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Q8VCU2 (Q8VCU2_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names

Glycosylphosphatidylinositol specific phospholipase D1, isoform CRA_b EMBL EDL32466.1

Phosphatidylinositol-glycan-specific phospholipase D Ensembl ENSMUSP00000021773
Gene names
Name:Gpld1 EMBL AAH19146.1 Ensembl ENSMUSP00000021773 MGI 106604
ORF Names:mCG_3149 EMBL EDL32466.1
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAH19146.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length842 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processGPI anchor release

Inferred from direct assay PubMed 9716655. Source: MGI

cell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

cellular response to calcium ion

Inferred from electronic annotation. Source: Ensembl

cellular response to cholesterol

Inferred from electronic annotation. Source: Ensembl

cellular response to drug

Inferred from electronic annotation. Source: Ensembl

cellular response to pH

Inferred from electronic annotation. Source: Ensembl

cellular response to triglyceride

Inferred from electronic annotation. Source: Ensembl

complement receptor mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

insulin receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytolysis

Inferred from electronic annotation. Source: Ensembl

positive regulation of endothelial cell migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of membrane protein ectodomain proteolysis

Inferred from electronic annotation. Source: Ensembl

regulation of cellular response to insulin stimulus

Inferred from electronic annotation. Source: Ensembl

response to glucose

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

intracellular membrane-bounded organelle

Inferred from electronic annotation. Source: Ensembl

proteinaceous extracellular matrix

Inferred from direct assay PubMed 15946906. Source: MGI

   Molecular_functionglycosylphosphatidylinositol phospholipase D activity

Inferred from electronic annotation. Source: Ensembl

phospholipase D activity

Inferred from direct assay PubMed 9716655. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8VCU2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 2458B409EB550DD2

FASTA84293,624
        10         20         30         40         50         60 
MSAGRLWSSL LLLLPLFCSK SSSCGLSTHV EIGHRALEFL RLQDGRINYK ELILEHQDAY 

        70         80         90        100        110        120 
QAGTVFPDAF YPSICKRGKY HDVSERTHWT PFLNASIHYI RENYPLPWEK DTEKLVAFLF 

       130        140        150        160        170        180 
GITSHMVADV SWHSLGIEQG FLRTMGAIDF YNSYSDAHSA GDFGGDVLSQ FEFNFNYLSR 

       190        200        210        220        230        240 
RWYVPVRDLL RIYDNLYGRK VITKDVLVDC TYLQFLEMHG EMFAVSKLYS TYSTKSPFLV 

       250        260        270        280        290        300 
EQFQDYFLGG LDDMAFWSTN IYRLTSFMLE NGTSDCNLPE NPLFISCDGR NHTLSGSKVQ 

       310        320        330        340        350        360 
KNDFHRNLTM FISRDIRKNL NYTERGVFYS TGSWAPESVT FMYQTLERNL RLMLAGSSQK 

       370        380        390        400        410        420 
NLNHVSSPSA SYTLSVPYAR LGWVMTSADL NQDGHGDLVV GAPGYSHPGR FQIGRVYIIY 

       430        440        450        460        470        480 
GNDLGLPPID LDLDKEAHGI LEGFQPSGRF GSALAVLDFN QDGLPDLAVG APSVGSGQLT 

       490        500        510        520        530        540 
YNGSVYVYYG SQQGRLSSSP NVTISCKDTY CNLGWTLLAT DADGDGRHDL VISSPFAPGG 

       550        560        570        580        590        600 
GKQRGIVATF YSHPRRNDKE LLTLEEADWK VNGEEDFSWF GYSLHGVTVA NRSLLLIGSP 

       610        620        630        640        650        660 
TWKNVSRMAR SSHKKNQEEK SLGKVYGYFL PNRQSTITIS GDKAMGKLGT SLSSGYVRVN 

       670        680        690        700        710        720 
GTLTQVLLVG APTHDDVSKM AFLTMTLHQG GATRMYELAP EKTQPALLST FSGDRRFSRF 

       730        740        750        760        770        780 
GSVLHLTDLD DDGLDEIIMA APLRITDVTS GLLGGEDGRV YIYNGMYTTL GDMTGKCKSW 

       790        800        810        820        830        840 
MTPCPEEKAQ YVLTSPEASS RFGSSLVSVR SKGRNQVVVA AGRSSWGARL SGALHVYSFS 


SD 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL32466.1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N EMBL AAH19146.1.
Tissue: Liver EMBL AAH19146.1.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL32466.1.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000021773.
[5]Pelan S.
Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[6]Ensembl
Submitted (FEB-2012) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000021773.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC019146 mRNA. Translation: AAH19146.1.
AL589699, AL645533 Genomic DNA. Translation: CAI26087.1.
CH466561 Genomic DNA. Translation: EDL32466.1.
RefSeqNP_032182.2. NM_008156.2.
UniGeneMm.291831.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000021773; ENSMUSP00000021773; ENSMUSG00000021340.
GeneID14756.
KEGGmmu:14756.
UCSCuc007pws.1. mouse.

Organism-specific databases

CTD2822.
MGIMGI:106604. Gpld1.

Phylogenomic databases

GeneTreeENSGT00390000013522.
HOVERGENHBG008185.
InParanoidQ8VCU2.
KOK01127.
OMASYSEAHS.
OrthoDBEOG7MD4PC.
TreeFamTF335726.

Gene expression databases

GenevestigatorQ8VCU2.

Family and domain databases

InterProIPR013517. FG-GAP.
IPR001028. Gprt_PLipase_D.
IPR013519. Int_alpha_beta-p.
[Graphical view]
PANTHERPTHR23221:SF2. PTHR23221:SF2. 1 hit.
PfamPF01839. FG-GAP. 2 hits.
[Graphical view]
PRINTSPR00718. PHPHLIPASED.
SMARTSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEPS51470. FG_GAP. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio286823.
SOURCESearch...

Entry information

Entry nameQ8VCU2_MOUSE
AccessionPrimary (citable) accession number: Q8VCU2
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)