ID   S35C2_MOUSE             Reviewed;         364 AA.
AC   Q8VCX2;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 141.
DE   RecName: Full=Solute carrier family 35 member C2;
DE   AltName: Full=Ovarian cancer-overexpressed gene 1 protein;
GN   Name=Slc35c2; Synonyms=Ovcov1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Salivary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=12461647; DOI=10.1007/s00335-002-2185-4;
RA   Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H.,
RA   Armant D.R., Krawetz S.A.;
RT   "Identification, molecular characterization, and tissue expression of
RT   OVCOV1.";
RL   Mamm. Genome 13:619-624(2002).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC   and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May play an important role in the cellular response to tissue
CC       hypoxia. May be either a GDP-fucose transporter that competes with
CC       SLC35C1 for GDP-fucose, or a factor that otherwise enhances the
CC       fucosylation of Notch and is required for optimal Notch signaling in
CC       mammalian cells (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q9NQQ7}; Multi-pass membrane protein
CC       {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment
CC       membrane {ECO:0000250|UniProtKB:Q9NQQ7}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- DEVELOPMENTAL STAGE: Higher expression at embryo stage 7.5 dpc than 11-
CC       17 dpc. {ECO:0000269|PubMed:12461647}.
CC   -!- SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC018327; AAH18327.1; -; mRNA.
DR   CCDS; CCDS17074.1; -.
DR   RefSeq; NP_001239502.1; NM_001252573.1.
DR   RefSeq; NP_001239503.1; NM_001252574.1.
DR   RefSeq; NP_659142.1; NM_144893.2.
DR   RefSeq; XP_006499433.1; XM_006499370.3.
DR   RefSeq; XP_006499434.1; XM_006499371.3.
DR   RefSeq; XP_006499435.1; XM_006499372.3.
DR   RefSeq; XP_006499438.1; XM_006499375.3.
DR   AlphaFoldDB; Q8VCX2; -.
DR   SMR; Q8VCX2; -.
DR   STRING; 10090.ENSMUSP00000104923; -.
DR   TCDB; 2.A.7.9.8; the drug/metabolite transporter (dmt) superfamily.
DR   GlyCosmos; Q8VCX2; 1 site, No reported glycans.
DR   GlyGen; Q8VCX2; 1 site.
DR   iPTMnet; Q8VCX2; -.
DR   PhosphoSitePlus; Q8VCX2; -.
DR   jPOST; Q8VCX2; -.
DR   MaxQB; Q8VCX2; -.
DR   PaxDb; 10090-ENSMUSP00000104923; -.
DR   ProteomicsDB; 256885; -.
DR   Antibodypedia; 53835; 66 antibodies from 14 providers.
DR   DNASU; 228875; -.
DR   Ensembl; ENSMUST00000017808.14; ENSMUSP00000017808.8; ENSMUSG00000017664.17.
DR   Ensembl; ENSMUST00000109298.8; ENSMUSP00000104921.2; ENSMUSG00000017664.17.
DR   Ensembl; ENSMUST00000109299.8; ENSMUSP00000104922.2; ENSMUSG00000017664.17.
DR   Ensembl; ENSMUST00000109300.9; ENSMUSP00000104923.3; ENSMUSG00000017664.17.
DR   GeneID; 228875; -.
DR   KEGG; mmu:228875; -.
DR   UCSC; uc008nxd.2; mouse.
DR   AGR; MGI:2385166; -.
DR   CTD; 51006; -.
DR   MGI; MGI:2385166; Slc35c2.
DR   VEuPathDB; HostDB:ENSMUSG00000017664; -.
DR   eggNOG; KOG1443; Eukaryota.
DR   GeneTree; ENSGT00510000048078; -.
DR   HOGENOM; CLU_022332_1_3_1; -.
DR   InParanoid; Q8VCX2; -.
DR   OMA; CEFKLLT; -.
DR   OrthoDB; 72049at2759; -.
DR   PhylomeDB; Q8VCX2; -.
DR   TreeFam; TF314994; -.
DR   BioGRID-ORCS; 228875; 4 hits in 76 CRISPR screens.
DR   ChiTaRS; Slc35c2; mouse.
DR   PRO; PR:Q8VCX2; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; Q8VCX2; Protein.
DR   Bgee; ENSMUSG00000017664; Expressed in lacrimal gland and 260 other cell types or tissues.
DR   ExpressionAtlas; Q8VCX2; baseline and differential.
DR   GO; GO:0005801; C:cis-Golgi network; ISO:MGI.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; ISO:MGI.
DR   GO; GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
DR   GO; GO:0036065; P:fucosylation; IDA:MGI.
DR   GO; GO:0010629; P:negative regulation of gene expression; IDA:MGI.
DR   GO; GO:0045747; P:positive regulation of Notch signaling pathway; IDA:MGI.
DR   GO; GO:0036066; P:protein O-linked fucosylation; IDA:MGI.
DR   GO; GO:0015786; P:UDP-glucose transmembrane transport; IBA:GO_Central.
DR   CDD; cd21092; TPT_S35C2; 1.
DR   InterPro; IPR004853; Sugar_P_trans_dom.
DR   PANTHER; PTHR11132; SOLUTE CARRIER FAMILY 35; 1.
DR   PANTHER; PTHR11132:SF238; SOLUTE CARRIER FAMILY 35 MEMBER C2; 1.
DR   Pfam; PF03151; TPT; 1.
DR   Genevisible; Q8VCX2; MM.
PE   1: Evidence at protein level;
KW   Glycoprotein; Golgi apparatus; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..364
FT                   /note="Solute carrier family 35 member C2"
FT                   /id="PRO_0000213400"
FT   TRANSMEM        14..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        295..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         335
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19144319,
FT                   ECO:0007744|PubMed:21183079"
FT   MOD_RES         336
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NQQ7"
FT   CARBOHYD        102
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   364 AA;  40302 MW;  334B742A566FB891 CRC64;
     MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS
     ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL SNWSFLYITV SLYTMTKSSA
     VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW
     TLTQILLQKA DLGLQNPIDT MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL
     WVLGSLLLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
     LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE EDGEEEYFVT
     QGQQ
//