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Protein

C-type lectin domain family 14 member A

Gene

Clec14a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 14 member A
Gene namesi
Name:Clec14a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1914114. Clec14a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 386ExtracellularSequence analysisAdd BLAST365
Transmembranei387 – 407HelicalSequence analysisAdd BLAST21
Topological domaini408 – 459CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001737822 – 459C-type lectin domain family 14 member AAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi143 ↔ 162PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...)Sequence analysis1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1
Glycosylationi317N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1
Modified residuei440PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ8VCP9.
PaxDbiQ8VCP9.
PeptideAtlasiQ8VCP9.
PRIDEiQ8VCP9.

PTM databases

iPTMnetiQ8VCP9.
PhosphoSitePlusiQ8VCP9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045930.
CleanExiMM_CLEC14A.
GenevisibleiQ8VCP9. MM.

Interactioni

Protein-protein interaction databases

IntActiQ8VCP9. 1 interactor.
MINTiMINT-4091163.
STRINGi10090.ENSMUSP00000054451.

Structurei

3D structure databases

ProteinModelPortaliQ8VCP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 173C-type lectinPROSITE-ProRule annotationAdd BLAST141
Domaini246 – 288EGF-likeAdd BLAST43

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGD4. Eukaryota.
ENOG41119V9. LUCA.
GeneTreeiENSGT00840000130081.
HOGENOMiHOG000111782.
HOVERGENiHBG051004.
InParanoidiQ8VCP9.
KOiK17528.
OMAiCYSLHHA.
OrthoDBiEOG091G0O44.
PhylomeDBiQ8VCP9.
TreeFamiTF330714.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPALALCLL CPAFWPRPGN GEHPTADRAA CSASGACYSL HHATFKRRAA
60 70 80 90 100
EEACSLRGGT LSTVHSGSEF QAVLLLLRAG PGPGGGSKDL LFWVALERSI
110 120 130 140 150
SQCTQEKEPL RGFSWLHPDS EDSEDSPLPW VEEPQRSCTV RKCAALQATR
160 170 180 190 200
GVEPAGWKEM RCHLRTDGYL CKYQFEVLCP APRPGAASNL SFQAPFRLSS
210 220 230 240 250
SALDFSPPGT EVSAMCPGDL SVSSTCIQEE TSAHWDGLFP GTVLCPCSGR
260 270 280 290 300
YLLAGKCVEL PDCLDHLGDF TCECAVGFEL GKDGRSCETK VEEQLTLEGT
310 320 330 340 350
KLPTRNVTAT PAGAVTNRTW PGQVYDKPGE MPQVTEILQW GTQSTLPTIQ
360 370 380 390 400
KTPQTKPKVT GTPSGSVVLN YTSSPPVSLT FDTSSTVVFI LVSIAVIVLV
410 420 430 440 450
VLTITVLGLF KLCFHKSRSS RTGKGALDSP GVECDAEATS LHHSSTQCTD

IGVKSGTVA
Length:459
Mass (Da):49,066
Last modified:September 9, 2003 - v2
Checksum:iA257B38DA598EC8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30A → R in BAB31209 (PubMed:16141072).Curated1
Sequence conflicti44T → P in BAB23370 (PubMed:16141072).Curated1
Sequence conflicti166T → A in AAH19452 (PubMed:15489334).Curated1
Sequence conflicti349I → V in AAH19452 (PubMed:15489334).Curated1
Sequence conflicti384S → C in BAB23370 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004557 mRNA. Translation: BAB23370.2.
AK014681 mRNA. Translation: BAB29502.1.
AK018432 mRNA. Translation: BAB31209.1.
AK033733 mRNA. Translation: BAC28454.1.
AK045596 mRNA. Translation: BAC32430.1.
AK080201 mRNA. Translation: BAC37846.1.
AK164665 mRNA. Translation: BAE37865.1.
BC019452 mRNA. Translation: AAH19452.1.
CCDSiCCDS25930.1.
RefSeqiNP_080085.3. NM_025809.5.
UniGeneiMm.280563.

Genome annotation databases

EnsembliENSMUST00000062254; ENSMUSP00000054451; ENSMUSG00000045930.
GeneIDi66864.
KEGGimmu:66864.
UCSCiuc007npv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004557 mRNA. Translation: BAB23370.2.
AK014681 mRNA. Translation: BAB29502.1.
AK018432 mRNA. Translation: BAB31209.1.
AK033733 mRNA. Translation: BAC28454.1.
AK045596 mRNA. Translation: BAC32430.1.
AK080201 mRNA. Translation: BAC37846.1.
AK164665 mRNA. Translation: BAE37865.1.
BC019452 mRNA. Translation: AAH19452.1.
CCDSiCCDS25930.1.
RefSeqiNP_080085.3. NM_025809.5.
UniGeneiMm.280563.

3D structure databases

ProteinModelPortaliQ8VCP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCP9. 1 interactor.
MINTiMINT-4091163.
STRINGi10090.ENSMUSP00000054451.

PTM databases

iPTMnetiQ8VCP9.
PhosphoSitePlusiQ8VCP9.

Proteomic databases

MaxQBiQ8VCP9.
PaxDbiQ8VCP9.
PeptideAtlasiQ8VCP9.
PRIDEiQ8VCP9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062254; ENSMUSP00000054451; ENSMUSG00000045930.
GeneIDi66864.
KEGGimmu:66864.
UCSCiuc007npv.2. mouse.

Organism-specific databases

CTDi161198.
MGIiMGI:1914114. Clec14a.

Phylogenomic databases

eggNOGiENOG410IGD4. Eukaryota.
ENOG41119V9. LUCA.
GeneTreeiENSGT00840000130081.
HOGENOMiHOG000111782.
HOVERGENiHBG051004.
InParanoidiQ8VCP9.
KOiK17528.
OMAiCYSLHHA.
OrthoDBiEOG091G0O44.
PhylomeDBiQ8VCP9.
TreeFamiTF330714.

Miscellaneous databases

PROiQ8VCP9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045930.
CleanExiMM_CLEC14A.
GenevisibleiQ8VCP9. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC14_MOUSE
AccessioniPrimary (citable) accession number: Q8VCP9
Secondary accession number(s): Q3TP72
, Q9CXA8, Q9D624, Q9DC55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: September 9, 2003
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.