary (citable) accession number: Q8VCX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: October 25, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot