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Protein
Submitted name:

Glycosylphosphatidylinositol specific phospholipase D1

Gene

Gpld1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. glycosylphosphatidylinositol phospholipase D activity Source: MGI
  2. phospholipase D activity Source: MGI

GO - Biological processi

  1. cell migration involved in sprouting angiogenesis Source: MGI
  2. cellular response to calcium ion Source: MGI
  3. cellular response to cholesterol Source: MGI
  4. cellular response to drug Source: MGI
  5. cellular response to insulin stimulus Source: MGI
  6. cellular response to pH Source: MGI
  7. cellular response to triglyceride Source: MGI
  8. complement receptor mediated signaling pathway Source: MGI
  9. GPI anchor release Source: MGI
  10. insulin receptor signaling pathway Source: MGI
  11. negative regulation of cell proliferation Source: MGI
  12. positive regulation of apoptotic process Source: MGI
  13. positive regulation of cytolysis Source: MGI
  14. positive regulation of endothelial cell migration Source: MGI
  15. positive regulation of membrane protein ectodomain proteolysis Source: MGI
  16. regulation of cellular response to insulin stimulus Source: MGI
  17. response to glucose Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Glycosylphosphatidylinositol specific phospholipase D1Imported
Submitted name:
Glycosylphosphatidylinositol specific phospholipase D1, isoform CRA_bImported
Submitted name:
Phosphatidylinositol-glycan-specific phospholipase DImported
Gene namesi
Name:Gpld1Imported
ORF Names:mCG_3149Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:106604. Gpld1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular space Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. intracellular Source: MGI
  5. intracellular membrane-bounded organelle Source: MGI
  6. lysosomal membrane Source: MGI
  7. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8VCU2.

Family & Domainsi

Keywords - Domaini

RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00390000013522.
HOVERGENiHBG008185.
KOiK01127.
OMAiFHGSYSE.
OrthoDBiEOG7MD4PC.
TreeFamiTF335726.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR001028. Gprt_PLipase_D.
IPR013519. Int_alpha_beta-p.
IPR029002. PLPC/GPLD1.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00882. Zn_dep_PLPC. 1 hit.
[Graphical view]
PRINTSiPR00718. PHPHLIPASED.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCU2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGRLWSSL LLLLPLFCSK SSSCGLSTHV EIGHRALEFL RLQDGRINYK
60 70 80 90 100
ELILEHQDAY QAGTVFPDAF YPSICKRGKY HDVSERTHWT PFLNASIHYI
110 120 130 140 150
RENYPLPWEK DTEKLVAFLF GITSHMVADV SWHSLGIEQG FLRTMGAIDF
160 170 180 190 200
YNSYSDAHSA GDFGGDVLSQ FEFNFNYLSR RWYVPVRDLL RIYDNLYGRK
210 220 230 240 250
VITKDVLVDC TYLQFLEMHG EMFAVSKLYS TYSTKSPFLV EQFQDYFLGG
260 270 280 290 300
LDDMAFWSTN IYRLTSFMLE NGTSDCNLPE NPLFISCDGR NHTLSGSKVQ
310 320 330 340 350
KNDFHRNLTM FISRDIRKNL NYTERGVFYS TGSWAPESVT FMYQTLERNL
360 370 380 390 400
RLMLAGSSQK NLNHVSSPSA SYTLSVPYAR LGWVMTSADL NQDGHGDLVV
410 420 430 440 450
GAPGYSHPGR FQIGRVYIIY GNDLGLPPID LDLDKEAHGI LEGFQPSGRF
460 470 480 490 500
GSALAVLDFN QDGLPDLAVG APSVGSGQLT YNGSVYVYYG SQQGRLSSSP
510 520 530 540 550
NVTISCKDTY CNLGWTLLAT DADGDGRHDL VISSPFAPGG GKQRGIVATF
560 570 580 590 600
YSHPRRNDKE LLTLEEADWK VNGEEDFSWF GYSLHGVTVA NRSLLLIGSP
610 620 630 640 650
TWKNVSRMAR SSHKKNQEEK SLGKVYGYFL PNRQSTITIS GDKAMGKLGT
660 670 680 690 700
SLSSGYVRVN GTLTQVLLVG APTHDDVSKM AFLTMTLHQG GATRMYELAP
710 720 730 740 750
EKTQPALLST FSGDRRFSRF GSVLHLTDLD DDGLDEIIMA APLRITDVTS
760 770 780 790 800
GLLGGEDGRV YIYNGMYTTL GDMTGKCKSW MTPCPEEKAQ YVLTSPEASS
810 820 830 840
RFGSSLVSVR SKGRNQVVVA AGRSSWGARL SGALHVYSFS SD
Length:842
Mass (Da):93,624
Last modified:March 1, 2002 - v1
Checksum:i2458B409EB550DD2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019146 mRNA. Translation: AAH19146.1.
AL589699, AL645533 Genomic DNA. Translation: CAI26087.1.
CH466561 Genomic DNA. Translation: EDL32466.1.
RefSeqiNP_032182.2. NM_008156.2.
UniGeneiMm.291831.

Genome annotation databases

EnsembliENSMUST00000021773; ENSMUSP00000021773; ENSMUSG00000021340.
GeneIDi14756.
KEGGimmu:14756.
UCSCiuc007pws.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019146 mRNA. Translation: AAH19146.1.
AL589699, AL645533 Genomic DNA. Translation: CAI26087.1.
CH466561 Genomic DNA. Translation: EDL32466.1.
RefSeqiNP_032182.2. NM_008156.2.
UniGeneiMm.291831.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021773; ENSMUSP00000021773; ENSMUSG00000021340.
GeneIDi14756.
KEGGimmu:14756.
UCSCiuc007pws.1. mouse.

Organism-specific databases

CTDi2822.
MGIiMGI:106604. Gpld1.

Phylogenomic databases

GeneTreeiENSGT00390000013522.
HOVERGENiHBG008185.
KOiK01127.
OMAiFHGSYSE.
OrthoDBiEOG7MD4PC.
TreeFamiTF335726.

Miscellaneous databases

NextBioi286823.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8VCU2.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR001028. Gprt_PLipase_D.
IPR013519. Int_alpha_beta-p.
IPR029002. PLPC/GPLD1.
[Graphical view]
PfamiPF01839. FG-GAP. 2 hits.
PF00882. Zn_dep_PLPC. 1 hit.
[Graphical view]
PRINTSiPR00718. PHPHLIPASED.
SMARTiSM00191. Int_alpha. 5 hits.
[Graphical view]
PROSITEiPS51470. FG_GAP. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: LiverImported.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Pelan S.
    Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8VCU2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCU2
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: March 4, 2015
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.