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Protein

Fibrinogen gamma chain

Gene

Fgg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix (By similarity). Fibrin has a major function in hemostasis as one of the primary components of blood clots (By similarity). In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization (By similarity). Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo (By similarity). Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway (PubMed:19332769). Maternal fibrinogen is essential for successful pregnancy (By similarity). Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage (By similarity). May also facilitate the immune response via both innate and T-cell mediated pathways (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi343 – 3431CalciumBy similarity
Metal bindingi345 – 3451CalciumBy similarity
Metal bindingi349 – 3491Calcium; via carbonyl oxygenBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Blood coagulation, Hemostasis, Immunity, Innate immunity

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen gamma chain
Gene namesi
Name:Fgg
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:95526. Fgg.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi432 – 4365Missing : Impairs induction of SELP in activated platelets. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525By similarityAdd
BLAST
Chaini26 – 436411Fibrinogen gamma chainPRO_0000009100Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi33 – 33Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi34 – 34Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi44 – 44Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi48 – 48Interchain (with alpha chain)PROSITE-ProRule annotation
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi160 – 160Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi164 – 164Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi178 ↔ 207PROSITE-ProRule annotation
Disulfide bondi351 ↔ 364PROSITE-ProRule annotation
Cross-linki423 – 423Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-431)By similarity
Modified residuei430 – 4301PhosphoserineBy similarity
Cross-linki431 – 431Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-423)By similarity

Post-translational modificationi

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein

Proteomic databases

EPDiQ8VCM7.
MaxQBiQ8VCM7.
PaxDbiQ8VCM7.
PRIDEiQ8VCM7.

2D gel databases

REPRODUCTION-2DPAGEQ8VCM7.

PTM databases

iPTMnetiQ8VCM7.
PhosphoSiteiQ8VCM7.

Expressioni

Gene expression databases

BgeeiQ8VCM7.
CleanExiMM_FGG.
ExpressionAtlasiQ8VCM7. baseline and differential.
GenevisibleiQ8VCM7. MM.

Interactioni

Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8VCM7. 4 interactions.
MINTiMINT-1863605.
STRINGi10090.ENSMUSP00000037018.

Structurei

3D structure databases

ProteinModelPortaliQ8VCM7.
SMRiQ8VCM7. Positions 27-420.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 415247Fibrinogen C-terminalPROSITE-ProRule annotationAdd
BLAST

Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.By similarity

Sequence similaritiesi

Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOVERGENiHBG099783.
InParanoidiQ8VCM7.
KOiK03905.
OrthoDBiEOG7X9G60.
PhylomeDBiQ8VCM7.
TreeFamiTF336658.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
SM01212. Fib_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWSLQPPSF LLCCLLLLFS PTGLAYVATR DNCCILDERF GSFCPTTCGI
60 70 80 90 100
ADFLSSYQTD VDNDLRTLED ILFRAENRTT EAKELIKAIQ VYYNPDQPPK
110 120 130 140 150
PGMIDSATQK SKKMVEEIVK YEALLLTHET SIRYLQEIYN SNNQKITNLK
160 170 180 190 200
QKVAQLEAQC QEPCKDSVQI HDTTGKDCQE IANKGAKESG LYFIRPLKAK
210 220 230 240 250
QQFLVYCEID GSGNGWTVLQ KRIDGSLDFK KNWIQYKEGF GHLSPTGTTE
260 270 280 290 300
FWLGNEKIHL ISMQSTIPYA LRIQLKDWNG RTSTADYAMF RVGPESDKYR
310 320 330 340 350
LTYAYFIGGD AGDAFDGYDF GDDPSDKFFT SHNGMQFSTW DNDNDKFEGN
360 370 380 390 400
CAEQDGSGWW MNKCHAGHLN GVYHQGGTYS KSSTTNGFDD GIIWATWKSR
410 420 430
WYSMKETTMK IIPFNRLSIG EGQQHHMGGS KQAGDV
Length:436
Mass (Da):49,391
Last modified:March 1, 2002 - v1
Checksum:iFF45A34B6C92143E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019506 mRNA. Translation: AAH19506.1.
BC019828 mRNA. Translation: AAH19828.1.
AF413206 mRNA. Translation: AAL02226.1.
CCDSiCCDS38462.1.
RefSeqiNP_598623.1. NM_133862.2.
UniGeneiMm.16422.

Genome annotation databases

EnsembliENSMUST00000048486; ENSMUSP00000037018; ENSMUSG00000033860.
GeneIDi99571.
KEGGimmu:99571.
UCSCiuc008ppe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019506 mRNA. Translation: AAH19506.1.
BC019828 mRNA. Translation: AAH19828.1.
AF413206 mRNA. Translation: AAL02226.1.
CCDSiCCDS38462.1.
RefSeqiNP_598623.1. NM_133862.2.
UniGeneiMm.16422.

3D structure databases

ProteinModelPortaliQ8VCM7.
SMRiQ8VCM7. Positions 27-420.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8VCM7. 4 interactions.
MINTiMINT-1863605.
STRINGi10090.ENSMUSP00000037018.

PTM databases

iPTMnetiQ8VCM7.
PhosphoSiteiQ8VCM7.

2D gel databases

REPRODUCTION-2DPAGEQ8VCM7.

Proteomic databases

EPDiQ8VCM7.
MaxQBiQ8VCM7.
PaxDbiQ8VCM7.
PRIDEiQ8VCM7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048486; ENSMUSP00000037018; ENSMUSG00000033860.
GeneIDi99571.
KEGGimmu:99571.
UCSCiuc008ppe.1. mouse.

Organism-specific databases

CTDi2266.
MGIiMGI:95526. Fgg.

Phylogenomic databases

eggNOGiKOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00760000118809.
HOVERGENiHBG099783.
InParanoidiQ8VCM7.
KOiK03905.
OrthoDBiEOG7X9G60.
PhylomeDBiQ8VCM7.
TreeFamiTF336658.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.
R-MMU-140875. Common Pathway of Fibrin Clot Formation.
R-MMU-216083. Integrin cell surface interactions.
R-MMU-354192. Integrin alphaIIb beta3 signaling.
R-MMU-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-MMU-372708. p130Cas linkage to MAPK signaling for integrins.

Miscellaneous databases

PROiQ8VCM7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8VCM7.
CleanExiMM_FGG.
ExpressionAtlasiQ8VCM7. baseline and differential.
GenevisibleiQ8VCM7. MM.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR012290. Fibrinogen_a/b/g_coil_dom.
IPR020837. Fibrinogen_CS.
[Graphical view]
PfamiPF08702. Fib_alpha. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
[Graphical view]
SMARTiSM00186. FBG. 1 hit.
SM01212. Fib_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF56496. SSF56496. 1 hit.
PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
PS51406. FIBRINOGEN_C_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver and Salivary gland.
  2. "Mouse fibrinogen gamma-chain."
    Murakawa M., Freeman M.W.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 170-352.
  3. "Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression."
    Yang H., Lang S., Zhai Z., Li L., Kahr W.H., Chen P., Brkic J., Spring C.M., Flick M.J., Degen J.L., Freedman J., Ni H.
    Blood 114:425-436(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF 432-GLN--VAL-436.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiFIBG_MOUSE
AccessioniPrimary (citable) accession number: Q8VCM7
Secondary accession number(s): Q8WUR3, Q91ZP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.