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Protein

Acyl-CoA synthetase family member 2, mitochondrial

Gene

Acsf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei493ATPBy similarity1
Binding sitei508ATPBy similarity1
Binding sitei599ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi263 – 271ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase family member 2, mitochondrial (EC:6.2.1.-)
Gene namesi
Name:Acsf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2388287 Acsf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000031579542 – 615Acyl-CoA synthetase family member 2, mitochondrialAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179N6-acetyllysineCombined sources1
Modified residuei182N6-acetyllysine; alternateCombined sources1
Modified residuei182N6-succinyllysine; alternateCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei340N6-acetyllysineCombined sources1
Modified residuei398N6-acetyllysineCombined sources1
Modified residuei478N6-succinyllysineCombined sources1
Modified residuei510N6-acetyllysineCombined sources1
Modified residuei544N6-acetyllysine; alternateCombined sources1
Modified residuei544N6-succinyllysine; alternateCombined sources1
Modified residuei570N6-acetyllysine; alternateCombined sources1
Modified residuei570N6-succinyllysine; alternateCombined sources1
Modified residuei599N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VCW8
MaxQBiQ8VCW8
PaxDbiQ8VCW8
PeptideAtlasiQ8VCW8
PRIDEiQ8VCW8

PTM databases

iPTMnetiQ8VCW8
PhosphoSitePlusiQ8VCW8
SwissPalmiQ8VCW8

Expressioni

Gene expression databases

BgeeiENSMUSG00000076435
CleanExiMM_ACSF2
GenevisibleiQ8VCW8 MM

Interactioni

Protein-protein interaction databases

BioGridi234459, 1 interactor
IntActiQ8VCW8, 3 interactors
MINTiQ8VCW8
STRINGi10090.ENSMUSP00000099453

Structurei

3D structure databases

ProteinModelPortaliQ8VCW8
SMRiQ8VCW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1177 Eukaryota
COG0318 LUCA
GeneTreeiENSGT00760000119304
HOGENOMiHOG000229999
HOVERGENiHBG103408
InParanoidiQ8VCW8
KOiK00666
OMAiEDFFHTH
OrthoDBiEOG091G0XVH
PhylomeDBiQ8VCW8
TreeFamiTF313466

Family and domain databases

InterProiView protein in InterPro
IPR025110 AMP-bd_C
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PF13193 AMP-binding_C, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYHGMLRF GRLCIASLGA RGPRTLLSRP RPNSKLQSVR ALSSGMVNCT
60 70 80 90 100
NPLPIGGLSY IQGHTDSHLV NTTVGECLDA TAQRFPDREA LVILHENIRL
110 120 130 140 150
NFAQLKEEVD KAASGLLSIG LRKGDRLGMW GPNSYAWVLI QLATAQAGII
160 170 180 190 200
LVSVNPAYQS SELEYVLRKV GCKGIVFPKQ FKTQQYYDIL KQVCPELEKA
210 220 230 240 250
QPGALKSERL PDLTTVISVD APLPGTLLLD DIVAAGGKEQ NLAQLRYNQR
260 270 280 290 300
FLSCYDPINI QFTSGTTGNP KGATLSHHNI VNNSMLIGQR LKMPTKTAEE
310 320 330 340 350
LRLVLPSPLY HCLGSVGGTM VSMMHGATLL LSSPSFNGKK ALEAISREKG
360 370 380 390 400
TLLYGTPTMF VDILNQPDFS SYDFTSIRGG VIAGSPAPPE LIRAIINKMN
410 420 430 440 450
MKELVVVYGT TENSPVTFMN FPEDTLEQKA GSVGRIMPHT EAQIVNVETG
460 470 480 490 500
ELTNLNVPGE LYIRGYCVMQ GYWGEPQKTF ETVGQDKWYR TGDIALMDEQ
510 520 530 540 550
GFCKIVGRSK DMIIRGGENI YPAELEDFFL KHPQVQEAQV VGVKDERMGE
560 570 580 590 600
EICACIRLKS GETTTAEEIK AFCKGKISHF KIPRYIVFVE GYPLTISGKI
610
QKFKLREQME QHLKL
Length:615
Mass (Da):67,951
Last modified:March 1, 2002 - v1
Checksum:i84AF2B6FA13D91A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176V → L in BAE32109 (PubMed:19468303).Curated1
Sequence conflicti200A → G in BAE32109 (PubMed:19468303).Curated1
Sequence conflicti231D → Y in BAE32109 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034209 mRNA Translation: BAC28632.1
AK153582 mRNA Translation: BAE32109.1
AK169987 mRNA Translation: BAE41499.1
AL645764, AL645809 Genomic DNA Translation: CAI24962.1
AL645809, AL645764 Genomic DNA Translation: CAI25585.1
BC018371 mRNA Translation: AAH18371.1
BC063269 mRNA Translation: AAH63269.1
CCDSiCCDS25259.1
RefSeqiNP_722502.1, NM_153807.2
UniGeneiMm.386885

Genome annotation databases

EnsembliENSMUST00000103164; ENSMUSP00000099453; ENSMUSG00000076435
GeneIDi264895
KEGGimmu:264895
UCSCiuc007kzc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiACSF2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCW8
Secondary accession number(s): Q3TDU9, Q3U5G9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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