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Protein

Solute carrier family 35 member C2

Gene

Slc35c2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play an important role in the cellular response to tissue hypoxia. May be either a GDP-fucose transporter that competes with SLC35C1 for GDP-fucose, or a factor that otherwise enhances the fucosylation of Notch and is required for optimal Notch signaling in mammalian cells (By similarity).By similarity

GO - Biological processi

  • fucosylation Source: MGI
  • negative regulation of gene expression Source: MGI
  • positive regulation of Notch signaling pathway Source: MGI
  • protein O-linked fucosylation Source: MGI
  • UDP-glucose transport Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Protein family/group databases

TCDBi2.A.7.9.8. the drug/metabolite transporter (dmt) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 35 member C2
Alternative name(s):
Ovarian cancer-overexpressed gene 1 protein
Gene namesi
Name:Slc35c2
Synonyms:Ovcov1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385166. Slc35c2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei14 – 34HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei136 – 156HelicalSequence analysisAdd BLAST21
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Transmembranei238 – 258HelicalSequence analysisAdd BLAST21
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002134001 – 364Solute carrier family 35 member C2Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...)Sequence analysis1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8VCX2.
PRIDEiQ8VCX2.

PTM databases

iPTMnetiQ8VCX2.
PhosphoSitePlusiQ8VCX2.

Expressioni

Developmental stagei

Higher expression at embryo stage 7.5 dpc than 11-17 dpc.1 Publication

Gene expression databases

BgeeiENSMUSG00000017664.
CleanExiMM_SLC35C2.
ExpressionAtlasiQ8VCX2. baseline and differential.
GenevisibleiQ8VCX2. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017808.

Structurei

3D structure databases

ProteinModelPortaliQ8VCX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1443. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00510000048078.
HOGENOMiHOG000007454.
HOVERGENiHBG055852.
InParanoidiQ8VCX2.
KOiK15280.
OMAiRMGRWAL.
OrthoDBiEOG091G09SR.
PhylomeDBiQ8VCX2.
TreeFamiTF314994.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRWALDVAF VWKAALTLGL VLLYYCFSIG ITFYNKWLTK SFHFPLFMTM
60 70 80 90 100
LHLAVIFLFS ALSRALVQCS SHKARVVLSW TDYLRRVAPT ALATALDVGL
110 120 130 140 150
SNWSFLYITV SLYTMTKSSA VLFILIFSLI FKLEELRAAL VLVVLLIAGG
160 170 180 190 200
LFMFTYKSTQ FNVEGFALVL GASFIGGIRW TLTQILLQKA DLGLQNPIDT
210 220 230 240 250
MFHLQPLMFL GLFPLFAIFE GLHLSTSEKI FRFQDTGLLL WVLGSLLLGG
260 270 280 290 300
ILAFGLGFSE FLLVSRTSSL TLSIAGIFKE VCTLLLAAHL LGDQISLLNW
310 320 330 340 350
LGFALCLSGI SLHVALKALH SRGDGGPKPL KSLGSSADLE LLLRSSQQEE
360
EDGEEEYFVT QGQQ
Length:364
Mass (Da):40,302
Last modified:March 1, 2002 - v1
Checksum:i334B742A566FB891
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018327 mRNA. Translation: AAH18327.1.
CCDSiCCDS17074.1.
RefSeqiNP_001239502.1. NM_001252573.1.
NP_001239503.1. NM_001252574.1.
NP_659142.1. NM_144893.2.
XP_006499433.1. XM_006499370.3.
XP_006499434.1. XM_006499371.3.
XP_006499435.1. XM_006499372.3.
XP_006499438.1. XM_006499375.3.
UniGeneiMm.21184.
Mm.488746.

Genome annotation databases

EnsembliENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664.
ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664.
ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664.
ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664.
GeneIDi228875.
KEGGimmu:228875.
UCSCiuc008nxd.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC018327 mRNA. Translation: AAH18327.1.
CCDSiCCDS17074.1.
RefSeqiNP_001239502.1. NM_001252573.1.
NP_001239503.1. NM_001252574.1.
NP_659142.1. NM_144893.2.
XP_006499433.1. XM_006499370.3.
XP_006499434.1. XM_006499371.3.
XP_006499435.1. XM_006499372.3.
XP_006499438.1. XM_006499375.3.
UniGeneiMm.21184.
Mm.488746.

3D structure databases

ProteinModelPortaliQ8VCX2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000017808.

Protein family/group databases

TCDBi2.A.7.9.8. the drug/metabolite transporter (dmt) superfamily.

PTM databases

iPTMnetiQ8VCX2.
PhosphoSitePlusiQ8VCX2.

Proteomic databases

PaxDbiQ8VCX2.
PRIDEiQ8VCX2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017808; ENSMUSP00000017808; ENSMUSG00000017664.
ENSMUST00000109298; ENSMUSP00000104921; ENSMUSG00000017664.
ENSMUST00000109299; ENSMUSP00000104922; ENSMUSG00000017664.
ENSMUST00000109300; ENSMUSP00000104923; ENSMUSG00000017664.
GeneIDi228875.
KEGGimmu:228875.
UCSCiuc008nxd.2. mouse.

Organism-specific databases

CTDi51006.
MGIiMGI:2385166. Slc35c2.

Phylogenomic databases

eggNOGiKOG1443. Eukaryota.
COG0697. LUCA.
GeneTreeiENSGT00510000048078.
HOGENOMiHOG000007454.
HOVERGENiHBG055852.
InParanoidiQ8VCX2.
KOiK15280.
OMAiRMGRWAL.
OrthoDBiEOG091G09SR.
PhylomeDBiQ8VCX2.
TreeFamiTF314994.

Miscellaneous databases

ChiTaRSiSlc35c2. mouse.
PROiQ8VCX2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017664.
CleanExiMM_SLC35C2.
ExpressionAtlasiQ8VCX2. baseline and differential.
GenevisibleiQ8VCX2. MM.

Family and domain databases

InterProiIPR004853. Sugar_P_trans_dom.
[Graphical view]
PfamiPF03151. TPT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS35C2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.