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Protein

Fibrinogen gamma chain

Gene

Fgg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi343CalciumBy similarity1
Metal bindingi345CalciumBy similarity1
Metal bindingi349Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation
R-MMU-140875 Common Pathway of Fibrin Clot Formation
R-MMU-216083 Integrin cell surface interactions
R-MMU-354192 Integrin alphaIIb beta3 signaling
R-MMU-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-MMU-372708 p130Cas linkage to MAPK signaling for integrins
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-5674135 MAP2K and MAPK activation
R-MMU-5686938 Regulation of TLR by endogenous ligand
R-MMU-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen gamma chain
Gene namesi
Name:Fgg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95526 Fgg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi432 – 436Missing : Impairs induction of SELP in activated platelets. 1 Publication5

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000000910026 – 436Fibrinogen gamma chainAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi34Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi44Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi48Interchain (with alpha chain)PROSITE-ProRule annotation
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi160Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi164Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi178 ↔ 207PROSITE-ProRule annotation
Disulfide bondi351 ↔ 364PROSITE-ProRule annotation
Cross-linki423Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-431)By similarity
Modified residuei430PhosphoserineBy similarity1
Cross-linki431Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-423)By similarity

Post-translational modificationi

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein

Proteomic databases

MaxQBiQ8VCM7
PaxDbiQ8VCM7
PRIDEiQ8VCM7

2D gel databases

REPRODUCTION-2DPAGEiQ8VCM7

PTM databases

iPTMnetiQ8VCM7
PhosphoSitePlusiQ8VCM7

Expressioni

Gene expression databases

BgeeiENSMUSG00000033860
CleanExiMM_FGG
ExpressionAtlasiQ8VCM7 baseline and differential
GenevisibleiQ8VCM7 MM

Interactioni

Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi221284, 1 interactor
IntActiQ8VCM7, 4 interactors
MINTiQ8VCM7
STRINGi10090.ENSMUSP00000037018

Structurei

3D structure databases

ProteinModelPortaliQ8VCM7
SMRiQ8VCM7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini169 – 415Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST247

Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.By similarity

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOVERGENiHBG099783
InParanoidiQ8VCM7
KOiK03905
PhylomeDBiQ8VCM7
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR012290 Fibrinogen_a/b/g_coil_dom
IPR020837 Fibrinogen_CS
IPR037581 Fibrinogen_gamma
PANTHERiPTHR19143:SF338 PTHR19143:SF338, 1 hit
PfamiView protein in Pfam
PF08702 Fib_alpha, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SM01212 Fib_alpha, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSLQPPSF LLCCLLLLFS PTGLAYVATR DNCCILDERF GSFCPTTCGI
60 70 80 90 100
ADFLSSYQTD VDNDLRTLED ILFRAENRTT EAKELIKAIQ VYYNPDQPPK
110 120 130 140 150
PGMIDSATQK SKKMVEEIVK YEALLLTHET SIRYLQEIYN SNNQKITNLK
160 170 180 190 200
QKVAQLEAQC QEPCKDSVQI HDTTGKDCQE IANKGAKESG LYFIRPLKAK
210 220 230 240 250
QQFLVYCEID GSGNGWTVLQ KRIDGSLDFK KNWIQYKEGF GHLSPTGTTE
260 270 280 290 300
FWLGNEKIHL ISMQSTIPYA LRIQLKDWNG RTSTADYAMF RVGPESDKYR
310 320 330 340 350
LTYAYFIGGD AGDAFDGYDF GDDPSDKFFT SHNGMQFSTW DNDNDKFEGN
360 370 380 390 400
CAEQDGSGWW MNKCHAGHLN GVYHQGGTYS KSSTTNGFDD GIIWATWKSR
410 420 430
WYSMKETTMK IIPFNRLSIG EGQQHHMGGS KQAGDV
Length:436
Mass (Da):49,391
Last modified:March 1, 2002 - v1
Checksum:iFF45A34B6C92143E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019506 mRNA Translation: AAH19506.1
BC019828 mRNA Translation: AAH19828.1
AF413206 mRNA Translation: AAL02226.1
CCDSiCCDS38462.1
RefSeqiNP_598623.1, NM_133862.2
UniGeneiMm.16422

Genome annotation databases

EnsembliENSMUST00000048486; ENSMUSP00000037018; ENSMUSG00000033860
GeneIDi99571
KEGGimmu:99571
UCSCiuc008ppe.1 mouse

Similar proteinsi

Entry informationi

Entry nameiFIBG_MOUSE
AccessioniPrimary (citable) accession number: Q8VCM7
Secondary accession number(s): Q8WUR3, Q91ZP0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health