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Protein

Acyl-CoA synthetase family member 2, mitochondrial

Gene

Acsf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei493ATPBy similarity1
Binding sitei508ATPBy similarity1
Binding sitei599ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi263 – 271ATPBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA synthetase family member 2, mitochondrial (EC:6.2.1.-)
Gene namesi
Name:Acsf2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2388287. Acsf2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000031579542 – 615Acyl-CoA synthetase family member 2, mitochondrialAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179N6-acetyllysineCombined sources1
Modified residuei182N6-acetyllysine; alternateCombined sources1
Modified residuei182N6-succinyllysine; alternateCombined sources1
Modified residuei199N6-acetyllysineCombined sources1
Modified residuei340N6-acetyllysineCombined sources1
Modified residuei398N6-acetyllysineCombined sources1
Modified residuei478N6-succinyllysineCombined sources1
Modified residuei510N6-acetyllysineCombined sources1
Modified residuei544N6-acetyllysine; alternateCombined sources1
Modified residuei544N6-succinyllysine; alternateCombined sources1
Modified residuei570N6-acetyllysine; alternateCombined sources1
Modified residuei570N6-succinyllysine; alternateCombined sources1
Modified residuei599N6-succinyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8VCW8.
MaxQBiQ8VCW8.
PaxDbiQ8VCW8.
PeptideAtlasiQ8VCW8.
PRIDEiQ8VCW8.

PTM databases

iPTMnetiQ8VCW8.
PhosphoSitePlusiQ8VCW8.
SwissPalmiQ8VCW8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000076435.
CleanExiMM_ACSF2.
GenevisibleiQ8VCW8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VCW8. 3 interactors.
MINTiMINT-1860401.
STRINGi10090.ENSMUSP00000099453.

Structurei

3D structure databases

ProteinModelPortaliQ8VCW8.
SMRiQ8VCW8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1177. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229999.
HOVERGENiHBG103408.
InParanoidiQ8VCW8.
KOiK00666.
OMAiMYSIPEI.
OrthoDBiEOG091G0XVH.
PhylomeDBiQ8VCW8.
TreeFamiTF313466.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVYHGMLRF GRLCIASLGA RGPRTLLSRP RPNSKLQSVR ALSSGMVNCT
60 70 80 90 100
NPLPIGGLSY IQGHTDSHLV NTTVGECLDA TAQRFPDREA LVILHENIRL
110 120 130 140 150
NFAQLKEEVD KAASGLLSIG LRKGDRLGMW GPNSYAWVLI QLATAQAGII
160 170 180 190 200
LVSVNPAYQS SELEYVLRKV GCKGIVFPKQ FKTQQYYDIL KQVCPELEKA
210 220 230 240 250
QPGALKSERL PDLTTVISVD APLPGTLLLD DIVAAGGKEQ NLAQLRYNQR
260 270 280 290 300
FLSCYDPINI QFTSGTTGNP KGATLSHHNI VNNSMLIGQR LKMPTKTAEE
310 320 330 340 350
LRLVLPSPLY HCLGSVGGTM VSMMHGATLL LSSPSFNGKK ALEAISREKG
360 370 380 390 400
TLLYGTPTMF VDILNQPDFS SYDFTSIRGG VIAGSPAPPE LIRAIINKMN
410 420 430 440 450
MKELVVVYGT TENSPVTFMN FPEDTLEQKA GSVGRIMPHT EAQIVNVETG
460 470 480 490 500
ELTNLNVPGE LYIRGYCVMQ GYWGEPQKTF ETVGQDKWYR TGDIALMDEQ
510 520 530 540 550
GFCKIVGRSK DMIIRGGENI YPAELEDFFL KHPQVQEAQV VGVKDERMGE
560 570 580 590 600
EICACIRLKS GETTTAEEIK AFCKGKISHF KIPRYIVFVE GYPLTISGKI
610
QKFKLREQME QHLKL
Length:615
Mass (Da):67,951
Last modified:March 1, 2002 - v1
Checksum:i84AF2B6FA13D91A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti176V → L in BAE32109 (PubMed:19468303).Curated1
Sequence conflicti200A → G in BAE32109 (PubMed:19468303).Curated1
Sequence conflicti231D → Y in BAE32109 (PubMed:19468303).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034209 mRNA. Translation: BAC28632.1.
AK153582 mRNA. Translation: BAE32109.1.
AK169987 mRNA. Translation: BAE41499.1.
AL645764, AL645809 Genomic DNA. Translation: CAI24962.1.
AL645809, AL645764 Genomic DNA. Translation: CAI25585.1.
BC018371 mRNA. Translation: AAH18371.1.
BC063269 mRNA. Translation: AAH63269.1.
CCDSiCCDS25259.1.
RefSeqiNP_722502.1. NM_153807.2.
UniGeneiMm.386885.

Genome annotation databases

EnsembliENSMUST00000103164; ENSMUSP00000099453; ENSMUSG00000076435.
GeneIDi264895.
KEGGimmu:264895.
UCSCiuc007kzc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK034209 mRNA. Translation: BAC28632.1.
AK153582 mRNA. Translation: BAE32109.1.
AK169987 mRNA. Translation: BAE41499.1.
AL645764, AL645809 Genomic DNA. Translation: CAI24962.1.
AL645809, AL645764 Genomic DNA. Translation: CAI25585.1.
BC018371 mRNA. Translation: AAH18371.1.
BC063269 mRNA. Translation: AAH63269.1.
CCDSiCCDS25259.1.
RefSeqiNP_722502.1. NM_153807.2.
UniGeneiMm.386885.

3D structure databases

ProteinModelPortaliQ8VCW8.
SMRiQ8VCW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCW8. 3 interactors.
MINTiMINT-1860401.
STRINGi10090.ENSMUSP00000099453.

PTM databases

iPTMnetiQ8VCW8.
PhosphoSitePlusiQ8VCW8.
SwissPalmiQ8VCW8.

Proteomic databases

EPDiQ8VCW8.
MaxQBiQ8VCW8.
PaxDbiQ8VCW8.
PeptideAtlasiQ8VCW8.
PRIDEiQ8VCW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103164; ENSMUSP00000099453; ENSMUSG00000076435.
GeneIDi264895.
KEGGimmu:264895.
UCSCiuc007kzc.1. mouse.

Organism-specific databases

CTDi80221.
MGIiMGI:2388287. Acsf2.

Phylogenomic databases

eggNOGiKOG1177. Eukaryota.
COG0318. LUCA.
GeneTreeiENSGT00760000119304.
HOGENOMiHOG000229999.
HOVERGENiHBG103408.
InParanoidiQ8VCW8.
KOiK00666.
OMAiMYSIPEI.
OrthoDBiEOG091G0XVH.
PhylomeDBiQ8VCW8.
TreeFamiTF313466.

Enzyme and pathway databases

ReactomeiR-MMU-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

ChiTaRSiAcsf2. mouse.
PROiQ8VCW8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000076435.
CleanExiMM_ACSF2.
GenevisibleiQ8VCW8. MM.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACSF2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCW8
Secondary accession number(s): Q3TDU9, Q3U5G9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.