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Q8VCX2

- S35C2_MOUSE

UniProt

Q8VCX2 - S35C2_MOUSE

Protein

Solute carrier family 35 member C2

Gene

Slc35c2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells By similarity.By similarity

    GO - Biological processi

    1. fucosylation Source: MGI
    2. negative regulation of gene expression Source: MGI
    3. positive regulation of Notch signaling pathway Source: MGI
    4. protein O-linked fucosylation Source: MGI
    5. transport Source: UniProtKB-KW

    Keywords - Biological processi

    Transport

    Protein family/group databases

    TCDBi2.A.7.9.8. the drug/metabolite transporter (dmt) superfamily.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 35 member C2
    Alternative name(s):
    Ovarian cancer-overexpressed gene 1 protein
    Gene namesi
    Name:Slc35c2
    Synonyms:Ovcov1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:2385166. Slc35c2.

    Subcellular locationi

    GO - Cellular componenti

    1. cis-Golgi network Source: MGI
    2. endoplasmic reticulum-Golgi intermediate compartment Source: MGI
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 364364Solute carrier family 35 member C2PRO_0000213400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Modified residuei335 – 3351Phosphoserine1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8VCX2.
    PRIDEiQ8VCX2.

    PTM databases

    PhosphoSiteiQ8VCX2.

    Expressioni

    Developmental stagei

    Higher expression at embryo stage 7.5 dpc than 11-17 dpc.1 Publication

    Gene expression databases

    ArrayExpressiQ8VCX2.
    BgeeiQ8VCX2.
    CleanExiMM_SLC35C2.
    GenevestigatoriQ8VCX2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VCX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei42 – 6221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei136 – 15621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei166 – 18621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei295 – 31521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0697.
    GeneTreeiENSGT00510000048078.
    HOGENOMiHOG000007454.
    HOVERGENiHBG055852.
    InParanoidiQ8VCX2.
    KOiK15280.
    OMAiRMGRWAL.
    OrthoDBiEOG7TTQ93.
    PhylomeDBiQ8VCX2.
    TreeFamiTF314994.

    Family and domain databases

    InterProiIPR004853. Tpt_PEP_trans_dom.
    [Graphical view]
    PfamiPF03151. TPT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VCX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM    50
    LHLAVIFLFS ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL 100
    SNWSFLYITV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG 150
    LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQILLQKA DLGLQNPIDT 200
    MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL WVLGSLLLGG 250
    ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 300
    LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE 350
    EDGEEEYFVT QGQQ 364
    Length:364
    Mass (Da):40,302
    Last modified:March 1, 2002 - v1
    Checksum:i334B742A566FB891
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC018327 mRNA. Translation: AAH18327.1.
    CCDSiCCDS17074.1.
    RefSeqiNP_001239502.1. NM_001252573.1.
    NP_001239503.1. NM_001252574.1.
    NP_659142.1. NM_144893.2.
    XP_006499433.1. XM_006499370.1.
    XP_006499434.1. XM_006499371.1.
    XP_006499435.1. XM_006499372.1.
    XP_006499436.1. XM_006499373.1.
    XP_006499437.1. XM_006499374.1.
    XP_006499438.1. XM_006499375.1.
    UniGeneiMm.21184.
    Mm.488746.

    Genome annotation databases

    EnsembliENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664.
    ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664.
    ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664.
    ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664.
    GeneIDi228875.
    KEGGimmu:228875.
    UCSCiuc008nxd.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC018327 mRNA. Translation: AAH18327.1 .
    CCDSi CCDS17074.1.
    RefSeqi NP_001239502.1. NM_001252573.1.
    NP_001239503.1. NM_001252574.1.
    NP_659142.1. NM_144893.2.
    XP_006499433.1. XM_006499370.1.
    XP_006499434.1. XM_006499371.1.
    XP_006499435.1. XM_006499372.1.
    XP_006499436.1. XM_006499373.1.
    XP_006499437.1. XM_006499374.1.
    XP_006499438.1. XM_006499375.1.
    UniGenei Mm.21184.
    Mm.488746.

    3D structure databases

    ProteinModelPortali Q8VCX2.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 2.A.7.9.8. the drug/metabolite transporter (dmt) superfamily.

    PTM databases

    PhosphoSitei Q8VCX2.

    Proteomic databases

    PaxDbi Q8VCX2.
    PRIDEi Q8VCX2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000017808 ; ENSMUSP00000017808 ; ENSMUSG00000017664 .
    ENSMUST00000109298 ; ENSMUSP00000104921 ; ENSMUSG00000017664 .
    ENSMUST00000109299 ; ENSMUSP00000104922 ; ENSMUSG00000017664 .
    ENSMUST00000109300 ; ENSMUSP00000104923 ; ENSMUSG00000017664 .
    GeneIDi 228875.
    KEGGi mmu:228875.
    UCSCi uc008nxd.2. mouse.

    Organism-specific databases

    CTDi 51006.
    MGIi MGI:2385166. Slc35c2.

    Phylogenomic databases

    eggNOGi COG0697.
    GeneTreei ENSGT00510000048078.
    HOGENOMi HOG000007454.
    HOVERGENi HBG055852.
    InParanoidi Q8VCX2.
    KOi K15280.
    OMAi RMGRWAL.
    OrthoDBi EOG7TTQ93.
    PhylomeDBi Q8VCX2.
    TreeFami TF314994.

    Miscellaneous databases

    ChiTaRSi SLC35C2. mouse.
    NextBioi 379228.
    PROi Q8VCX2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VCX2.
    Bgeei Q8VCX2.
    CleanExi MM_SLC35C2.
    Genevestigatori Q8VCX2.

    Family and domain databases

    InterProi IPR004853. Tpt_PEP_trans_dom.
    [Graphical view ]
    Pfami PF03151. TPT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Salivary gland.
    2. "Identification, molecular characterization, and tissue expression of OVCOV1."
      Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H., Armant D.R., Krawetz S.A.
      Mamm. Genome 13:619-624(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.
    3. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiS35C2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VCX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3