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Q8VCT9

- TESK2_MOUSE

UniProt

Q8VCT9 - TESK2_MOUSE

Protein

Dual specificity testis-specific protein kinase 2

Gene

Tesk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity
    Manganese.By similarity

    Enzyme regulationi

    Activated by autophosphorylation on Ser-219.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei87 – 871ATPPROSITE-ProRule annotation
    Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi64 – 729ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
    4. protein serine/threonine kinase activity Source: UniProtKB
    5. protein tyrosine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. actin cytoskeleton organization Source: UniProtKB
    2. focal adhesion assembly Source: UniProtKB
    3. protein phosphorylation Source: UniProtKB
    4. spermatogenesis Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity testis-specific protein kinase 2 (EC:2.7.12.1)
    Alternative name(s):
    Testicular protein kinase 2
    Gene namesi
    Name:Tesk2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:2385204. Tesk2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 570570Dual specificity testis-specific protein kinase 2PRO_0000086750Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei219 – 2191Phosphoserine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8VCT9.
    PRIDEiQ8VCT9.

    PTM databases

    PhosphoSiteiQ8VCT9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8VCT9.
    BgeeiQ8VCT9.
    CleanExiMM_TESK2.
    GenevestigatoriQ8VCT9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8VCT9.
    SMRiQ8VCT9. Positions 62-378.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini58 – 313256Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00530000063025.
    HOGENOMiHOG000231415.
    HOVERGENiHBG058204.
    InParanoidiQ8VCT9.
    KOiK08842.
    OMAiNVLDPYY.
    OrthoDBiEOG7V7664.
    PhylomeDBiQ8VCT9.
    TreeFamiTF318014.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    [Graphical view]
    PRINTSiPR00109. TYRKINASE.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8VCT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF    50
    SRLTSLDDFT REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK 100
    EMQLMNRLSH PNILRFMGVC VHQGQLHALT EYINSGNLEQ LLDSDLYLPW 150
    TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK NCLIKRDENG YSAVVADFGL 200
    AEKIPDASIG REKLAVVGSP FWMAPEVLRD EPYNEKADVF SYGIILCEII 250
    ARIQADPDYL PRTENFGLDY DAFQNMVGDC PSDFLQLTFN CCNMDPKLRP 300
    SFEEIGKTLK EIMSRLPEEE LERDRKLQPT AKGPLEKVPG GKRLSSLDDK 350
    IPHKSPRPRR TIWLSRSQSD IFSHKPPRTV SVLDPYYQPR DGATHTPKVN 400
    PFSARQDLKG GKVKFFDLPS KSVISLVFDL DAPGPGSTTL ADCQEPLAMS 450
    SRRWRSLPGS PEFLHQACPF MGCEESLSDG PPPRLSSLKY GVREIPPFRT 500
    SALSAASGHE AMDCSNPQEE NGFGPRLKGT SLCTGAASEE MEVEEERPRR 550
    ASVYFSISGI SLQTQAKQDG 570
    Length:570
    Mass (Da):63,470
    Last modified:March 1, 2002 - v1
    Checksum:i7B5A48E16655EAD1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019149 mRNA. Translation: AAH19149.1.
    BC029766 mRNA. Translation: AAH29766.1.
    CCDSiCCDS18516.1.
    RefSeqiNP_666263.3. NM_146151.4.
    UniGeneiMm.482431.

    Genome annotation databases

    EnsembliENSMUST00000045542; ENSMUSP00000041009; ENSMUSG00000033985.
    GeneIDi230661.
    KEGGimmu:230661.
    UCSCiuc008uhj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC019149 mRNA. Translation: AAH19149.1 .
    BC029766 mRNA. Translation: AAH29766.1 .
    CCDSi CCDS18516.1.
    RefSeqi NP_666263.3. NM_146151.4.
    UniGenei Mm.482431.

    3D structure databases

    ProteinModelPortali Q8VCT9.
    SMRi Q8VCT9. Positions 62-378.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8VCT9.

    Proteomic databases

    PaxDbi Q8VCT9.
    PRIDEi Q8VCT9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000045542 ; ENSMUSP00000041009 ; ENSMUSG00000033985 .
    GeneIDi 230661.
    KEGGi mmu:230661.
    UCSCi uc008uhj.2. mouse.

    Organism-specific databases

    CTDi 10420.
    MGIi MGI:2385204. Tesk2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00530000063025.
    HOGENOMi HOG000231415.
    HOVERGENi HBG058204.
    InParanoidi Q8VCT9.
    KOi K08842.
    OMAi NVLDPYY.
    OrthoDBi EOG7V7664.
    PhylomeDBi Q8VCT9.
    TreeFami TF318014.

    Miscellaneous databases

    NextBioi 380033.
    PROi Q8VCT9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8VCT9.
    Bgeei Q8VCT9.
    CleanExi MM_TESK2.
    Genevestigatori Q8VCT9.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    [Graphical view ]
    PRINTSi PR00109. TYRKINASE.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiTESK2_MOUSE
    AccessioniPrimary (citable) accession number: Q8VCT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 118 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3