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Protein

Fibrinogen gamma chain

Gene

Fgg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi343CalciumBy similarity1
Metal bindingi345CalciumBy similarity1
Metal bindingi349Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.
R-MMU-5686938. Regulation of TLR by endogenous ligand.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen gamma chain
Gene namesi
Name:Fgg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95526. Fgg.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi432 – 436Missing : Impairs induction of SELP in activated platelets. 1 Publication5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000000910026 – 436Fibrinogen gamma chainAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi34Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi44Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi48Interchain (with alpha chain)PROSITE-ProRule annotation
Glycosylationi77N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi160Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi164Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi178 ↔ 207PROSITE-ProRule annotation
Disulfide bondi351 ↔ 364PROSITE-ProRule annotation
Cross-linki423Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-431)By similarity
Modified residuei430PhosphoserineBy similarity1
Cross-linki431Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-423)By similarity

Post-translational modificationi

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein

Proteomic databases

MaxQBiQ8VCM7.
PaxDbiQ8VCM7.
PRIDEiQ8VCM7.

2D gel databases

REPRODUCTION-2DPAGEQ8VCM7.

PTM databases

iPTMnetiQ8VCM7.
PhosphoSitePlusiQ8VCM7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033860.
CleanExiMM_FGG.
ExpressionAtlasiQ8VCM7. baseline and differential.
GenevisibleiQ8VCM7. MM.

Interactioni

Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VCM7. 4 interactors.
MINTiMINT-1863605.
STRINGi10090.ENSMUSP00000037018.

Structurei

3D structure databases

ProteinModelPortaliQ8VCM7.
SMRiQ8VCM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 415Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST247

Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.By similarity

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOVERGENiHBG099783.
InParanoidiQ8VCM7.
KOiK03905.
PhylomeDBiQ8VCM7.
TreeFamiTF336658.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
SM01212. Fib_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSLQPPSF LLCCLLLLFS PTGLAYVATR DNCCILDERF GSFCPTTCGI
60 70 80 90 100
ADFLSSYQTD VDNDLRTLED ILFRAENRTT EAKELIKAIQ VYYNPDQPPK
110 120 130 140 150
PGMIDSATQK SKKMVEEIVK YEALLLTHET SIRYLQEIYN SNNQKITNLK
160 170 180 190 200
QKVAQLEAQC QEPCKDSVQI HDTTGKDCQE IANKGAKESG LYFIRPLKAK
210 220 230 240 250
QQFLVYCEID GSGNGWTVLQ KRIDGSLDFK KNWIQYKEGF GHLSPTGTTE
260 270 280 290 300
FWLGNEKIHL ISMQSTIPYA LRIQLKDWNG RTSTADYAMF RVGPESDKYR
310 320 330 340 350
LTYAYFIGGD AGDAFDGYDF GDDPSDKFFT SHNGMQFSTW DNDNDKFEGN
360 370 380 390 400
CAEQDGSGWW MNKCHAGHLN GVYHQGGTYS KSSTTNGFDD GIIWATWKSR
410 420 430
WYSMKETTMK IIPFNRLSIG EGQQHHMGGS KQAGDV
Length:436
Mass (Da):49,391
Last modified:March 1, 2002 - v1
Checksum:iFF45A34B6C92143E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019506 mRNA. Translation: AAH19506.1.
BC019828 mRNA. Translation: AAH19828.1.
AF413206 mRNA. Translation: AAL02226.1.
CCDSiCCDS38462.1.
RefSeqiNP_598623.1. NM_133862.2.
UniGeneiMm.16422.

Genome annotation databases

EnsembliENSMUST00000048486; ENSMUSP00000037018; ENSMUSG00000033860.
GeneIDi99571.
KEGGimmu:99571.
UCSCiuc008ppe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019506 mRNA. Translation: AAH19506.1.
BC019828 mRNA. Translation: AAH19828.1.
AF413206 mRNA. Translation: AAL02226.1.
CCDSiCCDS38462.1.
RefSeqiNP_598623.1. NM_133862.2.
UniGeneiMm.16422.

3D structure databases

ProteinModelPortaliQ8VCM7.
SMRiQ8VCM7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCM7. 4 interactors.
MINTiMINT-1863605.
STRINGi10090.ENSMUSP00000037018.

PTM databases

iPTMnetiQ8VCM7.
PhosphoSitePlusiQ8VCM7.

2D gel databases

REPRODUCTION-2DPAGEQ8VCM7.

Proteomic databases

MaxQBiQ8VCM7.
PaxDbiQ8VCM7.
PRIDEiQ8VCM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048486; ENSMUSP00000037018; ENSMUSG00000033860.
GeneIDi99571.
KEGGimmu:99571.
UCSCiuc008ppe.1. mouse.

Organism-specific databases

CTDi2266.
MGIiMGI:95526. Fgg.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOVERGENiHBG099783.
InParanoidiQ8VCM7.
KOiK03905.
PhylomeDBiQ8VCM7.
TreeFamiTF336658.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.
R-MMU-5686938. Regulation of TLR by endogenous ligand.

Miscellaneous databases

PROiQ8VCM7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033860.
CleanExiMM_FGG.
ExpressionAtlasiQ8VCM7. baseline and differential.
GenevisibleiQ8VCM7. MM.

Family and domain databases

CDDicd00087. FReD. 1 hit.
Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
SM01212. Fib_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFIBG_MOUSE
AccessioniPrimary (citable) accession number: Q8VCM7
Secondary accession number(s): Q8WUR3, Q91ZP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.