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Protein

Dual specificity testis-specific protein kinase 2

Gene

Tesk2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Phosphorylates cofilin at 'Ser-3'. May play an important role in spermatogenesis (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Protein has several cofactor binding sites:

Enzyme regulationi

Activated by autophosphorylation on Ser-219.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei87ATPPROSITE-ProRule annotation1
Active sitei176Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 72ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity testis-specific protein kinase 2 (EC:2.7.12.1)
Alternative name(s):
Testicular protein kinase 2
Gene namesi
Name:Tesk2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2385204. Tesk2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000867501 – 570Dual specificity testis-specific protein kinase 2Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219Phosphoserine; by autocatalysisBy similarity1
Modified residuei369PhosphoserineBy similarity1
Modified residuei456PhosphoserineCombined sources1
Modified residuei460PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8VCT9.
PRIDEiQ8VCT9.

PTM databases

iPTMnetiQ8VCT9.
PhosphoSitePlusiQ8VCT9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033985.
CleanExiMM_TESK2.
ExpressionAtlasiQ8VCT9. baseline and differential.
GenevisibleiQ8VCT9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041009.

Structurei

3D structure databases

ProteinModelPortaliQ8VCT9.
SMRiQ8VCT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 313Protein kinasePROSITE-ProRule annotationAdd BLAST256

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IF1S. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063025.
HOGENOMiHOG000231415.
HOVERGENiHBG058204.
InParanoidiQ8VCT9.
KOiK08842.
OMAiNVLDPYY.
OrthoDBiEOG091G0HLL.
PhylomeDBiQ8VCT9.
TreeFamiTF318014.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSKRNSIA GFPPRVERLE EFEGGGGGDG NTVQVGRVSS SSYRAIISAF
60 70 80 90 100
SRLTSLDDFT REKIGSGFFS EVFKVRHRAS GQVMALKMNT LSSNRANLLK
110 120 130 140 150
EMQLMNRLSH PNILRFMGVC VHQGQLHALT EYINSGNLEQ LLDSDLYLPW
160 170 180 190 200
TVRVKLAYDI AVGLSYLHFK GIFHRDLTSK NCLIKRDENG YSAVVADFGL
210 220 230 240 250
AEKIPDASIG REKLAVVGSP FWMAPEVLRD EPYNEKADVF SYGIILCEII
260 270 280 290 300
ARIQADPDYL PRTENFGLDY DAFQNMVGDC PSDFLQLTFN CCNMDPKLRP
310 320 330 340 350
SFEEIGKTLK EIMSRLPEEE LERDRKLQPT AKGPLEKVPG GKRLSSLDDK
360 370 380 390 400
IPHKSPRPRR TIWLSRSQSD IFSHKPPRTV SVLDPYYQPR DGATHTPKVN
410 420 430 440 450
PFSARQDLKG GKVKFFDLPS KSVISLVFDL DAPGPGSTTL ADCQEPLAMS
460 470 480 490 500
SRRWRSLPGS PEFLHQACPF MGCEESLSDG PPPRLSSLKY GVREIPPFRT
510 520 530 540 550
SALSAASGHE AMDCSNPQEE NGFGPRLKGT SLCTGAASEE MEVEEERPRR
560 570
ASVYFSISGI SLQTQAKQDG
Length:570
Mass (Da):63,470
Last modified:March 1, 2002 - v1
Checksum:i7B5A48E16655EAD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019149 mRNA. Translation: AAH19149.1.
BC029766 mRNA. Translation: AAH29766.1.
CCDSiCCDS18516.1.
RefSeqiNP_666263.3. NM_146151.4.
UniGeneiMm.482431.

Genome annotation databases

EnsembliENSMUST00000045542; ENSMUSP00000041009; ENSMUSG00000033985.
GeneIDi230661.
KEGGimmu:230661.
UCSCiuc008uhj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019149 mRNA. Translation: AAH19149.1.
BC029766 mRNA. Translation: AAH29766.1.
CCDSiCCDS18516.1.
RefSeqiNP_666263.3. NM_146151.4.
UniGeneiMm.482431.

3D structure databases

ProteinModelPortaliQ8VCT9.
SMRiQ8VCT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000041009.

PTM databases

iPTMnetiQ8VCT9.
PhosphoSitePlusiQ8VCT9.

Proteomic databases

PaxDbiQ8VCT9.
PRIDEiQ8VCT9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045542; ENSMUSP00000041009; ENSMUSG00000033985.
GeneIDi230661.
KEGGimmu:230661.
UCSCiuc008uhj.2. mouse.

Organism-specific databases

CTDi10420.
MGIiMGI:2385204. Tesk2.

Phylogenomic databases

eggNOGiENOG410IF1S. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00530000063025.
HOGENOMiHOG000231415.
HOVERGENiHBG058204.
InParanoidiQ8VCT9.
KOiK08842.
OMAiNVLDPYY.
OrthoDBiEOG091G0HLL.
PhylomeDBiQ8VCT9.
TreeFamiTF318014.

Miscellaneous databases

ChiTaRSiTesk2. mouse.
PROiQ8VCT9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033985.
CleanExiMM_TESK2.
ExpressionAtlasiQ8VCT9. baseline and differential.
GenevisibleiQ8VCT9. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTESK2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.