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Q8VCT9

- TESK2_MOUSE

UniProt

Q8VCT9 - TESK2_MOUSE

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Protein

Dual specificity testis-specific protein kinase 2

Gene

Tesk2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:

Enzyme regulationi

Activated by autophosphorylation on Ser-219.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei87 – 871ATPPROSITE-ProRule annotation
Active sitei176 – 1761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi64 – 729ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine/tyrosine kinase activity Source: UniProtKB-EC
  4. protein serine/threonine kinase activity Source: UniProtKB
  5. protein tyrosine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. actin cytoskeleton organization Source: UniProtKB
  2. focal adhesion assembly Source: UniProtKB
  3. protein phosphorylation Source: UniProtKB
  4. spermatogenesis Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity testis-specific protein kinase 2 (EC:2.7.12.1)
Alternative name(s):
Testicular protein kinase 2
Gene namesi
Name:Tesk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:2385204. Tesk2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 570570Dual specificity testis-specific protein kinase 2PRO_0000086750Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei219 – 2191Phosphoserine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VCT9.
PRIDEiQ8VCT9.

PTM databases

PhosphoSiteiQ8VCT9.

Expressioni

Gene expression databases

BgeeiQ8VCT9.
CleanExiMM_TESK2.
ExpressionAtlasiQ8VCT9. baseline and differential.
GenevestigatoriQ8VCT9.

Structurei

3D structure databases

ProteinModelPortaliQ8VCT9.
SMRiQ8VCT9. Positions 62-378.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 313256Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00530000063025.
HOGENOMiHOG000231415.
HOVERGENiHBG058204.
InParanoidiQ8VCT9.
KOiK08842.
OMAiNVLDPYY.
OrthoDBiEOG7V7664.
PhylomeDBiQ8VCT9.
TreeFamiTF318014.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCT9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF
60 70 80 90 100
SRLTSLDDFT REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK
110 120 130 140 150
EMQLMNRLSH PNILRFMGVC VHQGQLHALT EYINSGNLEQ LLDSDLYLPW
160 170 180 190 200
TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK NCLIKRDENG YSAVVADFGL
210 220 230 240 250
AEKIPDASIG REKLAVVGSP FWMAPEVLRD EPYNEKADVF SYGIILCEII
260 270 280 290 300
ARIQADPDYL PRTENFGLDY DAFQNMVGDC PSDFLQLTFN CCNMDPKLRP
310 320 330 340 350
SFEEIGKTLK EIMSRLPEEE LERDRKLQPT AKGPLEKVPG GKRLSSLDDK
360 370 380 390 400
IPHKSPRPRR TIWLSRSQSD IFSHKPPRTV SVLDPYYQPR DGATHTPKVN
410 420 430 440 450
PFSARQDLKG GKVKFFDLPS KSVISLVFDL DAPGPGSTTL ADCQEPLAMS
460 470 480 490 500
SRRWRSLPGS PEFLHQACPF MGCEESLSDG PPPRLSSLKY GVREIPPFRT
510 520 530 540 550
SALSAASGHE AMDCSNPQEE NGFGPRLKGT SLCTGAASEE MEVEEERPRR
560 570
ASVYFSISGI SLQTQAKQDG
Length:570
Mass (Da):63,470
Last modified:March 1, 2002 - v1
Checksum:i7B5A48E16655EAD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019149 mRNA. Translation: AAH19149.1.
BC029766 mRNA. Translation: AAH29766.1.
CCDSiCCDS18516.1.
RefSeqiNP_666263.3. NM_146151.4.
UniGeneiMm.482431.

Genome annotation databases

EnsembliENSMUST00000045542; ENSMUSP00000041009; ENSMUSG00000033985.
GeneIDi230661.
KEGGimmu:230661.
UCSCiuc008uhj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019149 mRNA. Translation: AAH19149.1 .
BC029766 mRNA. Translation: AAH29766.1 .
CCDSi CCDS18516.1.
RefSeqi NP_666263.3. NM_146151.4.
UniGenei Mm.482431.

3D structure databases

ProteinModelPortali Q8VCT9.
SMRi Q8VCT9. Positions 62-378.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8VCT9.

Proteomic databases

PaxDbi Q8VCT9.
PRIDEi Q8VCT9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000045542 ; ENSMUSP00000041009 ; ENSMUSG00000033985 .
GeneIDi 230661.
KEGGi mmu:230661.
UCSCi uc008uhj.2. mouse.

Organism-specific databases

CTDi 10420.
MGIi MGI:2385204. Tesk2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00530000063025.
HOGENOMi HOG000231415.
HOVERGENi HBG058204.
InParanoidi Q8VCT9.
KOi K08842.
OMAi NVLDPYY.
OrthoDBi EOG7V7664.
PhylomeDBi Q8VCT9.
TreeFami TF318014.

Miscellaneous databases

ChiTaRSi Tesk2. mouse.
NextBioi 380033.
PROi Q8VCT9.
SOURCEi Search...

Gene expression databases

Bgeei Q8VCT9.
CleanExi MM_TESK2.
ExpressionAtlasi Q8VCT9. baseline and differential.
Genevestigatori Q8VCT9.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
[Graphical view ]
PRINTSi PR00109. TYRKINASE.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiTESK2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3