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Protein

Tubulin gamma-2 chain

Gene

Tubg2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi142 – 1487GTPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubulin gamma-2 chain
Alternative name(s):
Gamma-2-tubulin
Gene namesi
Name:Tubg2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2144208. Tubg2.

Subcellular locationi

GO - Cellular componenti

  • centrosome Source: MGI
  • cytoplasmic microtubule Source: MGI
  • gamma-tubulin complex Source: InterPro
  • microtubule Source: MGI
  • pericentriolar material Source: MGI
  • spindle microtubule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi131 – 1311S → A: Weak effect possibly due to low expression of this mutant. 1 Publication
Mutagenesisi131 – 1311S → D: Phosphomimetic mutant that lead to increased centrosome number. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 451451Tubulin gamma-2 chainPRO_0000048469Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei131 – 1311Phosphoserine; by BRSK11 Publication

Post-translational modificationi

Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8VCK3.
PaxDbiQ8VCK3.
PRIDEiQ8VCK3.

2D gel databases

REPRODUCTION-2DPAGEQ8VCK3.

PTM databases

iPTMnetiQ8VCK3.
PhosphoSiteiQ8VCK3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045007.
CleanExiMM_TUBG2.
ExpressionAtlasiQ8VCK3. baseline and differential.
GenevisibleiQ8VCK3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045901.

Structurei

3D structure databases

ProteinModelPortaliQ8VCK3.
SMRiQ8VCK3. Positions 2-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tubulin family.Curated

Phylogenomic databases

eggNOGiKOG1374. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000165714.
HOVERGENiHBG098558.
InParanoidiQ8VCK3.
KOiK10389.
OMAiNRMVSTQ.
OrthoDBiEOG091G08A9.
PhylomeDBiQ8VCK3.
TreeFamiTF300477.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPREIITLQL GQCGNQIGFE FWKQLCAEHG ISPEGIVEEF ATEGTDRKDV
60 70 80 90 100
FFYQADDEHY IPRAVLLDLE PRVIHSILNS SYAKLYNPEN IYLSEHGGGA
110 120 130 140 150
GNNWGRGFSQ GEKIHEDIFD IIDREADGSD SLEGFVLCHS IAGGTGSGLG
160 170 180 190 200
SYLLERLNDR YPKKLVQTYS VFPNQDEMSD VVVQPYNSLL TLKRLTQNAD
210 220 230 240 250
CVVVLDNTAL NRIATDRLHI QNPSFSQINQ LVSTIMSAST TTLRYPGYMN
260 270 280 290 300
NDLIGLIASL IPTPRLHFLM TGYTPLTTDQ SVASVRKTTV LDVMRRLLQP
310 320 330 340 350
KNVMVSTGRD RQTNHCYIAI LNIIQGEVDP TQVHKSLQRI RERKLANFIP
360 370 380 390 400
WGPASIQVAL SRKSPYLPSA HRVSGLMMAN HTSISSLFES SCQQYDKLWK
410 420 430 440 450
RGAFLEQFRK EDIFKDNFEE MHRSREVVQE LIDEYHAATR PDYISWGTQE

Q
Length:451
Mass (Da):51,122
Last modified:March 1, 2002 - v1
Checksum:i1FCC0FF1E04839AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019652 mRNA. Translation: AAH19652.1.
BC051439 mRNA. Translation: AAH51439.1.
CCDSiCCDS25452.1.
RefSeqiNP_598789.1. NM_134028.2.
UniGeneiMm.142348.

Genome annotation databases

EnsembliENSMUST00000043654; ENSMUSP00000045901; ENSMUSG00000045007.
GeneIDi103768.
KEGGimmu:103768.
UCSCiuc007lnm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019652 mRNA. Translation: AAH19652.1.
BC051439 mRNA. Translation: AAH51439.1.
CCDSiCCDS25452.1.
RefSeqiNP_598789.1. NM_134028.2.
UniGeneiMm.142348.

3D structure databases

ProteinModelPortaliQ8VCK3.
SMRiQ8VCK3. Positions 2-446.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045901.

PTM databases

iPTMnetiQ8VCK3.
PhosphoSiteiQ8VCK3.

2D gel databases

REPRODUCTION-2DPAGEQ8VCK3.

Proteomic databases

MaxQBiQ8VCK3.
PaxDbiQ8VCK3.
PRIDEiQ8VCK3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043654; ENSMUSP00000045901; ENSMUSG00000045007.
GeneIDi103768.
KEGGimmu:103768.
UCSCiuc007lnm.2. mouse.

Organism-specific databases

CTDi27175.
MGIiMGI:2144208. Tubg2.

Phylogenomic databases

eggNOGiKOG1374. Eukaryota.
COG5023. LUCA.
GeneTreeiENSGT00530000063251.
HOGENOMiHOG000165714.
HOVERGENiHBG098558.
InParanoidiQ8VCK3.
KOiK10389.
OMAiNRMVSTQ.
OrthoDBiEOG091G08A9.
PhylomeDBiQ8VCK3.
TreeFamiTF300477.

Enzyme and pathway databases

ReactomeiR-MMU-380270. Recruitment of mitotic centrosome proteins and complexes.
R-MMU-380320. Recruitment of NuMA to mitotic centrosomes.

Miscellaneous databases

PROiQ8VCK3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045007.
CleanExiMM_TUBG2.
ExpressionAtlasiQ8VCK3. baseline and differential.
GenevisibleiQ8VCK3. MM.

Family and domain databases

Gene3Di1.10.287.600. 1 hit.
3.30.1330.20. 1 hit.
3.40.50.1440. 1 hit.
InterProiIPR002454. Gamma_tubulin.
IPR008280. Tub_FtsZ_C.
IPR000217. Tubulin.
IPR018316. Tubulin/FtsZ_2-layer-sand-dom.
IPR023123. Tubulin_C.
IPR017975. Tubulin_CS.
IPR003008. Tubulin_FtsZ_GTPase.
[Graphical view]
PANTHERiPTHR11588. PTHR11588. 1 hit.
PfamiPF00091. Tubulin. 1 hit.
PF03953. Tubulin_C. 1 hit.
[Graphical view]
PRINTSiPR01164. GAMMATUBULIN.
PR01161. TUBULIN.
SMARTiSM00864. Tubulin. 1 hit.
SM00865. Tubulin_C. 1 hit.
[Graphical view]
SUPFAMiSSF52490. SSF52490. 1 hit.
SSF55307. SSF55307. 1 hit.
PROSITEiPS00227. TUBULIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBG2_MOUSE
AccessioniPrimary (citable) accession number: Q8VCK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.