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Q8VCU2

- Q8VCU2_MOUSE

UniProt

Q8VCU2 - Q8VCU2_MOUSE

Protein
Submitted name:

Glycosylphosphatidylinositol specific phospholipase D1

Gene

Gpld1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. glycosylphosphatidylinositol phospholipase D activity Source: Ensembl
    2. phospholipase D activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. cell migration involved in sprouting angiogenesis Source: Ensembl
    2. cellular response to calcium ion Source: Ensembl
    3. cellular response to cholesterol Source: Ensembl
    4. cellular response to drug Source: Ensembl
    5. cellular response to pH Source: Ensembl
    6. cellular response to triglyceride Source: Ensembl
    7. complement receptor mediated signaling pathway Source: Ensembl
    8. GPI anchor release Source: MGI
    9. insulin receptor signaling pathway Source: Ensembl
    10. negative regulation of cell proliferation Source: Ensembl
    11. positive regulation of apoptotic process Source: Ensembl
    12. positive regulation of cytolysis Source: Ensembl
    13. positive regulation of endothelial cell migration Source: Ensembl
    14. positive regulation of membrane protein ectodomain proteolysis Source: Ensembl
    15. regulation of cellular response to insulin stimulus Source: Ensembl
    16. response to glucose Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Glycosylphosphatidylinositol specific phospholipase D1Imported
    Submitted name:
    Glycosylphosphatidylinositol specific phospholipase D1, isoform CRA_bImported
    Submitted name:
    Phosphatidylinositol-glycan-specific phospholipase DImported
    Gene namesi
    Name:Gpld1Imported
    ORF Names:mCG_3149Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:106604. Gpld1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. lysosomal membrane Source: Ensembl
    3. proteinaceous extracellular matrix Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ8VCU2.

    Family & Domainsi

    Keywords - Domaini

    RepeatSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000013522.
    HOVERGENiHBG008185.
    InParanoidiQ8VCU2.
    KOiK01127.
    OMAiSYSEAHS.
    OrthoDBiEOG7MD4PC.
    TreeFamiTF335726.

    Family and domain databases

    InterProiIPR013517. FG-GAP.
    IPR001028. Gprt_PLipase_D.
    IPR013519. Int_alpha_beta-p.
    IPR029002. PLPC/GPLD1.
    [Graphical view]
    PfamiPF01839. FG-GAP. 2 hits.
    PF00882. Zn_dep_PLPC. 1 hit.
    [Graphical view]
    PRINTSiPR00718. PHPHLIPASED.
    SMARTiSM00191. Int_alpha. 5 hits.
    [Graphical view]
    PROSITEiPS51470. FG_GAP. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VCU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAGRLWSSL LLLLPLFCSK SSSCGLSTHV EIGHRALEFL RLQDGRINYK    50
    ELILEHQDAY QAGTVFPDAF YPSICKRGKY HDVSERTHWT PFLNASIHYI 100
    RENYPLPWEK DTEKLVAFLF GITSHMVADV SWHSLGIEQG FLRTMGAIDF 150
    YNSYSDAHSA GDFGGDVLSQ FEFNFNYLSR RWYVPVRDLL RIYDNLYGRK 200
    VITKDVLVDC TYLQFLEMHG EMFAVSKLYS TYSTKSPFLV EQFQDYFLGG 250
    LDDMAFWSTN IYRLTSFMLE NGTSDCNLPE NPLFISCDGR NHTLSGSKVQ 300
    KNDFHRNLTM FISRDIRKNL NYTERGVFYS TGSWAPESVT FMYQTLERNL 350
    RLMLAGSSQK NLNHVSSPSA SYTLSVPYAR LGWVMTSADL NQDGHGDLVV 400
    GAPGYSHPGR FQIGRVYIIY GNDLGLPPID LDLDKEAHGI LEGFQPSGRF 450
    GSALAVLDFN QDGLPDLAVG APSVGSGQLT YNGSVYVYYG SQQGRLSSSP 500
    NVTISCKDTY CNLGWTLLAT DADGDGRHDL VISSPFAPGG GKQRGIVATF 550
    YSHPRRNDKE LLTLEEADWK VNGEEDFSWF GYSLHGVTVA NRSLLLIGSP 600
    TWKNVSRMAR SSHKKNQEEK SLGKVYGYFL PNRQSTITIS GDKAMGKLGT 650
    SLSSGYVRVN GTLTQVLLVG APTHDDVSKM AFLTMTLHQG GATRMYELAP 700
    EKTQPALLST FSGDRRFSRF GSVLHLTDLD DDGLDEIIMA APLRITDVTS 750
    GLLGGEDGRV YIYNGMYTTL GDMTGKCKSW MTPCPEEKAQ YVLTSPEASS 800
    RFGSSLVSVR SKGRNQVVVA AGRSSWGARL SGALHVYSFS SD 842
    Length:842
    Mass (Da):93,624
    Last modified:March 1, 2002 - v1
    Checksum:i2458B409EB550DD2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019146 mRNA. Translation: AAH19146.1.
    AL589699, AL645533 Genomic DNA. Translation: CAI26087.1.
    CH466561 Genomic DNA. Translation: EDL32466.1.
    RefSeqiNP_032182.2. NM_008156.2.
    UniGeneiMm.291831.

    Genome annotation databases

    EnsembliENSMUST00000021773; ENSMUSP00000021773; ENSMUSG00000021340.
    GeneIDi14756.
    KEGGimmu:14756.
    UCSCiuc007pws.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019146 mRNA. Translation: AAH19146.1 .
    AL589699 , AL645533 Genomic DNA. Translation: CAI26087.1 .
    CH466561 Genomic DNA. Translation: EDL32466.1 .
    RefSeqi NP_032182.2. NM_008156.2.
    UniGenei Mm.291831.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021773 ; ENSMUSP00000021773 ; ENSMUSG00000021340 .
    GeneIDi 14756.
    KEGGi mmu:14756.
    UCSCi uc007pws.1. mouse.

    Organism-specific databases

    CTDi 2822.
    MGIi MGI:106604. Gpld1.

    Phylogenomic databases

    GeneTreei ENSGT00390000013522.
    HOVERGENi HBG008185.
    InParanoidi Q8VCU2.
    KOi K01127.
    OMAi SYSEAHS.
    OrthoDBi EOG7MD4PC.
    TreeFami TF335726.

    Miscellaneous databases

    NextBioi 286823.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8VCU2.

    Family and domain databases

    InterProi IPR013517. FG-GAP.
    IPR001028. Gprt_PLipase_D.
    IPR013519. Int_alpha_beta-p.
    IPR029002. PLPC/GPLD1.
    [Graphical view ]
    Pfami PF01839. FG-GAP. 2 hits.
    PF00882. Zn_dep_PLPC. 1 hit.
    [Graphical view ]
    PRINTSi PR00718. PHPHLIPASED.
    SMARTi SM00191. Int_alpha. 5 hits.
    [Graphical view ]
    PROSITEi PS51470. FG_GAP. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: LiverImported.
    3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Pelan S.
      Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8VCU2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VCU2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3