Reviewed, UniProtKB/Swiss-Prot Q8VCJ6 (MRGRF_MOUSE)

Names and origin

Protein names

Recommended name:
    Mas-related G-protein coupled receptor member F
      Short name=Mas-related gene F protein

Gene names

Name:	Mrgprf
Synonyms:	Mrgf

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	343 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 343	343	Mas-related G-protein coupled receptor member F		PRO_0000069765
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 66	22	1 Potential
	Topological domain	67 – 82	16	Cytoplasmic Potential
	Transmembrane	83 – 104	22	2 Potential
	Topological domain	105 – 123	19	Extracellular Potential
	Transmembrane	124 – 144	21	3 Potential
	Topological domain	145 – 160	16	Cytoplasmic Potential
	Transmembrane	161 – 181	21	4 Potential
	Topological domain	182 – 198	17	Extracellular Potential
	Transmembrane	199 – 220	22	5 Potential
	Topological domain	221 – 241	21	Cytoplasmic Potential
	Transmembrane	242 – 263	22	6 Potential
	Topological domain	264 – 273	10	Extracellular Potential
	Transmembrane	274 – 294	21	7 Potential
	Topological domain	295 – 343	49	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	4	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8VCJ6-1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 358ED59587C9A317	FASTA	343	38,523
	10 20 30 40 50 60 MAGNCSWEAH STNQNKMCPG MSEARELYSR GFLTIEQIAT LPPPAVTNYI FLLLCLCGLV 70 80 90 100 110 120 GNGLVLWFFG FSIKRTPFSI YFLHLASADG MYLFSKAVIA LLNMGTFLGS FPDYIRRVSR 130 140 150 160 170 180 IVGLCTFFTG VSLLPAISIE RCVSVIFPTW YWRRRPKRLS AGVCALLWML SFLVTSIHNY 190 200 210 220 230 240 FCMFLGHEAP GTVCRNMDIA LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV 250 260 270 280 290 300 VLAIVSVFLV SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ 310 320 330 340 RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.
[2]	"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons." Dong X., Han S.-K., Zylka M.J., Simon M.I., Anderson D.J. Cell 106:619-632(2001) [PubMed: 11551509] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 25-343. Strain: C57BL/6.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC019711 mRNA. Translation: AAH19711.1. AY042211 Genomic DNA. Translation: AAK91802.1.
IPI	IPI00311019.
RefSeq	NP_663354.1.
UniGene	Mm.215151
3D structure databases
SMR	Q8VCJ6. Positions 50-328.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8VCJ6.
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q8VCJ6.
Genome annotation databases
Ensembl	ENSMUST00000033386; ENSMUSP00000033386; ENSMUSG00000031070; Mus musculus. [Genome view]
GeneID	211577.
KEGG	mmu:211577.
UCSC	uc009kqz.1. mouse.
Organism-specific databases
CTD	211577.
MGI	MGI:2384823. Mrgprf.
Phylogenomic databases
HOGENOM	HBG126829.
HOVERGEN	Q8VCJ6.
InParanoid	Q8VCJ6.
OMA	CPLMVLP.
OrthoDB	EOG92C0TX.
PhylomeDB	Q8VCJ6.
Gene expression databases
ArrayExpress	Q8VCJ6.
Bgee	Q8VCJ6.
CleanEx	MM_MRGPRF.
Genevestigator	Q8VCJ6.
GermOnline	ENSMUSG00000031070. Mus musculus.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	373289.
SOURCE	Search...

Entry information

Entry name

MRGRF_MOUSE

Accession

Primary (citable) accession number: Q8VCJ6
Secondary accession number(s): Q91ZB6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	March 1, 2002
Last modified:	January 19, 2010
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)