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Protein

Dual specificity testis-specific protein kinase 2

Gene

Tesk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:

Enzyme regulationi

Activated by autophosphorylation on Ser-219.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87ATPPROSITE-ProRule annotation1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 72ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity testis-specific protein kinase 2 (EC:2.7.12.1)
Alternative name(s):
Testicular protein kinase 2
Gene namesi
Name:Tesk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385204 Tesk2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867501 – 570Dual specificity testis-specific protein kinase 2Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219Phosphoserine; by autocatalysisBy similarity1
Modified residuei369PhosphoserineBy similarity1
Modified residuei456PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VCT9
PaxDbiQ8VCT9
PRIDEiQ8VCT9

PTM databases

iPTMnetiQ8VCT9
PhosphoSitePlusiQ8VCT9

Expressioni

Gene expression databases

BgeeiENSMUSG00000033985
CleanExiMM_TESK2
ExpressionAtlasiQ8VCT9 baseline and differential
GenevisibleiQ8VCT9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041009

Structurei

3D structure databases

ProteinModelPortaliQ8VCT9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF1S Eukaryota
COG0515 LUCA
GeneTreeiENSGT00530000063025
HOGENOMiHOG000231415
HOVERGENiHBG058204
InParanoidiQ8VCT9
KOiK08842
OMAiNVLDPYY
OrthoDBiEOG091G0HLL
PhylomeDBiQ8VCT9
TreeFamiTF318014

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Q8VCT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF
60 70 80 90 100
SRLTSLDDFT REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK
110 120 130 140 150
EMQLMNRLSH PNILRFMGVC VHQGQLHALT EYINSGNLEQ LLDSDLYLPW
160 170 180 190 200
TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK NCLIKRDENG YSAVVADFGL
210 220 230 240 250
AEKIPDASIG REKLAVVGSP FWMAPEVLRD EPYNEKADVF SYGIILCEII
260 270 280 290 300
ARIQADPDYL PRTENFGLDY DAFQNMVGDC PSDFLQLTFN CCNMDPKLRP
310 320 330 340 350
SFEEIGKTLK EIMSRLPEEE LERDRKLQPT AKGPLEKVPG GKRLSSLDDK
360 370 380 390 400
IPHKSPRPRR TIWLSRSQSD IFSHKPPRTV SVLDPYYQPR DGATHTPKVN
410 420 430 440 450
PFSARQDLKG GKVKFFDLPS KSVISLVFDL DAPGPGSTTL ADCQEPLAMS
460 470 480 490 500
SRRWRSLPGS PEFLHQACPF MGCEESLSDG PPPRLSSLKY GVREIPPFRT
510 520 530 540 550
SALSAASGHE AMDCSNPQEE NGFGPRLKGT SLCTGAASEE MEVEEERPRR
560 570
ASVYFSISGI SLQTQAKQDG
Length:570
Mass (Da):63,470
Last modified:March 1, 2002 - v1
Checksum:i7B5A48E16655EAD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019149 mRNA Translation: AAH19149.1
BC029766 mRNA Translation: AAH29766.1
CCDSiCCDS18516.1
RefSeqiNP_666263.3, NM_146151.4
UniGeneiMm.482431

Genome annotation databases

EnsembliENSMUST00000045542; ENSMUSP00000041009; ENSMUSG00000033985
GeneIDi230661
KEGGimmu:230661
UCSCiuc008uhj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTESK2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health