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Q8VCS0

- PGRP2_MOUSE

UniProt

Q8VCS0 - PGRP2_MOUSE

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Protein
N-acetylmuramoyl-L-alanine amidase
Gene
Pglyrp2, Pglyrpl, Pgrpl
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity.

Catalytic activityi

Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.

Cofactori

Zinc By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi391 – 3911Zinc By similarity
Metal bindingi427 – 4271Zinc By similarity
Metal bindingi502 – 5021Zinc By similarity
Metal bindingi510 – 5101Zinc By similarity

GO - Molecular functioni

  1. N-acetylmuramoyl-L-alanine amidase activity Source: UniProtKB-EC
  2. peptidoglycan binding Source: UniProtKB
  3. peptidoglycan receptor activity Source: UniProtKB
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. defense response to Gram-positive bacterium Source: UniProtKB
  2. detection of bacterium Source: UniProtKB
  3. growth of symbiont in host Source: MGI
  4. negative regulation of interferon-gamma production Source: MGI
  5. negative regulation of natural killer cell differentiation involved in immune response Source: MGI
  6. pattern recognition receptor signaling pathway Source: GOC
  7. peptidoglycan catabolic process Source: InterPro
  8. regulation of inflammatory response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Immunity

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetylmuramoyl-L-alanine amidase (EC:3.5.1.28)
Alternative name(s):
Peptidoglycan recognition protein 2
Peptidoglycan recognition protein long
Short name:
PGRP-L
TagL
Gene namesi
Name:Pglyrp2
Synonyms:Pglyrpl, Pgrpl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1928099. Pglyrp2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 Publication
Add
BLAST
Chaini23 – 530508N-acetylmuramoyl-L-alanine amidase
PRO_0000023921Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi61 – 611N-linked (GlcNAc...) Reviewed prediction
Glycosylationi80 – 801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Modified residuei219 – 2191Phosphoserine By similarity
Glycosylationi335 – 3351N-linked (GlcNAc...)1 Publication
Disulfide bondi399 ↔ 405 By similarity
Glycosylationi465 – 4651N-linked (GlcNAc...) By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8VCS0.
PRIDEiQ8VCS0.

Expressioni

Tissue specificityi

Strongly expressed in liver and fetal liver.

Gene expression databases

ArrayExpressiQ8VCS0.
BgeeiQ8VCS0.
CleanExiMM_PGLYRP2.
GenevestigatoriQ8VCS0.

Structurei

3D structure databases

ProteinModelPortaliQ8VCS0.
SMRiQ8VCS0. Positions 359-525.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG248951.
GeneTreeiENSGT00390000016833.
HOGENOMiHOG000276878.
HOVERGENiHBG053578.
InParanoidiQ8VCS0.
KOiK01446.
OMAiMAFLNGA.
OrthoDBiEOG757CZ5.
PhylomeDBiQ8VCS0.
TreeFamiTF323898.

Family and domain databases

Gene3Di3.40.80.10. 1 hit.
InterProiIPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view]
PANTHERiPTHR11022. PTHR11022. 1 hit.
PfamiPF01510. Amidase_2. 1 hit.
[Graphical view]
SMARTiSM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view]
SUPFAMiSSF55846. SSF55846. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8VCS0-1) [UniParc]FASTAAdd to Basket

Also known as: TagL-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKAWGALWIV LGLLLWPEPG AASSLPLLMD SIIQALAELE QKVPVTEASI    50
TASAWILSAK NSSTHNSLHQ RLLLKAPSHN TTEPDPHSLS PELQALISEV 100
AQHDVQNGRE YGVVLAPDGS TVAVKPLLFG LEAGLQAHSV ANLPSDCLAI 150
PCDTGDTLAN IRATWPGLMD AFPNASSPDV GATLPNDKAK TPTTVDRLLA 200
ITLAGDLGLT FLHRSQTWSP PGLGTEGCWD QLTAPRVFTL LDPQASRLTM 250
AFLNGALDGA LLGNHLSQIP RPHPPLSHLL REYYGAGVNG DPVFRSNFRR 300
QNGAALTSAP TLAQQVWEAL VLLQKLEPEH LQLQNISQEQ LAQVATLATK 350
EFTEAFLGCP AIHPRCRWGA APYRGHPTPL RLPLGFLYVH HTYVPAPPCT 400
TFQSCAADMR SMQRFHQDVR KWDDIGYSFV VGSDGYLYQG RGWHWVGAHT 450
RGYNSRGFGV AFVGNYTGSL PNEAALNTVR DALPSCAIRA GLLRPDYKLL 500
GHRQLVLTHC PGNALFNLLR TWPHFTEVEN 530
Length:530
Mass (Da):57,707
Last modified:March 1, 2002 - v1
Checksum:iD3BF52597CE5D1F9
GO
Isoform 2 (identifier: Q8VCS0-2) [UniParc]FASTAAdd to Basket

Also known as: TagL-beta

The sequence of this isoform differs from the canonical sequence as follows:
     338-366: Missing.

Show »
Length:501
Mass (Da):54,551
Checksum:i83886A94BEA80347
GO
Isoform 3 (identifier: Q8VCS0-3) [UniParc]FASTAAdd to Basket

Also known as: TagL-epsilon

The sequence of this isoform differs from the canonical sequence as follows:
     428-450: SFVVGSDGYLYQGRGWHWVGAHT → RLKTKNSFERPLKIQEVLSLMIL
     451-530: Missing.

Show »
Length:450
Mass (Da):49,063
Checksum:iA5C5E0D48E4287B1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei338 – 36629Missing in isoform 2.
VSP_009081Add
BLAST
Alternative sequencei428 – 45023SFVVG…VGAHT → RLKTKNSFERPLKIQEVLSL MIL in isoform 3.
VSP_009079Add
BLAST
Alternative sequencei451 – 53080Missing in isoform 3.
VSP_009080Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861Missing in AAF22233. 1 Publication
Sequence conflicti486 – 4861Missing in AAF22234. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY282722 mRNA. Translation: AAP22283.1.
AF392055 mRNA. Translation: AAM73674.1.
AF149837 mRNA. Translation: AAF22233.1.
AF149838 mRNA. Translation: AAF22234.1.
BC019396 mRNA. Translation: AAH19396.1.
CCDSiCCDS37557.1. [Q8VCS0-1]
RefSeqiNP_001258405.1. NM_001271476.1. [Q8VCS0-1]
NP_001258407.1. NM_001271478.1. [Q8VCS0-3]
NP_001258408.1. NM_001271479.1.
NP_067294.2. NM_021319.5. [Q8VCS0-1]
XP_006524777.1. XM_006524714.1. [Q8VCS0-3]
UniGeneiMm.86752.

Genome annotation databases

EnsembliENSMUST00000114455; ENSMUSP00000110099; ENSMUSG00000079563. [Q8VCS0-1]
ENSMUST00000170392; ENSMUSP00000129964; ENSMUSG00000079563. [Q8VCS0-1]
GeneIDi57757.
KEGGimmu:57757.
UCSCiuc008bxa.2. mouse. [Q8VCS0-1]
uc008bxc.2. mouse. [Q8VCS0-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY282722 mRNA. Translation: AAP22283.1 .
AF392055 mRNA. Translation: AAM73674.1 .
AF149837 mRNA. Translation: AAF22233.1 .
AF149838 mRNA. Translation: AAF22234.1 .
BC019396 mRNA. Translation: AAH19396.1 .
CCDSi CCDS37557.1. [Q8VCS0-1 ]
RefSeqi NP_001258405.1. NM_001271476.1. [Q8VCS0-1 ]
NP_001258407.1. NM_001271478.1. [Q8VCS0-3 ]
NP_001258408.1. NM_001271479.1.
NP_067294.2. NM_021319.5. [Q8VCS0-1 ]
XP_006524777.1. XM_006524714.1. [Q8VCS0-3 ]
UniGenei Mm.86752.

3D structure databases

ProteinModelPortali Q8VCS0.
SMRi Q8VCS0. Positions 359-525.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8VCS0.
PRIDEi Q8VCS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114455 ; ENSMUSP00000110099 ; ENSMUSG00000079563 . [Q8VCS0-1 ]
ENSMUST00000170392 ; ENSMUSP00000129964 ; ENSMUSG00000079563 . [Q8VCS0-1 ]
GeneIDi 57757.
KEGGi mmu:57757.
UCSCi uc008bxa.2. mouse. [Q8VCS0-1 ]
uc008bxc.2. mouse. [Q8VCS0-3 ]

Organism-specific databases

CTDi 114770.
MGIi MGI:1928099. Pglyrp2.

Phylogenomic databases

eggNOGi NOG248951.
GeneTreei ENSGT00390000016833.
HOGENOMi HOG000276878.
HOVERGENi HBG053578.
InParanoidi Q8VCS0.
KOi K01446.
OMAi MAFLNGA.
OrthoDBi EOG757CZ5.
PhylomeDBi Q8VCS0.
TreeFami TF323898.

Miscellaneous databases

NextBioi 313928.
PROi Q8VCS0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8VCS0.
Bgeei Q8VCS0.
CleanExi MM_PGLYRP2.
Genevestigatori Q8VCS0.

Family and domain databases

Gene3Di 3.40.80.10. 1 hit.
InterProi IPR002502. Amidase_domain.
IPR015510. PGRP.
IPR006619. PGRP_domain_met/bac.
[Graphical view ]
PANTHERi PTHR11022. PTHR11022. 1 hit.
Pfami PF01510. Amidase_2. 1 hit.
[Graphical view ]
SMARTi SM00644. Ami_2. 1 hit.
SM00701. PGRP. 1 hit.
[Graphical view ]
SUPFAMi SSF55846. SSF55846. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A mammalian peptidoglycan recognition protein with N-acetylmuramoyl-L-alanine amidase activity."
    Gelius E., Persson C., Karlsson J., Steiner H.
    Biochem. Biophys. Res. Commun. 306:988-994(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 23-37.
    Strain: C57BL/6J.
  2. "The differentially spliced mouse tagL gene, homolog of tag7/PGRP gene family in mammals and Drosophila, can recognize Gram-positive and Gram-negative bacterial cell wall independently of T phage lysozyme homology domain."
    Kibardin A.V., Mirkina I.I., Baranova E.V., Zakeyeva I.R., Georgiev G.P., Kiselev S.L.
    J. Mol. Biol. 326:467-474(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver.
  4. "Proteome-wide characterization of N-glycosylation events by diagonal chromatography."
    Ghesquiere B., Van Damme J., Martens L., Vandekerckhove J., Gevaert K.
    J. Proteome Res. 5:2438-2447(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-335.
    Strain: C57BL/6.
    Tissue: Plasma.

Entry informationi

Entry nameiPGRP2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCS0
Secondary accession number(s): Q8K4I8, Q9QXZ1, Q9QXZ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi