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Q8VCU2

- Q8VCU2_MOUSE

UniProt

Q8VCU2 - Q8VCU2_MOUSE

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Protein
Submitted name: Glycosylphosphatidylinositol specific phospholipase D1
Gene
Gpld1, mCG_3149
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glycosylphosphatidylinositol phospholipase D activity Source: Ensembl
  2. phospholipase D activity Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. GPI anchor release Source: MGI
  2. cell migration involved in sprouting angiogenesis Source: Ensembl
  3. cellular response to calcium ion Source: Ensembl
  4. cellular response to cholesterol Source: Ensembl
  5. cellular response to drug Source: Ensembl
  6. cellular response to pH Source: Ensembl
  7. cellular response to triglyceride Source: Ensembl
  8. complement receptor mediated signaling pathway Source: Ensembl
  9. insulin receptor signaling pathway Source: Ensembl
  10. negative regulation of cell proliferation Source: Ensembl
  11. positive regulation of apoptotic process Source: Ensembl
  12. positive regulation of cytolysis Source: Ensembl
  13. positive regulation of endothelial cell migration Source: Ensembl
  14. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
  15. regulation of cellular response to insulin stimulus Source: Ensembl
  16. response to glucose Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Glycosylphosphatidylinositol specific phospholipase D1Imported
Submitted name:
Glycosylphosphatidylinositol specific phospholipase D1, isoform CRA_bImported
Submitted name:
Phosphatidylinositol-glycan-specific phospholipase DImported
Gene namesi
Name:Gpld1Imported
ORF Names:mCG_3149Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:106604. Gpld1.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. lysosomal membrane Source: Ensembl
  3. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8VCU2.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00390000013522.
HOVERGENiHBG008185.
InParanoidiQ8VCU2.
KOiK01127.
OMAiSYSEAHS.
OrthoDBiEOG7MD4PC.
TreeFamiTF335726.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR001028. Gprt_PLipase_D.
IPR013519. Int_alpha_beta-p.
IPR029002. PLPC/GPLD1.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00882. Zn_dep_PLPC. 1 hit.
[Graphical view]
PRINTSiPR00718. PHPHLIPASED.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCU2-1 [UniParc]FASTAAdd to Basket

« Hide

MSAGRLWSSL LLLLPLFCSK SSSCGLSTHV EIGHRALEFL RLQDGRINYK    50
ELILEHQDAY QAGTVFPDAF YPSICKRGKY HDVSERTHWT PFLNASIHYI 100
RENYPLPWEK DTEKLVAFLF GITSHMVADV SWHSLGIEQG FLRTMGAIDF 150
YNSYSDAHSA GDFGGDVLSQ FEFNFNYLSR RWYVPVRDLL RIYDNLYGRK 200
VITKDVLVDC TYLQFLEMHG EMFAVSKLYS TYSTKSPFLV EQFQDYFLGG 250
LDDMAFWSTN IYRLTSFMLE NGTSDCNLPE NPLFISCDGR NHTLSGSKVQ 300
KNDFHRNLTM FISRDIRKNL NYTERGVFYS TGSWAPESVT FMYQTLERNL 350
RLMLAGSSQK NLNHVSSPSA SYTLSVPYAR LGWVMTSADL NQDGHGDLVV 400
GAPGYSHPGR FQIGRVYIIY GNDLGLPPID LDLDKEAHGI LEGFQPSGRF 450
GSALAVLDFN QDGLPDLAVG APSVGSGQLT YNGSVYVYYG SQQGRLSSSP 500
NVTISCKDTY CNLGWTLLAT DADGDGRHDL VISSPFAPGG GKQRGIVATF 550
YSHPRRNDKE LLTLEEADWK VNGEEDFSWF GYSLHGVTVA NRSLLLIGSP 600
TWKNVSRMAR SSHKKNQEEK SLGKVYGYFL PNRQSTITIS GDKAMGKLGT 650
SLSSGYVRVN GTLTQVLLVG APTHDDVSKM AFLTMTLHQG GATRMYELAP 700
EKTQPALLST FSGDRRFSRF GSVLHLTDLD DDGLDEIIMA APLRITDVTS 750
GLLGGEDGRV YIYNGMYTTL GDMTGKCKSW MTPCPEEKAQ YVLTSPEASS 800
RFGSSLVSVR SKGRNQVVVA AGRSSWGARL SGALHVYSFS SD 842
Length:842
Mass (Da):93,624
Last modified:March 1, 2002 - v1
Checksum:i2458B409EB550DD2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC019146 mRNA. Translation: AAH19146.1.
AL589699, AL645533 Genomic DNA. Translation: CAI26087.1.
CH466561 Genomic DNA. Translation: EDL32466.1.
RefSeqiNP_032182.2. NM_008156.2.
UniGeneiMm.291831.

Genome annotation databases

EnsembliENSMUST00000021773; ENSMUSP00000021773; ENSMUSG00000021340.
GeneIDi14756.
KEGGimmu:14756.
UCSCiuc007pws.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC019146 mRNA. Translation: AAH19146.1 .
AL589699 , AL645533 Genomic DNA. Translation: CAI26087.1 .
CH466561 Genomic DNA. Translation: EDL32466.1 .
RefSeqi NP_032182.2. NM_008156.2.
UniGenei Mm.291831.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000021773 ; ENSMUSP00000021773 ; ENSMUSG00000021340 .
GeneIDi 14756.
KEGGi mmu:14756.
UCSCi uc007pws.1. mouse.

Organism-specific databases

CTDi 2822.
MGIi MGI:106604. Gpld1.

Phylogenomic databases

GeneTreei ENSGT00390000013522.
HOVERGENi HBG008185.
InParanoidi Q8VCU2.
KOi K01127.
OMAi SYSEAHS.
OrthoDBi EOG7MD4PC.
TreeFami TF335726.

Miscellaneous databases

NextBioi 286823.
SOURCEi Search...

Gene expression databases

Genevestigatori Q8VCU2.

Family and domain databases

InterProi IPR013517. FG-GAP.
IPR001028. Gprt_PLipase_D.
IPR013519. Int_alpha_beta-p.
IPR029002. PLPC/GPLD1.
[Graphical view ]
Pfami PF01839. FG-GAP. 2 hits.
PF00882. Zn_dep_PLPC. 1 hit.
[Graphical view ]
PRINTSi PR00718. PHPHLIPASED.
SMARTi SM00191. Int_alpha. 5 hits.
[Graphical view ]
PROSITEi PS51470. FG_GAP. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Pelan S.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8VCU2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCU2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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