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Q8VCX6 (KPTN_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kaptin
Gene names
Name:Kptn
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length430 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Necessary for normal neuromorphogenesis. May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation By similarity.

Subunit structure

Associates with one end of F-actin filaments By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Cell projectionstereocilium By similarity. Cell projectiongrowth cone By similarity. Note: Perinuclear at the tips of stereocilium in the inner ear. Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones By similarity.

Ontologies

Keywords
   Cellular componentCell projection
Cytoplasm
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentgrowth cone

Inferred from electronic annotation. Source: UniProtKB-SubCell

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

stereocilium

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 430430Kaptin
PRO_0000239235

Sequences

Sequence LengthMass (Da)Tools
Q8VCX6 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 9A4A897DCFF8C2CC

FASTA43047,545
        10         20         30         40         50         60 
MGEAAVAEGP CPLLEDSFTR FSSQSNVYGL AGGADGRGEL LAATLKGKVL GFRYQDLRQK 

        70         80         90        100        110        120 
IRPVAKELQF NYIPVDAEIV SIDTFNKSPP KRGLVVGITF IKDSGDKGSP FLNIYCDYEP 

       130        140        150        160        170        180 
GSEYNLDSIA ESCLNLELQF TPFQLCHAEV QVGDQLETVF LLSGNDPAIH LYKENEGLHQ 

       190        200        210        220        230        240 
FEEQPVENLF PELTNLTSSV LWLDVHNLPG SSQRLSALGC QSGYVRVAHV DQKNQEILQT 

       250        260        270        280        290        300 
WTIQQDGPIS RVIVFSLSAS EATQDSPQQE GYSLLVASML EPAVVYWDLL NKGLDDQLLL 

       310        320        330        340        350        360 
PGSDQFDSVL CGLVTDVDLD GQLEVLVATY GQELLCYKYR GLPEDSRGFR LLWRRSFASP 

       370        380        390        400        410        420 
LLAMAHVDLT GDGLRELAVI SLKGVHILQH SLIQASELVL TRLRHQVEQR KHQQGLGDRV 

       430 
GPRPVEHPAS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC018316 mRNA. Translation: AAH18316.1.
CCDSCCDS20844.1.
UniGeneMm.41101.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8VCX6.

Proteomic databases

PaxDbQ8VCX6.
PRIDEQ8VCX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1890380. Kptn.

Phylogenomic databases

eggNOGNOG38850.
HOGENOMHOG000008052.
HOVERGENHBG061148.
InParanoidQ8VCX6.
PhylomeDBQ8VCX6.

Gene expression databases

CleanExMM_KPTN.
GenevestigatorQ8VCX6.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSKPTN. mouse.
PROQ8VCX6.
SOURCESearch...

Entry information

Entry nameKPTN_MOUSE
AccessionPrimary (citable) accession number: Q8VCX6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot