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Protein

Solute carrier family 35 member C2

Gene

Slc35c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity).By similarity

GO - Biological processi

  1. fucosylation Source: MGI
  2. negative regulation of gene expression Source: MGI
  3. positive regulation of Notch signaling pathway Source: MGI
  4. protein O-linked fucosylation Source: MGI
  5. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.9.8. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene namesi
Name:Slc35c2
Synonyms:Ovcov1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385166. Slc35c2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST
Transmembranei42 – 6221HelicalSequence AnalysisAdd
BLAST
Transmembranei104 – 12421HelicalSequence AnalysisAdd
BLAST
Transmembranei136 – 15621HelicalSequence AnalysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei238 – 25821HelicalSequence AnalysisAdd
BLAST
Transmembranei272 – 29221HelicalSequence AnalysisAdd
BLAST
Transmembranei295 – 31521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cis-Golgi network Source: MGI
  2. endoplasmic reticulum-Golgi intermediate compartment Source: MGI
  3. endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
  4. Golgi apparatus Source: UniProtKB-SubCell
  5. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 364364Solute carrier family 35 member C2PRO_0000213400Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
Modified residuei335 – 3351Phosphoserine1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8VCX2.
PRIDEiQ8VCX2.

PTM databases

PhosphoSiteiQ8VCX2.

Expressioni

Developmental stagei

Higher expression at embryo stage 7.5 dpc than 11-17 dpc.1 Publication

Gene expression databases

BgeeiQ8VCX2.
CleanExiMM_SLC35C2.
ExpressionAtlasiQ8VCX2. baseline and differential.
GenevestigatoriQ8VCX2.

Structurei

3D structure databases

ProteinModelPortaliQ8VCX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00510000048078.
HOGENOMiHOG000007454.
HOVERGENiHBG055852.
InParanoidiQ8VCX2.
KOiK15280.
OMAiRMGRWAL.
OrthoDBiEOG7TTQ93.
PhylomeDBiQ8VCX2.
TreeFamiTF314994.

Family and domain databases

InterProiIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM
60 70 80 90 100
LHLAVIFLFS ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL
110 120 130 140 150
SNWSFLYITV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG
160 170 180 190 200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQILLQKA DLGLQNPIDT
210 220 230 240 250
MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL WVLGSLLLGG
260 270 280 290 300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
310 320 330 340 350
LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE
360
EDGEEEYFVT QGQQ
Length:364
Mass (Da):40,302
Last modified:March 1, 2002 - v1
Checksum:i334B742A566FB891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018327 mRNA. Translation: AAH18327.1.
CCDSiCCDS17074.1.
RefSeqiNP_001239502.1. NM_001252573.1.
NP_001239503.1. NM_001252574.1.
NP_659142.1. NM_144893.2.
XP_006499433.1. XM_006499370.2.
XP_006499434.1. XM_006499371.2.
XP_006499435.1. XM_006499372.2.
XP_006499438.1. XM_006499375.2.
UniGeneiMm.21184.
Mm.488746.

Genome annotation databases

EnsembliENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664.
ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664.
ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664.
ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664.
GeneIDi228875.
KEGGimmu:228875.
UCSCiuc008nxd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018327 mRNA. Translation: AAH18327.1.
CCDSiCCDS17074.1.
RefSeqiNP_001239502.1. NM_001252573.1.
NP_001239503.1. NM_001252574.1.
NP_659142.1. NM_144893.2.
XP_006499433.1. XM_006499370.2.
XP_006499434.1. XM_006499371.2.
XP_006499435.1. XM_006499372.2.
XP_006499438.1. XM_006499375.2.
UniGeneiMm.21184.
Mm.488746.

3D structure databases

ProteinModelPortaliQ8VCX2.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi2.A.7.9.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteiQ8VCX2.

Proteomic databases

PaxDbiQ8VCX2.
PRIDEiQ8VCX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664.
ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664.
ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664.
ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664.
GeneIDi228875.
KEGGimmu:228875.
UCSCiuc008nxd.2. mouse.

Organism-specific databases

CTDi51006.
MGIiMGI:2385166. Slc35c2.

Phylogenomic databases

eggNOGiCOG0697.
GeneTreeiENSGT00510000048078.
HOGENOMiHOG000007454.
HOVERGENiHBG055852.
InParanoidiQ8VCX2.
KOiK15280.
OMAiRMGRWAL.
OrthoDBiEOG7TTQ93.
PhylomeDBiQ8VCX2.
TreeFamiTF314994.

Miscellaneous databases

ChiTaRSiSlc35c2. mouse.
NextBioi379228.
PROiQ8VCX2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VCX2.
CleanExiMM_SLC35C2.
ExpressionAtlasiQ8VCX2. baseline and differential.
GenevestigatoriQ8VCX2.

Family and domain databases

InterProiIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Salivary gland.
  2. "Identification, molecular characterization, and tissue expression of OVCOV1."
    Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H., Armant D.R., Krawetz S.A.
    Mamm. Genome 13:619-624(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  3. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS35C2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: April 1, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.