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Protein

Mas-related G-protein coupled receptor member F

Gene

Mrgprf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor. May bind to a neuropeptide and may regulate nociceptor function and/or development, including the sensation or modulation of pain.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Mas-related G-protein coupled receptor member F
Short name:
Mas-related gene F protein
Gene namesi
Name:Mrgprf
Synonyms:Mrgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2384823. Mrgprf.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44ExtracellularSequence analysisAdd BLAST44
Transmembranei45 – 66Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini67 – 82CytoplasmicSequence analysisAdd BLAST16
Transmembranei83 – 104Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini105 – 123ExtracellularSequence analysisAdd BLAST19
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 160CytoplasmicSequence analysisAdd BLAST16
Transmembranei161 – 181Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini182 – 198ExtracellularSequence analysisAdd BLAST17
Transmembranei199 – 220Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini221 – 241CytoplasmicSequence analysisAdd BLAST21
Transmembranei242 – 263Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini264 – 273ExtracellularSequence analysis10
Transmembranei274 – 294Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini295 – 343CytoplasmicSequence analysisAdd BLAST49

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000697651 – 343Mas-related G-protein coupled receptor member FAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ8VCJ6.
PaxDbiQ8VCJ6.
PRIDEiQ8VCJ6.

PTM databases

PhosphoSitePlusiQ8VCJ6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031070.
CleanExiMM_MRGPRF.
ExpressionAtlasiQ8VCJ6. baseline and differential.
GenevisibleiQ8VCJ6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033386.

Structurei

3D structure databases

ProteinModelPortaliQ8VCJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Mas subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiQ8VCJ6.
KOiK08394.
OMAiGAACRHM.
OrthoDBiEOG091G0EB8.
PhylomeDBiQ8VCJ6.
TreeFamiTF336336.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8VCJ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGNCSWEAH STNQNKMCPG MSEARELYSR GFLTIEQIAT LPPPAVTNYI
60 70 80 90 100
FLLLCLCGLV GNGLVLWFFG FSIKRTPFSI YFLHLASADG MYLFSKAVIA
110 120 130 140 150
LLNMGTFLGS FPDYIRRVSR IVGLCTFFTG VSLLPAISIE RCVSVIFPTW
160 170 180 190 200
YWRRRPKRLS AGVCALLWML SFLVTSIHNY FCMFLGHEAP GTVCRNMDIA
210 220 230 240 250
LGILLFFLFC PLMVLPCLAL ILHVECRARR RQRSAKLNHV VLAIVSVFLV
260 270 280 290 300
SSIYLGIDWF LFWVFQIPAP FPEYVTDLCI CINSSAKPIV YFLAGRDKSQ
310 320 330 340
RLWEPLRVVF QRALRDGAEP GDAASSTPNT VTMEMQCPSG NAS
Length:343
Mass (Da):38,523
Last modified:March 1, 2002 - v1
Checksum:i358ED59587C9A317
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019711 mRNA. Translation: AAH19711.1.
AY042211 Genomic DNA. Translation: AAK91802.1.
CCDSiCCDS22056.1.
RefSeqiNP_663354.1. NM_145379.2.
UniGeneiMm.215151.

Genome annotation databases

EnsembliENSMUST00000033386; ENSMUSP00000033386; ENSMUSG00000031070.
GeneIDi211577.
KEGGimmu:211577.
UCSCiuc009kqz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC019711 mRNA. Translation: AAH19711.1.
AY042211 Genomic DNA. Translation: AAK91802.1.
CCDSiCCDS22056.1.
RefSeqiNP_663354.1. NM_145379.2.
UniGeneiMm.215151.

3D structure databases

ProteinModelPortaliQ8VCJ6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033386.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ8VCJ6.

Proteomic databases

MaxQBiQ8VCJ6.
PaxDbiQ8VCJ6.
PRIDEiQ8VCJ6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033386; ENSMUSP00000033386; ENSMUSG00000031070.
GeneIDi211577.
KEGGimmu:211577.
UCSCiuc009kqz.1. mouse.

Organism-specific databases

CTDi116535.
MGIiMGI:2384823. Mrgprf.

Phylogenomic databases

eggNOGiENOG410IJRZ. Eukaryota.
ENOG4111BJC. LUCA.
GeneTreeiENSGT00550000074531.
HOGENOMiHOG000015412.
HOVERGENiHBG102190.
InParanoidiQ8VCJ6.
KOiK08394.
OMAiGAACRHM.
OrthoDBiEOG091G0EB8.
PhylomeDBiQ8VCJ6.
TreeFamiTF336336.

Miscellaneous databases

PROiQ8VCJ6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031070.
CleanExiMM_MRGPRF.
ExpressionAtlasiQ8VCJ6. baseline and differential.
GenevisibleiQ8VCJ6. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR026228. MRGPCRF.
IPR026234. MRGPCRFAMILY.
[Graphical view]
PANTHERiPTHR11334. PTHR11334. 1 hit.
PTHR11334:SF3. PTHR11334:SF3. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR02112. MRGPCRF.
PR02108. MRGPCRFAMILY.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMRGRF_MOUSE
AccessioniPrimary (citable) accession number: Q8VCJ6
Secondary accession number(s): Q91ZB6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.