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Protein

Protein SCO2 homolog, mitochondrial

Gene

Sco2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a copper chaperone, transporting copper to the Cu(A) site on the cytochrome c oxidase subunit II (COX2).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi122 – 1221CopperBy similarity
Metal bindingi126 – 1261CopperBy similarity
Metal bindingi213 – 2131CopperBy similarity

GO - Molecular functioni

GO - Biological processi

  • cellular copper ion homeostasis Source: InterPro
  • copper ion homeostasis Source: MGI
  • copper ion transport Source: InterPro
  • eye development Source: UniProtKB
  • in utero embryonic development Source: MGI
  • muscle system process Source: MGI
  • respiratory chain complex IV assembly Source: MGI
  • respiratory electron transport chain Source: MGI
  • response to activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCO2 homolog, mitochondrial
Gene namesi
Name:Sco2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3818630. Sco2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: InterPro
  • mitochondrion Source: MGI
  • myofibril Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 255Protein SCO2 homolog, mitochondrialPRO_0000354068
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ8VCL2.
MaxQBiQ8VCL2.
PaxDbiQ8VCL2.
PeptideAtlasiQ8VCL2.
PRIDEiQ8VCL2.

PTM databases

PhosphoSiteiQ8VCL2.

Expressioni

Tissue specificityi

Expressed in retina, retinal pigment epithelium, and sclera.1 Publication

Gene expression databases

BgeeiENSMUSG00000091780.
GenevisibleiQ8VCL2. MM.

Interactioni

Subunit structurei

Interacts with COA6.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131943.

Structurei

3D structure databases

ProteinModelPortaliQ8VCL2.
SMRiQ8VCL2. Positions 89-254.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini74 – 248175ThioredoxinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the SCO1/2 family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2792. Eukaryota.
COG1999. LUCA.
GeneTreeiENSGT00390000004323.
HOVERGENiHBG000428.
InParanoidiQ8VCL2.
KOiK07152.
OMAiFTDYYGR.
OrthoDBiEOG091G0DJ5.
PhylomeDBiQ8VCL2.
TreeFamiTF313752.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiPF02630. SCO1-SenC. 1 hit.
[Graphical view]
PIRSFiPIRSF037736. SCO1. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLALGPKAW PKLSQFKPLL RISGGETLHR NSRHWAGQGQ RQGPGLRTRL
60 70 80 90 100
LITALFGAGL GWAWLAARAE KEQWRQQQRT EALRQAAVGQ GDFSLLDHKG
110 120 130 140 150
QPRCKADFRG QWVLMYFGFT HCPDICPDEL EKLVQVVRKL EAEPDLPLVQ
160 170 180 190 200
PVFITVDPER DDVAAMARYV QEFHPRLLGL TGSTEQVAHA SRNYRVYYSA
210 220 230 240 250
GPKDEDQDYI VDHSIAIYLL NPDGLFTDYY GRSRSAEQIV ESIRRHIAAF

HSVLP
Length:255
Mass (Da):28,944
Last modified:March 1, 2002 - v1
Checksum:i4EEB327CA12D89B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019554 mRNA. Translation: AAH19554.1.
CCDSiCCDS49701.1.
RefSeqiNP_001104758.1. NM_001111288.1.
UniGeneiMm.287977.

Genome annotation databases

EnsembliENSMUST00000167643; ENSMUSP00000131943; ENSMUSG00000091780.
GeneIDi100126824.
KEGGimmu:100126824.
UCSCiuc033gwc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019554 mRNA. Translation: AAH19554.1.
CCDSiCCDS49701.1.
RefSeqiNP_001104758.1. NM_001111288.1.
UniGeneiMm.287977.

3D structure databases

ProteinModelPortaliQ8VCL2.
SMRiQ8VCL2. Positions 89-254.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131943.

PTM databases

PhosphoSiteiQ8VCL2.

Proteomic databases

EPDiQ8VCL2.
MaxQBiQ8VCL2.
PaxDbiQ8VCL2.
PeptideAtlasiQ8VCL2.
PRIDEiQ8VCL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000167643; ENSMUSP00000131943; ENSMUSG00000091780.
GeneIDi100126824.
KEGGimmu:100126824.
UCSCiuc033gwc.1. mouse.

Organism-specific databases

CTDi9997.
MGIiMGI:3818630. Sco2.

Phylogenomic databases

eggNOGiKOG2792. Eukaryota.
COG1999. LUCA.
GeneTreeiENSGT00390000004323.
HOVERGENiHBG000428.
InParanoidiQ8VCL2.
KOiK07152.
OMAiFTDYYGR.
OrthoDBiEOG091G0DJ5.
PhylomeDBiQ8VCL2.
TreeFamiTF313752.

Miscellaneous databases

PROiQ8VCL2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000091780.
GenevisibleiQ8VCL2. MM.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR003782. SCO1/SenC.
IPR017276. Synth_of_cyt-c-oxidase_Sco1/2.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR12151. PTHR12151. 1 hit.
PfamiPF02630. SCO1-SenC. 1 hit.
[Graphical view]
PIRSFiPIRSF037736. SCO1. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSCO2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.