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Q8VCX6

- KPTN_MOUSE

UniProt

Q8VCX6 - KPTN_MOUSE

Protein

Kaptin

Gene

Kptn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Necessary for normal neuromorphogenesis. May be involved in actin dynamics. May play a role in producing the sensory apparatus in hair cells. May play a role in actin rearrangements that accompany platelet activation and stereocilia formation By similarity.By similarity

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kaptin
    Gene namesi
    Name:Kptn
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1890380. Kptn.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmperinuclear region By similarity. Cell projectionstereocilium By similarity. Cell projectiongrowth cone By similarity
    Note: Perinuclear at the tips of stereocilium in the inner ear. Localized at sites of actin polymerization in motile fibroblasts and neuronal growth cones By similarity.By similarity

    GO - Cellular componenti

    1. growth cone Source: UniProtKB-SubCell
    2. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    3. stereocilium Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 430430KaptinPRO_0000239235Add
    BLAST

    Proteomic databases

    PaxDbiQ8VCX6.
    PRIDEiQ8VCX6.

    PTM databases

    PhosphoSiteiQ8VCX6.

    Expressioni

    Gene expression databases

    CleanExiMM_KPTN.
    GenevestigatoriQ8VCX6.

    Interactioni

    Subunit structurei

    Associates with one end of F-actin filaments.By similarity

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG38850.
    HOGENOMiHOG000008052.
    HOVERGENiHBG061148.
    InParanoidiQ8VCX6.
    PhylomeDBiQ8VCX6.

    Sequencei

    Sequence statusi: Complete.

    Q8VCX6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEAAVAEGP CPLLEDSFTR FSSQSNVYGL AGGADGRGEL LAATLKGKVL    50
    GFRYQDLRQK IRPVAKELQF NYIPVDAEIV SIDTFNKSPP KRGLVVGITF 100
    IKDSGDKGSP FLNIYCDYEP GSEYNLDSIA ESCLNLELQF TPFQLCHAEV 150
    QVGDQLETVF LLSGNDPAIH LYKENEGLHQ FEEQPVENLF PELTNLTSSV 200
    LWLDVHNLPG SSQRLSALGC QSGYVRVAHV DQKNQEILQT WTIQQDGPIS 250
    RVIVFSLSAS EATQDSPQQE GYSLLVASML EPAVVYWDLL NKGLDDQLLL 300
    PGSDQFDSVL CGLVTDVDLD GQLEVLVATY GQELLCYKYR GLPEDSRGFR 350
    LLWRRSFASP LLAMAHVDLT GDGLRELAVI SLKGVHILQH SLIQASELVL 400
    TRLRHQVEQR KHQQGLGDRV GPRPVEHPAS 430
    Length:430
    Mass (Da):47,545
    Last modified:March 1, 2002 - v1
    Checksum:i9A4A897DCFF8C2CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC018316 mRNA. Translation: AAH18316.1.
    CCDSiCCDS20844.1.
    UniGeneiMm.41101.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC018316 mRNA. Translation: AAH18316.1 .
    CCDSi CCDS20844.1.
    UniGenei Mm.41101.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8VCX6.

    Proteomic databases

    PaxDbi Q8VCX6.
    PRIDEi Q8VCX6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1890380. Kptn.

    Phylogenomic databases

    eggNOGi NOG38850.
    HOGENOMi HOG000008052.
    HOVERGENi HBG061148.
    InParanoidi Q8VCX6.
    PhylomeDBi Q8VCX6.

    Miscellaneous databases

    ChiTaRSi KPTN. mouse.
    PROi Q8VCX6.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_KPTN.
    Genevestigatori Q8VCX6.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.

    Entry informationi

    Entry nameiKPTN_MOUSE
    AccessioniPrimary (citable) accession number: Q8VCX6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3