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Protein

CD99 antigen

Gene

Cd99

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.2 Publications

GO - Biological processi

  • myeloid dendritic cell activation Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen
Alternative name(s):
Paired immunoglobin-like type 2 receptor-ligand
Short name:
PILR-L
CD_antigen: CD99
Gene namesi
Name:Cd99
Synonyms:Pilrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913728 Cd99

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 137ExtracellularSequence analysisAdd BLAST109
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 175CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000022682029 – 175CD99 antigenAdd BLAST147

Proteomic databases

MaxQBiQ8VCN6
PRIDEiQ8VCN6

PTM databases

PhosphoSitePlusiQ8VCN6

Expressioni

Tissue specificityi

Widely expressed with high levels in lung, spleen, thymus, liver and spinal chord. Expressed on leukocytes and endothelial cell contacts. Detected in a wide range of T-cells, including CD4-/CD8- and CD4+/CD8+ thymocytes. Expression is much lower in peripheral T-cells than in thymocytes.2 Publications

Gene expression databases

CleanExiMM_CD99

Interactioni

Subunit structurei

Homodimer. Interacts with PILRB.2 Publications

Protein-protein interaction databases

IntActiQ8VCN6, 2 interactors

Structurei

3D structure databases

SMRiQ8VCN6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ8VCN6
KOiK06520

Family and domain databases

InterProiView protein in InterPro
IPR022078 CD99L2
PANTHERiPTHR15076 PTHR15076, 1 hit
PfamiView protein in Pfam
PF12301 CD99L2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAAMEAAA TVVLALALLG AAARGAASDD FNLGDALEDP NMKPTPKAPT
60 70 80 90 100
PKKPSGGFDL EDALPGGGGG GAGEKPGNRP QPDPKPPRPH GDSGGISDSD
110 120 130 140 150
LADAAGQGGG GAGRRGSGDE GGHGGAGGAE PEGTPQGLVP GVVAAVVAAV
160 170
AGAVSSFVAY QRRRLCFREG GSAPV
Length:175
Mass (Da):16,783
Last modified:March 1, 2002 - v1
Checksum:iA309E6E2494FBFE1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100D → G in BAC31754 (PubMed:16141072).Curated1
Sequence conflicti111Missing in AAP91687 (PubMed:15978751).Curated1
Sequence conflicti111Missing in AAP91691 (PubMed:15978751).Curated1
Sequence conflicti111Missing in BAC31754 (PubMed:16141072).Curated1
Sequence conflicti114R → P in AAP91687 (PubMed:15978751).Curated1
Sequence conflicti114R → P in AAP91691 (PubMed:15978751).Curated1
Sequence conflicti128G → R in AAP91687 (PubMed:15978751).Curated1
Sequence conflicti148 – 149AA → PP in BAC31754 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262359 Genomic DNA Translation: AAP91691.1
AY262355 mRNA Translation: AAP91687.1
AK044051 mRNA Translation: BAC31754.1
BC019482 mRNA Translation: AAH19482.1
RefSeqiNP_079860.2, NM_025584.2
UniGeneiMm.423040

Genome annotation databases

GeneIDi673094
KEGGimmu:673094

Similar proteinsi

Entry informationi

Entry nameiCD99_MOUSE
AccessioniPrimary (citable) accession number: Q8VCN6
Secondary accession number(s): Q4L299, Q4L2A4, Q8BLN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health