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Protein

CD99 antigen

Gene

Cd99

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.2 Publications

GO - Biological processi

  • leukocyte migration Source: Reactome
  • myeloid dendritic cell activation Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen
Alternative name(s):
Paired immunoglobin-like type 2 receptor-ligand
Short name:
PILR-L
CD_antigen: CD99
Gene namesi
Name:Cd99
Synonyms:Pilrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913728. Cd99.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 137ExtracellularSequence analysisAdd BLAST109
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 175CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000022682029 – 175CD99 antigenAdd BLAST147

Proteomic databases

MaxQBiQ8VCN6.
PRIDEiQ8VCN6.

PTM databases

PhosphoSitePlusiQ8VCN6.

Expressioni

Tissue specificityi

Widely expressed with high levels in lung, spleen, thymus, liver and spinal chord. Expressed on leukocytes and endothelial cell contacts. Detected in a wide range of T-cells, including CD4-/CD8- and CD4+/CD8+ thymocytes. Expression is much lower in peripheral T-cells than in thymocytes.2 Publications

Gene expression databases

CleanExiMM_CD99.

Interactioni

Subunit structurei

Homodimer. Interacts with PILRB.2 Publications

Protein-protein interaction databases

IntActiQ8VCN6. 2 interactors.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ8VCN6.
KOiK06520.

Family and domain databases

InterProiView protein in InterPro
IPR022078. CD99L2.
PANTHERiPTHR15076. PTHR15076. 1 hit.
PfamiView protein in Pfam
PF12301. CD99L2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAAMEAAA TVVLALALLG AAARGAASDD FNLGDALEDP NMKPTPKAPT
60 70 80 90 100
PKKPSGGFDL EDALPGGGGG GAGEKPGNRP QPDPKPPRPH GDSGGISDSD
110 120 130 140 150
LADAAGQGGG GAGRRGSGDE GGHGGAGGAE PEGTPQGLVP GVVAAVVAAV
160 170
AGAVSSFVAY QRRRLCFREG GSAPV
Length:175
Mass (Da):16,783
Last modified:March 1, 2002 - v1
Checksum:iA309E6E2494FBFE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100D → G in BAC31754 (PubMed:16141072).Curated1
Sequence conflicti111Missing in AAP91687 (PubMed:15978751).Curated1
Sequence conflicti111Missing in AAP91691 (PubMed:15978751).Curated1
Sequence conflicti111Missing in BAC31754 (PubMed:16141072).Curated1
Sequence conflicti114R → P in AAP91687 (PubMed:15978751).Curated1
Sequence conflicti114R → P in AAP91691 (PubMed:15978751).Curated1
Sequence conflicti128G → R in AAP91687 (PubMed:15978751).Curated1
Sequence conflicti148 – 149AA → PP in BAC31754 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262359 Genomic DNA. Translation: AAP91691.1.
AY262355 mRNA. Translation: AAP91687.1.
AK044051 mRNA. Translation: BAC31754.1.
BC019482 mRNA. Translation: AAH19482.1.
RefSeqiNP_079860.2. NM_025584.2.
UniGeneiMm.423040.

Genome annotation databases

GeneIDi673094.
KEGGimmu:673094.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCD99_MOUSE
AccessioniPrimary (citable) accession number: Q8VCN6
Secondary accession number(s): Q4L299, Q4L2A4, Q8BLN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2002
Last modified: May 10, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families