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Q8VCX2 (S35C2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene names
Name:Slc35c2
Synonyms:Ovcov1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play an important role in the cellular response to tissue hypoxia By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Developmental stage

Higher expression at embryo stage 7.5 dpc than 11-17 dpc.

Sequence similarities

Belongs to the TPT transporter family. SLC35C subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 364364Solute carrier family 35 member C2
PRO_0000213400

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane104 – 12421Helical; Potential
Transmembrane136 – 15621Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane238 – 25821Helical; Potential
Transmembrane272 – 29221Helical; Potential
Transmembrane295 – 31521Helical; Potential

Amino acid modifications

Modified residue3351Phosphoserine Ref.3
Glycosylation1021N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q8VCX2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 334B742A566FB891

FASTA36440,302
        10         20         30         40         50         60 
MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM LHLAVIFLFS 

        70         80         90        100        110        120 
ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL SNWSFLYITV SLYTMTKSSA 

       130        140        150        160        170        180 
VLFILIFSLI FKLEELRAAL VLVVLLIAGG LFMFTYKSTQ FNVEGFALVL GASFIGGIRW 

       190        200        210        220        230        240 
TLTQILLQKA DLGLQNPIDT MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL 

       250        260        270        280        290        300 
WVLGSLLLGG ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW 

       310        320        330        340        350        360 
LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE EDGEEEYFVT 


QGQQ 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Salivary gland.
[2]"Identification, molecular characterization, and tissue expression of OVCOV1."
Leach R.E., Duniec-Dmuchowski Z.M., Pesole G., Tanaka T.S., Ko M.S.H., Armant D.R., Krawetz S.A.
Mamm. Genome 13:619-624(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[3]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC018327 mRNA. Translation: AAH18327.1.
CCDSCCDS17074.1.
RefSeqNP_001239502.1. NM_001252573.1.
NP_001239503.1. NM_001252574.1.
NP_659142.1. NM_144893.2.
XP_006499433.1. XM_006499370.1.
XP_006499434.1. XM_006499371.1.
XP_006499435.1. XM_006499372.1.
XP_006499436.1. XM_006499373.1.
XP_006499437.1. XM_006499374.1.
XP_006499438.1. XM_006499375.1.
UniGeneMm.21184.
Mm.488746.

3D structure databases

ProteinModelPortalQ8VCX2.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

TCDB2.A.7.9.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

PhosphoSiteQ8VCX2.

Proteomic databases

PaxDbQ8VCX2.
PRIDEQ8VCX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664.
ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664.
ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664.
ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664.
GeneID228875.
KEGGmmu:228875.
UCSCuc008nxd.2. mouse.

Organism-specific databases

CTD51006.
MGIMGI:2385166. Slc35c2.

Phylogenomic databases

eggNOGCOG0697.
GeneTreeENSGT00510000048078.
HOGENOMHOG000007454.
HOVERGENHBG055852.
InParanoidQ8VCX2.
KOK15280.
OMARMGRWAL.
OrthoDBEOG7TTQ93.
PhylomeDBQ8VCX2.
TreeFamTF314994.

Gene expression databases

ArrayExpressQ8VCX2.
BgeeQ8VCX2.
CleanExMM_SLC35C2.
GenevestigatorQ8VCX2.

Family and domain databases

InterProIPR004853. Tpt_PEP_trans_dom.
[Graphical view]
PfamPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSLC35C2. mouse.
NextBio379228.
PROQ8VCX2.
SOURCESearch...

Entry information

Entry nameS35C2_MOUSE
AccessionPrimary (citable) accession number: Q8VCX2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot