Q8VCP8 (KAD6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenylate kinase isoenzyme 6
Short name=AK6
EC=2.7.4.3

Alternative name(s):
Coilin-interacting nuclear ATPase protein
Dual activity adenylate kinase/ATPase
Short name=AK/ATPase

Gene names

Name:	Taf9
Synonyms:	Ak6, Cinap

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer and homodimer By similarity. Interacts with COIL (via C-terminus).
Subcellular location	Nucleus › nucleoplasm By similarity. Nucleus › Cajal body By similarity. Note: Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells By similarity.
Sequence similarities	Belongs to the adenylate kinase family. AK6 subfamily.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	Cajal body Inferred from sequence or structural similarity. Source: UniProtKB transcription factor TFIID complex Inferred from sequence orthology PubMed 14580349. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from direct assay PubMed 18722179. Source: MGI adenylate kinase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Note: Isoform 1 and isoform 2 are produced by the same gene but are translated from different initiation codons and use different reading frames so they display no identity in their protein sequences. This arrangement is conserved in mammals but these proteins are produced by separate genes in non-mammalian species.

Isoform 1 (identifier: Q8VCP8-1)

Also known as: AK6;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8VI33-1)

Also known as: TAF9;

The sequence of this isoform can be found in the external entry Q8VI33.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Adenylate kinase isoenzyme 6		PRO_0000153897
Regions
	Nucleotide binding	13 – 18	6	ATP By similarity
	Nucleotide binding	148 – 149	2	ATP By similarity
	Region	33 – 56	24	NMPbind By similarity
	Region	108 – 118	11	LID By similarity
Sites
	Binding site	39	1	AMP By similarity
	Binding site	79	1	ATP By similarity
	Binding site	105	1	ATP By similarity
	Binding site	109	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (AK6) [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 55F56E3420103514	FASTA	172	19,947
	10 20 30 40 50 60 MKLPNILLTG TPGVGKTTLG KELASRSGLK YVNVGDLARE GQLYDGYDEE YGCPILDEDR 70 80 90 100 110 120 VVDELEHQMQ EGGVIVDYHG CDFFPERWFH IVFVLRTDNG VLYKRLETRG YNEKKLQDNI 130 140 150 160 170 QCEIFQVLYE EAIASYKEEI VHQLPSNEPE QLEDNINQIS KWIEQWVKDH NP
	Isoform 2 (TAF9) [UniParc]. See Q8VI33.		–	–

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Mammary tumor.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC019453 mRNA. Translation: AAH19453.1.
IPI	IPI00122412.
RefSeq	NP_081868.1. NM_027592.2.
UniGene	Mm.301148.
3D structure databases
ProteinModelPortal	Q8VCP8.
SMR	Q8VCP8. Positions 1-171.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000022135.
Proteomic databases
PaxDb	Q8VCP8.
PRIDE	Q8VCP8.
Protocols and materials databases
DNASU	108143.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000022135; ENSMUSP00000022135; ENSMUSG00000078941.
GeneID	108143.
KEGG	mmu:108143.
UCSC	uc007rrg.2. mouse.
Organism-specific databases
CTD	6880.
MGI	MGI:1888697. Taf9.
Phylogenomic databases
eggNOG	COG1936.
GeneTree	ENSGT00390000015930.
HOGENOM	HOG000224472.
HOVERGEN	HBG052207.
InParanoid	Q8VCP8.
KO	K14535.
OMA	FPERLID.
OrthoDB	EOG4X3H2N.
Gene expression databases
Bgee	Q8VCP8.
Genevestigator	Q8VCP8.
GermOnline	ENSMUSG00000052293. Mus musculus.
Family and domain databases
HAMAP	MF_00039. Adenylate_kinase_AK6.
ProtoNet	Search...
Other
NextBio	360144.
SOURCE	Search...

Entry information

Entry name

KAD6_MOUSE

Accession

Primary (citable) accession number: Q8VCP8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2005
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program