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Protein

Adenylate kinase isoenzyme 6

Gene

Ak6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391AMPUniRule annotation
Binding sitei79 – 791ATPUniRule annotation
Binding sitei105 – 1051ATPUniRule annotation
Binding sitei109 – 1091ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186ATPUniRule annotation
Nucleotide bindingi148 – 1492ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 6UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK6UniRule annotation
Alternative name(s):
Coilin-interacting nuclear ATPase proteinUniRule annotation
Dual activity adenylate kinase/ATPaseUniRule annotation
Short name:
AK/ATPaseUniRule annotation
Gene namesi
Name:Ak6
Synonyms:Cinap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:5510732. Ak6.

Subcellular locationi

  • Nucleusnucleoplasm UniRule annotation
  • NucleusCajal body UniRule annotation

  • Note: Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 172172Adenylate kinase isoenzyme 6PRO_0000153897Add
BLAST

Proteomic databases

EPDiQ8VCP8.
PaxDbiQ8VCP8.
PeptideAtlasiQ8VCP8.
PRIDEiQ8VCP8.

PTM databases

iPTMnetiQ8VCP8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000078941.
ExpressionAtlasiQ8VCP8. baseline and differential.
GenevisibleiQ8VCP8. MM.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with COIL (via C-terminus).UniRule annotation

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022135.

Structurei

3D structure databases

ProteinModelPortaliQ8VCP8.
SMRiQ8VCP8. Positions 1-171.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni33 – 5624NMPbindUniRule annotationAdd
BLAST
Regioni108 – 11811LIDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
GeneTreeiENSGT00390000001626.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
KOiK18532.
OMAiRWKEENI.
PhylomeDBiQ8VCP8.
TreeFamiTF313388.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8VCP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPNILLTG TPGVGKTTLG KELASRSGLK YVNVGDLARE GQLYDGYDEE
60 70 80 90 100
YGCPILDEDR VVDELEHQMQ EGGVIVDYHG CDFFPERWFH IVFVLRTDNG
110 120 130 140 150
VLYKRLETRG YNEKKLQDNI QCEIFQVLYE EAIASYKEEI VHQLPSNEPE
160 170
QLEDNINQIS KWIEQWVKDH NP
Length:172
Mass (Da):19,947
Last modified:March 1, 2002 - v1
Checksum:i55F56E3420103514
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019453 mRNA. Translation: AAH19453.1.
CCDSiCCDS26734.1.
RefSeqiNP_081868.1. NM_027592.3.
UniGeneiMm.301148.

Genome annotation databases

EnsembliENSMUST00000022135; ENSMUSP00000022135; ENSMUSG00000078941.
GeneIDi102216272.
KEGGimmu:102216272.
UCSCiuc007rrg.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019453 mRNA. Translation: AAH19453.1.
CCDSiCCDS26734.1.
RefSeqiNP_081868.1. NM_027592.3.
UniGeneiMm.301148.

3D structure databases

ProteinModelPortaliQ8VCP8.
SMRiQ8VCP8. Positions 1-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022135.

PTM databases

iPTMnetiQ8VCP8.

Proteomic databases

EPDiQ8VCP8.
PaxDbiQ8VCP8.
PeptideAtlasiQ8VCP8.
PRIDEiQ8VCP8.

Protocols and materials databases

DNASUi108143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022135; ENSMUSP00000022135; ENSMUSG00000078941.
GeneIDi102216272.
KEGGimmu:102216272.
UCSCiuc007rrg.3. mouse.

Organism-specific databases

CTDi102157402.
MGIiMGI:5510732. Ak6.

Phylogenomic databases

eggNOGiKOG3347. Eukaryota.
COG1936. LUCA.
GeneTreeiENSGT00390000001626.
HOGENOMiHOG000224472.
HOVERGENiHBG052207.
KOiK18532.
OMAiRWKEENI.
PhylomeDBiQ8VCP8.
TreeFamiTF313388.

Enzyme and pathway databases

ReactomeiR-MMU-674695. RNA Polymerase II Pre-transcription Events.
R-MMU-6804756. Regulation of TP53 Activity through Phosphorylation.
R-MMU-6807505. RNA polymerase II transcribes snRNA genes.
R-MMU-73776. RNA Polymerase II Promoter Escape.
R-MMU-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-MMU-75953. RNA Polymerase II Transcription Initiation.
R-MMU-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiQ8VCP8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000078941.
ExpressionAtlasiQ8VCP8. baseline and differential.
GenevisibleiQ8VCP8. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAD6_MOUSE
AccessioniPrimary (citable) accession number: Q8VCP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

AK6 and TAF9 were initially considered as products of the same gene since they share two exons. However, they are translated from different initiation codons and reading frames and encode unrelated proteins. This arrangement is conserved in some mammalian species.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.