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Protein

Protein SCO2 homolog, mitochondrial

Gene

Sco2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi122CopperBy similarity1
Metal bindingi126CopperBy similarity1
Metal bindingi213CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cell redox homeostasis Source: InterPro
  • cellular copper ion homeostasis Source: InterPro
  • copper ion homeostasis Source: MGI
  • copper ion transport Source: InterPro
  • eye development Source: UniProtKB
  • in utero embryonic development Source: MGI
  • mitochondrial respiratory chain complex IV assembly Source: UniProtKB
  • muscle system process Source: MGI
  • respiratory chain complex IV assembly Source: MGI
  • respiratory electron transport chain Source: MGI
  • response to activity Source: MGI

Keywordsi

Molecular functionChaperone
LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SCO2 homolog, mitochondrial
Gene namesi
Name:Sco2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:3818630 Sco2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini42 – 49Mitochondrial matrixBy similarity8
Transmembranei50 – 67HelicalSequence analysisAdd BLAST18
Topological domaini68 – 255Mitochondrial intermembraneBy similarityAdd BLAST188

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 41MitochondrionSequence analysisAdd BLAST41
ChainiPRO_000035406842 – 255Protein SCO2 homolog, mitochondrialAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi122 ↔ 126Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8VCL2
MaxQBiQ8VCL2
PaxDbiQ8VCL2
PeptideAtlasiQ8VCL2
PRIDEiQ8VCL2

PTM databases

PhosphoSitePlusiQ8VCL2

Expressioni

Tissue specificityi

Expressed in retina, retinal pigment epithelium, and sclera.1 Publication

Gene expression databases

BgeeiENSMUSG00000091780
GenevisibleiQ8VCL2 MM

Interactioni

Subunit structurei

Homodimer. Interacts with COA6. Found in a complex with TMEM177, COX20, COA6, MT-CO2/COX2, COX18 and SCO1. Interacts with TMEM177 in a COX20-dependent manner. Interacts with COX20 in a MT-CO2/COX2- and COX18-dependent manner. Interacts with COX16.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131943

Structurei

3D structure databases

ProteinModelPortaliQ8VCL2
SMRiQ8VCL2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 248ThioredoxinPROSITE-ProRule annotationAdd BLAST175

Sequence similaritiesi

Belongs to the SCO1/2 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2792 Eukaryota
COG1999 LUCA
GeneTreeiENSGT00390000004323
HOVERGENiHBG000428
InParanoidiQ8VCL2
KOiK07152
OMAiFTDYYGR
OrthoDBiEOG091G0DJ5
PhylomeDBiQ8VCL2
TreeFamiTF313752

Family and domain databases

CDDicd02968 SCO, 1 hit
InterProiView protein in InterPro
IPR003782 SCO1/SenC
IPR017276 Synth_of_cyt-c-oxidase_Sco1/2
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain
PANTHERiPTHR12151 PTHR12151, 1 hit
PfamiView protein in Pfam
PF02630 SCO1-SenC, 1 hit
PIRSFiPIRSF037736 SCO1, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51352 THIOREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8VCL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLALGPKAW PKLSQFKPLL RISGGETLHR NSRHWAGQGQ RQGPGLRTRL
60 70 80 90 100
LITALFGAGL GWAWLAARAE KEQWRQQQRT EALRQAAVGQ GDFSLLDHKG
110 120 130 140 150
QPRCKADFRG QWVLMYFGFT HCPDICPDEL EKLVQVVRKL EAEPDLPLVQ
160 170 180 190 200
PVFITVDPER DDVAAMARYV QEFHPRLLGL TGSTEQVAHA SRNYRVYYSA
210 220 230 240 250
GPKDEDQDYI VDHSIAIYLL NPDGLFTDYY GRSRSAEQIV ESIRRHIAAF

HSVLP
Length:255
Mass (Da):28,944
Last modified:March 1, 2002 - v1
Checksum:i4EEB327CA12D89B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019554 mRNA Translation: AAH19554.1
CCDSiCCDS49701.1
RefSeqiNP_001104758.1, NM_001111288.1
UniGeneiMm.287977

Genome annotation databases

EnsembliENSMUST00000167643; ENSMUSP00000131943; ENSMUSG00000091780
GeneIDi100126824
KEGGimmu:100126824
UCSCiuc033gwc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSCO2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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