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Q8VCT9 (TESK2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity testis-specific protein kinase 2

EC=2.7.12.1
Alternative name(s):
Testicular protein kinase 2
Gene names
Name:Tesk2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Manganese By similarity.

Enzyme regulation

Activated by autophosphorylation on Ser-219 By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Dual specificity testis-specific protein kinase 2
PRO_0000086750

Regions

Domain58 – 313256Protein kinase
Nucleotide binding64 – 729ATP By similarity

Sites

Active site1761Proton acceptor By similarity
Binding site871ATP By similarity

Amino acid modifications

Modified residue2191Phosphoserine; by autocatalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8VCT9 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 7B5A48E16655EAD1

FASTA57063,470
        10         20         30         40         50         60 
MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF SRLTSLDDFT 

        70         80         90        100        110        120 
REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK EMQLMNRLSH PNILRFMGVC 

       130        140        150        160        170        180 
VHQGQLHALT EYINSGNLEQ LLDSDLYLPW TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK 

       190        200        210        220        230        240 
NCLIKRDENG YSAVVADFGL AEKIPDASIG REKLAVVGSP FWMAPEVLRD EPYNEKADVF 

       250        260        270        280        290        300 
SYGIILCEII ARIQADPDYL PRTENFGLDY DAFQNMVGDC PSDFLQLTFN CCNMDPKLRP 

       310        320        330        340        350        360 
SFEEIGKTLK EIMSRLPEEE LERDRKLQPT AKGPLEKVPG GKRLSSLDDK IPHKSPRPRR 

       370        380        390        400        410        420 
TIWLSRSQSD IFSHKPPRTV SVLDPYYQPR DGATHTPKVN PFSARQDLKG GKVKFFDLPS 

       430        440        450        460        470        480 
KSVISLVFDL DAPGPGSTTL ADCQEPLAMS SRRWRSLPGS PEFLHQACPF MGCEESLSDG 

       490        500        510        520        530        540 
PPPRLSSLKY GVREIPPFRT SALSAASGHE AMDCSNPQEE NGFGPRLKGT SLCTGAASEE 

       550        560        570 
MEVEEERPRR ASVYFSISGI SLQTQAKQDG 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC019149 mRNA. Translation: AAH19149.1.
BC029766 mRNA. Translation: AAH29766.1.
CCDSCCDS18516.1.
RefSeqNP_666263.3. NM_146151.4.
UniGeneMm.482431.

3D structure databases

ProteinModelPortalQ8VCT9.
SMRQ8VCT9. Positions 62-378.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8VCT9.

Proteomic databases

PaxDbQ8VCT9.
PRIDEQ8VCT9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000045542; ENSMUSP00000041009; ENSMUSG00000033985.
GeneID230661.
KEGGmmu:230661.
UCSCuc008uhj.2. mouse.

Organism-specific databases

CTD10420.
MGIMGI:2385204. Tesk2.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00530000063025.
HOGENOMHOG000231415.
HOVERGENHBG058204.
InParanoidQ8VCT9.
KOK08842.
OMANVLDPYY.
OrthoDBEOG7V7664.
PhylomeDBQ8VCT9.
TreeFamTF318014.

Gene expression databases

ArrayExpressQ8VCT9.
BgeeQ8VCT9.
CleanExMM_TESK2.
GenevestigatorQ8VCT9.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSPR00109. TYRKINASE.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio380033.
PROQ8VCT9.
SOURCESearch...

Entry information

Entry nameTESK2_MOUSE
AccessionPrimary (citable) accession number: Q8VCT9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot