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Protein

CD99 antigen

Gene

Cd99

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in T-cell adhesion processes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1.2 Publications

GO - Biological processi

  • myeloid dendritic cell activation Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
CD99 antigen
Alternative name(s):
Paired immunoglobin-like type 2 receptor-ligand
Short name:
PILR-L
CD_antigen: CD99
Gene namesi
Name:Cd99
Synonyms:Pilrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1913728. Cd99.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 137109ExtracellularSequence analysisAdd
BLAST
Transmembranei138 – 15821HelicalSequence analysisAdd
BLAST
Topological domaini159 – 17517CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 175147CD99 antigenPRO_0000226820Add
BLAST

Proteomic databases

MaxQBiQ8VCN6.
PRIDEiQ8VCN6.

PTM databases

PhosphoSiteiQ8VCN6.

Expressioni

Tissue specificityi

Widely expressed with high levels in lung, spleen, thymus, liver and spinal chord. Expressed on leukocytes and endothelial cell contacts. Detected in a wide range of T-cells, including CD4-/CD8- and CD4+/CD8+ thymocytes. Expression is much lower in peripheral T-cells than in thymocytes.2 Publications

Gene expression databases

CleanExiMM_CD99.

Interactioni

Subunit structurei

Homodimer. Interacts with PILRB.2 Publications

Protein-protein interaction databases

IntActiQ8VCN6. 2 interactions.

Family & Domainsi

Sequence similaritiesi

Belongs to the CD99 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ8VCN6.
KOiK06520.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARAAMEAAA TVVLALALLG AAARGAASDD FNLGDALEDP NMKPTPKAPT
60 70 80 90 100
PKKPSGGFDL EDALPGGGGG GAGEKPGNRP QPDPKPPRPH GDSGGISDSD
110 120 130 140 150
LADAAGQGGG GAGRRGSGDE GGHGGAGGAE PEGTPQGLVP GVVAAVVAAV
160 170
AGAVSSFVAY QRRRLCFREG GSAPV
Length:175
Mass (Da):16,783
Last modified:March 1, 2002 - v1
Checksum:iA309E6E2494FBFE1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001D → G in BAC31754 (PubMed:16141072).Curated
Sequence conflicti111 – 1111Missing in AAP91687 (PubMed:15978751).Curated
Sequence conflicti111 – 1111Missing in AAP91691 (PubMed:15978751).Curated
Sequence conflicti111 – 1111Missing in BAC31754 (PubMed:16141072).Curated
Sequence conflicti114 – 1141R → P in AAP91687 (PubMed:15978751).Curated
Sequence conflicti114 – 1141R → P in AAP91691 (PubMed:15978751).Curated
Sequence conflicti128 – 1281G → R in AAP91687 (PubMed:15978751).Curated
Sequence conflicti148 – 1492AA → PP in BAC31754 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262359 Genomic DNA. Translation: AAP91691.1.
AY262355 mRNA. Translation: AAP91687.1.
AK044051 mRNA. Translation: BAC31754.1.
BC019482 mRNA. Translation: AAH19482.1.
RefSeqiNP_079860.2. NM_025584.2.
UniGeneiMm.423040.

Genome annotation databases

GeneIDi673094.
KEGGimmu:673094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262359 Genomic DNA. Translation: AAP91691.1.
AY262355 mRNA. Translation: AAP91687.1.
AK044051 mRNA. Translation: BAC31754.1.
BC019482 mRNA. Translation: AAH19482.1.
RefSeqiNP_079860.2. NM_025584.2.
UniGeneiMm.423040.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCN6. 2 interactions.

PTM databases

PhosphoSiteiQ8VCN6.

Proteomic databases

MaxQBiQ8VCN6.
PRIDEiQ8VCN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi673094.
KEGGimmu:673094.

Organism-specific databases

CTDi4267.
MGIiMGI:1913728. Cd99.

Phylogenomic databases

InParanoidiQ8VCN6.
KOiK06520.

Miscellaneous databases

PROiQ8VCN6.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CD99.

Family and domain databases

InterProiIPR022078. CD99L2.
[Graphical view]
PfamiPF12301. CD99L2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD99_MOUSE
AccessioniPrimary (citable) accession number: Q8VCN6
Secondary accession number(s): Q4L299, Q4L2A4, Q8BLN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.