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Q8VCX6

- KPTN_MOUSE

UniProt

Q8VCX6 - KPTN_MOUSE

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Protein

Kaptin

Gene
Kptn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Necessary for normal neuromorphogenesis. May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation By similarity.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kaptin
Gene namesi
Name:Kptn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1890380. Kptn.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Cell projectionstereocilium By similarity. Cell projectiongrowth cone By similarity
Note: Perinuclear at the tips of stereocilium in the inner ear. Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones By similarity.

GO - Cellular componenti

  1. growth cone Source: UniProtKB-SubCell
  2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
  3. stereocilium Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430KaptinPRO_0000239235Add
BLAST

Proteomic databases

PaxDbiQ8VCX6.
PRIDEiQ8VCX6.

PTM databases

PhosphoSiteiQ8VCX6.

Expressioni

Gene expression databases

CleanExiMM_KPTN.
GenevestigatoriQ8VCX6.

Interactioni

Subunit structurei

Associates with one end of F-actin filaments By similarity.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG38850.
HOGENOMiHOG000008052.
HOVERGENiHBG061148.
InParanoidiQ8VCX6.
PhylomeDBiQ8VCX6.

Sequencei

Sequence statusi: Complete.

Q8VCX6-1 [UniParc]FASTAAdd to Basket

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MGEAAVAEGP CPLLEDSFTR FSSQSNVYGL AGGADGRGEL LAATLKGKVL    50
GFRYQDLRQK IRPVAKELQF NYIPVDAEIV SIDTFNKSPP KRGLVVGITF 100
IKDSGDKGSP FLNIYCDYEP GSEYNLDSIA ESCLNLELQF TPFQLCHAEV 150
QVGDQLETVF LLSGNDPAIH LYKENEGLHQ FEEQPVENLF PELTNLTSSV 200
LWLDVHNLPG SSQRLSALGC QSGYVRVAHV DQKNQEILQT WTIQQDGPIS 250
RVIVFSLSAS EATQDSPQQE GYSLLVASML EPAVVYWDLL NKGLDDQLLL 300
PGSDQFDSVL CGLVTDVDLD GQLEVLVATY GQELLCYKYR GLPEDSRGFR 350
LLWRRSFASP LLAMAHVDLT GDGLRELAVI SLKGVHILQH SLIQASELVL 400
TRLRHQVEQR KHQQGLGDRV GPRPVEHPAS 430
Length:430
Mass (Da):47,545
Last modified:March 1, 2002 - v1
Checksum:i9A4A897DCFF8C2CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC018316 mRNA. Translation: AAH18316.1.
CCDSiCCDS20844.1.
UniGeneiMm.41101.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC018316 mRNA. Translation: AAH18316.1 .
CCDSi CCDS20844.1.
UniGenei Mm.41101.

3D structure databases

ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VCX6.

Proteomic databases

PaxDbi Q8VCX6.
PRIDEi Q8VCX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:1890380. Kptn.

Phylogenomic databases

eggNOGi NOG38850.
HOGENOMi HOG000008052.
HOVERGENi HBG061148.
InParanoidi Q8VCX6.
PhylomeDBi Q8VCX6.

Miscellaneous databases

ChiTaRSi KPTN. mouse.
PROi Q8VCX6.
SOURCEi Search...

Gene expression databases

CleanExi MM_KPTN.
Genevestigatori Q8VCX6.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.

Entry informationi

Entry nameiKPTN_MOUSE
AccessioniPrimary (citable) accession number: Q8VCX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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